Hub : Genes

PDE1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0270	1.1e-03	0.016	0.035	0.005	0.035	0.015	4.4e-03	3.3e-05	7.3e-02	3.5e-05	5.8e-03
2	GTEx	Brain Caudate basal ganglia	0.2450	0.0750	6.1e-04	0.104	NA	0.136	NA	0.148	6.5e-04	NA	1.0e-04	NA	5.1e-05
3	GTEx	Brain Cerebellar Hemisphere	0.4080	0.1180	4.9e-03	0.104	NA	0.076	NA	0.172	1.3e-03	NA	5.4e-03	NA	3.5e-05
4	GTEx	Brain Hypothalamus	0.2380	0.0930	5.8e-03	-0.010	NA	-0.012	NA	-0.012	6.4e-01	NA	7.6e-01	NA	8.0e-01
5	GTEx	Brain Putamen basal ganglia	0.4760	0.1110	1.1e-04	0.251	NA	0.230	NA	0.369	1.2e-06	NA	3.6e-06	NA	1.1e-09
6	GTEx	Skin Sun Exposed Lower leg	0.1130	0.0420	1.1e-03	0.068	NA	0.018	NA	0.035	2.5e-06	NA	1.2e-02	NA	6.1e-04
7	ROSMAP	Brain Pre-frontal Cortex	0.1062	0.0320	4.2e-07	0.026	0.060	0.056	0.060	0.051	2.1e-04	3.7e-08	1.0e-07	3.2e-08	3.9e-07
8	TCGA	Breast Invasive Carcinoma	0.0338	0.0136	4.2e-05	0.005	0.023	0.005	NA	0.005	2.5e-02	1.3e-05	2.7e-02	NA	3.0e-02
9	TCGA	Lung Squamous Cell Carcinoma	0.0489	0.0231	1.7e-03	0.043	0.036	0.034	NA	0.036	1.2e-05	5.0e-05	9.2e-05	NA	5.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.2	0.3	1.0	-0.2	0.4	0.6	-0.5	0.7	0.8	0.2	1.0	0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.1	-0.5	1.1	0.5	-0.9	0.3	0.6	1.0	0.4
Depressed Affect (Nagel 2018)	0.7	1.4	4.2	2.1	-0.9	0.6	0.3	-1.6	0.4	1.8	-0.4	1.0
Depression (Nagel 2018)	0.5	0.8	3.0	1.7	0.1	0.5	0.4	0.0	-0.0	1.4	-1.2	-0.3
Intelligence (Savage-Jansen 2018)	1.6	4.8	17.0	-0.6	3.2	-1.1	1.7	4.1	-3.2	-0.7	1.0	-0.2
Neuroticism (Nagel 2018)	0.7	1.5	4.8	2.2	-0.4	0.7	0.0	-1.1	1.1	1.9	-1.3	0.9
Schizophrenia (2018)	0.4	0.7	2.9	0.3	-1.0	0.9	1.0	-1.7	-0.2	0.5	0.4	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	4.5	0.4	-1.2	-0.5	0.2	-2.1	-1.0	-0.4	-0.6	0.2
Worry (Nagel 2018)	0.2	0.5	1.9	0.8	0.1	1.4	0.1	-0.5	0.8	0.4	-1.0	-0.0
Alzheimer’s Disease (in mother)	2.1	2.5	6.2	1.1	2.1	-1.0	1.4	1.7	-2.5	1.1	1.6	1.0
Alzheimer’s Disease (in father)	0.7	0.8	3.0	0.5	0.1	-0.6	1.0	0.7	-1.7	0.9	0.8	0.7
Alzheimer’s Disease (including proxy)	1.2	1.7	5.9	0.9	0.9	-0.8	1.3	1.0	-2.4	1.2	1.5	1.0
Crohns Disease (2017)	0.5	1.1	5.4	2.3	-0.2	0.3	0.5	-0.9	-0.1	1.7	-0.4	-0.0
Irritable Bowel Disease (IBD)	0.7	1.6	8.1	2.9	0.1	0.2	1.4	-0.1	-0.8	1.6	0.4	0.8
Ulcerative Colitis (UC)	1.3	2.4	7.8	2.8	0.4	-0.5	1.5	0.8	-1.5	1.7	1.5	1.7
Major Depression (MDD)	2.5	3.0	7.1	-1.4	-2.3	0.1	0.7	-1.4	-0.6	-2.4	2.7	1.9
Reaction Time	1.1	2.2	5.4	0.8	-0.4	0.2	2.2	-0.3	-1.7	1.5	1.7	2.3
Verbal and Numeric Reasoning (VNR)	1.3	3.2	10.4	-0.6	2.6	-0.7	0.8	3.2	-2.3	-1.3	1.7	0.5
Breast Cancer	0.5	1.1	7.0	0.6	0.4	-2.6	-0.4	0.0	-0.3	-1.0	1.0	0.4
Ovarian Cancer	0.6	0.7	2.1	-1.4	-0.5	0.8	-0.7	-0.2	0.9	-1.4	-0.4	-0.6
Prostate Cancer	0.5	0.7	1.8	-0.4	-0.2	-1.3	-1.4	0.1	0.9	-0.8	-0.4	-0.8
Age at First Birth	0.6	0.8	4.6	-0.4	0.6	0.3	2.1	0.5	-0.9	-0.7	-0.2	-0.8
Bipolar Disorder (2011)	1.2	1.1	5.1	-0.8	0.9	2.3	-0.1	1.2	0.4	0.2	-0.4	-1.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.7	-0.2	0.3	0.3	-0.5	0.8	1.3	-0.1	0.7	0.6
Coronary Artery Disease (CAD)	1.0	1.1	4.5	-1.9	-0.6	2.1	-0.8	-0.1	0.4	-1.1	-0.2	-0.0
Crohns Disease (2012)	0.4	0.7	1.7	1.3	0.3	1.2	0.7	0.0	0.5	1.1	-1.2	-0.1
Mean Putamen Volume	0.3	0.4	1.0	-0.1	-0.8	0.6	-0.6	-1.0	-0.8	0.5	-0.3	0.2
Fasting Glucose	0.9	1.1	3.0	0.4	0.5	1.2	1.0	1.1	-0.7	0.6	1.2	1.7
HbA1C	0.7	0.8	1.9	0.8	0.6	0.2	-0.2	0.5	0.9	1.3	1.3	1.4
HDL Cholesterol	0.6	1.0	1.8	1.4	1.2	-1.3	1.4	0.8	-0.7	1.0	0.1	-0.4
LDL Cholesterol	1.3	2.1	4.4	-1.0	-1.8	0.3	-1.8	-2.1	2.0	-1.5	0.1	-0.1
Lupus	0.3	0.5	1.6	-0.4	-0.6	-0.4	0.1	-1.3	-0.0	1.0	0.0	0.9
Neuroticism (2016)	0.9	1.3	3.2	1.3	0.1	0.2	1.2	-0.1	-1.8	1.3	0.9	1.6
