Hub : Genes

EIF4E2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0936	0.0365	2.8e-03	0.062	NA	0.042	NA	0.045	1.2e-05	NA	3.2e-04	NA	1.7e-04
2	GTEx	Cells Transformed fibroblasts	0.1570	0.0480	3.5e-04	0.060	NA	0.013	NA	0.046	2.9e-05	NA	3.2e-02	NA	2.2e-04
3	GTEx	Colon Transverse	0.2700	0.0680	3.8e-05	0.167	NA	0.178	NA	0.176	2.3e-08	NA	7.7e-09	NA	9.0e-09
4	GTEx	Heart Atrial Appendage	0.3910	0.0690	1.0e-07	0.264	NA	0.248	NA	0.269	3.2e-12	NA	1.6e-11	NA	1.7e-12
5	GTEx	Heart Left Ventricle	0.4098	0.0708	3.5e-09	0.229	NA	0.265	NA	0.267	2.0e-12	NA	2.1e-14	NA	1.6e-14
6	ROSMAP	Brain Pre-frontal Cortex	0.1158	0.0348	9.6e-06	0.067	0.050	0.042	0.046	0.056	4.8e-09	4.9e-07	3.9e-06	1.4e-06	9.4e-08
7	YFS	Blood	0.0608	0.0159	1.0e-09	0.037	0.038	0.041	NA	0.039	2.4e-12	1.7e-12	2.8e-13	NA	9.6e-13
8	TCGA	Breast Invasive Carcinoma	0.0269	0.0118	5.6e-07	0.028	0.034	0.037	NA	0.036	1.4e-06	1.5e-07	4.4e-08	NA	6.4e-08
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1190	0.0440	1.2e-06	0.120	0.109	0.088	NA	0.114	2.3e-07	8.8e-07	9.4e-06	NA	4.8e-07
10	TCGA	Brain Lower Grade Glioma	0.0259	0.0151	5.9e-03	0.014	0.019	0.017	NA	0.018	8.2e-03	2.7e-03	4.4e-03	NA	3.8e-03
11	TCGA	Thyroid Carcinoma	0.0270	0.0150	6.0e-03	0.012	0.020	0.011	NA	0.006	2.3e-02	4.7e-03	2.4e-02	NA	7.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.3	0.4	1.5	-1.0	-0.2	0.4	0.2	0.1	0.0	1.2	-0.8	-0.1	-0.6	-0.8
Bipolar Disorder or Schizophrenia	1.1	2.6	5.2	-1.9	-1.3	1.3	0.9	1.2	-1.4	2.3	-2.0	1.3	-1.8	-1.8
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	0.0	-0.3	0.0	0.1	0.2	-0.3	1.5	-1.0	0.3	-1.4	-1.2
Depression (Nagel 2018)	1.0	1.6	2.7	0.0	-1.3	1.2	1.0	1.3	-1.1	1.2	-1.6	1.1	-1.6	-1.5
Intelligence (Savage-Jansen 2018)	0.1	0.2	1.3	0.0	0.2	-0.5	-0.4	-0.3	0.4	1.1	-0.4	-0.4	-0.1	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	2.5	0.0	0.1	-0.3	-0.3	-0.2	0.1	1.6	-0.5	-0.1	-0.8	-0.7
Schizophrenia (2018)	1.3	2.7	3.8	-1.6	-1.5	1.3	1.1	1.5	-1.8	1.9	-1.9	1.7	-1.8	-1.7
Schizophrenia vs Biploar Disorder	0.8	1.0	2.0	-0.3	-1.2	1.2	1.1	1.4	-1.1	0.6	-0.7	1.3	-0.8	-0.7
Worry (Nagel 2018)	0.0	0.1	0.3	0.0	0.1	-0.2	-0.3	-0.0	0.1	0.6	0.1	-0.2	0.2	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	-0.8	-0.4	0.4	0.3	0.3	-0.7	1.2	-0.7	0.6	-0.3	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.0	0.5	-0.0	-0.4	-0.7	0.1	0.2	0.2	-0.5	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.8	0.1	0.1	0.0	-0.3	-0.5	0.2	0.5	0.1	0.8	0.6
Crohns Disease (2017)	0.0	0.0	0.2	0.1	0.2	-0.2	-0.2	-0.2	0.1	0.5	0.1	-0.2	-0.1	-0.1
Irritable Bowel Disease (IBD)	0.5	1.1	3.8	2.0	-0.1	0.0	0.4	0.2	0.1	-1.0	1.3	-0.1	1.4	1.7
Ulcerative Colitis (UC)	0.8	1.6	4.7	2.2	-0.3	0.1	0.6	0.2	0.3	-1.6	1.4	0.0	1.8	2.0
Major Depression (MDD)	0.7	0.8	1.8	-0.8	-0.8	0.9	0.7	0.7	-0.5	0.8	-1.1	0.8	-1.3	-1.3
Reaction Time	0.5	1.0	1.8	0.5	-1.3	1.1	1.4	1.3	-1.3	-0.4	-0.5	1.2	-0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.7	-1.1	-0.8	0.6	0.5	0.8	-0.7	1.3	-1.0	0.7	-0.5	-0.4
Breast Cancer	0.1	0.3	0.8	-0.1	0.7	-0.7	-0.5	-0.8	0.9	-0.3	0.2	-0.8	-0.2	-0.2
Ovarian Cancer	0.1	0.2	0.8	0.5	-0.2	0.4	0.4	0.4	0.1	0.2	0.2	-0.0	0.9	0.7
Prostate Cancer	0.7	0.9	5.2	-1.5	-0.0	-0.2	-0.2	-0.1	0.3	2.3	-1.0	-0.4	-0.8	-1.1
Age at First Birth	0.8	1.2	3.4	-0.7	-0.8	0.8	0.7	0.7	-0.7	1.4	-1.2	1.0	-1.8	-1.5
Bipolar Disorder (2011)	0.7	0.6	2.1	-0.3	-1.3	1.2	1.4	1.1	0.0	0.7	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	2.1	0.6	1.4	-1.3	-1.2	-1.4	1.2	-1.2	1.3	-1.2	1.3	1.3
Coronary Artery Disease (CAD)	0.5	0.7	1.7	0.8	0.8	-0.9	-1.2	-0.6	0.6	-1.3	1.0	-0.7	0.5	0.2
Crohns Disease (2012)	0.1	0.1	0.5	-0.2	0.2	-0.2	-0.2	-0.3	0.1	0.7	-0.0	-0.1	-0.4	-0.2
Mean Putamen Volume	0.1	0.1	0.4	0.2	0.3	-0.1	-0.2	-0.4	-0.0	-0.1	0.3	-0.1	0.6	0.3
Fasting Glucose	0.4	0.5	0.9	0.8	0.8	-0.5	-0.9	-0.7	0.9	-0.9	0.5	-0.6	0.4	0.6
HbA1C	0.5	0.5	2.0	1.3	-0.1	0.4	0.2	0.2	0.6	-1.4	0.8	-0.1	0.5	0.7
HDL Cholesterol	0.7	1.2	2.1	-0.9	-1.2	1.0	1.0	1.0	-1.2	0.8	-1.3	1.0	-1.4	-1.3
LDL Cholesterol	2.1	3.3	4.6	1.0	2.0	-2.0	-1.9	-1.9	1.6	-1.3	1.9	-2.0	2.1	1.7
Lupus	0.2	0.3	1.4	-1.2	0.2	-0.2	-0.5	-0.3	-0.1	0.8	-0.6	-0.4	-0.2	-0.4
