Hub : Traits :

Mouth/teeth dental problems: Loose teeth

11 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 27587038 29432481 2 1 2.4e-09 9.1e-08 0.38 97 CCDC91

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heel T-Score 7.4 1 1 2.2 0 1 CCDC91
BMI 2.4 1 0 0.0 0 1 CCDC91
Height 25.1 1 1 2.2 0 1 CCDC91
Lung FVC 32.2 1 1 2.2 0 1 CCDC91
Hand grip strength (left) 3.2 1 0 0.0 0 1 CCDC91
Impedance of leg (right) 1.8 1 0 0.0 0 1 CCDC91
Leg fat-free mass (left) 5.5 1 1 2.2 0 1 CCDC91
Sitting height 10.8 1 1 2.2 0 1 CCDC91
Impedance of leg (left) 2.7 1 0 0.0 0 1 CCDC91
Leg predicted mass (left) 5.6 1 1 2.2 0 1 CCDC91
Trunk fat mass 3.3 1 0 0.0 0 1 CCDC91
Weight 4.9 1 0 0.0 0 1 CCDC91
Impedance of arm (right) 1.9 1 0 0.0 0 1 CCDC91
Trunk fat-free mass 9.8 1 1 2.2 0 1 CCDC91
Hip circumference 3.0 1 0 0.0 0 1 CCDC91
Trunk predicted mass 9.9 1 1 2.2 0 1 CCDC91
Standing height 25.8 1 1 2.2 0 1 CCDC91
Arm fat-free mass (right) 7.4 1 1 2.2 0 1 CCDC91
Arm predicted mass (right) 7.5 1 1 2.2 0 1 CCDC91
Comparative height size at age 10 29.8 1 1 2.2 0 1 CCDC91
Forced expiratory volume in 1-second (FEV1), predicted 24.9 1 1 2.2 0 1 CCDC91
Whole body fat-free mass 8.6 1 1 2.2 0 1 CCDC91
Leg fat-free mass (right) 5.8 1 1 2.2 0 1 CCDC91
Forced expiratory volume in 1-second (FEV1), predicted percentage 12.1 1 0 0.0 0 1 CCDC91
Whole body water mass 8.2 1 1 2.2 0 1 CCDC91
Leg predicted mass (right) 5.8 1 1 2.2 0 1 CCDC91
Basal metabolic rate 8.0 1 1 2.2 0 1 CCDC91
Arm fat-free mass (left) 8.2 1 1 2.2 0 1 CCDC91
Myopia 6.5 1 0 0.0 0 1 CCDC91
Impedance of whole body 2.6 1 0 0.0 0 1 CCDC91
Arm predicted mass (left) 8.4 1 1 2.2 0 1 CCDC91

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.1
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 1 0.027 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 1 0.024 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 2 0.097 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 1 0.031 1.2
GTEx Heart Atrial Appendage 1 0.063 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.2
GTEx Skin Sun Exposed Lower leg 1 0.027 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.1
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 1 0.042 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3