Hub : Traits :

High blood pressure

1217 significantly associated models · 361 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	7715776	9571422	2	1	2.2e-08	6.7e-08	2.9e-01	96	RP5-1115A15.1
2	1	10435170	12600396	7	7	5.2e-28	9.5e-31	7.3e-03	95	CLCN6 MTHFR NPPA-AS1 RP4-635E18.7
3	1	26428864	28406173	4	2	3.2e-09	3.6e-07	4.8e-01	98	FCN3 PIGV
4	1	88621347	90053563	1	1	1.5e-10	2.5e-10	1.2e-01	94	GTF2B
5	1	112312154	113941737	5	3	3.5e-17	1.8e-20	5.8e-08	66	RHOC RP4-671G15.2 WNT2B
6	1	115136771	116579779	1	1	1.2e-07	1.5e-11	1.1e-10	9	NGF
7	1	230142626	231548480	1	1	6.4e-12	3.7e-10	6.4e-02	91	AGT
8	2	24021231	26068509	4	1	7.9e-11	5.6e-10	3.1e-02	88	NCOA1
9	2	26223547	27689899	2	2	1.7e-08	2.0e-33	1.3e-24	28	KCNK3 SLC35F6
10	2	36778887	38298877	2	1	6.8e-10	3.6e-09	1.0e+00	100	PRKD3
11	2	181139278	184084221	2	2	7.7e-08	3.7e-08	1.1e-11	-52	PDE1A UBE2E3
12	3	10617048	12293966	1	1	3.9e-08	1.7e-10	9.1e-04	73	ATG7
13	3	19382787	20893060	2	1	3.5e-08	1.3e-08	7.1e-02	90	KAT2B
14	3	26563909	28211713	2	2	1.1e-16	4.2e-18	4.1e-02	94	SLC4A7
15	3	47204518	49365269	7	1	3.7e-11	2.5e-11	1.0e+00	100	FCF1P2
16	3	127097277	128821807	2	1	1.1e-07	5.8e-09	2.4e-03	73	RUVBL1
17	3	133088362	134666475	1	1	2.5e-07	8.1e-10	5.9e-04	69	RYK
18	3	137189600	138819532	2	1	1.1e-08	9.0e-09	2.3e-01	96	DBR1
19	3	157125828	158980014	2	1	7.3e-09	1.3e-07	2.9e-01	96	RP11-538P18.2
20	3	183204923	184607480	1	1	1.0e-07	3.4e-07	3.9e-01	97	ABCF3
21	4	17104059	18507692	2	1	1.8e-09	4.3e-09	1.8e-02	84	DCAF16
22	4	25880334	27452482	1	2	1.6e-11	1.2e-14	2.0e-09	40	TBC1D19
23	4	80407869	82578407	3	2	4.3e-20	1.1e-65	1.8e-42	36	C4orf22 PRDM8
24	4	102868793	104627833	5	1	2.3e-11	3.7e-10	8.2e-01	100	CISD2
25	4	110590479	112179424	1	1	2.9e-07	6.4e-13	5.9e-09	34	ENPEP
26	4	155890241	157354250	2	1	2.2e-08	6.7e-12	8.1e-11	10	RP11-588K22.2
27	5	32015725	33484084	1	1	1.1e-07	7.3e-31	5.4e-25	20	NPR3
28	5	60903201	62529686	2	1	4.0e-08	9.8e-08	4.0e-02	85	IPO11
29	5	130830617	132425049	8	1	1.4e-08	4.4e-08	2.1e-01	95	PDLIM4
30	6	14551209	16209635	1	1	2.5e-07	6.9e-07	1.1e-02	74	JARID2
31	6	42586058	44034691	2	1	8.1e-13	2.6e-13	1.0e+00	100	ZNF318
32	6	78946797	80486611	1	1	6.2e-08	3.1e-07	4.7e-01	98	PHIP