Neuroticism (2016)	0.2	0.3	0.8	-0.5	-0.3	0.4	0.4	0.2	-0.6	0.9	-0.6	0.7	-0.5	-0.2
Primary Biliary Cirrhosis	0.2	0.4	0.7	-0.6	0.6	-0.8	-0.8	-0.6	0.5	-0.8	-0.1	-0.6	-0.2	-0.3
Rheumatoid Arthritis	0.3	0.4	1.1	1.0	-0.2	0.2	0.5	0.3	-0.2	-0.9	0.8	0.0	0.9	1.1
Schizophrenia (2014)	1.8	4.0	6.7	-1.5	-2.1	2.0	1.8	2.1	-1.9	2.6	-2.1	2.1	-1.8	-1.7
Triglycerides	0.1	0.2	0.7	0.6	-0.0	0.4	0.3	0.1	-0.1	-0.8	0.6	-0.1	0.7	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.2	0.5	-0.4	-0.6	-0.7	0.3	-0.5	0.3	-0.8	0.0	0.0
Ulcerative Colitis	2.1	3.1	9.6	3.1	-0.1	-0.0	0.4	0.1	0.6	-2.3	2.3	0.1	2.4	2.8
Blood Eosinophil Count	0.1	0.4	1.1	-0.1	0.6	-1.0	-0.8	-0.5	0.8	0.9	0.2	-0.5	-0.2	0.1
Blood Platelet Count	1.0	11.8	31.2	-5.6	-1.2	1.4	0.5	1.1	-1.5	4.1	-4.6	1.1	-4.8	-5.3
Blood Red Count	0.2	2.0	5.7	2.4	-0.5	0.3	0.8	0.4	-0.8	-1.5	1.5	0.8	1.9	2.3
Blood White Count	0.8	5.7	16.0	-4.0	-0.8	0.7	0.1	0.8	-0.5	3.5	-3.2	0.5	-3.1	-3.6
Heel T-Score	0.3	2.5	6.8	2.3	0.9	-0.8	-0.3	-0.7	0.5	-1.2	2.2	-0.9	2.5	2.6
BMI	0.1	0.5	1.2	-0.7	-0.7	0.6	0.6	0.7	-1.1	0.4	-0.7	0.9	0.0	-0.4
Height	3.3	64.2	158.8	-11.4	-4.0	3.2	1.8	3.7	-2.9	12.6	-10.4	4.0	-10.9	-11.1
Waist Hip Ratio (WHR)	0.0	0.2	0.5	0.3	-0.4	0.6	0.3	0.4	-0.4	-0.5	0.1	0.3	0.7	0.2
Systolic Blood Pressure	0.0	0.1	0.5	0.7	-0.3	0.1	0.2	0.2	-0.3	-0.2	0.4	0.2	0.2	0.1
Smoking Status	2.5	5.9	9.4	1.0	2.8	-2.8	-2.8	-2.8	3.0	-0.3	2.0	-3.1	2.5	2.1
Allergy or Eczema	0.0	0.1	0.3	-0.5	-0.2	0.0	-0.0	0.2	-0.3	-0.1	-0.4	0.2	-0.1	-0.2
Cardiovascular Disease	0.2	0.7	1.6	-0.4	0.9	-0.8	-0.9	-0.9	0.8	1.0	0.2	-1.3	0.7	-0.0
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.7	-0.4	0.6	0.5	0.5	-0.1	0.9	-0.7	0.1	-0.6	-0.8
Respiratory disease	0.5	1.1	2.9	-0.3	1.4	-1.7	-1.5	-1.4	0.9	0.3	0.4	-1.4	0.4	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.3	-0.8	0.1	-0.3	-0.1	-0.2	0.3	1.1	-0.5	0.0	-0.4	-0.5
Lung FEV1/FVC ratio	0.4	2.2	6.7	-2.5	-0.1	0.5	-0.3	0.0	-0.1	2.1	-1.9	0.1	-1.7	-2.6
Lung FVC	3.3	16.8	30.0	5.1	2.9	-2.9	-2.0	-2.6	3.1	-5.2	5.1	-3.1	5.4	5.5
Neuroticism	0.1	0.3	0.6	0.1	0.7	-0.8	-0.7	-0.7	0.4	0.7	0.4	-0.7	0.2	0.4
Chronotype (morning person)	0.0	0.1	0.4	-0.1	-0.3	0.3	0.3	0.7	0.1	0.1	-0.2	0.3	-0.1	-0.2
Hair Pigment	0.5	14.1	18.7	-2.7	-4.3	4.0	3.9	4.3	-3.9	3.4	-3.9	4.0	-3.4	-3.2
Tanning	0.0	0.3	0.6	0.6	0.6	-0.1	-0.4	-0.6	0.6	0.3	0.4	-0.4	0.7	0.8
Hand grip strength (left)	0.6	1.7	3.3	0.7	1.6	-1.6	-1.3	-1.6	1.8	-0.3	1.1	-1.3	0.9	1.1
Number of treatments/medications taken	1.1	1.9	4.2	0.5	1.7	-2.1	-1.7	-1.6	1.3	-0.6	1.3	-1.8	1.2	0.7
Average weekly spirits intake	2.1	2.5	5.3	0.2	1.9	-2.0	-1.9	-1.9	2.3	0.5	1.2	-1.9	1.3	0.9
Sensitivity / hurt feelings	0.6	1.0	4.5	-1.2	-0.2	0.0	-0.1	0.1	-0.0	2.1	-1.0	0.3	-1.3	-1.6
Frequency of depressed mood in last 2 weeks	3.5	5.0	8.7	-2.8	-1.7	1.7	1.1	1.6	-1.8	2.9	-2.9	1.5	-2.7	-2.7
Hearing difficulty/problems: Yes	0.4	0.5	2.1	-0.7	-0.4	0.5	0.2	0.4	-0.3	1.5	-0.8	0.5	-1.0	-0.9
Relative age of first facial hair	10.0	20.5	33.2	-5.3	-3.8	3.8	3.1	3.9	-3.4	4.8	-5.8	3.6	-5.6	-5.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-1.1	-0.2	0.0	-0.2	0.1	-0.3	0.7	-1.0	0.1	-0.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.5	-0.5	0.7	0.5	0.6	-0.2	0.3	-0.6	0.5	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.7	0.7	2.7	-1.7	0.2	-0.2	-0.3	-0.1	0.3	1.0	-1.1	-0.0	-1.1	-1.3
Systolic blood pressure, automated reading	0.4	1.2	3.6	1.8	-0.7	0.8	0.9	0.7	-0.7	-1.9	1.0	0.9	0.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	0.2	0.8	-1.0	-0.8	-0.6	0.8	-0.1	0.4	-0.8	-0.2	-0.1
Angina	3.8	5.0	6.9	1.4	2.5	-2.6	-2.2	-2.4	2.3	-1.8	2.4	-2.3	2.3	2.1
Medication for hormone replacement therapy	0.4	0.4	1.2	0.1	-0.8	1.1	1.0	0.8	-0.4	-0.1	-0.2	0.8	-0.6	-0.4
Vitamin and mineral supplements	0.5	0.7	1.7	0.7	-1.1	0.9	1.3	1.0	-0.8	-0.4	0.0	0.8	0.5	0.8
Supplements: Zinc	0.9	1.0	2.5	0.8	0.8	-1.1	-0.6	-0.7	0.8	-0.6	1.2	-0.7	1.6	1.5
Medication: Co-codamol	1.9	2.2	4.3	-1.5	-1.4	1.4	1.3	1.2	-1.3	2.1	-1.7	1.1	-1.5	-1.4
Medication: Metformin	0.6	0.8	1.9	-0.5	1.2	-1.3	-1.2	-1.2	1.4	0.2	0.1	-1.0	0.1	-0.0