Primary Biliary Cirrhosis	0.7	1.0	8.2	0.5	-0.5	2.9	0.3	-0.1	0.5	0.1	-0.3	-0.1
Rheumatoid Arthritis	1.0	1.3	3.1	1.7	-1.4	-0.9	-0.7	-1.8	0.5	1.1	0.4	1.1
Schizophrenia (2014)	0.2	0.5	1.4	0.3	-0.1	1.2	1.0	-0.9	-0.5	0.7	0.8	0.5
Triglycerides	0.7	1.2	3.8	-0.7	-0.3	1.4	-1.9	0.3	0.9	-1.6	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	0.6	0.7	1.3	1.3	1.1	-0.2	1.4	0.1	0.2
Ulcerative Colitis	2.8	4.1	10.5	3.2	1.1	0.9	2.8	1.2	-1.1	1.9	2.0	2.5
Blood Eosinophil Count	0.1	0.8	4.8	0.8	-0.6	0.2	-0.4	-0.4	0.2	0.0	0.9	2.2
Blood Platelet Count	0.7	7.9	13.4	-2.0	-2.2	-2.6	-3.4	-2.8	3.7	-2.3	-2.5	-3.4
Blood Red Count	0.1	1.0	4.4	-0.3	1.5	0.6	0.2	2.1	-1.3	-0.4	0.2	-0.2
Blood White Count	0.5	3.8	12.7	-1.3	-3.6	0.0	-2.1	-3.0	1.8	-1.4	-1.0	0.1
Heel T-Score	0.5	4.2	18.1	0.7	1.6	2.6	4.3	1.8	-2.3	-0.9	0.7	0.4
BMI	0.8	4.4	21.9	0.5	-2.6	0.4	-0.8	-1.9	0.1	1.3	2.2	4.7
Height	1.4	26.5	63.7	2.3	4.4	0.5	8.0	5.4	-7.9	4.4	5.1	3.7
Waist Hip Ratio (WHR)	1.3	6.1	11.9	-1.8	-2.3	-0.6	-1.5	-2.1	2.2	-3.4	-3.5	-3.2
Systolic Blood Pressure	1.7	8.4	23.3	0.8	-1.2	1.1	-4.4	-0.3	3.0	-1.6	4.3	4.8
Smoking Status	0.8	1.8	6.6	0.4	-2.6	1.4	-0.0	-2.2	-0.1	-0.1	-0.6	1.5
Allergy or Eczema	0.3	0.8	3.2	-0.9	0.4	-0.4	0.4	0.1	-1.2	-0.1	1.2	1.8
Cardiovascular Disease	2.5	8.1	28.0	0.2	-2.5	1.2	-5.3	-2.7	3.6	-0.0	0.2	4.1
Hypothyroidism (self reported)	2.0	4.5	11.1	1.7	0.9	-2.7	1.5	0.9	-2.5	1.2	3.3	2.8
Respiratory disease	0.5	1.1	6.9	0.6	0.6	1.0	0.7	0.7	-0.4	2.6	-0.5	-0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.8	-0.4	-1.2	1.9	-0.2	-0.9	-0.7	1.4	0.3	1.4
Lung FEV1/FVC ratio	0.1	0.7	2.7	0.7	0.6	1.6	-0.0	0.7	-0.8	0.5	-1.0	-0.9
Lung FVC	0.3	1.5	6.9	1.7	0.8	-0.8	2.6	0.6	-0.8	0.4	0.9	0.7
Neuroticism	0.6	1.4	3.6	1.5	-1.0	-0.1	-0.3	-1.9	0.3	1.8	-1.1	0.8
Chronotype (morning person)	1.1	2.5	10.3	3.2	1.2	1.7	1.4	0.8	-1.3	1.9	0.1	0.6
Hair Pigment	0.1	3.7	13.6	0.8	2.5	1.6	1.5	3.7	-2.2	0.8	1.4	0.5
Tanning	0.1	0.9	1.8	1.0	-0.3	1.1	-0.1	-0.9	1.1	0.8	-1.2	-1.3
Hand grip strength (left)	0.4	1.1	3.9	-1.2	-0.3	1.4	2.0	0.3	-0.7	-1.0	0.6	-0.5
Number of treatments/medications taken	1.9	3.4	8.6	-0.2	-2.9	-0.1	-2.1	-2.6	1.1	1.7	0.1	2.6
Average weekly spirits intake	0.7	0.8	3.2	-0.9	-0.8	1.8	-0.4	-0.7	0.5	1.0	0.3	1.0
Sensitivity / hurt feelings	1.1	1.8	4.0	1.1	-1.8	0.5	-1.0	-2.0	1.6	0.8	-1.8	0.7
Frequency of depressed mood in last 2 weeks	1.4	1.9	7.2	2.7	-0.2	0.3	-0.5	-0.8	0.2	2.1	-2.1	-0.2
Hearing difficulty/problems: Yes	1.3	1.9	3.4	1.6	1.8	0.1	1.6	1.6	-1.5	1.9	0.5	0.4
Relative age of first facial hair	0.8	1.7	6.4	-0.4	1.1	-0.3	1.6	1.2	-2.5	-0.8	1.7	0.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.9	1.4	0.4	-1.4	0.9	1.0	-1.6	1.9	1.8	2.6
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.7	0.3	0.8	-0.8	0.9	1.3	-1.7	0.8	1.3	1.4
Ever had hysterectomy (womb removed)	0.6	0.6	3.0	-0.4	-0.2	-0.1	1.0	-0.1	-1.7	0.8	0.4	0.8
Systolic blood pressure, automated reading	1.7	4.8	17.9	0.7	-0.6	0.4	-1.9	0.4	1.2	-1.1	4.2	4.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	-0.3	1.1	1.5	-0.6	1.2	1.1	1.0	0.7	0.1
Angina	0.6	0.7	1.9	0.9	-0.7	1.3	0.1	-0.4	1.2	0.3	0.2	1.4
Medication for hormone replacement therapy	0.3	0.3	1.3	0.0	-1.1	-0.1	0.5	-0.5	-0.0	0.4	-0.1	1.1
Vitamin and mineral supplements	0.3	0.3	1.4	1.2	0.4	-0.4	-0.5	0.4	0.2	-0.5	-0.6	-0.6
Supplements: Zinc	0.7	0.7	2.9	-1.7	-1.1	-0.6	-0.8	-0.9	0.5	0.4	0.3	0.4
Medication: Co-codamol	0.8	0.9	2.0	1.0	-1.2	-1.3	0.7	-1.4	-0.4	0.5	-0.2	0.9
Medication: Metformin	0.7	1.0	2.8	-0.5	-1.7	1.6	0.1	-1.0	-0.7	0.6	0.6	1.2
Diabetes (father)	0.7	0.9	2.6	0.8	-1.0	0.6	0.7	-1.1	-0.2	1.6	-0.7	1.1
Diabetes (mother)	1.3	1.7	5.7	0.2	-2.4	-1.3	-1.6	-1.6	1.3	0.2	0.0	0.9
