TWAS
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Models
Genes
Traits
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Traits
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High blood pressure
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chr4:25,880,334-27,452,482
Best TWAS P=1.6e-11 · Best GWAS P=1.2e-14 conditioned to 1.96e-09
25.8M
26M
26.2M
26.4M
26.6M
26.8M
27M
27.2M
27.4M
0
5
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
TBC1D19
0.14
0.05
lasso
4
0.06
5.4e-05
-6.7
6.7
1.6e-11
0.57
0.71
0.26
TRUE
3
The Cancer Genome Atlas
Rectum Adenocarcinoma
TBC1D19
0.56
0.18
blup
24
0.17
7.0e-05
7.5
-5.8
9.0e-09
-0.81
0.00
0.85
TRUE
2
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
TBC1D19
0.04
0.01
enet
14
0.00
6.7e-01
-6.0
5.8
6.7e-09
0.39
0.02
0.05
FALSE