Diabetes (father)	6.5	8.0	14.6	-1.4	-3.1	3.2	3.1	3.2	-3.8	1.3	-2.4	3.3	-2.8	-2.5
Diabetes (mother)	0.6	0.7	1.2	-1.0	-1.0	0.9	0.7	1.0	-0.7	0.9	-1.1	0.8	-0.4	-0.7
Severe depression (siblings)	1.6	1.8	2.6	-1.6	-1.2	1.1	1.1	1.5	-1.2	1.2	-1.6	1.2	-1.3	-1.6
Pack years adult smoking proportion	2.6	4.0	5.6	-1.4	-2.3	2.4	2.1	2.2	-2.3	1.5	-2.1	2.1	-1.7	-1.6
Impedance of leg (right)	0.6	2.7	5.6	-1.4	-1.4	1.6	1.4	1.5	-1.3	0.9	-2.0	1.3	-2.4	-2.3
Leg fat-free mass (left)	1.1	6.1	17.9	-4.0	-0.7	0.3	-0.1	0.6	-0.6	4.2	-3.3	0.8	-2.9	-3.3
Trunk fat percentage	1.2	4.8	14.2	-3.8	-1.0	0.7	0.1	0.9	-0.8	2.6	-3.3	0.8	-2.6	-3.3
Hand grip strength (right)	1.1	2.9	6.6	0.1	2.2	-2.4	-2.1	-2.2	2.6	0.2	1.0	-2.0	0.6	0.6
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.8	-0.6	1.0	0.4	0.7	-0.8	0.6	-0.7	0.3	0.3	0.1
Current tobacco smoking	0.7	1.1	2.4	-0.6	1.1	-1.1	-1.2	-1.1	1.6	1.3	0.1	-1.3	0.7	0.3
Average weekly fortified wine intake	3.8	4.4	7.0	-2.5	-1.8	1.8	1.5	1.6	-1.6	2.6	-2.6	1.9	-2.5	-2.2
Maternal smoking around birth	2.6	3.8	5.3	1.1	2.1	-2.2	-2.0	-1.8	2.2	-1.3	1.9	-2.1	2.3	2.1
Fed-up feelings	0.2	0.3	1.2	-0.7	-0.1	-0.2	-0.1	-0.1	0.0	0.6	-0.6	0.2	-1.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	10.8	-3.3	-1.1	0.9	0.4	0.9	-1.1	3.2	-2.9	0.9	-2.5	-2.8
Relative age voice broke	9.8	14.9	21.2	-3.6	-3.8	3.7	3.4	3.7	-3.6	3.9	-4.6	3.7	-4.3	-4.1
Taking other prescription medications	0.4	0.6	1.3	0.4	1.0	-1.1	-0.9	-1.0	0.5	-0.5	1.0	-0.9	0.4	0.4
Age when periods started (menarche)	0.7	1.6	3.2	0.4	-1.6	1.7	1.8	1.7	-1.5	0.9	-0.5	1.5	-0.0	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	-0.6	0.3	-0.1	-0.3	-0.3	0.5	0.4	-0.3	-0.2	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.2	4.9	6.7	1.8	2.6	-2.5	-2.5	-2.2	2.4	-0.5	2.4	-2.6	2.4	1.8
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.8	1.3	1.2	-1.2	-1.1	-1.1	1.0	-1.1	1.6	-1.2	1.9	1.6
Qualifications: CSEs or equivalent	0.6	0.8	1.6	1.1	0.6	-0.5	-0.5	-0.7	1.0	-0.3	1.1	-0.9	1.2	1.1
Serious illness, injury or assault to yourself	0.1	0.1	0.8	-0.4	-0.1	-0.1	0.0	0.1	-0.2	0.9	-0.4	0.0	-0.0	0.1
High blood pressure	0.1	0.2	0.7	-0.0	0.3	-0.5	-0.2	-0.2	0.6	0.6	0.3	-0.7	0.8	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.4	0.4	-0.7	-0.6	-0.5	0.3	-0.3	-0.2	-0.3	-0.1	-0.2
Multivitamins +/- minerals	1.2	1.6	3.4	-0.0	1.7	-1.4	-1.8	-1.6	1.3	-0.5	0.9	-1.7	0.6	0.3
Stomach or abdominal pain in last month	0.5	0.7	2.3	-1.3	-0.1	-0.4	-0.2	0.1	0.1	1.5	-1.1	0.3	-1.0	-0.9
Supplements: Glucosamine	0.1	0.1	0.2	0.3	-0.2	0.4	0.3	0.4	0.2	0.3	0.1	-0.2	0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.5	-1.9	-0.6	0.9	0.4	0.7	-0.7	1.4	-1.6	0.7	-1.0	-1.6
Medication: Atenolol	0.6	0.8	1.7	1.1	0.6	-0.6	-0.3	-0.5	1.2	-1.3	1.1	-0.7	0.9	0.6
Medication: Levothyroxine sodium	0.4	0.6	2.5	-1.3	-0.1	0.1	-0.2	-0.1	0.4	1.6	-0.8	-0.2	-0.5	-1.1
Sitting height	2.0	14.2	57.5	-5.0	-1.3	0.8	0.4	1.1	-1.1	7.6	-4.4	1.5	-4.9	-4.8
Chronic bronchitis/emphysema (father)	2.3	2.7	5.4	0.7	2.0	-1.9	-1.9	-1.8	2.3	-0.0	1.5	-2.0	1.3	1.2
High blood pressure (mother)	0.8	1.2	3.2	1.7	0.5	-0.3	-0.1	-0.4	0.3	-1.2	1.4	-0.6	1.5	1.8
Body mass index (BMI)	0.2	0.8	3.1	-1.8	-0.5	0.4	0.1	0.5	-0.5	0.8	-1.4	0.3	-0.6	-1.3
Impedance of leg (left)	0.4	1.9	4.2	-1.3	-1.2	1.3	1.0	1.2	-0.9	1.2	-1.7	0.9	-2.0	-2.0
Leg predicted mass (left)	1.2	6.2	17.7	-4.0	-0.8	0.4	-0.0	0.7	-0.7	4.2	-3.4	0.9	-3.0	-3.3
Trunk fat mass	2.0	8.6	21.9	-4.7	-1.5	1.2	0.4	1.4	-1.2	3.9	-4.2	1.3	-3.5	-4.3
Waist circumference	0.8	2.9	6.7	-2.6	-1.3	1.2	0.6	1.3	-1.1	1.8	-2.5	1.1	-1.6	-2.3
Number of incorrect matches in round	0.3	0.5	1.4	1.0	-0.4	0.4	0.6	0.5	-0.4	-1.2	0.5	0.6	0.8	0.7
Past tobacco smoking	0.6	1.1	1.7	-1.2	-0.9	1.0	0.7	0.9	-1.2	0.7	-1.1	0.9	-1.2	-1.3
Alcohol usually taken with meals	0.2	0.4	1.3	-0.3	-0.5	0.4	0.5	0.3	-0.2	0.5	-0.4	0.6	-1.1	-1.1
Nervous feelings	0.3	0.6	1.5	-0.8	-1.0	0.8	0.7	1.0	-1.2	0.5	-1.0	0.7	-0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.8	-2.2	-0.8	0.7	0.3	0.9	-0.9	2.0	-2.0	0.6	-1.5	-1.7
Hearing difficulty/problems with background noise	0.4	0.6	2.7	-0.6	-0.6	0.4	0.4	0.6	-0.6	1.6	-0.8	0.8	-0.7	-0.5
