TWAS
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Traits
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Vascular/heart problems diagnosed by doctor
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chr19:7,793,502-9,200,017
Best TWAS P=1.93e-07 · Best GWAS P=1.25e-06 conditioned to 0.683
7.8M
8M
8.2M
8.4M
8.6M
8.8M
9M
9.2M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
MARCH2
0.34
0.30
enet
22
0.32
6.9e-20
-4.6
-5.2
1.9e-07
0.90
0.01
0.97
TRUE
2
GTEx
Lung
MARCH2
0.36
0.25
lasso
8
0.29
2.8e-22
-4.5
-5.2
2.5e-07
0.88
0.01
0.96
FALSE