Hub : Genes

LFNG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2490	0.079	0.00120	0.201	NA	0.114	NA	0.174	6.6e-10	NA	4.4e-06	NA	1.1e-08
2	METSIM	Adipose	0.0731	0.024	0.00013	0.024	0.025	0.059	0.047	0.052	1.2e-04	9.8e-05	3.4e-09	1.2e-07	2.8e-08
3	TCGA	Soft Tissue Sarcoma	0.1310	0.061	0.00240	0.016	0.048	-0.001	NA	0.011	3.5e-02	8.0e-04	4.1e-01	NA	6.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.5	2.8	0.4	1.7	1.3
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.3	-0.0	0.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.6	-0.1	0.8
Depression (Nagel 2018)	0.6	0.9	1.1	1.1	-0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.7	1.1	0.6	-1.3
Neuroticism (Nagel 2018)	0.7	1.6	3.8	-0.9	-2.0	-0.1
Schizophrenia (2018)	0.3	0.6	1.8	0.0	-1.3	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-1.2	0.0	0.5
Worry (Nagel 2018)	0.8	1.6	3.4	-0.4	-1.8	1.2
Alzheimer’s Disease (in mother)	0.8	0.9	2.7	-0.3	1.6	-0.1
Alzheimer’s Disease (in father)	0.9	1.0	1.8	-1.0	-0.3	1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	-0.5	1.1	0.8
Crohns Disease (2017)	4.2	9.2	12.8	2.4	-3.0	-3.6
Irritable Bowel Disease (IBD)	1.3	3.0	3.7	1.9	-1.4	-1.9
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.7	0.5	0.2
Major Depression (MDD)	0.3	0.4	1.2	-1.1	0.0	0.0
Reaction Time	0.4	0.7	1.8	-1.3	-0.0	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	0.9	-0.7	-1.3
Breast Cancer	0.3	0.6	1.3	0.8	1.1	-0.2
Ovarian Cancer	0.2	0.3	0.4	-0.6	-0.5	0.4
Prostate Cancer	1.4	2.0	3.4	1.6	1.9	-0.1
Age at First Birth	0.2	0.4	0.8	-0.9	0.3	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	0.1	1.1	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.7	-1.3	0.0	0.0
Crohns Disease (2012)	1.3	2.1	4.3	2.1	-0.9	-1.1
Mean Putamen Volume	0.3	0.3	0.8	0.1	-0.9	-0.4
Fasting Glucose	1.5	1.8	4.1	-0.5	1.0	2.0
HbA1C	1.2	1.4	3.8	0.4	-1.9	0.4
HDL Cholesterol	0.3	0.5	1.2	-0.2	-1.1	0.3
LDL Cholesterol	1.6	2.5	4.9	2.2	-0.8	-1.4
Lupus	1.1	1.7	2.3	-0.9	1.5	1.4
Neuroticism (2016)	0.4	0.6	1.7	1.3	0.3	0.2
Primary Biliary Cirrhosis	1.0	1.4	2.9	-1.1	1.7	0.4
Rheumatoid Arthritis	2.6	3.6	4.9	-1.2	2.1	2.2
Schizophrenia (2014)	0.3	0.7	1.6	-0.6	-1.3	-0.2
Triglycerides	0.3	0.6	1.3	0.6	0.1	-1.1
Type 2 Diabetes (T2D) (2012)	3.8	4.4	10.4	-1.2	3.2	1.2
Ulcerative Colitis	0.6	0.8	1.8	0.0	1.4	0.8
Blood Eosinophil Count	0.5	3.7	6.7	1.3	-2.6	-1.6
Blood Platelet Count	0.7	8.3	22.1	-4.7	-1.1	-1.2
Blood Red Count	0.9	9.1	13.5	3.7	-2.1	-3.0
Blood White Count	1.0	7.2	9.5	2.7	-2.2	-3.1
Heel T-Score	2.7	21.2	44.5	6.7	-1.2	-4.2
BMI	0.3	1.6	4.8	0.3	2.2	-0.1
Height	0.3	6.4	13.0	-2.4	-0.8	3.6
Waist Hip Ratio (WHR)	1.0	4.4	12.5	3.5	-0.7	0.3
Systolic Blood Pressure	6.2	30.8	52.3	7.2	-3.5	-5.3
Smoking Status	0.1	0.3	0.5	-0.7	0.6	0.1
