TWAS
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Models
Genes
Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr7:1,787,236-3,264,728
Best TWAS P=6.67e-11 · Best GWAS P=1.49e-10 conditioned to 1
1.8M
2M
2.2M
2.4M
2.6M
2.8M
3M
3.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Colon Transverse
LFNG
0.25
0.20
lasso
3
0.17
1.1e-08
-6.4
-6.5
6.7e-11
1.00
0.00
1.00
TRUE
2
GTEx
Esophagus Muscularis
AC004840.9
0.19
0.07
enet
34
0.10
1.2e-06
2.5
5.2
2.2e-07
-0.45
0.16
0.68
FALSE