Severe depression (siblings)	0.9	1.0	2.9	-0.5	1.2	0.9	-1.0	0.7	-0.3	1.7	-1.0	-0.7
Pack years adult smoking proportion	2.6	4.0	9.9	1.1	1.1	-1.2	1.6	0.9	-2.5	2.0	3.0	3.1
Impedance of leg (right)	1.7	8.0	17.8	-2.0	-0.3	-0.6	-3.7	-1.2	3.7	-3.0	-3.5	-4.2
Leg fat-free mass (left)	1.8	9.7	21.3	2.0	0.2	0.7	4.6	1.6	-3.8	3.4	3.6	4.4
Trunk fat percentage	0.7	3.0	6.9	0.4	-2.0	-0.0	-2.6	-2.1	2.5	0.7	0.2	2.2
Hand grip strength (right)	0.6	1.6	6.1	-2.5	-0.9	0.8	0.9	-0.2	-0.8	-1.6	-0.7	-1.5
Townsend deprivation index at recruitment	0.7	1.0	4.2	0.1	-1.6	1.2	0.1	-2.1	-0.0	0.2	0.2	0.6
Current tobacco smoking	0.5	0.9	3.3	-1.1	-0.9	0.3	0.1	-0.7	-1.8	0.1	-0.4	1.3
Average weekly fortified wine intake	2.0	2.3	4.5	-1.0	1.9	1.9	0.1	2.0	-1.8	-0.2	-0.8	-2.1
Maternal smoking around birth	0.4	0.6	2.7	0.9	0.4	0.0	0.7	0.6	0.1	1.6	-0.8	-0.1
Fed-up feelings	0.9	1.7	4.8	1.6	-1.7	0.3	-0.6	-2.2	0.5	1.8	-0.5	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	0.1	-1.1	0.5	0.1	-0.9	-0.6	0.4	-1.2	-0.9
Relative age voice broke	0.4	0.6	2.0	-1.4	0.8	1.4	-0.5	0.7	-0.1	-0.7	0.0	-0.0
Taking other prescription medications	1.3	2.1	6.8	0.1	-2.2	0.2	0.0	-1.6	-0.1	2.1	0.3	2.6
Age when periods started (menarche)	0.6	1.4	4.9	1.1	-1.4	-0.3	-0.8	-1.9	2.2	0.3	-0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	0.2	-0.1	-1.0	-0.3	-0.8	-0.6	1.4	0.1	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	5.3	-1.0	-2.3	2.0	2.2	-1.8	-1.7	-1.3	1.1	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	-1.1	-0.4	-0.2	-1.1	-0.2	0.7	-0.1	-0.5	-0.7
Qualifications: CSEs or equivalent	1.6	2.1	5.3	2.1	-1.0	-0.8	0.1	-1.9	-0.2	1.6	0.9	2.3
Serious illness, injury or assault to yourself	1.3	1.6	7.2	0.3	-1.5	0.2	-0.5	-1.5	0.9	0.5	1.1	2.7
High blood pressure	2.8	7.9	27.6	0.9	-1.4	0.5	-5.2	-1.7	3.4	0.4	1.7	4.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-0.7	0.5	-0.5	1.0	-0.0	-1.2	-0.5	1.0	1.3
Multivitamins +/- minerals	0.5	0.6	1.3	-0.8	-0.4	0.5	1.0	-0.2	-1.1	0.3	1.0	0.9
Stomach or abdominal pain in last month	0.6	0.7	3.9	0.7	1.0	-0.1	-0.4	0.4	-0.7	2.0	0.2	0.6
Supplements: Glucosamine	2.4	3.1	7.3	0.5	1.4	-0.8	2.5	2.1	-2.7	1.3	2.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.5	-1.6	-0.2	-0.2	-0.3	0.1	-1.2	-0.3	0.6	0.5
Medication: Atenolol	1.1	1.3	4.5	0.6	-0.8	-0.9	-1.3	-0.5	0.4	0.1	2.1	1.8
Medication: Levothyroxine sodium	2.0	3.3	9.3	0.3	-0.4	-2.6	0.6	0.6	-2.3	0.6	3.0	2.7
Sitting height	0.8	5.9	11.6	1.9	2.3	0.5	3.4	3.2	-3.0	1.9	2.3	1.9
Chronic bronchitis/emphysema (father)	1.6	1.8	4.7	2.2	1.4	0.8	0.4	1.5	-0.1	1.0	1.5	1.9
High blood pressure (mother)	4.0	5.6	17.1	-0.7	-2.4	1.6	-3.4	-2.7	4.1	-0.6	-2.3	-0.1
Body mass index (BMI)	1.1	4.8	22.2	1.8	-1.2	0.4	0.9	-0.5	-0.8	2.2	3.0	4.7
Impedance of leg (left)	1.4	6.9	15.1	-1.6	-0.4	-0.2	-3.7	-1.4	3.6	-2.3	-3.3	-3.9
Leg predicted mass (left)	1.8	9.4	20.7	2.0	0.1	0.8	4.5	1.4	-3.6	3.4	3.5	4.4
Trunk fat mass	0.6	2.6	11.0	0.9	-1.9	0.3	-0.5	-1.4	0.8	1.6	1.4	3.3
Waist circumference	0.6	2.2	9.2	0.6	-1.7	-0.4	0.3	-1.0	-0.3	1.4	1.9	3.0
Number of incorrect matches in round	1.2	1.9	7.3	1.6	0.0	2.7	1.6	-0.4	-0.5	1.9	-0.3	0.7
Past tobacco smoking	0.3	0.6	2.6	-0.5	1.6	-0.5	0.2	1.1	-0.3	-0.2	0.6	-0.7
Alcohol usually taken with meals	0.6	0.9	1.8	0.6	1.3	1.0	1.3	0.9	-0.9	0.0	-0.9	-0.9
Nervous feelings	0.5	0.9	2.7	1.4	0.0	1.4	0.5	-0.4	0.0	1.6	-1.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.5	-0.4	-0.8	-0.2	-0.7	-0.5	1.0	-1.2	0.3
Hearing difficulty/problems with background noise	1.5	2.3	5.5	1.9	2.4	-0.9	1.3	1.8	-1.6	1.8	0.5	0.5
Hair/balding pattern: Pattern 2	0.5	0.7	2.1	1.1	-1.1	1.4	-0.5	-1.1	-0.3	0.2	-0.1	-0.1
Had menopause	0.8	1.1	2.5	-0.4	1.3	0.5	1.4	1.6	-0.9	1.1	0.8	0.6