Hair/balding pattern: Pattern 2	3.0	3.9	12.8	3.6	0.5	-0.5	-0.0	-0.6	0.7	-3.2	2.6	-0.2	2.1	2.6
Had menopause	5.0	6.2	9.7	-2.6	-2.3	2.1	1.8	2.4	-2.2	2.1	-2.9	2.5	-3.1	-3.0
Had other major operations	2.9	3.5	6.8	-0.1	-2.5	2.2	2.6	2.5	-2.0	0.4	-1.2	2.4	-1.2	-1.1
Forced vital capacity (FVC)	0.3	1.0	2.3	1.1	0.7	-1.1	-0.5	-0.7	1.2	-1.5	1.0	-0.8	0.8	1.2
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	7.3	1.4	2.7	-2.6	-2.6	-2.3	2.4	-0.2	2.4	-2.6	2.5	1.9
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.4	-2.3	-0.7	0.7	0.4	0.5	-0.4	1.8	-2.0	0.6	-1.8	-2.0
Qualifications: None of the above	0.6	1.2	2.1	0.9	-1.1	1.4	1.2	1.1	-1.2	-1.2	0.2	1.0	1.0	1.1
Financial difficulties in last 2 years	3.0	4.0	6.2	-2.1	-2.1	1.9	1.8	1.9	-2.5	1.5	-2.5	1.9	-1.8	-1.8
Mouth/teeth dental problems	0.7	1.1	2.3	1.5	0.5	-0.5	-0.1	-0.5	0.3	-1.5	1.5	-0.5	1.3	1.5
Heart attack	0.4	0.5	1.0	0.1	-0.8	0.8	1.0	0.8	-1.0	-0.7	-0.4	0.7	-0.3	-0.3
Allergy	0.1	0.1	0.5	0.4	-0.4	0.7	0.6	0.4	-0.2	0.2	0.1	0.3	0.2	0.2
Pain all over the body in last month	0.4	0.4	1.4	-0.3	-0.8	0.6	0.7	0.9	-0.4	-0.6	-0.6	1.2	-0.4	-0.2
Diabetes (self-reported)	0.4	0.7	1.8	-0.8	0.8	-1.4	-0.9	-0.8	1.1	1.0	-0.1	-0.7	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	2.6	1.2	1.4	-1.6	-1.4	-1.6	1.3	-1.4	1.5	-1.0	1.1	1.2
Medication: Ramipril	1.2	1.6	2.6	1.3	0.8	-1.0	-0.5	-1.1	1.2	-1.6	1.4	-1.4	1.6	1.4
Medication: Simvastatin	0.7	1.0	1.7	0.0	1.2	-1.1	-1.1	-1.1	1.3	0.7	0.6	-1.3	1.0	0.8
Fluid intelligence score	0.7	1.4	2.4	0.7	1.1	-1.1	-1.1	-1.1	1.4	-0.4	1.3	-1.1	1.6	1.5
Illnesses of siblings	2.3	3.3	5.4	0.7	2.3	-2.3	-2.3	-2.2	2.1	-1.0	1.7	-2.0	1.3	1.1
Neuroticism score	0.1	0.3	1.5	-0.7	-0.2	0.1	0.1	0.1	-0.5	1.2	-0.6	0.2	-0.6	-0.6
Weight	2.0	10.0	24.8	-5.0	-1.6	1.2	0.5	1.5	-1.3	4.7	-4.4	1.5	-3.7	-4.4
Impedance of arm (right)	0.1	0.4	2.3	0.8	-0.1	0.1	0.2	0.1	0.1	-1.5	0.5	0.0	0.5	0.7
Arm fat percentage (right)	0.1	0.3	1.2	-1.1	-0.4	0.3	-0.1	0.4	-0.3	-0.1	-0.9	0.1	0.1	-0.6
Trunk fat-free mass	1.6	9.3	26.9	-4.4	-1.3	1.0	0.5	1.3	-0.9	5.2	-4.0	1.4	-3.9	-4.2
Hip circumference	1.2	5.1	13.5	-3.7	-1.0	0.8	0.2	1.0	-0.9	3.2	-3.2	0.9	-2.6	-3.2
Time employed in main current job	0.2	0.2	0.9	-1.0	0.0	0.2	-0.2	0.1	-0.2	0.6	-0.5	-0.1	-0.4	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.3	0.4	-0.4	-0.4	-0.4	0.6	-1.0	0.5	-0.5	0.8	0.7
Father’s age at death	1.2	1.6	5.1	-2.0	-0.3	0.3	0.0	0.4	-0.3	2.3	-1.6	0.4	-1.5	-1.8
Worrier / anxious feelings	0.1	0.1	0.4	0.3	-0.4	0.3	0.4	0.4	-0.4	0.0	-0.0	0.6	-0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	10.2	-3.2	-1.1	1.1	0.4	0.8	-1.1	2.3	-2.7	0.9	-2.2	-2.5
Falls in the last year	0.0	0.1	0.3	0.1	0.0	0.3	0.0	-0.2	0.1	-0.6	0.2	-0.4	0.2	-0.1
Hair/balding pattern: Pattern 3	2.1	3.1	6.1	-2.2	-1.6	1.5	1.2	1.6	-1.6	2.5	-2.1	1.5	-1.4	-1.8
Number of live births	0.1	0.1	0.5	-0.4	0.2	-0.0	-0.3	-0.0	0.2	-0.4	-0.0	-0.4	0.7	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.4	1.4	1.5	-1.6	-1.3	-1.5	1.8	-1.8	1.5	-1.5	1.1	1.3
Pulse rate	2.4	4.1	8.4	-2.9	-1.5	1.4	1.1	1.5	-1.3	2.4	-2.8	1.4	-2.5	-2.3
Happiness	0.9	1.1	3.5	-1.4	-0.1	-0.1	-0.1	0.0	-0.3	1.2	-1.2	0.2	-1.8	-1.9
Noisy workplace	0.0	0.1	0.3	0.2	0.0	-0.0	0.1	0.1	-0.3	-0.5	0.2	0.1	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.9	4.2	-0.1	1.7	-2.1	-1.8	-1.9	1.7	0.3	0.8	-1.7	0.0	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.6	-1.7	-0.5	0.9	0.3	0.4	-0.8	1.0	-1.6	0.7	-1.7	-1.9
Mouth/teeth dental problems: Dentures	0.7	1.1	4.3	-1.7	-0.4	0.5	0.2	0.6	-0.3	2.1	-1.4	0.4	-0.7	-1.3
Asthma	1.1	2.1	4.2	0.2	1.8	-1.9	-1.9	-1.6	1.4	-0.9	1.1	-2.0	1.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	0.5	-1.0	1.1	1.1	1.1	-1.1	0.0	-0.1	1.0	-0.3	-0.3
Medication: Cholesterol lowering	0.3	0.4	0.7	0.5	0.6	-0.6	-0.5	-0.7	0.1	-0.5	0.7	-0.7	0.9	0.8
Depression (self-reported)	0.2	0.3	0.5	0.6	0.6	-0.4	-0.5	-0.5	0.2	-0.7	0.5	-0.7	0.5	0.6
Medication: Lansoprazole	0.2	0.2	0.5	-0.6	0.6	-0.7	-0.7	-0.3	0.2	-0.4	0.1	-0.3	0.2	0.0
Prospective memory result	2.0	2.5	4.2	-1.0	-1.6	1.6	1.3	1.7	-1.7	0.5	-1.6	1.7	-2.0	-2.0
