Best TWAS P=3.82e-20 · Best GWAS P=6.57e-92 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | U91328.19 | 0.28 | 0.12 | lasso | 10 | 0.14 | 1.3e-05 | -5.3 | 7.7 | 1.1e-14 | -0.30 | 0.95 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | U91328.19 | 0.32 | 0.24 | lasso | 7 | 0.25 | 8.3e-14 | -5.6 | 5.8 | 6.0e-09 | -0.32 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | U91328.21 | 0.18 | 0.00 | lasso | 11 | 0.02 | 3.5e-02 | -2.9 | 8.0 | 1.1e-15 | -0.09 | 0.18 | 0.04 | TRUE |
| 4 | GTEx | Artery Tibial | TRIM38 | 0.08 | 0.00 | lasso | 9 | 0.00 | 3.7e-01 | 8.5 | 9.2 | 3.8e-20 | -0.28 | 0.31 | 0.03 | TRUE |
| 5 | GTEx | Brain Cerebellar Hemisphere | U91328.19 | 0.47 | 0.33 | enet | 44 | 0.26 | 2.8e-07 | -5.3 | 6.1 | 8.6e-10 | -0.34 | 0.98 | 0.00 | FALSE |
| 6 | GTEx | Brain Cerebellum | U91328.19 | 0.13 | 0.15 | lasso | 2 | 0.09 | 1.1e-03 | -5.8 | 5.6 | 2.6e-08 | -0.31 | 0.35 | 0.06 | TRUE |
| 7 | GTEx | Colon Transverse | TRIM38 | 0.15 | 0.00 | enet | 43 | 0.03 | 1.7e-02 | -1.5 | 5.6 | 1.7e-08 | -0.19 | 0.15 | 0.05 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | U91328.20 | 0.16 | 0.13 | enet | 16 | 0.13 | 2.0e-05 | -3.5 | 9.0 | 1.5e-19 | -0.31 | 0.45 | 0.03 | TRUE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | U91328.19 | 0.28 | 0.07 | lasso | 7 | 0.21 | 4.3e-08 | -3.5 | 6.8 | 1.1e-11 | -0.32 | 0.71 | 0.02 | TRUE |
| 10 | GTEx | Esophagus Mucosa | U91328.19 | 0.45 | 0.42 | lasso | 7 | 0.44 | 6.3e-32 | -4.1 | 5.5 | 3.7e-08 | -0.31 | 1.00 | 0.00 | TRUE |
| 11 | GTEx | Esophagus Muscularis | TRIM38 | 0.06 | 0.04 | lasso | 4 | 0.02 | 1.7e-02 | -5.6 | 7.8 | 5.1e-15 | -0.31 | 0.53 | 0.04 | FALSE |
| 12 | GTEx | Esophagus Muscularis | U91328.19 | 0.36 | 0.30 | lasso | 10 | 0.30 | 1.7e-18 | -5.6 | 6.5 | 6.9e-11 | -0.30 | 1.00 | 0.00 | TRUE |
| 13 | GTEx | Lung | TRIM38 | 0.09 | 0.03 | lasso | 4 | 0.05 | 1.3e-04 | 9.4 | 5.9 | 3.5e-09 | -0.14 | 0.49 | 0.03 | FALSE |
| 14 | GTEx | Lung | U91328.19 | 0.20 | 0.22 | enet | 15 | 0.24 | 2.9e-18 | -5.5 | 5.5 | 3.3e-08 | -0.31 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Ovary | U91328.19 | 0.37 | 0.17 | enet | 18 | 0.34 | 4.7e-09 | -3.5 | 6.9 | 4.8e-12 | -0.37 | 0.75 | 0.02 | TRUE |
| 16 | GTEx | Thyroid | U91328.21 | 0.08 | 0.04 | lasso | 3 | 0.05 | 5.5e-05 | -2.6 | 5.3 | 1.3e-07 | -0.21 | 0.74 | 0.01 | TRUE |
| 17 | GTEx | Whole Blood | TRIM38 | 0.08 | 0.04 | enet | 13 | 0.03 | 1.4e-03 | 7.8 | 8.0 | 1.2e-15 | -0.29 | 0.79 | 0.01 | FALSE |
| 18 | GTEx | Whole Blood | U91328.21 | 0.07 | 0.04 | lasso | 4 | 0.04 | 1.7e-04 | 7.8 | 7.9 | 3.7e-15 | -0.24 | 0.40 | 0.02 | FALSE |
| 19 | METSIM | Adipose | U91328.20 | 0.07 | 0.04 | bslmm | 658 | 0.04 | 8.9e-07 | -5.8 | 9.0 | 2.1e-19 | -0.46 | 0.93 | 0.02 | FALSE |
| 20 | YFS | Blood | TRIM38 | 0.37 | 0.31 | bslmm | 672 | 0.34 | 3.8e-115 | -5.8 | -8.3 | 1.5e-16 | 0.15 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC17A1 | 0.08 | 0.06 | lasso | 5 | 0.06 | 1.3e-07 | 6.0 | -5.6 | 2.0e-08 | 0.13 | 0.16 | 0.84 | TRUE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC17A3 | 0.03 | 0.01 | lasso | 2 | 0.01 | 4.9e-02 | 6.1 | -6.6 | 3.4e-11 | 0.20 | 0.03 | 0.79 | FALSE |