Had other major operations	4.2	5.1	9.1	1.6	2.4	-0.6	1.9	2.7	-2.0	2.8	3.0	2.3
Forced vital capacity (FVC)	0.7	2.6	9.8	0.4	1.7	0.2	3.1	1.5	-2.4	0.7	1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.5	-0.8	-1.6	2.3	2.5	-1.1	-1.9	-1.1	1.6	1.3
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	7.9	-0.7	-0.3	-0.8	0.4	0.3	-0.8	0.6	2.8	1.9
Qualifications: None of the above	1.2	2.6	7.5	1.3	-2.7	1.5	0.0	-2.5	1.3	1.1	0.1	1.6
Financial difficulties in last 2 years	0.7	0.9	3.0	-0.4	-1.0	-0.9	-0.4	-1.7	0.1	1.1	0.5	1.3
Mouth/teeth dental problems	0.8	1.2	4.5	0.7	0.7	-0.0	1.6	1.0	-0.7	0.3	2.1	1.2
Heart attack	1.2	1.5	4.1	-1.3	-0.8	2.0	-1.8	-0.6	1.3	-0.9	-0.6	0.3
Allergy	0.1	0.3	1.1	0.8	-0.3	-1.1	-0.2	0.1	1.0	-0.3	0.2	-0.4
Pain all over the body in last month	0.8	0.8	4.4	-0.3	-0.6	-0.1	0.9	-0.5	-0.3	0.2	-2.1	-1.3
Diabetes (self-reported)	0.5	0.8	4.1	0.6	0.4	0.8	0.7	0.5	-0.6	2.0	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.7	2.2	0.3	-0.7	-1.1	-0.4	0.9	0.5	0.4	0.8
Medication: Ramipril	2.8	3.6	15.7	0.0	-1.3	0.2	-4.0	-1.5	3.5	-0.2	-0.4	0.6
Medication: Simvastatin	0.8	1.2	5.6	-0.1	-0.6	0.9	-2.4	-0.7	1.7	0.2	-0.8	0.5
Fluid intelligence score	1.1	2.3	8.4	-0.2	2.1	0.4	1.1	2.9	-2.2	-0.6	1.2	0.2
Illnesses of siblings	1.7	2.4	8.9	0.4	1.7	-3.0	1.5	1.4	-2.0	0.4	0.1	-1.1
Neuroticism score	1.0	2.0	5.4	1.8	-1.6	-0.1	-0.4	-2.3	0.2	1.8	-0.6	1.8
Weight	1.5	7.5	24.6	1.8	-0.5	0.7	3.0	0.6	-2.7	3.0	3.6	5.0
Impedance of arm (right)	3.4	15.7	30.0	-3.6	-1.6	-1.2	-5.2	-2.6	4.4	-5.5	-4.5	-4.6
Arm fat percentage (right)	0.7	2.9	9.5	0.3	-2.5	0.0	-1.6	-2.0	1.5	0.1	1.2	3.1
Trunk fat-free mass	3.9	22.3	65.4	2.3	1.2	1.2	8.1	3.1	-6.5	4.7	5.1	5.2
Hip circumference	1.5	6.6	22.1	1.6	-0.4	0.2	1.9	0.4	-2.2	2.9	4.2	4.7
Time employed in main current job	0.8	0.9	5.2	0.1	-0.0	0.8	2.3	-0.4	-1.0	0.5	0.6	-0.5
Alcohol intake versus 10 years previously	1.4	2.1	7.6	-1.7	-2.8	0.1	-0.6	-2.3	0.2	-1.2	0.1	1.0
Father’s age at death	0.4	0.6	1.4	-0.0	1.2	0.9	-0.1	1.1	-1.0	0.2	-0.6	-0.8
Worrier / anxious feelings	0.5	1.0	3.7	1.9	1.0	0.4	0.4	0.4	0.4	1.4	-0.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.3	0.9	-1.7	-0.5	0.2	-1.8	-1.0	1.2	-0.4	1.8
Falls in the last year	2.0	2.8	9.1	-1.6	-3.0	-0.7	-0.6	-2.2	1.8	-1.3	0.5	1.5
Hair/balding pattern: Pattern 3	0.2	0.4	1.1	-1.0	0.5	-0.0	0.5	0.1	-0.7	0.2	-0.3	-1.0
Number of live births	3.5	5.0	13.5	1.7	2.2	0.1	3.2	2.1	-3.7	2.2	1.6	1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.3	0.1	1.2	0.3	2.3	1.1	-1.6	0.2	0.4	-0.3
Pulse rate	0.7	1.2	4.8	1.0	0.1	-0.0	-1.0	-0.0	1.4	1.4	-2.2	-0.4
Happiness	1.1	1.4	3.8	2.0	-1.6	-0.5	0.6	-1.5	-0.6	0.4	1.2	1.1
Noisy workplace	0.6	0.7	2.3	-0.7	-1.5	-0.4	-0.6	-1.2	1.2	0.2	0.2	0.1
Qualifications: A levels/AS levels or equivalent	1.8	3.9	13.7	1.0	3.7	-1.6	1.0	3.2	-2.1	-0.5	1.4	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.2	1.1	0.9	-0.2	-0.3	0.8	-1.0	0.8	0.0	0.2
Mouth/teeth dental problems: Dentures	0.3	0.4	1.5	0.6	-1.2	-0.5	-0.5	-1.0	0.1	0.1	0.2	0.7
Asthma	0.3	0.6	2.8	-0.5	0.2	1.2	-0.4	0.1	-0.2	1.7	-0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	-0.3	-0.6	0.5	-1.0	-1.2	0.8	1.2	-1.2	0.0
Medication: Cholesterol lowering	0.8	1.3	3.7	0.2	-1.5	1.0	-1.4	-1.4	1.9	0.3	-0.7	0.1
Depression (self-reported)	0.5	0.6	1.3	0.2	-0.6	1.1	1.1	-0.8	-0.7	1.0	-0.6	-0.2
Medication: Lansoprazole	0.5	0.6	2.7	-0.1	0.0	-0.8	-1.2	0.1	1.6	-0.4	-0.5	-0.2
Prospective memory result	1.2	1.5	3.9	0.9	-1.4	-0.7	-0.9	-1.5	2.0	0.8	-1.6	-0.1
Lung cancer (father)	0.2	0.2	0.8	-0.7	-0.3	-0.1	0.5	0.3	-0.4	-0.5	0.3	0.9
