Best TWAS P=2.11e-12 · Best GWAS P=8.01e-13 conditioned to 4.08e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SEC22A | 0.23 | 0.24 | lasso | 7 | 0.28 | 1.3e-22 | 6.46 | -5.3 | 1.2e-07 | 0.05 | 0.13 | 0.87 | FALSE |
2 | GTEx | Adipose Visceral Omentum | SEC22A | 0.19 | 0.16 | lasso | 5 | 0.17 | 3.2e-09 | 6.50 | -5.5 | 5.0e-08 | 0.08 | 0.15 | 0.85 | FALSE |
3 | GTEx | Artery Aorta | SEC22A | 0.35 | 0.28 | lasso | 5 | 0.32 | 3.2e-18 | 5.81 | -5.3 | 1.2e-07 | 0.07 | 0.13 | 0.87 | FALSE |
4 | GTEx | Artery Coronary | SEC22A | 0.24 | 0.13 | lasso | 5 | 0.09 | 5.5e-04 | 6.46 | -6.5 | 1.0e-10 | 0.16 | 0.12 | 0.82 | FALSE |
5 | GTEx | Artery Tibial | SEC22A | 0.31 | 0.34 | lasso | 8 | 0.33 | 7.4e-27 | 6.46 | -6.5 | 7.8e-11 | 0.15 | 0.13 | 0.87 | FALSE |
6 | GTEx | Artery Tibial | ADCY5 | 0.17 | 0.03 | lasso | 6 | 0.04 | 8.9e-04 | 5.63 | -6.3 | 3.0e-10 | 0.36 | 0.82 | 0.16 | FALSE |
7 | GTEx | Artery Tibial | RP11-797D24.4 | 0.20 | 0.03 | lasso | 5 | 0.05 | 9.4e-05 | 5.63 | -6.3 | 2.6e-10 | 0.37 | 0.59 | 0.40 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | SEC22A | 0.35 | 0.20 | enet | 31 | 0.26 | 1.9e-07 | 6.45 | -6.3 | 3.4e-10 | 0.17 | 0.14 | 0.82 | FALSE |
9 | GTEx | Brain Cerebellum | SEC22A | 0.25 | 0.16 | enet | 29 | 0.17 | 1.3e-05 | 6.50 | -6.4 | 2.0e-10 | 0.14 | 0.13 | 0.86 | FALSE |
10 | GTEx | Breast Mammary Tissue | SEC22A | 0.34 | 0.30 | lasso | 5 | 0.35 | 1.2e-18 | 6.48 | -5.5 | 4.8e-08 | 0.06 | 0.13 | 0.87 | FALSE |
11 | GTEx | Cells EBV-transformed lymphocytes | SEC22A | 0.37 | 0.29 | lasso | 17 | 0.30 | 1.5e-10 | 6.49 | -6.4 | 2.0e-10 | 0.15 | 0.13 | 0.87 | FALSE |
12 | GTEx | Colon Sigmoid | SEC22A | 0.16 | 0.12 | lasso | 3 | 0.11 | 1.2e-04 | 6.48 | -6.6 | 4.3e-11 | 0.14 | 0.11 | 0.71 | FALSE |
13 | GTEx | Colon Transverse | SEC22A | 0.18 | 0.11 | enet | 19 | 0.14 | 2.8e-07 | 6.48 | -6.5 | 9.1e-11 | 0.18 | 0.14 | 0.86 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | SEC22A | 0.22 | 0.10 | enet | 22 | 0.17 | 8.7e-07 | 6.46 | -5.8 | 5.1e-09 | 0.11 | 0.13 | 0.83 | FALSE |
15 | GTEx | Esophagus Mucosa | SEC22A | 0.22 | 0.31 | lasso | 17 | 0.30 | 1.3e-20 | 6.47 | -6.7 | 2.9e-11 | 0.16 | 0.13 | 0.87 | FALSE |
16 | GTEx | Esophagus Muscularis | SEC22A | 0.25 | 0.21 | lasso | 6 | 0.17 | 9.6e-11 | 6.48 | -6.3 | 2.3e-10 | 0.11 | 0.13 | 0.87 | FALSE |
17 | GTEx | Heart Left Ventricle | SEC22A | 0.11 | 0.09 | lasso | 5 | 0.08 | 7.0e-05 | 6.46 | -6.5 | 1.0e-10 | 0.15 | 0.13 | 0.85 | FALSE |
18 | GTEx | Liver | SEC22A | 0.21 | -0.01 | lasso | 5 | 0.00 | 2.3e-01 | 6.45 | -7.0 | 2.1e-12 | 0.14 | 0.07 | 0.36 | TRUE |
19 | GTEx | Lung | SEC22A | 0.22 | 0.24 | lasso | 4 | 0.26 | 6.8e-20 | 6.50 | -5.6 | 1.9e-08 | 0.08 | 0.13 | 0.87 | FALSE |
20 | GTEx | Lung | RP11-797D24.4 | 0.08 | 0.01 | enet | 10 | 0.03 | 4.1e-03 | 5.73 | -6.7 | 2.7e-11 | 0.50 | 0.24 | 0.45 | FALSE |