Allergy or Eczema	0.3	0.7	1.1	1.0	-1.0	0.1
Cardiovascular Disease	8.7	28.8	36.4	6.0	-4.2	-5.7
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.1	0.4	-0.1
Respiratory disease	0.3	0.7	1.8	0.6	0.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	0.9	1.2	-0.3
Lung FEV1/FVC ratio	0.2	1.0	2.5	0.6	0.4	-1.6
Lung FVC	0.2	0.9	1.9	0.3	0.7	-1.4
Neuroticism	0.6	1.5	2.7	0.8	-1.6	-1.1
Chronotype (morning person)	1.2	2.7	5.0	-2.2	0.5	1.7
Hair Pigment	0.1	3.1	5.2	2.3	1.8	1.0
Tanning	0.1	1.1	1.8	-1.1	-0.5	-1.3
Hand grip strength (left)	0.5	1.4	2.4	0.2	-1.4	-1.5
Number of treatments/medications taken	3.5	6.3	9.2	3.0	-2.1	-2.3
Average weekly spirits intake	0.1	0.1	0.2	0.3	-0.5	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.3	0.0	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.8	-0.3	-0.6
Hearing difficulty/problems: Yes	1.9	2.9	3.2	-1.7	1.8	1.7
Relative age of first facial hair	0.3	0.6	0.7	-0.7	0.8	0.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.4	-1.2	-1.2	0.0
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.3	0.7	-1.1	0.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.4	-0.2	0.1
Systolic blood pressure, automated reading	4.0	11.8	22.8	4.8	-2.0	-2.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-0.8	1.2	0.4
Angina	2.8	3.6	6.2	1.8	-2.5	-1.2
Medication for hormone replacement therapy	0.6	0.6	1.5	-0.3	-0.5	-1.2
Vitamin and mineral supplements	0.3	0.3	0.5	-0.6	0.3	0.7
Supplements: Zinc	0.8	0.8	2.3	0.3	-1.5	-0.3
Medication: Co-codamol	0.1	0.1	0.1	0.1	-0.3	-0.3
Medication: Metformin	0.8	1.2	2.6	1.6	1.0	0.3
Diabetes (father)	1.1	1.3	3.2	1.8	-0.8	-0.5
Diabetes (mother)	0.6	0.8	1.7	-1.3	0.6	0.5
Severe depression (siblings)	0.7	0.8	2.1	-0.3	-1.5	-0.2
Pack years adult smoking proportion	0.7	1.1	2.7	1.6	-0.7	-0.3
Impedance of leg (right)	0.2	1.1	1.8	1.3	-1.2	-0.4
Leg fat-free mass (left)	0.7	3.8	6.6	-1.9	1.2	2.6
Trunk fat percentage	0.9	3.5	9.7	-0.8	0.6	3.1
Hand grip strength (right)	0.4	1.1	1.3	1.1	-0.9	-1.1
Townsend deprivation index at recruitment	0.3	0.5	1.3	0.1	-0.4	-1.1
Current tobacco smoking	0.6	1.0	1.7	1.0	-0.5	-1.3
Average weekly fortified wine intake	0.3	0.3	0.5	-0.5	0.7	0.6
Maternal smoking around birth	0.0	0.1	0.1	-0.2	0.1	-0.4
Fed-up feelings	0.4	0.8	1.9	0.7	1.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	1.1	-0.2	-0.5
Relative age voice broke	0.1	0.1	0.1	-0.4	-0.3	0.1
Taking other prescription medications	0.5	0.8	1.7	1.3	-0.5	-0.7
Age when periods started (menarche)	0.3	0.8	1.4	-0.9	1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	-1.4	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.8	2.2	0.7	-0.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	2.7	-1.6	-1.6	0.4