Illnesses of mother	1.2	1.5	4.5	-0.3	1.3	-1.0	1.0	0.5	-1.9	-0.5	-0.9	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.2	0.0	1.0	-0.2	2.0	0.9	-1.4	0.4	-0.0	-0.5
Pulse wave Arterial Stiffness index	1.2	1.4	2.7	1.2	-0.7	-0.6	-1.6	-1.2	1.6	1.4	0.4	1.4
Impedance of arm (left)	4.1	19.1	36.5	-3.9	-1.2	-1.8	-6.0	-2.4	4.8	-5.3	-5.3	-5.6
Arm fat mass (right)	0.8	3.4	17.4	1.2	-1.4	0.4	0.8	-0.6	-0.4	1.7	2.5	4.2
Trunk predicted mass	4.0	22.8	67.4	2.3	1.3	1.2	8.2	3.2	-6.6	4.6	5.2	5.2
Standing height	0.7	6.7	24.8	0.4	1.6	0.5	5.0	2.6	-4.3	1.9	1.6	1.0
Length of working week for main job	1.7	1.9	3.7	-1.6	-1.6	-0.4	-1.6	-1.9	1.1	-0.8	-1.9	-0.2
Exposure to tobacco smoke at home	0.9	1.0	3.2	0.8	-1.1	1.1	0.7	-1.1	0.4	0.6	0.6	1.8
Breastfed as a baby	2.4	2.9	8.8	0.8	1.1	-0.2	2.4	0.8	-1.8	0.4	3.0	2.4
Tense / ‘highly strung’	0.3	0.4	1.3	-0.2	-0.6	1.1	-0.4	-0.9	-0.2	-0.1	-0.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.8	0.1	-1.4	-1.0	-0.0	-1.7	-0.7	1.3	0.3	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	1.0	1.5	-0.0	1.0	1.6	0.9	-0.2	1.2	0.6
Birth weight of first child	0.8	1.5	7.5	-1.0	0.3	-0.1	1.3	0.4	-0.9	-0.9	-1.3	-2.7
Peak expiratory flow (PEF)	0.6	1.4	7.2	-1.9	-0.4	-0.7	-0.2	-0.3	-0.4	-2.7	0.4	-1.1
Pulse wave reflection index	1.5	1.9	5.4	0.2	-1.5	0.5	-1.3	-1.3	0.9	-0.3	2.2	2.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.0	1.6	-1.1	0.7	0.5	-1.0	-0.9	1.7	0.7	1.3
Loud music exposure frequency	1.1	1.2	3.2	-1.3	-1.4	1.8	-0.9	-0.8	1.2	-0.2	-0.6	-0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	9.0	-1.0	2.9	-0.4	0.2	3.0	-1.0	0.6	0.2	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.1	0.7	0.8	0.6	-1.1	0.2	1.5	1.0	-1.8	-1.5
Blood clot in the leg (DVT)	0.9	1.2	3.8	0.5	1.1	1.9	1.3	1.2	-1.2	0.9	-0.2	-0.0
Medication: Paracetamol	0.9	1.4	3.3	0.8	-1.6	-0.1	-1.7	-1.5	-0.2	0.8	0.9	1.8
Headache pain in last month	0.8	1.4	7.1	0.2	0.3	2.7	-1.2	0.1	0.9	0.7	-1.7	-0.2
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	8.2	0.7	2.9	-0.2	2.8	2.3	-2.0	0.5	0.8	-0.8
Glaucoma (self-reported)	0.9	1.0	2.3	-0.7	-1.5	-0.4	-0.1	-1.4	1.3	-1.4	-0.4	-0.7
Gout (self-reported)	2.4	3.3	8.3	0.8	1.7	-0.1	1.3	1.6	-1.9	2.6	1.8	2.9
Hypothyroidism/myxoedema (self-reported)	2.3	4.4	10.5	1.0	0.5	-3.1	1.3	1.1	-2.4	1.3	3.2	2.9
Medication: Amlodipine	0.4	0.5	2.1	-0.3	0.4	0.3	-1.4	-0.2	0.9	0.1	-0.4	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.8	-0.8	-1.7	1.0	-1.2	-1.5	0.4	0.7	-0.2	1.6
Birth weight	0.1	0.3	0.8	0.6	0.6	-0.9	0.3	-0.0	-0.0	0.9	-0.0	-0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	-0.8	-1.0	-0.2	0.6	-0.3	-0.4	1.2	0.1	0.8
High blood pressure (siblings)	1.5	2.2	4.7	-0.9	-1.6	2.2	-1.8	-1.5	2.1	-0.5	-0.0	1.0
Forced vital capacity (FVC), Best measure	0.4	1.4	5.9	0.3	1.2	-0.5	2.4	1.0	-1.8	0.9	0.4	0.3
Body fat percentage	0.8	3.1	7.3	0.5	-2.4	0.1	-2.2	-2.2	2.0	0.7	0.8	2.7
Leg fat percentage (right)	0.7	2.4	8.2	0.7	-2.0	0.2	-1.3	-1.4	1.2	0.7	1.8	2.9
Arm fat-free mass (right)	3.5	18.1	41.0	3.1	1.0	1.0	6.4	2.3	-5.0	5.2	4.8	5.5
Exposure to tobacco smoke outside home	0.7	0.9	3.4	-0.9	-1.8	1.0	-0.6	-1.4	0.6	0.3	-0.5	-0.1
Comparative body size at age 10	0.9	2.5	4.9	-1.9	-1.9	0.0	-0.8	-2.1	0.8	-1.9	0.8	2.2
Number of full brothers	0.3	0.3	0.8	0.5	0.8	-0.2	0.9	0.7	-0.5	-0.1	0.6	0.5
Worry too long after embarrassment	0.7	1.2	3.6	1.6	-0.1	-0.0	1.9	0.4	-1.3	1.0	-0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.0	-1.0	-1.3	-1.1	0.7	-1.2	-0.4	-1.4	-0.8	-1.0
Wheeze or whistling in the chest in last year	0.7	1.3	3.2	-0.9	-1.6	1.1	-1.0	-1.8	0.1	1.1	-1.2	0.2
Number of children fathered	0.3	0.4	0.9	-0.4	0.8	-0.9	-0.5	0.7	-0.0	-0.3	0.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	2.3	-0.8	0.1	0.3	-1.5	0.1	0.7	-0.5	0.1	0.2