Lung cancer (father)	1.2	1.4	2.1	-0.6	-1.4	1.3	1.4	1.2	-0.9	0.4	-1.2	1.3	-1.4	-1.4
Illnesses of mother	1.0	1.2	2.9	-1.2	1.0	-0.9	-1.3	-1.1	1.2	1.7	-0.4	-1.2	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.5	0.3	1.3	-1.4	-1.2	-1.3	1.6	-0.5	0.7	-1.3	0.4	0.4
Pulse wave Arterial Stiffness index	4.2	4.9	8.0	-2.2	-2.1	2.3	1.7	1.8	-2.1	1.7	-2.7	1.8	-2.7	-2.8
Impedance of arm (left)	0.0	0.1	0.7	0.1	-0.0	-0.1	0.0	0.0	0.1	-0.8	-0.0	-0.0	-0.3	0.1
Arm fat mass (right)	0.6	2.5	7.8	-2.8	-0.8	0.6	0.1	0.8	-0.6	2.0	-2.4	0.6	-1.6	-2.3
Trunk predicted mass	1.7	9.5	27.4	-4.4	-1.4	1.0	0.5	1.4	-0.9	5.2	-4.0	1.4	-3.9	-4.2
Standing height	2.7	26.8	72.9	-7.4	-2.2	1.5	0.8	2.0	-1.5	8.5	-6.7	2.4	-7.1	-7.2
Length of working week for main job	1.0	1.1	2.4	-0.9	1.3	-1.3	-1.6	-1.4	0.9	0.9	0.1	-1.3	-0.2	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.8	0.9	0.1	-0.0	0.2	0.2	0.1	-0.8	0.7	0.0	0.2	0.3
Breastfed as a baby	2.4	2.9	3.9	1.9	1.6	-2.0	-1.5	-1.5	1.8	-1.6	2.0	-1.3	1.7	1.9
Tense / ‘highly strung’	0.6	1.0	2.1	-1.4	-0.5	0.3	0.0	0.6	-0.7	1.3	-1.4	0.4	-1.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.6	-2.1	-0.9	0.6	0.5	0.8	-0.6	1.2	-1.9	0.6	-2.1	-2.0
Hair/balding pattern: Pattern 4	0.1	0.2	1.0	-1.0	0.2	0.0	-0.3	-0.1	0.2	0.5	-0.4	-0.3	-0.3	-0.4
Birth weight of first child	1.5	2.7	4.7	-1.4	1.8	-1.9	-2.1	-1.6	2.1	2.2	-0.1	-2.0	-0.1	-0.7
Peak expiratory flow (PEF)	0.8	1.8	2.7	1.0	1.4	-1.5	-1.3	-1.4	1.5	-1.6	1.3	-1.3	0.9	1.2
Pulse wave reflection index	1.9	2.3	5.2	2.3	1.2	-1.1	-0.7	-1.3	1.3	-1.5	2.2	-1.2	1.6	1.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.5	-2.1	0.3	-0.1	-0.7	-0.3	-0.2	1.9	-1.4	-0.1	-1.1	-1.6
Loud music exposure frequency	0.2	0.2	0.7	0.8	0.2	0.0	0.1	-0.2	-0.0	-0.6	0.6	0.0	0.4	0.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.0	-1.0	2.1	-2.5	-2.2	-2.2	2.0	1.0	0.5	-2.3	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.9	-2.2	-0.2	0.1	-0.2	0.1	-0.2	1.4	-1.7	0.0	-1.6	-1.7
Blood clot in the leg (DVT)	2.8	3.7	7.3	0.0	-2.5	2.7	2.6	2.5	-2.1	0.3	-1.0	2.6	-1.1	-0.5
Medication: Paracetamol	0.3	0.5	1.5	0.9	-0.5	0.3	0.6	0.5	-0.8	-1.2	0.4	0.6	0.6	0.8
Headache pain in last month	0.2	0.4	0.8	-0.9	0.4	-0.7	-0.7	-0.5	0.5	0.9	-0.5	-0.3	-0.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.2	0.0	0.4	0.3	-0.3	0.1	-0.6	-0.3
Glaucoma (self-reported)	1.4	1.7	2.8	0.6	1.5	-1.5	-1.5	-1.5	1.4	-0.1	1.3	-1.7	1.2	1.2
Gout (self-reported)	0.2	0.3	1.1	-0.7	0.1	-0.2	-0.2	0.1	-0.0	1.1	-0.5	-0.4	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-1.0	-0.3	0.5	0.1	0.3	-0.2	0.9	-0.7	-0.0	-0.6	-1.0
Medication: Amlodipine	0.8	1.2	2.4	-0.1	-1.5	1.3	1.6	1.3	-1.2	0.3	-0.8	1.4	-0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.7	0.5	0.0	-0.1	0.0	0.2	-0.5	-0.9	0.3	0.1	0.0	0.2
Birth weight	0.6	1.2	2.4	-0.2	1.4	-1.4	-1.6	-1.4	1.4	0.9	0.4	-1.4	-0.2	-0.2
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.7	0.0	1.8	-1.8	-1.9	-1.8	1.5	-1.1	0.8	-1.4	0.1	-0.0
High blood pressure (siblings)	2.1	3.1	4.8	-1.6	-1.9	1.6	1.6	1.7	-1.7	1.6	-2.2	1.5	-1.9	-1.8
Forced vital capacity (FVC), Best measure	0.4	1.5	3.0	0.8	1.3	-1.5	-1.2	-1.2	1.7	-0.9	1.1	-1.3	0.8	1.1
Body fat percentage	1.1	4.4	11.4	-3.4	-1.3	1.2	0.5	1.3	-1.2	2.1	-3.2	1.1	-2.3	-3.0
Leg fat percentage (right)	1.4	5.2	9.6	-2.8	-2.2	2.2	1.6	2.2	-2.0	1.5	-3.1	1.8	-2.3	-2.9
Arm fat-free mass (right)	2.9	14.7	41.2	-5.8	-1.4	1.0	0.3	1.3	-1.1	6.4	-5.0	1.5	-5.0	-5.4
Exposure to tobacco smoke outside home	0.7	1.0	2.5	-0.9	-0.7	0.7	0.6	0.8	-0.8	1.6	-0.9	0.9	-1.4	-1.2
Comparative body size at age 10	0.1	0.2	0.5	-0.7	0.3	-0.2	-0.4	-0.2	0.5	0.2	-0.4	-0.6	-0.2	-0.4
Number of full brothers	1.9	2.4	4.5	1.4	1.4	-1.3	-1.3	-1.6	1.4	-1.1	1.7	-1.7	2.1	1.8
Worry too long after embarrassment	0.1	0.2	0.6	-0.6	-0.3	0.4	0.3	0.2	-0.4	0.8	-0.6	0.2	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.1	0.9	-1.1	-1.0	-0.9	1.0	0.3	0.7	-1.3	0.4	0.4
Wheeze or whistling in the chest in last year	0.5	0.8	1.8	-1.4	1.0	-1.2	-1.2	-1.0	0.7	0.8	-0.3	-1.0	0.2	0.0
Number of children fathered	0.2	0.2	1.2	0.6	-0.1	-0.3	0.2	0.2	0.3	-1.1	0.4	0.3	0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.7	0.7	-0.7	-0.4	-0.7	1.2	-0.2	0.8	-0.8	1.0	0.9
