TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Vascular/heart problems diagnosed by doctor
:
←
→
chr19:1,163,934-2,560,423
Best TWAS P=6.2e-08 · Best GWAS P=2.01e-08 conditioned to 1
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
CTB-31O20.6
0.16
0.07
lasso
5
0.05
7.8e-04
5.5
5.4
6.2e-08
0.99
0.01
0.99
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
KLF16
0.12
0.08
bslmm
372
0.08
1.0e-10
5.1
5.3
8.9e-08
0.43
0.03
0.97
TRUE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
ATP8B3
0.04
0.01
blup
49
0.02
2.2e-03
5.1
5.4
8.1e-08
0.55
0.01
0.25
FALSE