33	6	96275538	97699026	1	1	1.5e-07	7.3e-08	1.5e-01	93	UFL1
34	6	117187910	118613435	1	1	1.5e-07	4.4e-10	4.3e-10	0	GOPC
35	6	125970401	127355237	1	1	4.8e-09	1.2e-30	2.6e-24	22	CENPW
36	7	1854263	3264728	1	1	2.6e-10	4.5e-10	1.0e+00	100	LFNG
37	7	6502367	7988091	1	1	1.6e-13	4.9e-10	1.0e-01	93	C1GALT1
38	7	26969253	27533292	2	1	1.8e-15	1.9e-17	1.0e-03	85	HOXA10
39	7	73425238	75714883	6	2	6.9e-09	1.6e-08	3.8e-01	98	PMS2P5 STAG3L1
40	7	76506844	77966572	1	1	1.1e-07	8.0e-07	6.8e-02	86	PTPN12
41	7	99122437	100516003	1	1	7.2e-08	4.3e-07	5.1e-01	98	PVRIG
42	7	129342404	130779678	2	2	1.5e-08	1.2e-12	1.1e-05	62	CEP41 ZC3HC1
43	7	132241297	134834499	3	2	1.1e-07	8.6e-08	3.8e-01	97	AKR1B15 EXOC4
44	8	8092025	13120332	26	2	8.2e-16	8.2e-14	6.2e-04	79	MSRA NEIL2
45	8	29996824	31433801	1	1	6.3e-08	2.0e-08	1.3e-01	93	TEX15
46	8	90238179	91633434	1	1	2.1e-07	4.7e-08	4.2e-02	86	OSGIN2
47	8	95213858	96825195	1	1	1.3e-07	1.1e-06	3.6e-01	96	NDUFAF6
48	8	102002608	103832256	2	1	3.3e-09	9.5e-10	5.4e-04	68	KB-1107E3.1
49	9	221874	991114	1	1	2.6e-07	9.6e-08	2.3e-03	67	KANK1
50	9	35208145	36597142	1	1	6.3e-09	1.1e-08	2.1e-04	58	HRCT1
51	9	135883620	136399075	1	1	1.0e-09	1.2e-08	5.5e-01	99	ABO
52	10	18221643	19601824	2	2	8.8e-13	1.2e-16	5.2e-14	17	CACNB2 NSUN6
53	10	60026425	60829144	1	1	5.1e-08	2.5e-07	1.2e-01	91	BICC1
54	10	63856856	65606229	3	3	9.9e-13	6.7e-12	3.3e-01	98	NRBF2 RP11-436D10.3
55	10	87729214	88960852	1	1	2.5e-07	4.1e-07	7.0e-02	87	LDB3
56	10	95379543	96818402	1	1	1.9e-10	8.0e-13	1.2e-04	71	NOC3L
57	10	103313599	105850787	9	1	1.3e-14	3.0e-16	6.6e-03	89	NT5C2
58	10	115244596	116689519	3	3	2.3e-13	1.7e-21	1.6e-09	60	ADRB1 C10orf118 TDRD1
59	10	133777786	134395804	1	1	1.2e-07	2.8e-07	7.6e-07	7	STK32C
60	11	1213806	2705175	5	5	1.0e-20	3.5e-23	NaN	NaN	LSP1 TNNI2 TNNT3
61	11	9003306	10471931	1	1	1.0e-08	1.2e-11	1.2e-04	68	SWAP70
62	11	15741673	18106069	4	2	8.7e-09	8.5e-18	2.1e-10	45	NUCB2 SOX6
63	11	42881882	44596817	2	1	6.9e-08	2.4e-09	7.2e-03	80	RP11-613D13.5
64	11	46010847	48783497	20	1	4.2e-25	1.8e-20	5.7e-07	71	ACP2
65	11	56370106	57784307	1	1	2.7e-07	1.2e-08	1.1e-05	41	TNKS1BP1
66	11	64721908	66333072	3	1	7.4e-11	5.7e-12	4.3e-06	56	RNASEH2C