Age at first live birth	0.3	0.6	1.9	-1.2	0.2	-0.5	-0.4	-0.2	0.3	0.5	-0.7	-0.1	-1.4	-1.3
Pulse wave peak to peak time	2.5	2.9	4.5	1.5	1.7	-2.0	-1.5	-1.5	1.7	-1.1	2.0	-1.4	2.0	2.1
Health satisfaction	1.3	1.7	6.5	-2.6	-0.0	-0.2	-0.5	-0.1	-0.2	2.0	-1.8	-0.0	-1.4	-1.8
Shortness of breath walking on level ground	1.1	1.3	3.9	-2.0	-0.4	0.7	-0.0	0.4	-0.2	1.9	-1.5	0.1	-1.2	-1.6
Qualifications: College or University degree	0.0	0.1	0.5	-0.4	0.1	-0.1	-0.1	-0.2	-0.2	0.6	-0.4	0.1	-0.7	-0.6
Eye problems/disorders: None of the above	3.3	3.8	6.2	-1.9	-1.8	1.9	1.6	1.6	-1.8	2.0	-2.5	1.8	-2.1	-2.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.1	-0.4	0.4	0.3	0.4	-0.3	-0.7	-0.5	0.3	-0.4	-0.6
Emphysema/chronic bronchitis	0.8	0.9	2.2	-0.3	1.1	-1.5	-1.2	-1.2	1.0	0.3	0.4	-1.0	0.9	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	-1.0	-0.0	0.2	-0.1	0.0	0.1	0.6	-0.7	0.0	-0.8	-0.6
Neck or shoulder pain in last month	1.4	2.0	2.6	-1.1	-1.5	1.5	1.3	1.4	-1.6	1.3	-1.5	1.5	-1.2	-1.5
Medication: Blood pressure	0.5	0.9	2.2	1.2	-1.2	1.1	1.5	1.2	-1.0	-0.5	0.2	1.0	0.4	0.5
Angina (self-reported)	4.5	5.9	8.1	1.5	2.7	-2.8	-2.4	-2.6	2.5	-2.0	2.6	-2.6	2.5	2.2
Migraine (self-reported)	0.7	0.9	2.1	1.2	0.7	-0.6	-0.6	-0.5	0.7	-0.9	1.3	-0.6	1.5	1.3
Medication: Ibuprofen	0.2	0.3	1.1	1.1	-0.2	0.2	0.3	0.4	-0.1	-0.6	0.7	0.0	0.7	0.6
Medication: Allopurinol	2.6	3.5	5.6	-1.9	-1.7	1.6	1.5	1.9	-1.6	2.1	-2.2	1.5	-2.4	-1.9
Medication: Omeprazole	0.2	0.2	0.5	0.0	-0.6	0.7	0.6	0.7	-0.5	0.3	-0.3	0.5	0.2	-0.3
Medication: Seretide 50 evohaler	2.2	2.5	5.4	-1.1	2.1	-2.3	-2.3	-2.0	1.6	0.9	0.4	-2.0	0.2	0.1
Mean time to correctly identify matches	1.3	2.5	4.1	-0.2	-2.0	1.9	1.9	2.0	-1.9	0.2	-1.4	2.0	-1.2	-1.1
Heart disease (mother)	0.3	0.3	0.6	0.1	-0.7	0.8	0.8	0.7	-0.8	-0.4	-0.2	0.7	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.2	-1.3	-1.7	1.8	1.5	1.7	-1.5	1.3	-1.7	1.5	-1.3	-1.6
Whole body fat mass	1.5	6.4	16.6	-4.1	-1.3	1.0	0.3	1.2	-1.1	3.3	-3.7	1.1	-3.0	-3.7
Leg fat mass (right)	1.5	5.9	13.4	-3.7	-1.6	1.4	0.8	1.5	-1.4	2.9	-3.5	1.4	-2.8	-3.5
Arm predicted mass (right)	2.5	13.0	35.9	-5.5	-1.1	0.7	0.0	1.1	-0.9	6.0	-4.7	1.2	-4.7	-5.2
Pulse rate, automated reading	8.5	27.5	34.8	-4.1	-5.7	5.4	5.0	5.4	-5.4	4.3	-5.9	5.3	-5.6	-5.2
Alcohol intake frequency.	0.9	2.1	4.1	-0.2	-1.7	1.9	1.8	1.8	-2.0	-1.6	-0.7	1.6	-0.5	-0.3
Comparative height size at age 10	4.5	25.0	51.3	-6.7	-3.0	2.6	1.7	2.9	-2.6	7.2	-6.5	3.1	-6.7	-6.9
Number of full sisters	0.1	0.2	0.4	-0.7	0.0	-0.2	-0.1	0.1	0.3	0.4	-0.5	-0.0	-0.6	-0.7
Suffer from ‘nerves’	0.0	0.1	0.3	0.2	-0.2	0.2	0.2	0.0	-0.5	0.6	0.0	-0.0	0.2	0.2
Overall health rating	1.0	2.2	6.2	-2.5	-0.6	0.2	0.1	0.6	-0.5	2.5	-2.0	0.4	-1.6	-2.0
Chest pain or discomfort	1.9	2.7	5.0	-1.3	2.0	-2.2	-2.2	-2.2	1.7	1.9	-0.0	-1.7	-0.5	-0.5
Had major operations	0.4	0.5	1.5	-1.1	-0.1	-0.0	0.1	0.1	-0.2	1.0	-0.9	0.2	-1.2	-0.8
Age at last live birth	0.5	0.7	2.1	-1.4	-0.5	0.2	0.2	0.4	-0.7	-0.0	-1.1	0.5	-1.4	-1.2
Family relationship satisfaction	1.2	1.5	2.5	-0.9	-1.1	1.0	1.1	1.1	-1.6	1.3	-1.2	1.2	-1.6	-1.3
Leg pain on walking	3.7	4.6	10.9	-3.3	-0.8	0.7	0.2	0.8	-0.8	3.0	-2.9	0.7	-2.9	-3.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	-0.5	0.1	-0.6	-0.2	0.0	0.3	0.5	-0.2	-0.2	0.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.3	-0.5	0.5	0.5	0.8	-0.5	0.6	-0.5	0.6	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.3	1.5	1.4	-1.6	-1.1	-1.1	1.7	-1.1	1.8	-1.2	1.6	1.7
Medication: Aspirin	0.1	0.1	0.5	0.2	0.4	-0.7	-0.3	-0.5	0.2	0.4	0.3	-0.3	0.1	0.3
Supplements: Vitamin C	0.4	0.5	2.5	-0.8	0.4	-0.4	-0.5	-0.4	0.1	1.6	-0.6	0.0	-0.8	-1.0
Knee pain experienced in last month	0.7	1.1	1.6	-0.4	-1.2	1.3	1.1	1.2	-1.0	0.7	-1.1	1.2	-0.9	-1.0
Hypertension (Self-reported)	0.1	0.3	0.9	0.0	0.3	-0.5	-0.3	-0.3	0.6	0.6	0.4	-0.8	1.0	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	-0.3	1.2	-1.2	-1.4	-1.0	1.2	0.2	0.5	-1.1	0.4	0.2
Illnesses of father: Heart disease	2.1	3.0	4.8	0.9	2.0	-1.9	-1.7	-2.0	2.2	-1.9	1.6	-1.8	1.1	1.4