Qualifications: CSEs or equivalent	1.2	1.6	3.0	-1.7	0.2	1.4
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.7	1.0	0.0
High blood pressure	9.1	25.4	39.9	6.3	-3.7	-4.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.2	-0.7	0.6
Multivitamins +/- minerals	0.2	0.2	0.6	-0.8	0.3	0.0
Stomach or abdominal pain in last month	0.5	0.6	1.7	0.3	-1.3	-0.2
Supplements: Glucosamine	0.1	0.1	0.2	0.1	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	1.1	-0.4	-0.7
Medication: Atenolol	8.3	10.4	14.4	2.7	-3.1	-3.8
Medication: Levothyroxine sodium	0.5	0.9	2.0	1.4	-0.3	-0.9
Sitting height	0.3	1.9	5.1	-0.7	-2.3	0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	0.6	-0.1	-0.7
High blood pressure (mother)	1.7	2.3	5.9	1.0	-2.4	-0.2
Body mass index (BMI)	0.1	0.4	0.8	-0.1	0.6	0.9
Impedance of leg (left)	0.1	0.6	1.1	0.8	-1.1	0.3
Leg predicted mass (left)	0.7	3.7	6.3	-1.8	1.2	2.5
Trunk fat mass	0.9	3.9	9.9	-1.0	0.9	3.1
Waist circumference	0.5	1.9	4.2	0.4	1.1	2.1
Number of incorrect matches in round	0.0	0.1	0.1	-0.3	-0.2	0.3
Past tobacco smoking	0.2	0.4	1.1	0.4	-0.3	-1.0
Alcohol usually taken with meals	0.7	1.2	2.6	0.9	0.2	-1.6
Nervous feelings	0.4	0.8	1.4	-0.5	-1.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	0.4	-1.3	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.5	-0.1	0.6
Hair/balding pattern: Pattern 2	3.2	4.0	6.4	1.5	-2.5	-1.9
Had menopause	1.3	1.6	2.2	1.5	-1.1	-1.1
Had other major operations	2.1	2.6	6.5	1.0	-2.5	-0.6
Forced vital capacity (FVC)	0.4	1.4	2.4	-1.5	1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.8	2.2	-0.4	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.2	-0.7	0.4
Qualifications: None of the above	0.3	0.7	1.3	-0.7	0.7	1.1
Financial difficulties in last 2 years	1.0	1.4	3.3	1.8	0.8	-0.3
Mouth/teeth dental problems	0.3	0.4	1.1	-0.2	0.4	-1.1
Heart attack	1.6	2.1	2.6	1.6	-1.6	-1.0
Allergy	0.1	0.2	0.5	0.1	0.7	-0.3
Pain all over the body in last month	0.3	0.3	0.4	-0.5	0.5	0.6
Diabetes (self-reported)	0.1	0.2	0.5	0.7	-0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.9	0.9	-1.4	-0.5
Medication: Ramipril	1.8	2.3	4.0	2.0	-0.7	-1.5
Medication: Simvastatin	2.5	3.6	7.8	2.8	-0.6	-1.7
Fluid intelligence score	1.1	2.3	4.0	1.6	-0.4	-2.0
Illnesses of siblings	2.8	3.9	5.4	-1.4	2.0	2.3
Neuroticism score	0.3	0.6	0.6	0.7	-0.7	-0.8
Weight	0.5	2.5	5.6	-0.9	1.0	2.4
Impedance of arm (right)	0.5	2.4	5.0	-1.3	0.8	2.2
Arm fat percentage (right)	0.8	3.1	7.2	-0.8	1.2	2.7
Trunk fat-free mass	0.1	0.7	0.9	-0.9	0.7	0.9
Hip circumference	0.6	2.5	4.5	-1.3	1.2	2.1
Time employed in main current job	1.2	1.4	2.5	-1.2	-0.5	1.6
Alcohol intake versus 10 years previously	0.9	1.3	1.8	1.2	-0.7	-1.4
Father’s age at death	1.1	1.4	3.1	-1.1	-0.0	1.8
