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chr20:2,390,880-3,850,968

Best TWAS P=1.09e-09 · Best GWAS P=5.54e-08 conditioned to 0.91

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial UBOX5 0.18 0.07 lasso 4 0.05 5.4e-05 -5.4 5.7 9.2e-09 -0.90 0.00 1.00 FALSE
2 GTEx Cells EBV-transformed lymphocytes UBOX5 0.35 0.22 lasso 4 0.23 5.7e-08 4.9 5.4 7.4e-08 -0.71 0.02 0.97 FALSE
3 GTEx Esophagus Mucosa UBOX5 0.22 0.13 enet 10 0.18 6.8e-12 5.1 5.7 1.5e-08 -0.87 0.01 0.99 FALSE
4 GTEx Heart Atrial Appendage UBOX5 0.32 0.07 enet 14 0.13 1.5e-06 4.9 5.5 4.6e-08 -0.77 0.02 0.97 FALSE
5 GTEx Heart Left Ventricle UBOX5 0.20 0.09 enet 15 0.13 1.9e-07 4.3 5.7 1.3e-08 -0.79 0.01 0.98 FALSE
6 GTEx Muscle Skeletal UBOX5 0.12 0.09 enet 13 0.09 6.3e-09 5.1 5.5 4.3e-08 -0.81 0.01 0.98 FALSE
7 GTEx Nerve Tibial UBOX5 0.14 0.05 lasso 5 0.08 4.2e-06 -5.4 5.5 2.9e-08 -0.90 0.00 1.00 FALSE
8 GTEx Skin Sun Exposed Lower leg LZTS3 0.20 0.03 enet 28 0.06 5.1e-06 3.9 -5.5 3.3e-08 0.60 0.06 0.92 FALSE
9 GTEx Skin Sun Exposed Lower leg UBOX5 0.08 0.04 lasso 3 0.05 6.9e-05 5.1 5.5 4.8e-08 -0.61 0.02 0.94 FALSE
10 GTEx Thyroid UBOX5 0.15 0.07 lasso 2 0.12 1.2e-09 5.1 5.4 7.3e-08 -0.87 0.01 0.99 FALSE
11 ROSMAP Brain Pre-frontal Cortex UBOX5 0.26 0.17 lasso 8 0.16 4.1e-20 5.2 5.3 1.1e-07 -0.78 0.01 0.99 FALSE
12 YFS Blood FASTKD5 0.02 0.01 lasso 6 0.01 2.2e-05 5.1 -6.1 1.1e-09 0.88 0.00 0.99 TRUE