Best TWAS P=1.64e-08 · Best GWAS P=9.24e-10 conditioned to 0.00292
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | HSD17B12 | 0.28 | 0.25 | enet | 17 | 0.21 | 2.6e-11 | -4.3 | 5.3 | 1.3e-07 | 0.66 | 0.79 | 0.21 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | HSD17B12 | 0.50 | 0.41 | enet | 33 | 0.29 | 3.0e-08 | -4.9 | 5.6 | 1.6e-08 | 0.72 | 0.61 | 0.39 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | RP11-613D13.5 | 0.18 | 0.11 | lasso | 5 | 0.15 | 6.3e-08 | -4.3 | 5.4 | 6.2e-08 | 0.79 | 0.08 | 0.91 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-613D13.5 | 0.21 | 0.20 | lasso | 2 | 0.19 | 9.6e-12 | -4.3 | 5.3 | 1.2e-07 | 0.74 | 0.79 | 0.21 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-613D13.5 | 0.17 | 0.12 | enet | 19 | 0.15 | 2.2e-08 | -4.9 | 5.3 | 1.3e-07 | 0.77 | 0.48 | 0.51 | FALSE |
| 6 | GTEx | Whole Blood | RP11-613D13.5 | 0.06 | 0.01 | lasso | 4 | 0.00 | 1.2e-01 | 5.6 | 5.6 | 2.5e-08 | 0.83 | 0.04 | 0.58 | FALSE |
| 7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HSD17B12 | 0.39 | 0.25 | lasso | 4 | 0.26 | 7.2e-07 | -4.8 | 5.2 | 1.8e-07 | 0.70 | 0.56 | 0.35 | FALSE |