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chr1:242,590,540-244,359,621

Best TWAS P=3.18e-12 · Best GWAS P=3.21e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SDCCAG8	0.18	0.10	enet	25	0.11	1.4e-09	-6.9	-6.5	7.3e-11	0.91	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	SDCCAG8	0.15	0.00	enet	24	0.00	1.8e-01	-6.1	-6.4	1.6e-10	0.57	0.02	0.82	FALSE
3	GTEx	Artery Aorta	SDCCAG8	0.21	0.06	enet	21	0.09	8.9e-06	-6.1	-5.7	1.4e-08	0.87	0.10	0.90	FALSE
4	GTEx	Artery Tibial	SDCCAG8	0.14	0.02	lasso	3	0.03	1.9e-03	-5.5	-5.7	1.1e-08	0.94	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	SDCCAG8	0.15	0.04	enet	13	0.09	2.8e-05	-3.9	-5.8	6.8e-09	0.89	0.01	0.98	FALSE
6	GTEx	Breast Mammary Tissue	CEP170	0.16	0.09	enet	19	0.08	1.0e-04	-6.1	-6.4	1.3e-10	0.81	0.03	0.96	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	SDCCAG8	0.36	0.24	lasso	8	0.34	5.7e-12	-4.4	-6.1	1.1e-09	0.90	0.01	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	SDCCAG8	0.23	0.25	enet	13	0.28	3.5e-21	-6.9	-6.5	6.2e-11	0.96	0.01	0.99	FALSE
9	GTEx	Cells Transformed fibroblasts	CEP170	0.21	0.17	enet	15	0.19	5.3e-14	-7.0	-6.5	6.2e-11	0.95	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-261C10.5	0.15	0.13	lasso	2	0.14	2.2e-10	-7.0	-7.0	3.2e-12	1.00	0.00	1.00	TRUE
11	GTEx	Colon Transverse	SDCCAG8	0.17	0.02	lasso	3	0.02	2.8e-02	-6.9	-7.0	3.7e-12	0.97	0.01	0.97	FALSE
12	GTEx	Esophagus Mucosa	SDCCAG8	0.17	0.15	lasso	4	0.15	3.3e-10	-6.1	-6.1	1.2e-09	0.92	0.12	0.88	FALSE
13	GTEx	Esophagus Mucosa	CEP170	0.07	0.01	enet	25	0.00	2.5e-01	-5.6	-5.5	3.0e-08	0.72	0.09	0.29	FALSE
14	GTEx	Esophagus Muscularis	CEP170	0.09	0.11	lasso	4	0.10	1.2e-06	-6.1	-6.2	4.4e-10	0.92	0.12	0.87	FALSE
15	GTEx	Heart Atrial Appendage	SDCCAG8	0.14	0.06	lasso	7	0.06	1.6e-03	-6.1	-6.2	4.4e-10	0.90	0.02	0.94	FALSE
16	GTEx	Nerve Tibial	CEP170	0.09	0.08	lasso	1	0.05	1.1e-04	-6.1	-6.1	8.6e-10	0.92	0.11	0.88	FALSE
17	GTEx	Pancreas	SDCCAG8	0.16	0.08	enet	20	0.07	9.3e-04	2.9	-6.2	7.3e-10	0.79	0.03	0.96	FALSE
18	GTEx	Prostate	CEP170	0.28	0.05	lasso	4	0.12	6.9e-04	-6.8	-5.9	4.4e-09	0.82	0.02	0.83	FALSE
19	GTEx	Whole Blood	SDCCAG8	0.18	0.15	lasso	7	0.14	6.2e-13	-6.0	-6.6	4.6e-11	0.97	0.01	0.99	FALSE
20	METSIM	Adipose	SDCCAG8	0.12	0.13	enet	17	0.14	5.6e-21	-6.1	-6.5	6.5e-11	0.95	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SDCCAG8	0.09	0.04	blup	114	0.08	4.6e-07	-6.9	-6.0	1.9e-09	0.73	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	SDCCAG8	0.06	0.04	blup	115	0.04	2.0e-08	3.5	-5.2	1.7e-07	0.56	0.99	0.01	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP170	0.03	0.03	enet	4	0.02	7.9e-04	-6.9	-7.0	3.3e-12	0.98	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG8	0.06	0.02	blup	114	0.04	1.9e-05	2.8	-6.2	5.7e-10	0.70	0.06	0.92	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	SDCCAG8	0.11	0.04	blup	114	0.06	1.1e-07	3.2	-5.5	3.6e-08	0.71	0.13	0.86	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP170	0.08	0.06	enet	7	0.06	2.0e-03	-6.9	-6.2	4.8e-10	0.94	0.01	0.84	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SDCCAG8	0.19	0.18	lasso	5	0.16	1.9e-07	-6.0	-6.0	1.9e-09	0.91	0.02	0.97	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP170	0.03	0.01	lasso	4	0.02	4.4e-03	3.4	-5.7	9.7e-09	0.70	0.02	0.44	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG8	0.10	0.05	lasso	4	0.06	5.8e-07	3.4	-5.3	1.4e-07	0.64	0.80	0.16	FALSE
30	The Cancer Genome Atlas	Rectum Adenocarcinoma	SDCCAG8	0.30	0.06	blup	113	0.12	8.0e-04	-6.1	-6.5	1.0e-10	0.83	0.02	0.81	FALSE