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chr4:37,915,462-40,677,462

Best TWAS P=3.12e-14 · Best GWAS P=1.63e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDS5A	0.05	0.04	lasso	3	0.02	7.6e-04	-5.8	-6.1	8.1e-10	-0.11	0.97	0.00	TRUE
2	GTEx	Adipose Subcutaneous	WDR19	0.05	0.01	lasso	5	0.00	1.3e-01	-6.5	7.0	2.9e-12	0.90	0.07	0.85	FALSE
3	GTEx	Adipose Subcutaneous	AC021860.1	0.32	0.28	enet	20	0.36	2.7e-30	3.8	5.3	1.0e-07	-0.01	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	AC021860.1	0.33	0.08	lasso	9	0.13	3.2e-07	3.8	6.2	6.3e-10	0.02	0.50	0.38	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-617D20.1	0.31	0.10	enet	21	0.17	3.9e-09	3.6	6.5	7.7e-11	-0.03	0.25	0.75	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-360F5.3	0.18	0.13	enet	19	0.13	2.9e-07	-4.6	5.8	9.1e-09	0.80	0.21	0.79	FALSE
7	GTEx	Adrenal Gland	RP11-360F5.3	0.09	0.01	enet	12	0.02	6.2e-02	7.5	7.4	1.1e-13	0.88	0.02	0.92	FALSE
8	GTEx	Artery Aorta	AC021860.1	0.34	0.14	lasso	4	0.32	6.5e-18	4.5	5.4	6.8e-08	0.01	1.00	0.00	FALSE
9	GTEx	Artery Aorta	RP11-360F5.1	0.07	0.01	lasso	3	0.01	7.9e-02	-5.8	-6.0	2.4e-09	-0.78	0.09	0.76	FALSE
10	GTEx	Artery Tibial	AC021860.1	0.30	0.09	enet	30	0.22	1.5e-17	3.8	6.6	3.6e-11	0.05	1.00	0.00	FALSE
11	GTEx	Artery Tibial	RP11-617D20.1	0.32	0.23	enet	39	0.28	5.0e-22	3.8	5.9	4.5e-09	0.03	1.00	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	PDS5A	0.26	0.10	lasso	7	0.14	1.8e-04	-5.8	-5.3	1.2e-07	-0.08	0.15	0.07	FALSE
13	GTEx	Brain Frontal Cortex BA9	AC021860.1	0.52	0.23	lasso	13	0.24	3.6e-07	-3.8	5.6	2.4e-08	0.07	0.42	0.25	FALSE
14	GTEx	Brain Frontal Cortex BA9	RP11-617D20.1	0.34	0.14	lasso	4	0.14	1.7e-04	4.5	5.3	1.2e-07	0.02	0.16	0.31	FALSE
15	GTEx	Brain Putamen basal ganglia	RP11-360F5.3	0.24	0.15	enet	44	0.03	8.4e-02	2.0	5.7	1.1e-08	0.53	0.16	0.09	FALSE
16	GTEx	Breast Mammary Tissue	AC021860.1	0.49	0.13	enet	29	0.27	2.2e-14	3.8	5.2	1.7e-07	0.03	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	SMIM14	0.12	0.13	enet	13	0.11	2.5e-08	4.0	-6.2	4.8e-10	-0.34	0.99	0.00	FALSE
18	GTEx	Esophagus Muscularis	AC021860.1	0.40	0.19	enet	24	0.36	3.9e-23	3.8	5.3	1.0e-07	0.01	1.00	0.00	FALSE
19	GTEx	Heart Atrial Appendage	AC021860.1	0.48	0.07	lasso	15	0.19	8.1e-09	3.6	5.2	1.5e-07	-0.02	0.80	0.05	FALSE
20	GTEx	Lung	WDR19	0.07	0.10	lasso	1	0.07	2.8e-06	-5.8	5.8	7.5e-09	0.69	0.56	0.42	FALSE
21	GTEx	Lung	SMIM14	0.06	0.00	enet	5	0.00	3.7e-01	-4.4	-6.8	9.9e-12	-0.69	0.06	0.53	FALSE
22	GTEx	Lung	AC021860.1	0.19	0.07	enet	14	0.14	8.2e-11	4.5	5.8	6.3e-09	-0.01	0.98	0.01	FALSE
23	GTEx	Muscle Skeletal	RFC1	0.10	0.10	lasso	5	0.07	4.2e-07	5.8	5.6	1.9e-08	0.78	0.94	0.06	FALSE
24	GTEx	Muscle Skeletal	AC021860.1	0.16	0.10	lasso	7	0.13	1.1e-12	4.5	5.2	1.9e-07	-0.03	1.00	0.00	FALSE
25	GTEx	Nerve Tibial	KLHL5	0.13	0.07	enet	16	0.04	4.5e-04	-4.5	-5.2	1.6e-07	-0.72	0.92	0.06	FALSE
26	GTEx	Nerve Tibial	WDR19	0.08	0.06	lasso	2	0.05	1.2e-04	-5.5	6.0	2.7e-09	0.71	0.14	0.81	FALSE
27	GTEx	Nerve Tibial	AC021860.1	0.43	0.20	lasso	13	0.30	8.5e-22	-3.9	5.2	1.6e-07	0.03	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	RP11-617D20.1	0.35	0.10	enet	81	0.20	7.0e-14	3.8	5.4	5.3e-08	-0.06	0.93	0.07	FALSE
29	GTEx	Pancreas	AC021860.1	0.41	0.33	lasso	6	0.44	5.0e-20	4.5	5.3	1.1e-07	-0.01	1.00	0.00	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	FAM114A1	0.23	0.17	enet	14	0.13	1.0e-07	4.7	5.4	8.4e-08	0.03	1.00	0.00	TRUE
31	GTEx	Skin Sun Exposed Lower leg	RP11-360F5.3	0.10	0.08	enet	25	0.07	9.0e-07	-4.5	5.2	2.1e-07	0.74	0.76	0.24	FALSE
32	GTEx	Small Intestine Terminal Ileum	RP11-360F5.3	0.16	0.07	lasso	8	0.03	8.9e-02	-4.6	5.1	2.8e-07	0.76	0.10	0.45	FALSE
33	GTEx	Spleen	RP11-360F5.3	0.23	0.26	enet	18	0.23	1.7e-06	-4.6	5.4	7.5e-08	0.73	0.33	0.53	FALSE
