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chr5:12,225-1,169,112

Best TWAS P=2.94e-14 · Best GWAS P=4.3e-12 conditioned to 0.0156

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHRR	0.04	0.03	lasso	3	0.03	1.1e-06	5.9	7.6	2.9e-14	0.68	0.02	0.98	TRUE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	AHRR	0.30	0.17	lasso	3	0.25	7.9e-28	5.9	7.5	8.2e-14	0.65	0.42	0.58	FALSE
21	YFS	Blood	PDCD6	0.03	0.03	bslmm	276	0.03	1.6e-09	6.1	6.9	6.0e-12	0.60	0.39	0.61	FALSE
5	GTEx	Adipose Visceral Omentum	CCDC127	0.13	0.03	lasso	4	0.05	9.0e-04	6.3	6.7	1.7e-11	0.74	0.03	0.95	FALSE
13	GTEx	Nerve Tibial	CCDC127	0.05	0.01	lasso	4	0.02	2.2e-02	6.3	6.7	2.9e-11	0.80	0.04	0.81	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDHA	0.04	0.03	blup	62	0.05	3.3e-06	6.1	6.6	5.2e-11	0.49	0.03	0.97	FALSE
16	GTEx	Thyroid	CTD-2083E4.5	0.07	0.06	lasso	2	0.04	3.6e-04	6.1	-6.5	7.7e-11	-0.53	0.16	0.56	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AHRR	0.11	0.05	lasso	3	0.07	2.5e-04	6.0	6.4	1.2e-10	0.42	0.11	0.21	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AHRR	0.25	0.18	lasso	12	0.21	1.2e-25	6.0	6.3	2.2e-10	0.49	0.26	0.74	FALSE
3	GTEx	Adipose Subcutaneous	SDHA	0.10	0.09	lasso	5	0.07	1.9e-06	6.0	6.3	2.5e-10	0.53	0.25	0.75	FALSE
14	GTEx	Testis	SDHA	0.33	0.24	lasso	7	0.20	2.9e-09	4.4	6.3	4.0e-10	0.33	0.95	0.05	FALSE
12	GTEx	Heart Atrial Appendage	SDHA	0.15	0.04	lasso	3	0.02	4.3e-02	6.3	-6.2	5.5e-10	-0.82	0.02	0.94	FALSE
19	NTR	Blood	CCDC127	0.02	0.01	blup	284	0.02	1.5e-06	5.2	-6.2	6.6e-10	-0.45	0.76	0.19	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	AHRR	0.04	0.03	blup	100	0.04	9.1e-04	3.2	6.1	8.6e-10	0.37	0.05	0.38	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	AHRR	0.05	0.01	blup	99	0.01	1.4e-02	3.6	6.1	8.7e-10	0.35	0.10	0.32	FALSE
9	GTEx	Cells Transformed fibroblasts	SDHA	0.23	0.18	lasso	2	0.17	1.6e-12	6.0	6.1	1.4e-09	0.53	0.28	0.72	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDCD6	0.03	0.02	blup	49	0.02	2.9e-03	5.9	6.1	1.4e-09	0.66	0.24	0.38	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	SDHA	0.06	0.09	lasso	13	0.08	1.8e-08	6.1	6.0	2.0e-09	0.54	0.02	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	SDHA	0.10	0.05	lasso	3	0.07	1.5e-04	6.1	5.9	3.0e-09	0.48	0.20	0.42	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRC14B	0.08	0.04	lasso	5	0.03	6.7e-03	5.9	5.9	4.3e-09	0.58	0.01	0.95	FALSE
7	GTEx	Brain Cerebellum	CTD-2083E4.5	0.14	0.01	lasso	10	0.03	5.9e-02	4.6	-5.8	5.9e-09	-0.30	0.09	0.14	FALSE
8	GTEx	Brain Frontal Cortex BA9	AHRR	0.32	0.21	lasso	4	0.18	1.6e-05	6.0	5.8	6.5e-09	0.51	0.10	0.23	FALSE
15	GTEx	Thyroid	EXOC3	0.16	0.04	lasso	5	0.06	3.6e-05	5.4	5.8	6.9e-09	0.28	0.48	0.41	FALSE
11	GTEx	Cells Transformed fibroblasts	CTD-2083E4.5	0.09	0.07	lasso	3	0.05	1.2e-04	6.1	-5.7	1.1e-08	-0.52	0.20	0.56	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDHA	0.05	0.02	lasso	4	0.01	1.3e-01	4.5	5.7	1.4e-08	0.47	0.02	0.77	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	AHRR	0.13	0.04	blup	100	0.08	1.3e-08	5.9	5.6	2.1e-08	0.33	0.67	0.28	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	SDHA	0.07	0.04	lasso	4	0.04	2.3e-06	5.2	-5.6	2.2e-08	-0.25	0.92	0.04	FALSE
18	METSIM	Adipose	SDHA	0.09	0.04	lasso	12	0.03	8.5e-06	5.9	5.6	2.4e-08	0.55	0.44	0.56	FALSE
10	GTEx	Cells Transformed fibroblasts	CCDC127	0.25	0.13	lasso	5	0.14	9.0e-11	4.5	5.5	3.7e-08	0.49	0.57	0.43	FALSE
6	GTEx	Artery Aorta	PDCD6	0.26	0.17	lasso	4	0.14	2.8e-08	6.0	-5.5	4.2e-08	-0.52	0.30	0.70	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SDHA	0.12	0.06	bslmm	290	0.11	8.6e-14	5.9	-5.3	9.9e-08	-0.58	0.53	0.47	FALSE
17	GTEx	Whole Blood	SDHA	0.05	0.01	lasso	5	0.01	3.4e-02	5.1	-5.2	1.8e-07	-0.62	0.19	0.41	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	PDCD6	0.07	0.06	enet	5	0.07	2.0e-07	6.1	-5.2	1.8e-07	-0.53	0.34	0.65	FALSE