Worrier / anxious feelings	0.4	0.7	2.0	-0.2	-1.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.3	0.5	0.8
Falls in the last year	0.5	0.7	1.2	-0.4	-1.1	-0.8
Hair/balding pattern: Pattern 3	2.9	4.4	5.8	-1.4	2.3	2.4
Number of live births	1.0	1.4	4.2	0.1	2.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	1.8	-1.4	0.9	-1.3
Pulse rate	2.1	3.5	6.6	2.0	-0.1	-2.6
Happiness	0.8	1.0	1.2	0.9	-1.0	-1.1
Noisy workplace	0.1	0.1	0.2	-0.2	0.4	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.2	-1.1	1.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.9	1.1	0.4
Mouth/teeth dental problems: Dentures	1.3	2.2	4.8	1.4	-2.2	0.1
Asthma	0.1	0.1	0.1	-0.2	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	-1.7	0.0	0.4
Medication: Cholesterol lowering	6.5	10.1	15.9	3.5	-1.6	-4.0
Depression (self-reported)	0.2	0.2	0.5	0.4	-0.3	0.7
Medication: Lansoprazole	0.3	0.4	0.5	-0.7	-0.6	0.4
Prospective memory result	0.6	0.7	1.4	0.5	-1.2	-0.6
Lung cancer (father)	2.9	3.4	8.1	0.1	2.8	1.5
Illnesses of mother	2.1	2.6	5.2	-1.4	2.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.0	-1.0	1.0	-0.5
Pulse wave Arterial Stiffness index	3.4	4.0	8.2	1.8	-0.8	-2.9
Impedance of arm (left)	0.4	1.7	3.6	-1.3	-0.0	1.9
Arm fat mass (right)	0.6	2.4	5.7	-0.7	1.0	2.4
Trunk predicted mass	0.1	0.7	1.0	-0.9	0.7	1.0
Standing height	0.4	3.8	8.0	-1.7	0.7	2.8
Length of working week for main job	0.5	0.5	1.3	0.4	-1.1	-0.4
Exposure to tobacco smoke at home	1.6	1.8	3.1	1.7	-0.1	-1.5
Breastfed as a baby	0.5	0.6	1.6	-0.3	0.0	1.3
Tense / ‘highly strung’	0.3	0.5	1.2	0.0	-1.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.4	-0.6	1.1
Hair/balding pattern: Pattern 4	1.1	2.7	6.5	0.8	2.5	-1.0
Birth weight of first child	0.3	0.6	1.3	-0.6	-1.2	0.4
Peak expiratory flow (PEF)	0.4	1.0	1.6	-1.1	0.4	-1.3
Pulse wave reflection index	2.2	2.7	5.2	0.6	-2.3	-1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-0.3	-1.2	-0.9
Loud music exposure frequency	0.9	1.0	1.7	-1.3	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.8	1.3	1.2	0.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.7	-0.7	1.1	1.6
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.6	0.0	0.5
Medication: Paracetamol	0.8	1.3	3.4	-1.8	-0.1	0.7
Headache pain in last month	1.2	2.0	4.0	-2.0	-1.3	0.3
Medication for cholesterol, blood pressure or diabetes	11.5	19.0	25.1	-4.9	2.9	5.0
Glaucoma (self-reported)	1.6	1.8	2.7	1.6	1.1	-1.3
Gout (self-reported)	0.6	0.8	2.0	0.2	0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.5	0.4	-0.3
Medication: Amlodipine	4.9	6.9	10.5	3.2	-1.9	-2.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	1.4	-0.5	-1.9
Birth weight	0.4	1.0	1.8	0.8	1.4	0.6
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	0.7	-1.3	0.7
