[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr11:46,010,847-48,783,497

Best TWAS P=5.43e-21 · Best GWAS P=1.82e-18 conditioned to 7.12e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Cells EBV-transformed lymphocytes	ACP2	0.17	0.03	lasso	6	0.03	4.2e-02	6.7	-9.4	5.4e-21	-0.47	0.04	0.87	TRUE
18	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	7.9	-8.6	1.2e-17	-0.43	0.02	0.98	FALSE
34	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	-7.1	8.4	4.3e-17	0.40	0.13	0.82	FALSE
24	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	6.6	-8.1	5.9e-16	-0.39	0.06	0.89	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AGBL2	0.03	0.02	enet	7	0.03	7.9e-05	7.9	8.0	1.1e-15	0.70	0.45	0.50	FALSE
13	GTEx	Breast Mammary Tissue (Female)	ACP2	0.03	0.00	lasso	1	0.02	1.0e-01	8.0	-8.0	1.4e-15	-0.60	0.03	0.11	FALSE
22	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	8.5	-7.8	5.3e-15	-0.35	0.03	0.96	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	7.1	-7.8	5.6e-15	-0.39	0.17	0.78	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	7.7	7.8	8.1e-15	0.55	0.22	0.43	FALSE
21	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	8.5	-7.8	8.7e-15	-0.43	0.02	0.96	FALSE
37	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	6.5	-7.7	1.0e-14	-0.37	0.07	0.78	FALSE
6	GTEx	Adipose Visceral Omentum	ACP2	0.08	0.05	lasso	5	0.05	1.4e-03	7.4	-7.6	2.4e-14	-0.36	0.14	0.67	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	6.6	7.6	4.0e-14	0.36	0.30	0.70	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PTPRJ	0.06	0.04	lasso	4	0.05	7.6e-07	8.1	7.5	6.2e-14	0.68	0.32	0.68	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACP2	0.02	0.03	lasso	1	0.02	1.5e-03	7.4	-7.4	1.1e-13	-0.35	0.04	0.54	FALSE
33	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	7.4	-7.3	2.9e-13	-0.34	0.80	0.20	FALSE
32	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	7.1	-7.2	4.3e-13	-0.34	0.16	0.74	FALSE
11	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	7.2	7.2	4.8e-13	0.34	0.14	0.16	FALSE
36	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	7.9	-7.2	7.4e-13	-0.40	0.01	0.97	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	DDB2	0.06	0.04	enet	17	0.03	1.3e-03	8.6	7.1	1.3e-12	0.39	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	7.8	6.8	1.2e-11	0.57	0.00	0.94	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	6.6	6.6	3.6e-11	0.29	0.12	0.24	FALSE
9	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	6.6	-6.6	3.8e-11	-0.31	0.08	0.14	FALSE
7	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	3.1	-6.6	4.5e-11	-0.19	0.12	0.66	FALSE
25	GTEx	Muscle Skeletal	FNBP4	0.05	0.03	lasso	5	0.04	5.0e-05	7.7	6.5	6.0e-11	0.39	0.39	0.43	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	-6.5	6.5	8.6e-11	0.35	0.44	0.04	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	-4.1	6.4	1.9e-10	0.33	0.26	0.08	FALSE
14	GTEx	Breast Mammary Tissue (Female)	PSMC3	0.02	0.01	lasso	1	0.04	2.5e-02	6.3	-6.3	2.4e-10	-0.61	0.03	0.07	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	4.2	6.3	4.0e-10	0.31	0.49	0.47	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	NR1H3	0.06	0.01	blup	302	0.04	1.5e-05	7.9	6.2	5.1e-10	0.39	0.17	0.80	FALSE
51	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	8.4	-6.0	2.1e-09	-0.27	0.01	0.81	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-6.5	6.0	2.4e-09	0.20	0.08	0.11	FALSE
30	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	7.1	-5.9	2.9e-09	-0.30	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	7.1	-5.8	5.1e-09	-0.24	0.11	0.74	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	0.6	-5.8	5.3e-09	-0.40	0.13	0.71	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	7.9	-5.8	6.9e-09	-0.26	0.01	0.80	FALSE
54	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	6.2	-5.8	8.9e-09	-0.25	0.00	0.83	FALSE
26	GTEx	Nerve Tibial	C11orf49	0.17	0.01	enet	21	0.05	9.5e-05	8.4	5.7	1.1e-08	0.33	0.08	0.83	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CKAP5	0.11	0.04	lasso	3	0.03	2.1e-02	4.4	5.7	1.3e-08	0.26	0.23	0.24	FALSE
27	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	4.4	-5.6	2.7e-08	-0.26	0.87	0.06	FALSE
19	GTEx	Esophagus Mucosa	C11orf49	0.19	0.05	enet	21	0.12	3.2e-08	6.3	5.5	3.3e-08	0.28	0.71	0.11	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	6.6	5.5	4.1e-08	0.25	0.14	0.08	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf49	0.05	0.00	blup	90	0.02	3.0e-04	6.8	5.5	4.6e-08	0.26	0.00	0.98	FALSE
23	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	5.6	-5.4	5.3e-08	-0.24	0.07	0.70	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	ZNF408	0.04	0.02	blup	243	0.03	5.0e-05	4.3	-5.4	6.3e-08	-0.22	0.11	0.88	FALSE
12	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	8.6	5.4	6.9e-08	0.29	0.02	0.68	FALSE
20	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	6.7	-5.4	6.9e-08	-0.26	0.18	0.48	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	7.4	-5.4	7.2e-08	-0.26	0.03	0.32	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARHGAP1	0.16	0.04	enet	18	0.04	2.3e-05	-2.8	-5.4	8.1e-08	-0.22	0.67	0.02	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	PTPMT1	0.03	0.02	blup	270	0.02	3.8e-04	7.7	5.4	8.3e-08	0.48	0.08	0.86	FALSE
5	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	7.1	-5.4	8.4e-08	-0.30	0.21	0.44	FALSE
31	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	6.5	-5.3	1.4e-07	-0.29	0.07	0.42	FALSE
35	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	5.1	5.2	2.2e-07	0.36	0.98	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	5.0	5.2	2.5e-07	0.24	0.96	0.02	FALSE