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chr18:20,393,480-21,863,589

Best TWAS P=5.35e-09 · Best GWAS P=1.21e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	5.1	5.8	6.4e-09	-0.90	0.12	0.88	FALSE
2	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	5.1	5.6	1.9e-08	-0.82	0.10	0.90	FALSE
3	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	4.8	5.1	2.8e-07	-0.72	0.28	0.72	FALSE
4	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	-5.6	5.6	2.3e-08	-1.00	0.01	0.99	FALSE
5	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	5.1	5.6	2.3e-08	-0.86	0.03	0.92	FALSE
6	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	5.0	5.4	7.5e-08	-0.75	0.11	0.89	FALSE
7	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	5.1	5.2	2.5e-07	-0.83	0.03	0.96	FALSE
8	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	5.1	5.1	3.0e-07	-0.71	0.07	0.86	FALSE
9	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	4.8	5.1	2.8e-07	-0.74	0.14	0.85	FALSE
10	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	-5.7	5.8	5.3e-09	-0.99	0.01	0.99	TRUE
11	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	-5.7	5.8	6.0e-09	-0.93	0.01	0.99	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	5.0	5.7	1.2e-08	-0.86	0.04	0.96	FALSE
13	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	5.1	5.3	9.6e-08	-0.80	0.12	0.88	FALSE
14	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	4.8	5.5	3.9e-08	-0.87	0.02	0.98	FALSE
15	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	5.0	5.7	1.4e-08	-0.83	0.03	0.90	FALSE
16	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	4.8	5.2	2.0e-07	-0.78	0.14	0.86	FALSE
17	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	5.0	5.4	5.3e-08	-0.79	0.03	0.97	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	5.0	5.4	5.2e-08	-0.84	0.04	0.96	FALSE
19	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	-5.5	5.5	2.9e-08	-0.96	0.01	0.92	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	-5.6	5.6	1.6e-08	-0.99	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	-5.6	5.8	7.9e-09	-0.93	0.01	0.99	FALSE