Hub : Traits :

Myopia

15 significantly associated models · 8 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	52134325	53518049	1	1	1.9e-07	3.4e-06	5.5e-01	98	RP11-155O18.6
2	2	232714559	234168951	3	1	6.6e-11	3.7e-15	5.4e-06	67	PRSS56
3	7	1580921	2977732	1	1	3.0e-07	2.4e-07	2.0e-01	94	FTSJ2
4	8	59021648	60728159	1	1	3.5e-10	4.3e-12	2.1e-04	71	TOX
5	9	138850610	139328551	1	1	5.5e-08	7.2e-08	1.0e+00	100	QSOX2
6	10	85312966	86715813	1	1	1.2e-07	8.7e-07	1.7e-01	92	RGR

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Forced vital capacity (FVC), Best measure	4.92	1	1	2.2	1	QSOX2
Lung FVC	4.43	1	1	2.2	1	QSOX2
Forced vital capacity (FVC)	4.15	1	1	2.2	1	QSOX2
Forced expiratory volume in 1-second (FEV1), Best measure	3.82	1	1	2.2	1	QSOX2
Forced expiratory volume in 1-second (FEV1)	3.38	2	1	2.2	1	QSOX2 RP11-155O18.6
Ever had prostate specific antigen (PSA) test	3.36	1	0	0.0	1	RGR
Eye problems/disorders: None of the above	3.20	1	0	0.0	1	TOX
Eye problems/disorders: Cataract	2.87	1	0	0.0	1	TOX
Height	2.73	3	1	2.2	1	QSOX2 RP11-155O18.6 TOX
Sitting height	2.66	1	1	2.2	1	QSOX2
Ever taken oral contraceptive pill	2.62	1	0	0.0	1	QSOX2
Schizophrenia (2018)	2.54	1	0	0.0	1	FTSJ2
Qualifications: College or University degree	2.46	3	0	0.0	1	FTSJ2 RP11-155O18.6 TOX
Bipolar Disorder or Schizophrenia	2.36	1	1	2.2	1	FTSJ2
Comparative height size at age 10	2.34	1	1	2.2	1	QSOX2
Schizophrenia (2014)	2.30	1	0	0.0	1	FTSJ2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.30	1	0	0.0	1	QSOX2
Taking other prescription medications	2.20	1	0	0.0	1	TOX
Supplements: Fish oil (including cod liver oil)	2.17	1	0	0.0	1	TOX
Alcohol usually taken with meals	2.10	1	0	0.0	1	QSOX2
Standing height	2.09	1	1	2.2	1	QSOX2
Qualifications: A levels/AS levels or equivalent	2.01	1	0	0.0	1	FTSJ2
Medication: Aspirin	2.01	1	0	0.0	1	FTSJ2
Medication: Aspirin	1.94	1	0	0.0	1	FTSJ2
Neuroticism (Nagel 2018)	1.93	1	0	0.0	1	FTSJ2
Age at first live birth	1.84	1	0	0.0	1	TOX
Had other major operations	1.82	1	0	0.0	1	PRSS56
Worry (Nagel 2018)	1.80	1	0	0.0	1	RP11-155O18.6
Mineral and other dietary supplements	1.80	1	0	0.0	1	TOX
Reaction Time	1.73	1	0	0.0	1	RP11-155O18.6
Miserableness	1.70	1	0	0.0	1	FTSJ2
Handedness (chirality/laterality): Left-handed	1.69	1	0	0.0	1	RGR
Depressed Affect (Nagel 2018)	1.63	1	0	0.0	1	FTSJ2
Number of treatments/medications taken	1.50	1	0	0.0	1	FTSJ2
Forced expiratory volume in 1-second (FEV1), predicted	1.50	1	0	0.0	1	QSOX2
Pulse rate, automated reading	1.48	1	0	0.0	1	PRSS56
Neuroticism	1.44	1	0	0.0	1	FTSJ2
Wheeze or whistling in the chest in last year	1.38	1	0	0.0	1	QSOX2
Irritability	1.38	1	0	0.0	1	FTSJ2
Neuroticism (2016)	1.36	1	0	0.0	1	FTSJ2
Number of incorrect matches in round	1.31	1	0	0.0	1	QSOX2
Age when periods started (menarche)	1.30	1	0	0.0	1	RP11-155O18.6
Number of self-reported non-cancer illnesses	1.27	1	0	0.0	1	FTSJ2
Trunk fat-free mass	1.25	2	0	0.0	1	QSOX2 TOX
Trunk predicted mass	1.24	2	0	0.0	1	QSOX2 TOX
Impedance of arm (left)	1.17	2	0	0.0	1	FTSJ2 TOX
Diastolic blood pressure, automated reading	1.17	1	0	0.0	1	QSOX2
Arm fat-free mass (left)	1.15	2	0	0.0	1	QSOX2 TOX
Whole body fat-free mass	1.13	2	0	0.0	1	QSOX2 TOX
Whole body water mass	1.13	2	0	0.0	1	QSOX2 TOX
Basal metabolic rate	1.13	1	0	0.0	1	QSOX2
Arm predicted mass (left)	1.12	2	0	0.0	1	QSOX2 TOX
Leg fat-free mass (right)	1.10	1	0	0.0	1	QSOX2
Leg predicted mass (right)	1.07	1	0	0.0	1	QSOX2
Impedance of arm (right)	0.98	1	0	0.0	1	FTSJ2
Leg fat-free mass (left)	0.95	1	0	0.0	1	QSOX2
Leg predicted mass (left)	0.94	1	0	0.0	1	QSOX2
Arm fat-free mass (right)	0.91	1	0	0.0	1	QSOX2
Impedance of whole body	0.89	2	0	0.0	1	FTSJ2 TOX
Arm predicted mass (right)	0.86	1	0	0.0	1	TOX
Systolic Blood Pressure	0.80	2	0	0.0	1	FTSJ2 TOX
Lung FEV1/FVC ratio	0.77	1	0	0.0	1	QSOX2
Leg fat percentage (right)	0.62	1	0	0.0	1	QSOX2
Leg fat percentage (left)	0.59	1	0	0.0	1	QSOX2
Blood White Count	0.38	1	0	0.0	1	TOX

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellum	0	0.000	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Liver	0	0.000	1.6
GTEx	Muscle Skeletal	0	0.000	1.6
GTEx	Whole Blood	0	0.000	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
GTEx	Adipose Visceral Omentum	1	0.049	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	1	0.024	1.5
GTEx	Colon Transverse	2	0.097	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Atrial Appendage	1	0.063	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Testis	0	0.000	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
NTR	Blood	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
METSIM	Adipose	0	0.000	1.4
YFS	Blood	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.3