Best TWAS P=6.08e-08 · Best GWAS P=5.3e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-298I3.1 | 0.18 | 0.07 | enet | 12 | 0.08 | 2.6e-05 | -5.2 | 5.3 | 1.1e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Coronary | HAUS4 | 0.36 | 0.25 | lasso | 5 | 0.22 | 8.6e-08 | -5.4 | -5.2 | 2.5e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Cerebellum | RBM23 | 0.31 | 0.18 | lasso | 4 | 0.22 | 3.4e-07 | -5.1 | 5.3 | 1.3e-07 | -0.94 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | HAUS4 | 0.26 | 0.07 | lasso | 6 | 0.04 | 3.7e-02 | -5.1 | -5.1 | 2.9e-07 | 0.88 | 0.03 | 0.81 | FALSE |
| 5 | GTEx | Brain Hypothalamus | RBM23 | 0.30 | 0.06 | lasso | 5 | 0.15 | 2.2e-04 | -5.0 | 5.1 | 3.0e-07 | -0.73 | 0.05 | 0.60 | FALSE |
| 6 | GTEx | Muscle Skeletal | HAUS4 | 0.09 | 0.08 | lasso | 4 | 0.06 | 1.4e-06 | -5.1 | -5.2 | 2.5e-07 | 0.94 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Stomach | HAUS4 | 0.29 | 0.20 | enet | 13 | 0.20 | 6.0e-10 | -4.8 | -5.4 | 6.6e-08 | 0.96 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Stomach | RP11-298I3.1 | 0.29 | 0.16 | lasso | 9 | 0.14 | 2.4e-07 | -5.2 | 5.4 | 6.1e-08 | -0.97 | 0.02 | 0.98 | TRUE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | HAUS4 | 0.21 | 0.23 | blup | 40 | 0.28 | 4.5e-09 | -5.1 | -5.2 | 2.0e-07 | 0.97 | 0.02 | 0.98 | FALSE |