Best TWAS P=6.61e-11 · Best GWAS P=3.72e-15 conditioned to 5.41e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | EIF4E2 | 0.16 | 0.06 | lasso | 3 | 0.05 | 2.2e-04 | 5.4 | 5.4 | 7.0e-08 | 0.61 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Colon Transverse | EIF4E2 | 0.27 | 0.17 | enet | 19 | 0.18 | 7.7e-09 | 5.4 | -5.8 | 5.3e-09 | -0.62 | 0.06 | 0.94 | FALSE |
| 3 | GTEx | Colon Transverse | AC073254.1 | 0.22 | 0.13 | lasso | 4 | 0.15 | 9.3e-08 | 5.2 | -5.4 | 8.1e-08 | -0.62 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | EIF4E2 | 0.39 | 0.26 | lasso | 5 | 0.27 | 1.7e-12 | 5.4 | -5.4 | 7.4e-08 | -0.59 | 0.05 | 0.95 | FALSE |
| 5 | GTEx | Heart Left Ventricle | EIF4E2 | 0.41 | 0.23 | lasso | 3 | 0.27 | 1.6e-14 | 5.4 | -5.6 | 2.7e-08 | -0.60 | 0.05 | 0.95 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PRSS56 | 0.19 | 0.12 | enet | 16 | 0.15 | 5.7e-19 | 5.1 | 6.5 | 6.6e-11 | 0.72 | 0.99 | 0.01 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EIF4E2 | 0.12 | 0.12 | lasso | 10 | 0.11 | 4.8e-07 | 5.4 | -5.4 | 6.1e-08 | -0.62 | 0.99 | 0.00 | FALSE |