34	GTEx	Stomach	AC021860.1	0.37	0.14	enet	27	0.18	5.9e-09	3.6	6.2	5.1e-10	0.00	0.86	0.09	FALSE
35	GTEx	Stomach	UGDH-AS1	0.08	0.01	lasso	7	0.02	3.8e-02	-6.4	6.0	2.3e-09	0.81	0.06	0.70	FALSE
36	GTEx	Testis	WDR19	0.28	0.29	lasso	5	0.27	1.6e-12	-6.5	7.2	8.6e-13	0.88	0.38	0.62	FALSE
37	GTEx	Testis	AC021860.1	0.23	0.16	lasso	5	0.23	1.3e-10	3.8	5.2	2.1e-07	0.00	0.98	0.00	FALSE
38	GTEx	Thyroid	RP11-617D20.1	0.31	0.22	enet	20	0.29	3.5e-22	3.6	5.5	4.6e-08	-0.02	1.00	0.00	FALSE
39	GTEx	Whole Blood	AC021860.1	0.14	0.07	lasso	7	0.10	2.5e-09	3.8	5.8	6.4e-09	-0.01	0.99	0.01	FALSE
40	METSIM	Adipose	AC021860.1	0.18	0.07	bslmm	596	0.12	4.0e-17	3.6	7.2	5.0e-13	0.00	1.00	0.00	FALSE
41	METSIM	Adipose	UGDH	0.12	0.06	blup	366	0.07	2.6e-10	-3.1	6.9	3.9e-12	0.44	1.00	0.00	FALSE
42	METSIM	Adipose	WDR19	0.04	0.01	enet	20	0.02	7.7e-04	-6.4	7.2	5.0e-13	0.51	0.09	0.88	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	WDR19	0.02	0.02	enet	9	0.02	2.8e-03	7.5	7.6	3.1e-14	0.99	0.02	0.95	TRUE
44	ROSMAP	Brain Pre-frontal Cortex	RP11-617D20.1	0.14	0.08	enet	18	0.13	6.8e-16	3.6	5.9	4.6e-09	0.02	1.00	0.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	RP11-360F5.3	0.07	0.09	lasso	4	0.07	1.8e-09	-4.5	5.1	2.9e-07	0.75	0.60	0.40	FALSE
46	YFS	Blood	WDR19	0.06	0.08	blup	478	0.10	1.0e-29	-4.5	6.0	1.6e-09	0.66	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ13197	0.04	0.02	blup	80	0.03	3.2e-07	3.6	6.4	1.3e-10	-0.03	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	KLHL5	0.02	0.03	enet	9	0.02	2.3e-05	5.7	-5.4	5.3e-08	-0.67	0.04	0.95	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ13197	0.14	0.00	blup	81	0.04	6.7e-03	-6.1	5.3	9.4e-08	-0.02	0.01	0.49	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ13197	0.12	0.00	blup	85	0.05	9.1e-04	3.8	7.2	4.4e-13	-0.03	0.02	0.84	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	TLR6	0.16	0.03	enet	8	0.06	1.5e-04	-4.5	5.2	2.3e-07	-0.06	0.02	0.59	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ13197	0.11	0.07	blup	85	0.10	3.4e-11	3.8	6.3	3.3e-10	-0.03	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR19	0.03	0.04	blup	61	0.02	3.6e-03	-6.4	6.6	3.6e-11	0.90	0.08	0.92	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ13197	0.06	0.04	enet	9	0.06	1.3e-07	4.5	5.6	1.7e-08	-0.03	0.92	0.02	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ13197	0.11	0.07	blup	85	0.08	7.0e-10	3.8	7.4	1.6e-13	-0.03	0.55	0.45	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ13197	0.08	0.04	enet	11	0.06	1.7e-07	3.8	6.8	1.4e-11	-0.05	0.52	0.47	FALSE
57	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ13197	0.06	0.00	blup	81	0.01	3.4e-02	3.5	5.7	1.4e-08	-0.03	0.04	0.11	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ13197	0.13	0.07	blup	81	0.08	2.7e-04	4.5	5.9	3.7e-09	0.00	0.05	0.49	FALSE
59	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	WDR19	0.08	0.00	blup	61	0.03	1.9e-02	-6.5	6.8	7.1e-12	0.87	0.04	0.33	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ13197	0.20	0.10	blup	81	0.14	4.2e-14	3.6	5.8	6.7e-09	-0.01	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	N4BP2	0.06	0.07	lasso	2	0.06	3.1e-07	-5.1	5.2	2.3e-07	0.07	0.12	0.87	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR19	0.04	0.01	blup	61	0.02	2.4e-03	7.6	6.5	7.0e-11	0.90	0.02	0.97	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	WDR19	0.09	0.01	blup	61	0.03	4.1e-02	-6.5	6.7	1.7e-11	0.89	0.02	0.40	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ13197	0.16	0.08	blup	82	0.13	7.1e-13	4.5	7.4	1.4e-13	-0.02	0.67	0.32	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	WDR19	0.02	0.00	blup	61	0.01	2.8e-02	-5.7	6.9	5.4e-12	0.84	0.06	0.43	FALSE