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chr4:151,347,355-153,373,680

Best TWAS P=4.88e-13 · Best GWAS P=7.89e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Brain Cerebellar Hemisphere	RP11-164P12.4	0.47	0.44	enet	18	0.35	6.6e-10	7.1	7.2	4.9e-13	1.00	0.02	0.98	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	PET112	0.04	0.02	bslmm	410	0.04	5.2e-06	-6.0	7.1	1.1e-12	0.67	0.67	0.20	FALSE
2	GTEx	Brain Cerebellar Hemisphere	SH3D19	0.28	0.22	lasso	5	0.20	9.3e-06	7.1	-7.1	1.3e-12	-0.97	0.02	0.97	FALSE
15	GTEx	Spleen	RP11-164P12.4	0.36	0.26	lasso	10	0.20	5.8e-06	7.1	7.1	1.3e-12	1.00	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM160A1	0.09	0.10	lasso	2	0.10	3.3e-10	7.0	7.0	1.8e-12	0.94	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	FAM160A1	0.16	0.14	enet	33	0.11	6.6e-04	7.1	7.0	1.8e-12	0.98	0.02	0.97	FALSE
16	NTR	Blood	FAM160A1	0.03	0.02	enet	26	0.02	1.4e-07	-6.2	7.0	2.8e-12	0.91	0.03	0.97	FALSE
6	GTEx	Brain Cerebellum	RP11-164P12.4	0.48	0.40	lasso	17	0.49	2.2e-16	-6.2	6.7	1.7e-11	0.94	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM160A1	0.08	0.05	blup	99	0.05	2.9e-03	-5.4	6.7	2.1e-11	0.92	0.04	0.73	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM160A1	0.06	0.05	lasso	3	0.04	1.8e-03	-6.2	6.5	8.1e-11	0.85	0.05	0.70	FALSE
11	GTEx	Heart Atrial Appendage	PET112	0.20	0.11	enet	24	0.18	2.1e-08	-6.2	6.3	2.6e-10	0.70	0.14	0.84	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM160A1	0.04	0.02	blup	99	0.02	1.2e-05	7.1	6.3	3.6e-10	0.91	0.02	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM160A1	0.04	0.04	blup	436	0.06	1.8e-07	-6.0	6.1	1.0e-09	0.78	0.65	0.34	FALSE
13	GTEx	Heart Left Ventricle	PET112	0.14	0.06	lasso	4	0.04	5.0e-03	-6.0	5.9	3.4e-09	0.71	0.23	0.24	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FAM160A1	0.07	0.03	lasso	3	0.05	1.9e-04	-6.3	5.9	3.4e-09	0.85	0.05	0.90	FALSE
12	GTEx	Heart Atrial Appendage	RP11-164P12.3	0.13	0.03	lasso	5	0.02	4.4e-02	-5.4	5.8	7.9e-09	0.75	0.13	0.54	FALSE
14	GTEx	Nerve Tibial	RP11-164P12.3	0.08	0.14	lasso	6	0.14	8.3e-10	-5.1	5.7	1.3e-08	0.67	0.96	0.03	FALSE
5	GTEx	Brain Cerebellum	RP11-164P12.3	0.21	0.02	enet	19	0.03	3.4e-02	7.1	5.6	1.9e-08	0.83	0.03	0.90	FALSE
9	GTEx	Breast Mammary Tissue	PET112	0.12	0.03	enet	11	0.01	1.4e-01	-4.9	5.4	5.3e-08	0.68	0.59	0.14	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PET112L	0.09	0.04	blup	76	0.07	1.0e-03	-4.5	5.4	5.7e-08	0.64	0.12	0.65	FALSE
7	GTEx	Brain Cortex	PET112	0.11	0.13	enet	22	0.12	4.1e-04	-5.1	5.3	9.6e-08	0.74	0.16	0.66	FALSE
8	GTEx	Brain Frontal Cortex BA9	PET112	0.22	0.13	enet	14	0.05	1.6e-02	-6.0	5.3	9.7e-08	0.75	0.14	0.42	FALSE
3	GTEx	Brain Cerebellar Hemisphere	RP11-164P12.3	0.19	0.05	enet	20	0.02	8.8e-02	7.1	5.3	1.4e-07	0.82	0.02	0.93	FALSE
10	GTEx	Breast Mammary Tissue (Female)	PET112	0.03	0.00	lasso	4	0.00	3.2e-01	-3.9	5.2	1.5e-07	0.60	0.04	0.05	FALSE