Age at first live birth	1.6	2.8	10.6	-0.3	1.4	0.9	0.5	1.0	0.7	-1.4	-2.9	-3.2
Pulse wave peak to peak time	1.4	1.6	3.6	-1.0	0.9	0.5	1.9	1.5	-1.8	-1.2	-0.4	-1.4
Health satisfaction	1.3	1.7	4.8	0.4	-1.9	-2.2	-0.6	-1.1	-0.4	0.5	0.4	2.2
Shortness of breath walking on level ground	1.1	1.3	3.1	1.4	-0.6	-1.3	-1.0	-0.6	0.7	1.7	0.2	1.8
Qualifications: College or University degree	1.6	5.1	17.5	-0.6	4.2	-1.2	0.7	3.9	-2.7	-1.0	0.7	-1.3
Eye problems/disorders: None of the above	0.5	0.6	1.2	0.3	-0.1	-1.0	0.3	-0.9	-1.1	-0.9	-0.6	-0.9
Mouth/teeth dental problems: Loose teeth	1.8	2.2	13.2	-0.2	-0.9	0.6	-3.6	-1.4	1.4	0.7	-0.9	-0.1
Emphysema/chronic bronchitis	0.5	0.5	1.7	0.0	0.4	-0.3	0.7	0.1	-0.9	1.3	-1.0	-0.5
Medication for pain relief, constipation, heartburn	2.2	3.8	10.6	0.0	2.9	-1.5	2.3	3.3	-1.7	-1.4	0.9	-1.4
Neck or shoulder pain in last month	0.6	0.8	2.0	-1.0	-1.0	0.6	-0.7	-0.7	0.9	-0.5	0.9	1.4
Medication: Blood pressure	1.4	2.4	8.2	0.1	-1.6	-0.3	-2.9	-1.2	1.7	-0.1	1.0	2.3
Angina (self-reported)	0.4	0.5	1.8	0.8	-0.4	0.9	0.5	0.0	0.9	0.4	0.5	1.4
Migraine (self-reported)	0.3	0.4	0.7	0.9	0.3	-0.6	0.4	0.3	-0.8	0.9	0.4	0.8
Medication: Ibuprofen	0.8	1.0	2.2	-0.8	-0.8	0.9	-1.5	-1.3	0.9	0.7	-1.2	-0.2
Medication: Allopurinol	1.9	2.5	8.0	0.7	0.8	0.4	0.8	1.0	-1.7	2.4	1.7	2.8
Medication: Omeprazole	0.7	0.8	2.5	-0.0	-1.2	0.2	0.3	-0.8	-0.3	1.6	0.4	1.5
Medication: Seretide 50 evohaler	0.7	0.8	2.7	1.6	-0.3	1.5	0.9	-0.1	-0.6	1.0	0.1	0.1
Mean time to correctly identify matches	1.3	2.5	6.8	0.6	-0.3	-0.0	2.3	-0.1	-1.8	1.1	2.4	2.6
Heart disease (mother)	1.0	1.2	4.8	0.3	-0.2	0.6	0.8	0.6	-0.0	0.3	2.2	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.4	-1.1	-1.1	-0.6	0.6	-1.0	-1.5	-1.8	0.3	0.2
Whole body fat mass	0.7	3.1	14.2	1.1	-1.9	0.3	-0.1	-1.2	0.4	1.7	2.0	3.8
Leg fat mass (right)	1.0	3.8	16.9	1.6	-1.6	0.3	0.2	-0.9	0.2	2.2	2.5	4.1
Arm predicted mass (right)	3.5	17.7	43.2	3.0	1.2	1.2	6.6	2.6	-4.9	5.3	4.5	5.0
Pulse rate, automated reading	1.2	4.0	13.4	-0.2	0.0	1.1	-2.3	-0.6	2.7	1.0	-3.7	-2.8
Alcohol intake frequency.	0.7	1.7	8.5	-0.2	-0.7	-0.4	0.9	-0.6	-1.3	0.1	1.7	2.9
Comparative height size at age 10	1.0	5.8	18.2	0.6	1.6	0.3	4.1	2.2	-4.3	2.3	1.5	1.4
Number of full sisters	0.5	0.6	2.1	-1.3	-0.1	1.5	-0.3	0.5	0.7	-0.8	-0.5	-0.5
Suffer from ‘nerves’	0.1	0.2	1.0	-1.0	0.2	-0.5	0.1	0.2	-0.5	-0.4	-0.3	0.1
Overall health rating	1.5	3.2	11.3	-0.6	-3.4	-0.8	-0.1	-2.7	-0.3	0.9	-0.1	2.8
Chest pain or discomfort	2.1	3.1	10.9	-1.8	-3.1	0.7	-0.9	-3.3	1.1	-0.8	-1.0	-0.4
Had major operations	0.0	0.1	0.2	0.1	-0.4	0.2	-0.1	0.0	0.0	-0.3	-0.3	-0.3
Age at last live birth	2.1	3.0	9.4	-0.6	1.1	0.1	1.7	1.1	0.1	-1.8	-3.0	-3.1
Family relationship satisfaction	0.4	0.5	1.2	0.7	-1.1	1.0	0.0	-0.8	-0.3	0.7	0.4	0.5
Leg pain on walking	3.3	4.2	16.1	2.9	0.0	-1.1	1.1	0.0	-1.3	4.0	0.6	2.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.3	-0.1	0.3	-1.0	2.1	1.1	-1.5	0.6	1.5	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.7	0.2	0.4	1.2	-0.1	1.3	-0.2	0.4	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	4.7	-1.0	0.6	0.4	1.5	0.7	-0.3	-1.4	-0.6	-2.2
Medication: Aspirin	0.7	1.0	4.0	0.0	-1.1	2.0	-0.2	-1.1	0.9	0.9	-0.8	0.2
Supplements: Vitamin C	0.6	0.7	1.3	-0.6	0.6	0.1	1.1	0.8	-0.9	0.7	0.9	1.1
Knee pain experienced in last month	0.5	0.7	2.0	1.1	-0.6	-1.4	-1.0	0.2	0.2	0.8	0.3	1.1
Hypertension (Self-reported)	2.9	8.2	26.7	1.3	-1.5	0.3	-5.0	-1.7	3.3	0.6	1.9	5.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.6	-0.0	-1.3	0.5	0.2	-0.6	-0.1	0.7	-0.8	0.6
Illnesses of father: Heart disease	1.2	1.6	6.0	-1.1	-1.5	0.6	-2.5	-1.8	0.9	-0.2	-1.1	0.0