67	11	99859184	101559718	2	1	2.7e-35	1.4e-33	1.8e-01	99	TMEM133
68	11	106485489	108027561	2	1	4.7e-10	1.1e-10	1.3e-02	85	CWF19L2
69	11	110721187	112491227	5	1	3.1e-10	3.1e-10	1.0e+00	100	SIK2
70	12	26480758	27916206	1	1	1.7e-07	6.1e-07	1.0e+00	100	MED21
71	12	47737273	49444545	3	2	6.3e-09	1.3e-09	2.5e-01	96	HDAC7 SENP1
72	12	49780778	51256065	4	1	9.0e-11	4.5e-13	1.6e-10	22	CERS5
73	12	54158993	54760824	4	1	1.2e-11	1.6e-12	3.6e-02	91	HOXC8
74	12	66965631	68410906	1	1	3.4e-08	3.4e-08	1.0e+00	100	CAND1
75	12	69057879	70476863	1	1	1.2e-08	6.8e-08	1.0e+00	100	YEATS4
76	12	89116708	90799212	3	2	5.3e-16	3.8e-25	2.6e-13	50	ATP2B1 LOC338758
77	12	109591369	111015121	2	1	1.0e-08	2.2e-08	1.4e-01	93	GLTP
78	12	111102574	113517494	16	1	3.8e-21	7.3e-29	3.5e-11	65	SH2B3
79	12	121146219	123131824	3	3	1.7e-15	3.1e-15	1.0e+00	100	KDM2B RNF34 WDR66
80	15	40360741	42749023	8	1	4.6e-11	2.9e-11	9.9e-02	94	CHP1
81	15	67138238	68789191	1	1	8.9e-08	1.7e-08	3.3e-02	86	MAP2K5
82	15	73933444	76108550	14	10	2.4e-23	7.1e-23	1.0e+00	100	ARID3B COX5A CSK MPI RPP25 UBL7 ULK3
83	15	80377452	81936479	2	1	2.0e-11	1.2e-14	1.0e-04	75	FAM108C1
84	15	90712555	92187978	3	3	1.1e-38	8.7e-29	5.9e-01	100	FES FURIN
85	16	3025993	5441125	4	3	8.6e-11	1.8e-09	1.7e-06	36	AC006111.1 MGRN1 NAT15
86	16	29412503	31860399	16	2	7.1e-10	3.2e-09	6.5e-02	90	FAM57B KAT8
87	16	69337091	70978362	3	1	1.4e-07	5.0e-07	3.7e-01	97	RP11-296I10.6
88	16	74778006	76197034	1	1	1.5e-07	5.7e-06	9.5e-01	100	TMEM170A
89	16	81230341	81993974	1	1	4.2e-14	1.1e-13	2.9e-04	76	CMIP
90	16	89013848	90172696	9	8	6.9e-13	9.0e-13	NaN	NaN	CHMP1A DEF8 DPEP1 SPATA33
91	17	1517914	2918626	1	1	1.2e-07	1.3e-08	1.1e-03	67	SRR
92	17	3208350	4766937	2	1	3.1e-09	1.2e-08	3.5e-01	97	RP11-810M2.2
93	17	6202301	8484683	10	4	6.7e-12	6.7e-12	1.0e+00	100	ALOX12 CYB5D1 SENP3 SLC2A4
94	17	42976114	43383100	1	1	6.2e-08	1.2e-06	8.1e-02	87	HEXIM1
95	17	44788310	45597098	2	1	1.3e-07	2.9e-12	4.2e-12	2	WNT3
96	17	46258510	47718188	8	3	5.6e-12	2.4e-15	3.7e-05	73	AC091133.1 HOXB9 ZNF652
97	17	60858059	62279811	2	1	1.3e-15	1.3e-15	1.0e+00	100	ACE
98	17	73175294	74629867	3	1	1.2e-08	1.9e-08	2.0e-01	95	FBF1
