Best TWAS P=2.94e-14 · Best GWAS P=4.3e-12 conditioned to 0.0156
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | AHRR | 0.25 | 0.18 | lasso | 12 | 0.21 | 1.2e-25 | 6.0 | 6.3 | 2.2e-10 | 0.49 | 0.26 | 0.74 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SDHA | 0.12 | 0.06 | bslmm | 290 | 0.11 | 8.6e-14 | 5.9 | -5.3 | 9.9e-08 | -0.58 | 0.53 | 0.47 | FALSE |
3 | GTEx | Adipose Subcutaneous | SDHA | 0.10 | 0.09 | lasso | 5 | 0.07 | 1.9e-06 | 6.0 | 6.3 | 2.5e-10 | 0.53 | 0.25 | 0.75 | FALSE |
4 | GTEx | Adipose Visceral Omentum | SDHA | 0.10 | 0.05 | lasso | 3 | 0.07 | 1.5e-04 | 6.1 | 5.9 | 3.0e-09 | 0.48 | 0.20 | 0.42 | FALSE |
5 | GTEx | Adipose Visceral Omentum | CCDC127 | 0.13 | 0.03 | lasso | 4 | 0.05 | 9.0e-04 | 6.3 | 6.7 | 1.7e-11 | 0.74 | 0.03 | 0.95 | FALSE |
6 | GTEx | Artery Aorta | PDCD6 | 0.26 | 0.17 | lasso | 4 | 0.14 | 2.8e-08 | 6.0 | -5.5 | 4.2e-08 | -0.52 | 0.30 | 0.70 | FALSE |
7 | GTEx | Brain Cerebellum | CTD-2083E4.5 | 0.14 | 0.01 | lasso | 10 | 0.03 | 5.9e-02 | 4.6 | -5.8 | 5.9e-09 | -0.30 | 0.09 | 0.14 | FALSE |
8 | GTEx | Brain Frontal Cortex BA9 | AHRR | 0.32 | 0.21 | lasso | 4 | 0.18 | 1.6e-05 | 6.0 | 5.8 | 6.5e-09 | 0.51 | 0.10 | 0.23 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | SDHA | 0.23 | 0.18 | lasso | 2 | 0.17 | 1.6e-12 | 6.0 | 6.1 | 1.4e-09 | 0.53 | 0.28 | 0.72 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | CCDC127 | 0.25 | 0.13 | lasso | 5 | 0.14 | 9.0e-11 | 4.5 | 5.5 | 3.7e-08 | 0.49 | 0.57 | 0.43 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | CTD-2083E4.5 | 0.09 | 0.07 | lasso | 3 | 0.05 | 1.2e-04 | 6.1 | -5.7 | 1.1e-08 | -0.52 | 0.20 | 0.56 | FALSE |
12 | GTEx | Heart Atrial Appendage | SDHA | 0.15 | 0.04 | lasso | 3 | 0.02 | 4.3e-02 | 6.3 | -6.2 | 5.5e-10 | -0.82 | 0.02 | 0.94 | FALSE |
13 | GTEx | Nerve Tibial | CCDC127 | 0.05 | 0.01 | lasso | 4 | 0.02 | 2.2e-02 | 6.3 | 6.7 | 2.9e-11 | 0.80 | 0.04 | 0.81 | FALSE |
14 | GTEx | Testis | SDHA | 0.33 | 0.24 | lasso | 7 | 0.20 | 2.9e-09 | 4.4 | 6.3 | 4.0e-10 | 0.33 | 0.95 | 0.05 | FALSE |
15 | GTEx | Thyroid | EXOC3 | 0.16 | 0.04 | lasso | 5 | 0.06 | 3.6e-05 | 5.4 | 5.8 | 6.9e-09 | 0.28 | 0.48 | 0.41 | FALSE |
16 | GTEx | Thyroid | CTD-2083E4.5 | 0.07 | 0.06 | lasso | 2 | 0.04 | 3.6e-04 | 6.1 | -6.5 | 7.7e-11 | -0.53 | 0.16 | 0.56 | FALSE |
17 | GTEx | Whole Blood | SDHA | 0.05 | 0.01 | lasso | 5 | 0.01 | 3.4e-02 | 5.1 | -5.2 | 1.8e-07 | -0.62 | 0.19 | 0.41 | FALSE |