High blood pressure (siblings)	3.8	5.5	8.2	2.9	-1.1	-2.6
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.8	1.3	-0.2
Body fat percentage	0.6	2.3	6.6	-0.4	0.4	2.6
Leg fat percentage (right)	0.1	0.5	0.9	0.7	-0.0	1.0
Arm fat-free mass (right)	0.2	0.8	2.1	-0.5	0.2	1.4
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.2	-0.4	-0.4
Comparative body size at age 10	0.3	0.9	2.3	0.6	1.5	0.2
Number of full brothers	1.6	2.0	3.7	-0.8	1.2	1.9
Worry too long after embarrassment	0.6	1.0	2.6	-0.5	-1.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.9	1.0	-0.3	0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.8	1.3	-0.6	0.1
Number of children fathered	1.0	1.1	1.8	0.7	-1.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	-1.4	-1.9	-0.2
Age at first live birth	0.1	0.1	0.2	-0.4	-0.1	0.4
Pulse wave peak to peak time	3.8	4.4	9.1	-1.9	0.8	3.0
Health satisfaction	0.3	0.4	0.7	0.0	-0.7	0.8
Shortness of breath walking on level ground	0.3	0.4	1.1	-0.3	0.0	1.0
Qualifications: College or University degree	0.5	1.5	3.3	-1.8	0.6	-0.9
Eye problems/disorders: None of the above	0.7	0.8	2.3	0.2	-1.5	-0.5
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-0.6	0.8	1.4
Emphysema/chronic bronchitis	0.3	0.3	0.4	0.5	0.6	0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.2	1.0	0.3
Neck or shoulder pain in last month	1.2	1.7	4.2	0.7	-2.1	-0.7
Medication: Blood pressure	9.4	16.6	24.7	5.0	-2.5	-4.3
Angina (self-reported)	3.6	4.7	7.3	2.1	-2.7	-1.5
Migraine (self-reported)	1.9	2.3	5.1	-2.2	0.2	1.4
Medication: Ibuprofen	0.4	0.5	1.1	-1.0	0.0	0.6
Medication: Allopurinol	0.8	1.1	2.3	-0.9	1.5	-0.3
Medication: Omeprazole	0.5	0.6	1.7	0.2	-1.3	-0.4
Medication: Seretide 50 evohaler	2.5	2.9	4.6	1.8	-1.0	-2.1
Mean time to correctly identify matches	0.1	0.2	0.4	0.2	-0.6	0.5
Heart disease (mother)	1.5	1.9	4.1	2.0	-0.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.6	-1.4	1.9	0.2
Whole body fat mass	0.6	2.4	6.6	-0.5	0.5	2.6
Leg fat mass (right)	0.3	1.2	3.4	-0.2	0.4	1.9
Arm predicted mass (right)	0.1	0.8	1.8	-0.6	0.3	1.3
Pulse rate, automated reading	1.1	3.6	5.2	2.3	-0.9	-2.2
Alcohol intake frequency.	1.7	4.0	6.3	2.0	-2.5	-1.3
Comparative height size at age 10	0.3	1.6	3.8	-0.9	0.5	1.9
Number of full sisters	0.2	0.2	0.5	0.7	-0.1	-0.3
Suffer from ‘nerves’	0.4	0.6	1.1	0.1	-1.1	0.8
Overall health rating	0.8	1.8	3.9	2.0	-1.1	0.4
Chest pain or discomfort	0.3	0.5	1.0	1.0	-0.7	0.0
Had major operations	0.4	0.5	0.8	-0.2	-0.7	0.9
Age at last live birth	0.0	0.0	0.1	0.1	0.2	-0.1
Family relationship satisfaction	0.4	0.5	1.0	0.6	-0.3	-1.0
Leg pain on walking	0.7	0.8	2.1	0.4	-1.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.5	-0.1	0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.6	-1.1	-0.0	1.6
