Best TWAS P=1.77e-09 · Best GWAS P=4.25e-09 conditioned to 0.0182
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | 5.4 | -6.0 | 1.8e-09 | -0.69 | 0.07 | 0.72 | TRUE |
| 2 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | -4.0 | -5.3 | 1.2e-07 | -0.66 | 0.05 | 0.57 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | 5.2 | -5.2 | 1.8e-07 | -0.79 | 0.03 | 0.89 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | -4.3 | -5.9 | 4.1e-09 | -0.55 | 0.06 | 0.84 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | 5.2 | 5.2 | 2.2e-07 | 0.75 | 0.02 | 0.64 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | -4.2 | -5.4 | 7.4e-08 | -0.55 | 0.21 | 0.65 | FALSE |