Illnesses of siblings: Diabetes	1.1	1.3	5.5	-0.6	-1.2	2.3	-0.7	-0.8	0.9	-0.5	-1.6	0.1
Smoking status: Previous	0.5	0.7	2.4	1.1	-1.6	0.8	0.1	-1.1	0.9	0.3	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.3	-1.2	0.5	0.1	2.0	1.1	-2.1	-0.2	0.3	-0.2
Whole body fat-free mass	3.3	19.0	50.3	2.5	1.0	1.2	7.1	2.7	-5.8	4.6	4.8	5.2
Leg fat-free mass (right)	2.2	11.7	26.7	2.3	0.5	0.9	5.2	1.7	-4.2	4.0	3.8	4.6
Arm fat percentage (left)	0.7	2.7	6.7	0.1	-2.5	-0.2	-2.0	-2.1	1.7	0.1	0.7	2.6
Average weekly red wine intake	0.3	0.5	1.6	0.2	1.2	-0.5	-0.3	0.4	-0.1	-0.7	-0.8	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.8	0.7	0.2	2.2	-0.6	0.4	0.0	0.5	-0.8	0.2
Mood swings	2.8	5.1	19.1	0.4	-4.2	0.1	-1.7	-4.4	1.8	-1.1	-0.9	1.1
Loneliness, isolation	1.8	2.5	10.8	2.5	-0.4	0.5	0.2	-1.2	-0.6	3.3	-0.4	1.8
Long-standing illness, disability or infirmity	1.2	1.8	7.1	0.9	-0.8	-0.8	0.0	-0.3	-0.6	2.3	1.3	2.7
Ever had bowel cancer screening	0.6	0.8	1.6	0.9	1.2	-0.5	0.1	0.6	-0.7	1.3	1.2	0.5
Diabetes diagnosed by doctor	0.6	1.1	4.8	0.6	0.2	1.5	0.5	0.4	-0.2	2.2	0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.4	0.1	1.2	-0.0	2.1	1.4	-1.5	0.8	-0.8	-0.9
Friendships satisfaction	0.3	0.4	1.8	1.4	0.6	-0.1	0.3	0.4	-0.7	-0.5	0.4	0.2
Qualifications: nursing, teaching	1.6	2.5	9.1	0.1	3.0	0.2	-1.0	2.9	-1.2	0.9	-1.0	-0.8
Commuting to job workplace: Walk	0.3	0.3	1.1	0.1	0.4	1.0	0.1	-0.2	0.5	1.0	0.1	0.4
Eye problems/disorders: Cataract	1.8	2.1	5.8	1.2	-0.0	0.6	1.3	0.7	-0.7	2.4	1.9	2.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	-0.1	1.0	-0.4	-1.1	-0.0	1.1	-0.5	-1.4	-1.2
Medication for cholesterol	2.1	3.1	13.5	-1.9	-0.0	-1.0	2.2	0.3	-1.7	-1.4	-0.9	-3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.2	-0.0	0.3	1.7	-1.8	0.3	1.7	0.1	-0.4	-0.3
Back pain experienced in last month	0.9	1.3	4.3	0.1	-0.1	-1.8	2.1	0.2	-1.5	-0.3	1.2	0.3
Mineral and other dietary supplements	0.6	0.9	3.1	0.9	-0.2	0.0	-1.1	-0.7	1.8	0.7	-1.2	-0.0
Breast cancer (self-reported)	0.7	0.9	2.9	0.8	1.1	0.8	-0.5	0.7	1.0	-0.1	1.7	0.7
Asthma (self-reported)	0.3	0.6	3.4	-0.3	0.2	1.0	-0.4	0.1	-0.1	1.8	-0.8	-0.1
Osteoporosis (self-reported)	0.4	0.5	2.3	-0.3	0.0	-0.3	-1.5	0.3	1.2	0.2	0.1	0.4
Osteoarthritis (self-reported)	2.5	3.2	6.3	2.2	2.1	-0.8	1.3	2.0	-1.6	2.5	1.2	1.8
Medication: Aspirin	0.7	1.0	5.1	0.2	-0.9	2.3	0.2	-0.7	0.5	0.8	-0.1	1.1
Medication: Gliclazide	0.5	0.6	2.3	0.2	-1.5	-0.5	0.4	-1.0	0.5	-0.1	0.8	0.6
Illnesses of father: None of the above (group 1)	1.4	1.7	7.8	0.5	0.8	-0.5	2.8	1.1	-1.5	-0.3	1.6	-0.5
Smoking status: Current	0.6	0.9	2.5	-1.6	-1.1	0.2	0.1	-0.9	-1.5	-0.3	-0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.1	1.4	1.9	-0.3	2.0	1.6	-0.5	-0.1	-0.5	-1.3
Whole body water mass	3.2	18.5	48.7	2.5	1.1	1.2	7.0	2.7	-5.6	4.6	4.7	5.2
Leg predicted mass (right)	2.2	11.8	26.3	2.3	0.4	0.9	5.1	1.7	-4.3	4.0	3.8	4.7
Arm fat mass (left)	0.8	3.1	15.4	1.3	-1.3	0.2	0.6	-0.6	-0.4	1.7	2.3	3.9
Number of self-reported non-cancer illnesses	1.4	2.4	8.9	0.9	-1.2	0.4	-1.7	-1.2	1.1	1.9	0.8	3.0
Average weekly champagne plus white wine intake	2.0	2.7	6.2	0.1	2.1	-0.3	2.1	2.5	-2.1	0.9	1.4	1.6
Miserableness	0.3	0.6	1.6	1.1	-0.5	-0.2	-0.3	-1.2	0.7	0.4	-1.3	0.2
Guilty feelings	1.1	1.7	5.9	2.1	0.7	-1.5	0.2	0.1	0.8	2.4	-0.4	1.1
Wears glasses or contact lenses	2.9	3.4	7.3	-0.8	2.6	0.2	2.7	2.7	-2.7	-0.2	1.1	0.1
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.3	1.0	0.3	0.7	0.6	1.3	0.5	-1.2	-1.5
Hearing aid user	1.3	1.5	4.8	-0.3	0.2	-0.7	1.6	0.8	-1.6	-1.1	2.2	1.0
Mother’s age at death	0.6	0.8	3.3	-1.0	0.5	-1.2	0.2	0.5	-0.2	-0.5	-0.6	-1.8
Financial situation satisfaction	0.9	1.1	3.4	0.2	0.1	-0.9	1.5	-0.0	-1.8	1.3	1.0	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.4	0.5	0.6	0.0	0.2	0.8	-1.6	0.0	-0.0	-0.6