18 | METSIM | Adipose | SDHA | 0.09 | 0.04 | lasso | 12 | 0.03 | 8.5e-06 | 5.9 | 5.6 | 2.4e-08 | 0.55 | 0.44 | 0.56 | FALSE |
19 | NTR | Blood | CCDC127 | 0.02 | 0.01 | blup | 284 | 0.02 | 1.5e-06 | 5.2 | -6.2 | 6.6e-10 | -0.45 | 0.76 | 0.19 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | SDHA | 0.07 | 0.04 | lasso | 4 | 0.04 | 2.3e-06 | 5.2 | -5.6 | 2.2e-08 | -0.25 | 0.92 | 0.04 | FALSE |
21 | YFS | Blood | PDCD6 | 0.03 | 0.03 | bslmm | 276 | 0.03 | 1.6e-09 | 6.1 | 6.9 | 6.0e-12 | 0.60 | 0.39 | 0.61 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AHRR | 0.04 | 0.03 | lasso | 3 | 0.03 | 1.1e-06 | 5.9 | 7.6 | 2.9e-14 | 0.68 | 0.02 | 0.98 | TRUE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDCD6 | 0.03 | 0.02 | blup | 49 | 0.02 | 2.9e-03 | 5.9 | 6.1 | 1.4e-09 | 0.66 | 0.24 | 0.38 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SDHA | 0.04 | 0.03 | blup | 62 | 0.05 | 3.3e-06 | 6.1 | 6.6 | 5.2e-11 | 0.49 | 0.03 | 0.97 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LRRC14B | 0.08 | 0.04 | lasso | 5 | 0.03 | 6.7e-03 | 5.9 | 5.9 | 4.3e-09 | 0.58 | 0.01 | 0.95 | FALSE |
26 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SDHA | 0.05 | 0.02 | lasso | 4 | 0.01 | 1.3e-01 | 4.5 | 5.7 | 1.4e-08 | 0.47 | 0.02 | 0.77 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AHRR | 0.30 | 0.17 | lasso | 3 | 0.25 | 7.9e-28 | 5.9 | 7.5 | 8.2e-14 | 0.65 | 0.42 | 0.58 | FALSE |
28 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AHRR | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-04 | 6.0 | 6.4 | 1.2e-10 | 0.42 | 0.11 | 0.21 | FALSE |
29 | The Cancer Genome Atlas | Lung Adenocarcinoma | AHRR | 0.05 | 0.01 | blup | 99 | 0.01 | 1.4e-02 | 3.6 | 6.1 | 8.7e-10 | 0.35 | 0.10 | 0.32 | FALSE |
30 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AHRR | 0.04 | 0.03 | blup | 100 | 0.04 | 9.1e-04 | 3.2 | 6.1 | 8.6e-10 | 0.37 | 0.05 | 0.38 | FALSE |
31 | The Cancer Genome Atlas | Thyroid Carcinoma | AHRR | 0.13 | 0.04 | blup | 100 | 0.08 | 1.3e-08 | 5.9 | 5.6 | 2.1e-08 | 0.33 | 0.67 | 0.28 | FALSE |
32 | The Cancer Genome Atlas | Thyroid Carcinoma | PDCD6 | 0.07 | 0.06 | enet | 5 | 0.07 | 2.0e-07 | 6.1 | -5.2 | 1.8e-07 | -0.53 | 0.34 | 0.65 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | SDHA | 0.06 | 0.09 | lasso | 13 | 0.08 | 1.8e-08 | 6.1 | 6.0 | 2.0e-09 | 0.54 | 0.02 | 0.98 | FALSE |