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	6.4	-0.6	-2.5	-1.0
Medication: Aspirin	6.3	8.3	12.2	2.8	-3.5	-2.1
Supplements: Vitamin C	0.4	0.5	1.2	-0.3	1.1	0.4
Knee pain experienced in last month	0.1	0.2	0.7	0.8	0.0	0.0
Hypertension (Self-reported)	10.3	28.7	42.2	6.5	-4.0	-5.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.3	-0.3	-0.6
Illnesses of father: Heart disease	2.9	4.0	4.4	2.0	-1.9	-2.1
Illnesses of siblings: Diabetes	2.2	2.7	6.8	-2.6	0.3	1.1
Smoking status: Previous	1.6	2.3	4.2	-1.3	1.1	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-1.3	0.3	0.8
Whole body fat-free mass	0.3	1.9	3.2	-1.4	0.9	1.8
Leg fat-free mass (right)	0.9	4.8	7.3	-2.2	1.4	2.7
Arm fat percentage (left)	0.7	2.7	6.2	-1.0	0.9	2.5
Average weekly red wine intake	1.5	2.2	4.2	0.4	2.0	-1.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.4	0.8	0.4
Mood swings	0.1	0.1	0.2	-0.4	0.2	0.3
Loneliness, isolation	0.1	0.1	0.2	0.1	-0.1	-0.5
Long-standing illness, disability or infirmity	0.2	0.2	0.4	0.2	-0.6	0.5
Ever had bowel cancer screening	0.3	0.4	0.6	-0.1	0.7	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.8	0.9	0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.4	-0.6	0.7
Friendships satisfaction	0.1	0.1	0.1	0.3	-0.2	0.3
Qualifications: nursing, teaching	0.7	1.0	1.8	0.5	-1.0	-1.4
Commuting to job workplace: Walk	0.9	1.0	1.2	1.1	1.0	-0.8
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.2	-1.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.0	-1.0	1.7	0.9
Medication for cholesterol	4.6	7.0	8.8	-3.0	2.5	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	7.7	0.1	2.6	2.8
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.2	0.3
Mineral and other dietary supplements	0.5	0.7	1.5	0.8	0.1	-1.2
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	-0.1	-0.1
Asthma (self-reported)	0.1	0.2	0.4	-0.2	0.6	-0.4
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.1	0.1	1.4
Osteoarthritis (self-reported)	0.5	0.7	1.2	0.8	0.3	1.1
Medication: Aspirin	6.6	8.6	13.6	2.6	-3.7	-2.3
Medication: Gliclazide	0.2	0.2	0.5	0.7	0.2	-0.3
Illnesses of father: None of the above (group 1)	5.2	6.4	10.4	-3.2	2.5	1.6
Smoking status: Current	0.8	1.2	2.5	0.9	-0.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	7.3	1.2	-0.7	-2.7
Whole body water mass	0.4	2.1	3.4	-1.4	1.0	1.8
Leg predicted mass (right)	0.9	4.9	7.6	-2.2	1.5	2.8
Arm fat mass (left)	0.8	3.1	6.7	-1.3	1.0	2.6
Number of self-reported non-cancer illnesses	4.1	7.1	8.3	2.5	-2.9	-2.6
Average weekly champagne plus white wine intake	0.4	0.6	1.2	-0.8	-1.1	-0.1
Miserableness	0.1	0.1	0.2	0.2	0.5	0.1
Guilty feelings	1.9	2.9	3.7	1.2	-1.9	-1.9
Wears glasses or contact lenses	1.3	1.5	3.3	1.8	0.0	-1.1
