Best TWAS P=8.56e-43 · Best GWAS P=3.55e-47 conditioned to 0.00138
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 8.41 | 13.7 | 8.6e-43 | -0.62 | 0.10 | 0.87 | TRUE |
| 7 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -12.76 | 12.8 | 1.6e-37 | -0.84 | 0.11 | 0.41 | TRUE |
| 4 | GTEx | Esophagus Muscularis | IFT122 | 0.17 | 0.00 | enet | 21 | 0.02 | 1.9e-02 | 3.00 | -5.9 | 3.0e-09 | 0.13 | 0.08 | 0.04 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -14.43 | 13.5 | 2.0e-41 | -0.65 | 0.00 | 0.69 | FALSE |
| 6 | METSIM | Adipose | COPG1 | 0.04 | 0.02 | bslmm | 303 | 0.03 | 7.6e-06 | 7.79 | -8.7 | 5.0e-18 | 0.33 | 0.78 | 0.02 | FALSE |
| 5 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 8.11 | 8.1 | 6.6e-16 | -0.15 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | -12.76 | -7.9 | 2.6e-15 | 0.50 | 0.03 | 0.47 | FALSE |
| 1 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | -0.14 | 7.5 | 6.4e-14 | -0.52 | 0.08 | 0.87 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RPL32P3 | 0.42 | 0.01 | enet | 11 | -0.01 | 4.8e-01 | 3.14 | 5.8 | 7.2e-09 | -0.24 | 0.05 | 0.09 | FALSE |