99	19	1163934	2560423	3	2	1.4e-09	1.5e-09	1.0e+00	100	CTB-31O20.6 KLF16
100	19	16462417	18007950	3	2	1.5e-12	1.7e-13	2.2e-03	83	HAUS8 MYO9B
101	19	49148143	50557876	1	1	1.7e-07	7.6e-07	2.4e-02	79	TEAD2
102	20	7419920	9648826	1	2	1.4e-10	3.4e-19	3.1e-07	67	PLCB1
103	20	29927166	31615615	3	2	8.1e-09	8.8e-08	7.0e-06	29	C20orf160 TSPY26P
104	20	42040938	43508687	1	1	8.2e-08	2.4e-11	5.0e-06	53	JPH2
105	20	56858751	58262841	4	6	5.6e-18	1.4e-33	NaN	NaN	NELFCD TH1L TUBB1 ZNF831
106	20	61522825	62912463	8	4	2.5e-12	4.7e-12	1.0e+00	100	LIME1 RGS19 TPD52L2 ZBTB46
107	21	44512286	45879403	2	1	7.0e-08	2.5e-08	1.0e+00	100	PDXK
108	22	28794069	30261219	4	2	1.0e-12	6.7e-08	5.5e-01	99	C22orf31 ZNRF3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hypertension (Self-reported)	14.79	160	140	311.1	1.00	1.2e-241	ABCF3 ABO AC006111.1 AC091133.1 ACE ACP2 ADRB1 AGT AKR1B15 ALOX12 ARID3B ATG7 ATP2B1 BICC1 C10orf118 C1GALT1 C20orf160 C22orf31 C4orf22 CACNB2 CAND1 CENPW CEP41 CERS5 CHMP1A CHP1 CISD2 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 CYB5D1 DBR1 DCAF16 DEF8 DPEP1 ENPEP EXOC4 FAM108C1 FAM57B FBF1 FCF1P2 FCN3 FES FURIN GLTP GOPC GTF2B HAUS8 HDAC7 HEXIM1 HOXA10 HOXB9 HOXC8 HRCT1 IPO11 JARID2 JPH2 KANK1 KAT2B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 LDB3 LFNG LIME1 LOC338758 LSP1 MAP2K5 MED21 MGRN1 MPI MSRA MTHFR MYO9B NAT15 NCOA1 NDUFAF6 NEIL2 NELFCD NGF NOC3L NPPA-AS1 NPR3 NRBF2 NSUN6 NT5C2 NUCB2 OSGIN2 PDE1A PDLIM4 PDXK PHIP PIGV PLCB1 PMS2P5 PRDM8 PRKD3 PTPN12 PVRIG RGS19 RHOC RNASEH2C RNF34 RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP11-588K22.2 RP11-613D13.5 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RPP25 RUVBL1 RYK SENP1 SENP3 SH2B3 SIK2 SLC2A4 SLC35F6 SLC4A7 SOX6 SPATA33 SRR STAG3L1 STK32C SWAP70 TBC1D19 TDRD1 TEAD2 TEX15 TH1L TMEM133 TMEM170A TNKS1BP1 TNNI2 TNNT3 TPD52L2 TSPY26P TUBB1 UBE2E3 UBL7 UFL1 ULK3 WDR66 WNT2B WNT3 YEATS4 ZBTB46 ZC3HC1 ZNF318 ZNF652 ZNF831 ZNRF3