Ever taken oral contraceptive pill	1.3	1.5	1.9	-1.4	-0.8	1.4
Hearing aid user	1.6	1.8	2.9	-0.1	1.6	1.7
Mother’s age at death	1.7	2.2	5.0	-0.2	2.2	1.2
Financial situation satisfaction	1.4	1.8	4.3	2.1	-0.2	-1.0
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.9	1.7	0.3	0.1
Commuting to job workplace: Public transport	0.4	0.4	1.1	1.1	-0.1	0.4
Eye problems/disorders: Glaucoma	1.7	2.0	3.9	2.0	0.3	-1.4
Medication: Blood pressure	8.1	15.5	24.3	4.9	-3.2	-3.4
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.8	1.3	0.5	-0.7
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.5	-0.1	1.6	1.3
High cholesterol (Self-reported)	4.7	8.3	12.0	2.4	-2.6	-3.5
Medication: Bendroflumethiazide	2.9	4.4	5.8	2.1	-1.6	-2.4
Medication: Paracetamol	0.9	1.4	3.4	-1.8	-0.5	0.7
Medication: Lisinopril	3.1	4.1	7.2	1.3	-2.7	-1.8
Medication: Atorvastatin	1.5	1.9	2.3	1.2	-1.4	-1.5
Illnesses of father: High blood pressure	1.0	1.2	2.9	0.7	-1.7	-0.5
Alcohol drinker status: Never	0.4	0.4	0.5	0.6	-0.6	-0.7
Ever smoked	0.1	0.2	0.2	-0.4	0.5	0.5
Basal metabolic rate	0.4	2.2	4.1	-1.2	1.0	2.0
Leg fat percentage (left)	0.2	0.8	2.4	0.3	0.1	1.6
Arm fat-free mass (left)	0.2	1.0	2.2	-0.7	0.7	1.5
Number of operations (self-reported)	1.3	1.9	4.0	-0.7	-2.0	1.1
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.2	0.2	0.6
Irritability	0.2	0.3	0.4	0.6	-0.5	-0.6
Risk taking	0.4	0.5	0.9	-0.7	-0.5	-1.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.3	-0.9	-0.6
Fractured/broken bones in last 5 years	1.1	1.5	3.7	-0.4	0.7	1.9
Age started oral contraceptive pill	2.1	2.7	4.6	1.6	-2.1	-0.8
Diastolic blood pressure, automated reading	4.3	13.4	22.6	4.8	-3.4	-2.5
Ever depressed for a whole week	0.4	0.5	1.1	0.6	-1.0	-0.1
Unable to work because of sickness or disability	0.5	0.7	1.7	-0.4	1.3	0.3
Commuting to job workplace: Cycle	0.6	0.7	1.5	0.6	1.2	0.3
Myopia	0.5	0.8	1.1	-0.8	1.0	-0.8
Vascular/heart problems diagnosed by doctor	10.2	27.9	42.6	-6.5	4.1	4.9
Cholesterol lowering medication	0.9	1.3	2.6	1.6	-1.0	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.2	0.9	-2.1	-0.9
Pain experienced in last month	0.2	0.4	0.9	0.4	1.0	-0.2
Supplements: Calcium	0.1	0.1	0.2	0.4	-0.0	0.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.1	0.3	0.9
Heart attack/myocardial infarction (self-reported)	1.7	2.2	2.8	1.7	-1.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.6	0.0	0.4
Heart disease (siblings)	0.4	0.5	0.8	0.9	-0.8	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.4	-0.6	0.4
Pack years of smoking	1.2	1.8	3.4	1.8	-1.3	-0.4
Impedance of whole body	0.2	0.9	2.2	-0.4	-0.7	1.5
Leg fat mass (left)	0.4	1.7	4.6	-0.5	0.5	2.1
Arm predicted mass (left)	0.2	1.1	2.5	-0.7	0.6	1.6