Best TWAS P=4.88e-13 · Best GWAS P=7.89e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM160A1 | 0.04 | 0.04 | blup | 436 | 0.06 | 1.8e-07 | -6.0 | 6.1 | 1.0e-09 | 0.78 | 0.65 | 0.34 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | SH3D19 | 0.28 | 0.22 | lasso | 5 | 0.20 | 9.3e-06 | 7.1 | -7.1 | 1.3e-12 | -0.97 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | RP11-164P12.3 | 0.19 | 0.05 | enet | 20 | 0.02 | 8.8e-02 | 7.1 | 5.3 | 1.4e-07 | 0.82 | 0.02 | 0.93 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP11-164P12.4 | 0.47 | 0.44 | enet | 18 | 0.35 | 6.6e-10 | 7.1 | 7.2 | 4.9e-13 | 1.00 | 0.02 | 0.98 | TRUE |
| 5 | GTEx | Brain Cerebellum | RP11-164P12.3 | 0.21 | 0.02 | enet | 19 | 0.03 | 3.4e-02 | 7.1 | 5.6 | 1.9e-08 | 0.83 | 0.03 | 0.90 | FALSE |
| 6 | GTEx | Brain Cerebellum | RP11-164P12.4 | 0.48 | 0.40 | lasso | 17 | 0.49 | 2.2e-16 | -6.2 | 6.7 | 1.7e-11 | 0.94 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Brain Cortex | PET112 | 0.11 | 0.13 | enet | 22 | 0.12 | 4.1e-04 | -5.1 | 5.3 | 9.6e-08 | 0.74 | 0.16 | 0.66 | FALSE |
| 8 | GTEx | Brain Frontal Cortex BA9 | PET112 | 0.22 | 0.13 | enet | 14 | 0.05 | 1.6e-02 | -6.0 | 5.3 | 9.7e-08 | 0.75 | 0.14 | 0.42 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | PET112 | 0.12 | 0.03 | enet | 11 | 0.01 | 1.4e-01 | -4.9 | 5.4 | 5.3e-08 | 0.68 | 0.59 | 0.14 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | PET112 | 0.03 | 0.00 | lasso | 4 | 0.00 | 3.2e-01 | -3.9 | 5.2 | 1.5e-07 | 0.60 | 0.04 | 0.05 | FALSE |
| 11 | GTEx | Heart Atrial Appendage | PET112 | 0.20 | 0.11 | enet | 24 | 0.18 | 2.1e-08 | -6.2 | 6.3 | 2.6e-10 | 0.70 | 0.14 | 0.84 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | RP11-164P12.3 | 0.13 | 0.03 | lasso | 5 | 0.02 | 4.4e-02 | -5.4 | 5.8 | 7.9e-09 | 0.75 | 0.13 | 0.54 | FALSE |
| 13 | GTEx | Heart Left Ventricle | PET112 | 0.14 | 0.06 | lasso | 4 | 0.04 | 5.0e-03 | -6.0 | 5.9 | 3.4e-09 | 0.71 | 0.23 | 0.24 | FALSE |
| 14 | GTEx | Nerve Tibial | RP11-164P12.3 | 0.08 | 0.14 | lasso | 6 | 0.14 | 8.3e-10 | -5.1 | 5.7 | 1.3e-08 | 0.67 | 0.96 | 0.03 | FALSE |
| 15 | GTEx | Spleen | RP11-164P12.4 | 0.36 | 0.26 | lasso | 10 | 0.20 | 5.8e-06 | 7.1 | 7.1 | 1.3e-12 | 1.00 | 0.02 | 0.98 | FALSE |
| 16 | NTR | Blood | FAM160A1 | 0.03 | 0.02 | enet | 26 | 0.02 | 1.4e-07 | -6.2 | 7.0 | 2.8e-12 | 0.91 | 0.03 | 0.97 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | PET112 | 0.04 | 0.02 | bslmm | 410 | 0.04 | 5.2e-06 | -6.0 | 7.1 | 1.1e-12 | 0.67 | 0.67 | 0.20 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM160A1 | 0.04 | 0.02 | blup | 99 | 0.02 | 1.2e-05 | 7.1 | 6.3 | 3.6e-10 | 0.91 | 0.02 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160A1 | 0.06 | 0.05 | lasso | 3 | 0.04 | 1.8e-03 | -6.2 | 6.5 | 8.1e-11 | 0.85 | 0.05 | 0.70 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM160A1 | 0.07 | 0.03 | lasso | 3 | 0.05 | 1.9e-04 | -6.3 | 5.9 | 3.4e-09 | 0.85 | 0.05 | 0.90 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FAM160A1 | 0.08 | 0.05 | blup | 99 | 0.05 | 2.9e-03 | -5.4 | 6.7 | 2.1e-11 | 0.92 | 0.04 | 0.73 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PET112L | 0.09 | 0.04 | blup | 76 | 0.07 | 1.0e-03 | -4.5 | 5.4 | 5.7e-08 | 0.64 | 0.12 | 0.65 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160A1 | 0.09 | 0.10 | lasso | 2 | 0.10 | 3.3e-10 | 7.0 | 7.0 | 1.8e-12 | 0.94 | 0.02 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FAM160A1 | 0.16 | 0.14 | enet | 33 | 0.11 | 6.6e-04 | 7.1 | 7.0 | 1.8e-12 | 0.98 | 0.02 | 0.97 | FALSE |