21 | GTEx | Muscle Skeletal | SEC22A | 0.09 | 0.04 | lasso | 6 | 0.04 | 5.2e-05 | 6.48 | -5.5 | 2.8e-08 | 0.07 | 0.14 | 0.86 | FALSE |
22 | GTEx | Nerve Tibial | SEC22A | 0.30 | 0.27 | lasso | 11 | 0.30 | 1.1e-21 | 6.46 | -5.6 | 2.5e-08 | 0.06 | 0.13 | 0.87 | FALSE |
23 | GTEx | Ovary | SEC22A | 0.21 | 0.02 | lasso | 12 | 0.02 | 8.2e-02 | 6.46 | -6.5 | 1.0e-10 | 0.14 | 0.09 | 0.50 | FALSE |
24 | GTEx | Pancreas | SEC22A | 0.19 | 0.18 | enet | 41 | 0.20 | 6.8e-09 | 6.46 | -5.5 | 4.8e-08 | 0.16 | 0.13 | 0.87 | FALSE |
25 | GTEx | Prostate | SEC22A | 0.26 | 0.22 | lasso | 3 | 0.19 | 1.5e-05 | 6.45 | -6.3 | 2.1e-10 | 0.16 | 0.12 | 0.71 | FALSE |
26 | GTEx | Skin Not Sun Exposed Suprapubic | SEC22A | 0.17 | 0.23 | enet | 14 | 0.25 | 1.0e-13 | 6.46 | -6.1 | 1.0e-09 | 0.13 | 0.13 | 0.87 | FALSE |
27 | GTEx | Skin Sun Exposed Lower leg | SEC22A | 0.22 | 0.22 | enet | 25 | 0.23 | 3.3e-19 | 6.46 | -6.4 | 1.4e-10 | 0.10 | 0.13 | 0.87 | FALSE |
28 | GTEx | Spleen | SEC22A | 0.33 | 0.27 | lasso | 7 | 0.22 | 2.4e-06 | 6.46 | -6.2 | 7.8e-10 | 0.12 | 0.13 | 0.86 | FALSE |
29 | GTEx | Stomach | SEC22A | 0.14 | 0.07 | enet | 24 | 0.04 | 4.7e-03 | 6.47 | -6.7 | 2.7e-11 | 0.16 | 0.13 | 0.84 | FALSE |
30 | GTEx | Testis | SEC22A | 0.32 | 0.38 | enet | 31 | 0.39 | 2.7e-18 | 6.46 | -5.9 | 3.8e-09 | 0.09 | 0.13 | 0.87 | FALSE |
31 | GTEx | Thyroid | SEC22A | 0.17 | 0.20 | enet | 13 | 0.20 | 3.7e-15 | 6.48 | -6.5 | 6.4e-11 | 0.15 | 0.13 | 0.87 | FALSE |
32 | GTEx | Uterus | SEC22A | 0.33 | 0.17 | lasso | 5 | 0.10 | 3.9e-03 | 6.46 | -6.5 | 7.7e-11 | 0.16 | 0.09 | 0.47 | FALSE |
33 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC22A | 0.01 | 0.01 | blup | 76 | 0.01 | 2.4e-02 | 6.51 | -6.7 | 1.7e-11 | 0.18 | 0.10 | 0.77 | FALSE |
34 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SEC22A | 0.08 | 0.04 | blup | 76 | 0.03 | 1.5e-02 | 5.92 | -5.3 | 1.1e-07 | 0.09 | 0.06 | 0.24 | FALSE |
35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SEC22A | 0.03 | 0.05 | lasso | 2 | 0.03 | 9.3e-05 | 5.88 | -6.3 | 3.7e-10 | 0.19 | 0.20 | 0.74 | FALSE |
36 | The Cancer Genome Atlas | Lung Adenocarcinoma | SEC22A | 0.03 | 0.01 | blup | 76 | 0.02 | 3.1e-03 | 6.46 | -5.4 | 6.7e-08 | 0.06 | 0.12 | 0.79 | FALSE |
37 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SEC22A | 0.02 | 0.00 | blup | 76 | 0.01 | 3.2e-02 | 5.81 | -5.7 | 1.5e-08 | 0.09 | 0.09 | 0.63 | FALSE |
38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEC22A | 0.04 | 0.01 | blup | 76 | 0.04 | 2.1e-05 | -4.56 | -6.8 | 1.1e-11 | 0.27 | 0.14 | 0.82 | FALSE |
39 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SEC22A | 0.07 | 0.02 | blup | 76 | 0.02 | 2.1e-02 | -0.44 | -5.4 | 7.5e-08 | 0.07 | 0.03 | 0.39 | FALSE |
40 | The Cancer Genome Atlas | Thyroid Carcinoma | SEC22A | 0.04 | 0.04 | blup | 76 | 0.03 | 5.1e-04 | 5.62 | -5.8 | 6.4e-09 | 0.10 | 0.19 | 0.75 | FALSE |