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chr10:125,739,009-127,174,440

Best TWAS P=3.27e-09 · Best GWAS P=7.7e-08 conditioned to 0.626

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	METTL10	0.20	0.26	lasso	9	0.26	4.5e-31	5.2	5.2	2.0e-07	0.97	0.02	0.98	FALSE
2	GTEx	Breast Mammary Tissue	METTL10	0.13	0.08	enet	19	0.13	4.8e-07	4.3	5.4	8.6e-08	0.77	0.04	0.96	FALSE
3	GTEx	Lung	METTL10	0.11	0.06	enet	6	0.05	1.7e-04	5.2	5.3	1.4e-07	0.95	0.02	0.98	FALSE
4	GTEx	Skin Sun Exposed Lower leg	METTL10	0.05	0.04	enet	8	0.04	2.1e-04	4.2	5.4	7.6e-08	0.82	0.03	0.94	FALSE
5	GTEx	Testis	METTL10	0.26	0.14	lasso	9	0.08	2.3e-04	5.3	5.3	9.6e-08	0.94	0.02	0.98	FALSE
6	GTEx	Thyroid	METTL10	0.19	0.09	enet	33	0.10	3.0e-08	5.2	5.1	3.1e-07	0.83	0.02	0.98	FALSE
7	METSIM	Adipose	METTL10	0.12	0.15	enet	27	0.15	1.1e-21	5.2	5.2	1.7e-07	0.93	0.02	0.98	FALSE
8	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	METTL10	0.09	0.08	blup	43	0.11	1.2e-09	5.3	5.9	3.3e-09	0.94	0.01	0.99	TRUE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	METTL10	0.06	0.13	lasso	7	0.13	1.1e-25	5.4	5.3	1.0e-07	0.98	0.01	0.99	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	METTL10	0.09	0.14	lasso	9	0.12	3.1e-07	5.4	5.5	4.8e-08	1.00	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	METTL10	0.10	0.14	blup	43	0.14	7.4e-16	5.3	5.5	3.7e-08	0.97	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	METTL10	0.13	0.16	blup	43	0.18	1.8e-20	5.3	5.4	6.3e-08	0.89	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	METTL10	0.11	0.19	lasso	6	0.19	7.3e-22	5.2	5.3	1.1e-07	0.98	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	METTL10	0.05	0.06	lasso	4	0.06	9.2e-05	4.8	5.3	1.4e-07	0.91	0.02	0.96	FALSE
15	The Cancer Genome Atlas	Rectum Adenocarcinoma	METTL10	0.25	0.11	lasso	4	0.23	3.8e-06	5.4	5.8	5.1e-09	0.86	0.02	0.88	FALSE
16	The Cancer Genome Atlas	Skin Cutaneous Melanoma	METTL10	0.39	0.21	lasso	5	0.21	2.9e-06	4.8	5.2	2.3e-07	0.80	0.03	0.95	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	METTL10	0.25	0.35	lasso	5	0.36	5.9e-36	5.2	5.3	1.3e-07	0.96	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	METTL10	0.13	0.08	blup	43	0.12	2.4e-04	5.2	5.9	4.2e-09	0.95	0.01	0.93	FALSE