TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Vascular/heart problems diagnosed by doctor
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chr4:25,880,334-27,452,482
Best TWAS P=1.16e-10 · Best GWAS P=1.08e-14 conditioned to 5.06e-09
25.8M
26M
26.2M
26.4M
26.6M
26.8M
27M
27.2M
27.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
TBC1D19
0.14
0.05
lasso
4
0.06
5.4e-05
6.5
-6.4
1.2e-10
0.57
0.80
0.17
TRUE
3
The Cancer Genome Atlas
Rectum Adenocarcinoma
TBC1D19
0.56
0.18
blup
24
0.17
7.0e-05
-7.5
6.0
2.7e-09
-0.81
0.00
0.86
TRUE
2
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
TBC1D19
0.04
0.01
enet
14
0.00
6.7e-01
5.7
-5.4
5.4e-08
0.39
0.02
0.05
FALSE