Best TWAS P=2.39e-09 · Best GWAS P=9.14e-08 conditioned to 0.381
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-967K21.1 | 0.07 | 0.02 | lasso | 7 | 0.01 | 7.9e-02 | -4.6 | -5.8 | 5.3e-09 | -0.84 | 0.09 | 0.73 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-967K21.1 | 0.09 | 0.10 | lasso | 11 | 0.07 | 2.4e-06 | -5.1 | -5.5 | 3.6e-08 | -0.58 | 0.16 | 0.84 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-967K21.1 | 0.07 | 0.07 | lasso | 2 | 0.07 | 3.7e-06 | 5.2 | -5.4 | 7.2e-08 | -0.97 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Colon Transverse | CCDC91 | 0.11 | 0.01 | lasso | 6 | 0.00 | 4.6e-01 | 5.0 | 5.6 | 2.2e-08 | 0.80 | 0.08 | 0.76 | FALSE |
| 5 | GTEx | Colon Transverse | RP11-967K21.1 | 0.12 | 0.07 | lasso | 8 | 0.05 | 1.6e-03 | -5.1 | -5.2 | 2.3e-07 | -0.56 | 0.15 | 0.77 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RP11-967K21.1 | 0.07 | 0.06 | lasso | 5 | 0.04 | 2.2e-03 | -5.0 | -5.5 | 4.8e-08 | -0.55 | 0.15 | 0.57 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | RP11-967K21.1 | 0.08 | 0.09 | lasso | 1 | 0.08 | 2.3e-04 | 5.2 | -5.2 | 1.9e-07 | -0.96 | 0.06 | 0.87 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC91 | 0.26 | 0.05 | lasso | 15 | 0.04 | 4.1e-03 | 5.2 | 6.0 | 2.4e-09 | 0.81 | 0.09 | 0.90 | TRUE |
| 9 | GTEx | Skin Sun Exposed Lower leg | CCDC91 | 0.09 | 0.01 | enet | 8 | 0.01 | 2.6e-02 | 5.2 | 5.3 | 9.4e-08 | 0.91 | 0.10 | 0.84 | FALSE |
| 10 | NTR | Blood | CCDC91 | 0.01 | 0.01 | blup | 648 | 0.00 | 9.0e-03 | -4.9 | 5.4 | 8.1e-08 | 0.76 | 0.15 | 0.66 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC91 | 0.06 | 0.02 | blup | 174 | 0.04 | 2.9e-05 | -4.7 | 5.7 | 1.4e-08 | 0.80 | 0.21 | 0.77 | FALSE |