Best TWAS P=3.42e-09 · Best GWAS P=1.42e-09 conditioned to 0.0114
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hippocampus | FTH1P20 | 0.18 | 0.02 | lasso | 6 | 0.00 | 4.3e-01 | 6.0 | -5.4 | 5.5e-08 | -0.90 | 0.04 | 0.49 | FALSE |
| 2 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 7.6e-01 | 3.0 | 5.2 | 2.4e-07 | 0.00 | 0.07 | 0.09 | TRUE |
| 3 | GTEx | Esophagus Muscularis | UBE2E3 | 0.10 | 0.09 | lasso | 3 | 0.08 | 2.2e-05 | 5.2 | 5.5 | 4.6e-08 | 0.89 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Nerve Tibial | UBE2E3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 6.4e-03 | 4.9 | 5.2 | 2.2e-07 | 0.83 | 0.07 | 0.86 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | UBE2E3 | 0.25 | 0.06 | enet | 39 | 0.12 | 2.5e-07 | 5.1 | 5.6 | 1.9e-08 | 0.72 | 0.08 | 0.92 | FALSE |
| 6 | NTR | Blood | UBE2E3 | 0.02 | 0.00 | bslmm | 446 | 0.00 | 1.1e-02 | 5.2 | 5.9 | 3.4e-09 | 0.73 | 0.06 | 0.76 | TRUE |