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chr4:47,802,595-53,472,171

Best TWAS P=6e-14 · Best GWAS P=1.37e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SLC10A4	0.09	0.04	lasso	4	0.05	7.5e-03	7.5	7.5	6.0e-14	0.96	0.01	0.87	TRUE
14	GTEx	Ovary	FRYL	0.12	-0.01	enet	21	0.03	7.2e-02	7.0	7.3	2.9e-13	0.96	0.05	0.68	FALSE
10	GTEx	Esophagus Muscularis	OCIAD1	0.12	0.16	lasso	6	0.17	9.1e-11	6.5	-7.1	1.7e-12	-0.91	0.41	0.59	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	FRYL	0.02	0.01	blup	93	0.01	3.6e-02	6.6	7.0	1.7e-12	0.96	0.03	0.72	FALSE
9	GTEx	Esophagus Mucosa	OCIAD1	0.07	0.06	lasso	4	0.06	9.9e-05	7.1	-6.9	6.8e-12	-0.94	0.12	0.88	FALSE
12	GTEx	Nerve Tibial	OCIAD1	0.14	0.04	enet	25	0.03	3.7e-03	7.3	-6.7	2.2e-11	-0.79	0.06	0.94	FALSE
3	GTEx	Artery Tibial	OCIAD1	0.09	0.12	enet	6	0.11	1.1e-08	6.5	-6.5	7.0e-11	-0.90	0.37	0.63	FALSE
2	GTEx	Artery Aorta	OCIAD1	0.09	0.10	lasso	4	0.10	2.4e-06	6.3	-6.4	1.2e-10	-0.92	0.29	0.71	FALSE
18	NTR	Blood	OCIAD1	0.01	0.01	bslmm	207	0.00	1.8e-02	6.4	-6.4	1.2e-10	-0.85	0.30	0.62	FALSE
7	GTEx	Colon Transverse	OCIAD1	0.07	0.07	lasso	5	0.05	2.8e-03	6.5	-6.4	1.4e-10	-0.90	0.14	0.75	FALSE
1	GTEx	Adrenal Gland	OCIAD1	0.10	-0.01	enet	11	0.02	5.5e-02	-6.1	-6.4	1.5e-10	-0.82	0.05	0.67	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC10A4	0.05	0.02	blup	36	0.03	6.3e-03	-5.8	6.3	2.4e-10	0.87	0.04	0.51	FALSE
6	GTEx	Colon Sigmoid	OCIAD1	0.08	0.04	lasso	8	0.02	8.6e-02	7.0	-6.1	1.2e-09	-0.87	0.10	0.49	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC10A4	0.05	0.07	blup	36	0.07	6.0e-08	6.6	6.0	1.5e-09	0.88	0.02	0.97	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC66	0.07	0.03	lasso	3	0.05	8.0e-04	5.7	-5.9	4.6e-09	-0.51	0.01	0.74	FALSE
11	GTEx	Lung	OCIAD1	0.09	0.00	lasso	4	0.00	1.4e-01	-4.9	-5.7	1.0e-08	-0.62	0.05	0.42	FALSE
16	GTEx	Testis	DCUN1D4	0.19	0.17	enet	14	0.16	8.7e-08	5.6	5.6	2.2e-08	0.46	0.08	0.92	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	FRYL	0.03	0.03	enet	8	0.03	3.2e-04	6.0	5.6	2.3e-08	0.88	0.05	0.80	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	OCIAD1	0.08	0.05	enet	16	0.06	8.5e-07	6.5	-5.6	2.3e-08	-0.68	0.04	0.93	FALSE
13	GTEx	Nerve Tibial	DCUN1D4	0.10	0.09	lasso	3	0.10	6.8e-08	5.3	5.6	2.6e-08	0.48	0.10	0.90	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	OCIAD2	0.07	0.01	lasso	4	0.02	8.3e-02	-5.0	-5.4	5.7e-08	-0.75	0.07	0.51	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	FRYL	0.04	0.00	blup	93	0.01	1.6e-02	7.5	5.4	5.9e-08	0.67	0.02	0.57	FALSE
4	GTEx	Brain Cerebellum	OCIAD1	0.10	0.04	lasso	5	0.02	1.1e-01	6.4	-5.4	7.1e-08	-0.82	0.08	0.23	FALSE
5	GTEx	Breast Mammary Tissue (Female)	DCUN1D4	0.02	0.03	lasso	1	0.02	8.2e-02	5.4	5.4	8.0e-08	0.48	0.02	0.13	FALSE
17	GTEx	Thyroid	DCUN1D4	0.03	0.05	lasso	1	0.04	2.4e-04	5.4	5.4	8.0e-08	0.48	0.09	0.81	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	OCIAD1	0.06	0.07	enet	13	0.07	3.8e-09	6.5	-5.2	1.8e-07	-0.78	0.94	0.06	FALSE
15	GTEx	Skin Sun Exposed Lower leg	FRYL	0.05	0.01	enet	19	0.02	8.6e-03	-4.2	5.2	2.5e-07	0.69	0.10	0.73	FALSE