Best TWAS P=8.56e-09 · Best GWAS P=4.55e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TBCE | 0.12 | 0.10 | lasso | 2 | 0.08 | 2.6e-07 | -5.5 | -5.8 | 8.6e-09 | 0.97 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | TBCE | 0.16 | 0.19 | lasso | 2 | 0.15 | 1.1e-05 | 5.4 | -5.6 | 1.7e-08 | 0.86 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Lung | TBCE | 0.08 | 0.06 | lasso | 2 | 0.05 | 1.2e-04 | -5.5 | -5.6 | 2.0e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Nerve Tibial | TBCE | 0.09 | 0.04 | lasso | 4 | 0.04 | 1.1e-03 | -5.5 | -5.5 | 4.0e-08 | 0.97 | 0.03 | 0.87 | FALSE |
| 5 | GTEx | Whole Blood | TBCE | 0.06 | 0.03 | enet | 7 | 0.05 | 4.9e-05 | -5.3 | -5.4 | 5.6e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | B3GALNT2 | 0.04 | 0.01 | blup | 77 | 0.02 | 4.8e-03 | 5.4 | -5.2 | 2.0e-07 | 0.88 | 0.02 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TBCE | 0.04 | 0.02 | enet | 10 | 0.02 | 8.1e-05 | -5.4 | -5.4 | 7.4e-08 | 0.89 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TBCE | 0.04 | 0.05 | enet | 4 | 0.04 | 2.4e-05 | -5.5 | -5.7 | 1.1e-08 | 0.99 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBCE | 0.07 | 0.04 | blup | 58 | 0.05 | 6.8e-06 | -5.5 | -5.6 | 2.5e-08 | 0.89 | 0.01 | 0.99 | FALSE |