Best TWAS P=9.95e-20 · Best GWAS P=7.26e-28 conditioned to 3.27e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | 6.2 | -5.9 | 3.8e-09 | -0.46 | 0.36 | 0.23 | FALSE |
2 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | -3.6 | -7.7 | 1.2e-14 | -0.65 | 0.03 | 0.94 | FALSE |
3 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | -3.3 | -5.8 | 7.9e-09 | -0.43 | 0.28 | 0.60 | FALSE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | CLOCK | 0.08 | 0.08 | lasso | 5 | 0.05 | 1.4e-03 | 5.2 | 5.2 | 2.4e-07 | -0.06 | 0.02 | 0.96 | FALSE |
5 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | -5.4 | 7.1 | 9.4e-13 | 0.46 | 0.85 | 0.15 | TRUE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMEM165 | 0.06 | 0.07 | enet | 11 | 0.06 | 2.1e-04 | 5.1 | -5.4 | 5.3e-08 | 0.05 | 0.01 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | -6.2 | -5.7 | 1.1e-08 | -0.37 | 0.24 | 0.21 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CLOCK | 0.02 | 0.02 | enet | 5 | 0.02 | 1.9e-03 | 4.4 | 5.2 | 2.5e-07 | -0.03 | 0.03 | 0.80 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | -5.3 | -9.1 | 1.0e-19 | -0.70 | 0.06 | 0.72 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM165 | 0.08 | 0.06 | lasso | 3 | 0.09 | 1.5e-10 | 5.1 | -5.5 | 4.1e-08 | 0.03 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM165 | 0.19 | 0.16 | lasso | 4 | 0.17 | 2.1e-18 | 5.2 | -5.4 | 7.1e-08 | 0.05 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM165 | 0.05 | 0.06 | enet | 5 | 0.05 | 4.3e-06 | 5.1 | -5.5 | 3.4e-08 | 0.04 | 0.00 | 0.99 | TRUE |