Illnesses of siblings: Diabetes	0.9	1.1	3.7	-1.2	-0.9	1.0	0.8	0.9	-0.7	1.9	-1.3	0.6	-0.6	-1.1
Smoking status: Previous	1.0	1.5	2.6	1.6	0.9	-1.0	-0.7	-0.9	1.0	-1.2	1.5	-1.0	1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	13.8	-3.1	0.3	-0.5	-0.9	-0.4	0.6	3.7	-2.0	-0.4	-2.0	-2.4
Whole body fat-free mass	1.6	9.1	26.6	-4.6	-1.2	0.8	0.3	1.1	-0.8	5.2	-4.0	1.3	-3.8	-4.1
Leg fat-free mass (right)	1.0	5.4	18.2	-3.8	-0.6	0.3	-0.2	0.5	-0.5	4.3	-3.1	0.7	-2.7	-3.0
Arm fat percentage (left)	0.2	0.6	3.0	-1.7	-0.3	0.3	-0.2	0.4	-0.3	0.4	-1.4	0.1	-0.4	-1.1
Average weekly red wine intake	0.4	0.6	1.7	-0.7	-0.4	0.2	0.4	0.1	-0.2	1.1	-0.8	0.3	-1.3	-1.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.2	1.2	1.0	-1.1	-1.0	-1.3	1.1	-1.1	1.3	-1.1	1.4	1.5
Mood swings	1.0	1.8	4.8	-2.2	-0.3	0.0	-0.1	0.2	-0.4	2.2	-1.7	0.1	-1.9	-1.8
Loneliness, isolation	0.8	1.1	1.8	-0.6	-1.0	1.0	0.7	0.9	-1.4	1.0	-1.1	1.2	-1.3	-1.3
Long-standing illness, disability or infirmity	0.3	0.4	0.9	0.0	0.8	-0.9	-0.8	-0.6	0.7	0.4	0.4	-0.8	0.5	0.4
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	-0.2	0.2	0.1	0.2	0.0	0.5	-0.5	0.4	-0.2	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.2	-1.0	1.0	-1.5	-1.1	-1.1	1.4	1.0	-0.2	-0.9	-0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.0	1.2	0.8	-0.5	-0.4	-0.8	1.1	-1.4	1.4	-0.8	1.2	1.3
Friendships satisfaction	0.1	0.1	0.4	-0.1	0.2	-0.6	-0.3	-0.3	-0.1	0.5	0.0	-0.0	-0.4	-0.2
Qualifications: nursing, teaching	0.6	0.9	2.0	0.6	1.0	-1.4	-1.0	-1.2	1.3	-0.6	0.8	-1.3	0.1	0.1
Commuting to job workplace: Walk	1.8	1.9	4.8	2.2	0.9	-0.7	-0.6	-1.1	0.7	-1.2	1.9	-0.9	1.9	1.9
Eye problems/disorders: Cataract	1.0	1.2	2.1	0.6	1.1	-1.0	-1.0	-1.1	0.8	-0.8	1.3	-1.1	1.4	1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.5	-0.8	0.6	0.8	0.7	-0.6	-0.0	-0.2	1.0	-0.4	-0.3
Medication for cholesterol	0.6	0.9	1.9	1.0	-1.0	1.1	1.1	1.0	-1.3	-1.0	0.2	1.4	-0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.4	-1.6	0.5	-0.9	-0.9	-0.6	0.6	0.9	-1.1	-0.3	-0.8	-1.2
Back pain experienced in last month	0.4	0.6	2.0	-0.9	-0.8	0.7	0.6	0.8	-0.8	1.4	-0.9	0.4	0.0	-0.3
Mineral and other dietary supplements	0.0	0.1	0.2	0.0	0.2	-0.2	-0.2	-0.4	0.1	-0.3	0.2	-0.1	0.1	0.5
Breast cancer (self-reported)	0.7	0.9	1.5	-0.4	-1.2	1.2	1.1	1.1	-1.2	0.1	-0.8	1.2	-0.6	-0.8
Asthma (self-reported)	1.0	2.0	3.9	0.3	1.8	-1.9	-1.8	-1.6	1.4	-0.9	1.1	-2.0	1.0	0.9
Osteoporosis (self-reported)	0.7	0.9	2.9	-0.9	-0.5	0.5	0.4	0.5	-0.5	0.6	-1.1	0.8	-1.7	-1.5
Osteoarthritis (self-reported)	0.4	0.5	2.0	-0.9	-0.6	0.4	0.4	0.7	-0.2	1.4	-1.0	0.4	-0.7	-0.6
Medication: Aspirin	0.3	0.4	0.7	0.8	0.6	-0.8	-0.4	-0.7	0.4	-0.1	0.8	-0.6	0.8	0.9
Medication: Gliclazide	0.0	0.0	0.1	0.2	0.2	-0.3	-0.2	-0.2	-0.1	-0.2	0.3	-0.1	-0.1	-0.0
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.3	-0.7	0.8	0.6	0.7	-0.9	0.6	-0.6	0.6	-0.2	-0.3
Smoking status: Current	0.9	1.4	2.9	-0.8	1.3	-1.3	-1.5	-1.2	1.7	1.5	0.1	-1.4	0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	10.9	3.0	2.5	-2.5	-2.0	-2.4	2.6	-3.1	3.3	-2.5	2.9	2.8
Whole body water mass	1.5	8.7	26.2	-4.5	-1.1	0.7	0.2	1.0	-0.8	5.1	-3.9	1.2	-3.7	-4.0
Leg predicted mass (right)	1.0	5.5	18.5	-3.8	-0.6	0.2	-0.2	0.4	-0.4	4.3	-3.0	0.7	-2.7	-3.0
Arm fat mass (left)	0.7	3.0	9.9	-3.1	-0.6	0.4	-0.2	0.6	-0.5	2.3	-2.6	0.4	-1.8	-2.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	-1.0	0.3	-0.2	-0.5	-0.2	0.1	1.0	-0.6	-0.4	-0.5	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	1.7	-0.7	-1.1	1.0	1.1	1.1	-0.6	1.1	-1.0	1.2	-1.3	-1.1
Miserableness	0.3	0.6	3.0	-0.8	-0.3	0.1	0.1	0.1	-0.4	1.7	-0.9	0.2	-1.0	-1.0
Guilty feelings	0.9	1.4	2.3	-1.4	-0.9	1.2	0.6	0.8	-1.2	1.4	-1.5	0.7	-1.4	-1.3
Wears glasses or contact lenses	0.9	1.1	2.1	0.3	1.3	-1.1	-1.3	-1.4	1.2	-0.3	0.9	-1.4	0.4	0.5
Ever taken oral contraceptive pill	1.1	1.2	2.5	0.0	1.4	-1.3	-1.4	-1.3	1.6	-0.4	0.8	-1.4	0.6	0.1
Hearing aid user	0.2	0.2	1.1	0.4	-0.3	-0.1	0.3	0.2	-0.2	-1.1	0.3	0.4	-0.1	0.1
Mother’s age at death	0.9	1.1	2.2	-0.4	-1.3	1.2	1.2	1.3	-1.4	0.4	-1.0	1.5	-0.7	-0.3