Commuting to job workplace: Public transport	0.9	1.1	3.7	-1.9	-0.9	-1.3	0.6	-0.9	-0.9	-1.1	0.4	-0.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.7	-0.8	-0.8	0.1	0.1	-0.6	0.9	-1.3	-0.1	-0.6
Medication: Blood pressure	2.8	5.3	15.8	1.8	0.5	1.4	-3.7	-0.1	2.7	1.6	1.5	4.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	-0.2	-0.8	0.1	-0.1	0.5	-1.1	-0.5	1.4	1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.4	-0.2	0.9	0.8	1.3	1.5	-2.1	-0.6	0.4	-0.1
High cholesterol (Self-reported)	0.6	1.0	2.0	0.5	-1.3	1.3	-0.8	-1.4	0.8	0.4	-0.0	1.4
Medication: Bendroflumethiazide	1.4	2.2	8.9	0.7	-0.8	0.3	-3.0	-1.4	1.9	0.6	-0.4	1.8
Medication: Paracetamol	0.9	1.3	3.8	0.4	-1.3	-0.5	-1.1	-0.9	-1.3	0.7	1.4	2.0
Medication: Lisinopril	2.0	2.6	7.5	1.9	0.3	0.8	-2.5	0.2	1.3	1.8	0.3	2.7
Medication: Atorvastatin	0.4	0.5	1.9	0.7	-0.8	0.8	0.1	-0.8	0.1	0.2	0.3	1.4
Illnesses of father: High blood pressure	1.5	1.8	9.1	-0.4	-0.4	-0.2	-3.0	-0.8	2.2	-0.5	-1.0	0.6
Alcohol drinker status: Never	2.3	2.8	8.6	-0.6	0.8	0.4	1.6	1.5	-2.1	-0.3	2.9	2.4
Ever smoked	0.7	1.2	3.6	-0.4	-1.9	0.9	-1.1	-1.6	0.3	0.1	-1.3	0.8
Basal metabolic rate	2.9	16.3	38.7	2.5	0.7	1.1	6.2	2.2	-5.1	4.4	4.6	5.3
Leg fat percentage (left)	0.8	2.9	10.8	1.0	-2.0	0.7	-1.1	-1.5	1.0	1.1	2.0	3.3
Arm fat-free mass (left)	4.3	21.9	50.0	3.2	1.5	1.4	7.1	2.9	-5.7	5.0	5.6	5.9
Number of operations (self-reported)	0.4	0.6	1.2	0.3	0.5	-0.9	0.3	0.8	-1.0	1.1	1.0	0.8
Average weekly beer plus cider intake	0.6	0.9	4.3	0.9	0.1	-2.1	0.2	-0.1	0.3	0.0	-0.4	-1.5
Irritability	1.2	2.1	4.8	0.1	-1.4	-2.0	-1.1	-2.2	0.0	-0.4	1.4	2.2
Risk taking	1.0	1.5	6.1	-2.5	-1.8	0.1	-0.5	-1.3	0.1	-1.4	-0.1	0.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.3	-0.8	-0.4	1.5	-0.2	0.0	-0.6	-0.2	-0.1	-0.9
Fractured/broken bones in last 5 years	0.9	1.2	4.1	0.1	-2.0	-0.4	-1.1	-1.4	-0.1	-0.3	0.8	1.7
Age started oral contraceptive pill	1.9	2.3	7.5	-0.1	2.4	1.8	0.7	2.7	-0.4	0.5	-0.8	-1.7
Diastolic blood pressure, automated reading	3.4	10.4	44.7	-1.5	-1.3	0.6	-6.7	-1.5	5.0	-3.5	1.4	1.9
Ever depressed for a whole week	0.8	1.0	3.6	-1.2	-0.7	-1.4	-0.8	0.0	-0.5	-0.2	1.9	0.7
Unable to work because of sickness or disability	0.9	1.2	2.7	-0.2	-1.3	-0.8	0.3	-1.2	-1.6	1.4	0.2	1.5
Commuting to job workplace: Cycle	0.4	0.4	1.1	0.4	1.0	-0.8	-0.5	0.4	-0.1	1.1	0.7	-0.1
Myopia	0.1	0.2	0.6	-0.7	-0.1	-0.3	0.6	-0.6	-0.4	0.1	-0.3	0.3
Vascular/heart problems diagnosed by doctor	2.7	7.4	26.7	-0.6	1.8	-0.9	5.2	2.0	-3.2	0.0	-1.3	-4.5
Cholesterol lowering medication	0.4	0.7	4.6	0.2	-0.0	1.0	-0.2	-0.1	0.2	0.4	0.3	2.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.8	0.2	-1.2	-0.1	-0.2	-0.8	0.2	1.9	0.3	2.0
Pain experienced in last month	0.2	0.4	1.0	-0.5	0.1	-1.0	-0.5	-0.2	0.7	-1.0	0.3	-0.5
Supplements: Calcium	0.6	0.6	2.4	-1.5	0.3	-0.1	-0.5	0.1	1.2	1.2	0.4	-0.1
Basal cell carcinoma (self-reported)	0.8	1.0	2.6	0.8	1.1	-0.0	0.7	1.0	-0.0	1.1	1.6	1.4
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.8	-1.4	-0.8	2.0	-1.9	-0.6	1.6	-0.8	-0.6	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	0.5	1.1	1.6	1.2	1.2	-1.2	0.5	-0.1	0.0
Heart disease (siblings)	0.8	1.0	3.9	-0.1	-0.9	2.0	-0.0	-0.7	0.8	-0.3	0.7	1.6
Alcohol drinker status: Previous	0.9	1.1	2.6	-1.2	0.4	-0.4	0.6	0.8	-1.5	0.6	1.3	1.6
Pack years of smoking	2.0	2.9	8.5	1.0	0.9	-0.9	1.3	0.8	-1.9	1.8	2.5	2.9
Impedance of whole body	3.4	17.2	36.6	-3.1	-0.9	-1.0	-6.0	-2.3	5.1	-4.5	-5.0	-5.4
Leg fat mass (left)	1.1	4.4	18.8	1.8	-1.7	0.4	0.5	-0.9	-0.1	2.4	2.8	4.3
Arm predicted mass (left)	3.9	20.1	47.3	3.0	1.2	1.4	6.9	2.8	-5.5	4.8	5.3	5.7