Financial situation satisfaction	1.0	1.2	3.0	-0.3	-1.3	1.6	1.3	1.1	-1.7	0.4	-0.7	1.3	-0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.3	-0.0	-0.2	-0.1	0.4	-0.4	0.4	-0.2	0.2	0.2
Commuting to job workplace: Public transport	0.4	0.5	0.8	0.4	0.7	-0.6	-0.8	-0.9	0.6	-0.4	0.7	-0.7	0.9	0.8
Eye problems/disorders: Glaucoma	0.0	0.0	0.2	-0.0	0.2	-0.0	-0.2	-0.1	0.2	0.5	0.1	-0.4	-0.1	-0.1
Medication: Blood pressure	0.6	1.1	2.2	-1.0	1.0	-1.3	-1.2	-0.9	1.2	1.3	-0.1	-1.5	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	3.0	3.8	5.2	-1.4	-2.1	1.9	1.8	2.2	-2.1	1.5	-2.2	2.3	-1.9	-2.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.1	-0.4	0.2	0.4	0.5	-0.3	0.4	-0.2	0.5	-0.5	-0.6
High cholesterol (Self-reported)	0.6	1.1	3.4	-1.5	-0.7	0.6	0.4	0.4	-0.7	1.9	-1.5	0.5	-0.9	-1.1
Medication: Bendroflumethiazide	0.2	0.3	1.0	-1.0	0.1	-0.0	-0.2	0.1	0.2	0.9	-0.6	-0.5	-0.2	-0.6
Medication: Paracetamol	0.4	0.6	1.5	1.2	-0.4	0.1	0.5	0.4	-0.4	-1.1	0.7	0.3	1.2	1.2
Medication: Lisinopril	0.3	0.3	1.3	0.6	-0.4	0.5	0.6	0.6	-0.6	-1.1	0.2	0.5	0.2	0.2
Medication: Atorvastatin	0.3	0.4	0.9	-0.6	-0.6	0.4	0.5	0.5	-0.7	1.0	-0.8	0.5	-0.7	-0.6
Illnesses of father: High blood pressure	0.5	0.6	1.5	0.1	-0.9	0.9	0.9	0.8	-1.2	0.4	-0.4	1.1	-0.7	-0.7
Alcohol drinker status: Never	1.3	1.6	3.9	0.1	-1.6	2.0	1.7	1.7	-1.6	-0.1	-0.6	1.2	-0.5	-0.4
Ever smoked	0.4	0.6	1.3	1.0	0.7	-0.7	-0.5	-0.8	1.1	-0.3	0.8	-0.7	0.9	1.0
Basal metabolic rate	1.6	9.1	26.0	-4.7	-1.1	0.8	0.2	1.1	-0.8	5.1	-4.0	1.2	-3.7	-4.1
Leg fat percentage (left)	1.1	4.1	7.7	-2.6	-1.9	1.9	1.3	1.9	-1.7	1.6	-2.8	1.5	-1.9	-2.6
Arm fat-free mass (left)	2.6	13.0	34.7	-5.3	-1.7	1.3	0.7	1.6	-1.4	5.9	-4.8	1.8	-4.5	-5.0
Number of operations (self-reported)	1.2	1.8	3.4	-1.9	-1.2	1.3	1.1	1.1	-0.9	1.2	-1.7	1.0	-1.6	-1.6
Average weekly beer plus cider intake	1.5	2.1	2.8	1.1	1.6	-1.6	-1.6	-1.7	1.4	-0.4	1.6	-1.5	1.5	1.6
Irritability	0.5	0.9	2.4	-1.5	0.7	-1.1	-1.0	-0.8	0.6	1.6	-0.6	-0.7	-0.6	-0.8
Risk taking	0.7	1.0	1.5	0.5	1.0	-0.9	-1.0	-0.9	1.2	-0.8	1.0	-1.0	1.2	1.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.6	-1.1	-1.0	1.2	0.9	1.1	-1.4	0.8	-1.3	1.1	-1.6	-1.5
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.7	0.4	-0.5	-0.5	-0.6	0.5	0.3	-0.3	-0.6	-0.2	-0.4
Age started oral contraceptive pill	0.4	0.5	1.5	-1.0	0.3	-0.4	-0.4	-0.2	0.3	1.2	-0.8	-0.1	-0.9	-1.1
Diastolic blood pressure, automated reading	1.7	5.4	16.2	4.0	0.1	-0.1	0.4	-0.1	0.3	-3.3	3.0	-0.3	3.3	3.6
Ever depressed for a whole week	0.3	0.4	0.7	-0.8	0.5	-0.3	-0.7	-0.8	0.8	0.3	-0.3	-0.5	-0.6	-0.7
Unable to work because of sickness or disability	0.9	1.2	2.2	-1.4	-1.1	1.1	0.9	1.1	-1.2	0.7	-1.5	1.0	-0.8	-0.9
Commuting to job workplace: Cycle	0.4	0.5	2.0	-1.4	0.6	-0.5	-0.8	-0.7	0.8	0.0	-0.6	-0.5	-0.5	-0.5
Myopia	16.5	24.0	34.1	2.6	5.4	-5.8	-5.4	-5.6	4.8	-3.7	4.7	-5.4	5.0	4.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.4	-0.4	-0.4	0.6	0.3	0.4	-0.6	-0.1	-0.7	0.8	-1.2	-0.6
Cholesterol lowering medication	0.5	0.7	2.8	-1.5	0.2	-0.5	-0.6	-0.3	0.3	1.7	-0.9	-0.4	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.2	-0.1	-0.1	0.1	0.1	0.2	0.2	0.2	-0.0	-0.1	0.5	-0.0
Pain experienced in last month	0.4	0.6	1.0	0.7	0.9	-0.6	-0.6	-1.0	0.9	-0.8	0.9	-0.9	0.5	0.6
Supplements: Calcium	0.0	0.0	0.1	0.0	-0.1	0.2	0.2	0.1	-0.1	-0.3	0.0	0.2	0.1	-0.1
Basal cell carcinoma (self-reported)	2.2	2.6	4.8	2.1	-1.6	1.8	2.2	1.8	-1.7	-1.6	0.7	1.6	0.5	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	-0.1	-0.9	1.0	1.1	0.9	-1.0	-0.5	-0.6	0.8	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.9	-0.1	-2.2	2.4	2.3	2.1	-1.8	0.4	-1.0	2.3	-1.0	-0.5
Heart disease (siblings)	1.0	1.2	2.6	1.6	-0.9	0.9	1.3	0.8	-0.9	-0.9	0.9	0.7	1.0	1.6
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.4	-0.3	0.3	0.3	0.4	-0.8	-0.8	-0.3	0.2	0.1	-0.0
Pack years of smoking	3.0	4.4	6.3	-1.3	-2.5	2.5	2.3	2.4	-2.5	1.2	-2.2	2.4	-1.8	-1.5
Impedance of whole body	0.1	0.6	2.0	-0.8	-0.5	0.5	0.4	0.5	-0.4	0.3	-1.0	0.4	-1.4	-1.2
Leg fat mass (left)	1.3	5.2	12.7	-3.6	-1.4	1.2	0.6	1.3	-1.2	2.9	-3.3	1.1	-2.5	-3.3
Arm predicted mass (left)	2.5	12.7	32.7	-5.2	-1.7	1.4	0.7	1.6	-1.4	5.7	-4.7	1.8	-4.4	-5.0