Vascular/heart problems diagnosed by doctor	14.25	160	115	255.6	-1.00	2.5e-200	ABCF3 ABO AC006111.1 AC091133.1 ACE ACP2 ADRB1 AGT AKR1B15 ALOX12 ARID3B ATG7 ATP2B1 BICC1 C10orf118 C1GALT1 C20orf160 C22orf31 C4orf22 CACNB2 CAND1 CENPW CEP41 CERS5 CHMP1A CHP1 CISD2 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 CYB5D1 DBR1 DCAF16 DEF8 DPEP1 ENPEP EXOC4 FAM108C1 FAM57B FBF1 FCF1P2 FCN3 FES FURIN GLTP GOPC GTF2B HAUS8 HDAC7 HEXIM1 HOXA10 HOXB9 HOXC8 HRCT1 IPO11 JARID2 JPH2 KANK1 KAT2B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 LDB3 LFNG LIME1 LOC338758 LSP1 MAP2K5 MED21 MGRN1 MPI MSRA MTHFR MYO9B NAT15 NCOA1 NDUFAF6 NEIL2 NELFCD NGF NOC3L NPPA-AS1 NPR3 NRBF2 NSUN6 NT5C2 NUCB2 OSGIN2 PDE1A PDLIM4 PDXK PHIP PIGV PLCB1 PMS2P5 PRDM8 PRKD3 PTPN12 PVRIG RGS19 RHOC RNASEH2C RNF34 RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP11-588K22.2 RP11-613D13.5 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RPP25 RUVBL1 RYK SENP1 SENP3 SH2B3 SIK2 SLC2A4 SLC35F6 SLC4A7 SOX6 SPATA33 SRR STAG3L1 STK32C SWAP70 TBC1D19 TDRD1 TEAD2 TEX15 TH1L TMEM133 TMEM170A TNKS1BP1 TNNI2 TNNT3 TPD52L2 TSPY26P TUBB1 UBE2E3 UBL7 UFL1 ULK3 WDR66 WNT2B WNT3 YEATS4 ZBTB46 ZC3HC1 ZNF318 ZNF652 ZNF831 ZNRF3
Systolic Blood Pressure	13.11	132	109	242.2	0.96	4.1e-85	ABCF3 AC006111.1 AC091133.1 ACE ACP2 ADRB1 AGT AKR1B15 ALOX12 ARID3B ATG7 ATP2B1 BICC1 C10orf118 C1GALT1 C20orf160 C22orf31 C4orf22 CACNB2 CENPW CERS5 CHMP1A CHP1 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 CYB5D1 DBR1 DCAF16 ENPEP EXOC4 FAM108C1 FBF1 FCF1P2 FCN3 FES FURIN GLTP GOPC GTF2B HAUS8 HDAC7 HEXIM1 HOXA10 HOXB9 HOXC8 HRCT1 IPO11 JPH2 KANK1 KAT2B KB-1107E3.1 KDM2B KLF16 LDB3 LFNG LIME1 LOC338758 LSP1 MED21 MGRN1 MPI MTHFR MYO9B NAT15 NCOA1 NDUFAF6 NEIL2 NELFCD NOC3L NPPA-AS1 NPR3 NRBF2 NSUN6 NT5C2 NUCB2 PDE1A PDXK PHIP PIGV PLCB1 PRDM8 PRKD3 PTPN12 RGS19 RHOC RNASEH2C RNF34 RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP11-588K22.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RPP25 RUVBL1 RYK SENP1 SENP3 SH2B3 SIK2 SLC2A4 SLC4A7 SOX6 SPATA33 SRR STAG3L1 SWAP70 TBC1D19 TH1L TMEM133 TMEM170A TNNI2 TNNT3 TPD52L2 TUBB1 UBL7 UFL1 ULK3 WDR66 WNT2B WNT3 ZBTB46 ZC3HC1 ZNF318 ZNF652 ZNF831 ZNRF3
Cardiovascular Disease	12.76	145	113	251.1	0.99	3.4e-146	ABCF3 AC006111.1 AC091133.1 ACE ACP2 ADRB1 AGT AKR1B15 ARID3B ATG7 ATP2B1 BICC1 C10orf118 C1GALT1 C20orf160 C22orf31 C4orf22 CACNB2 CAND1 CENPW CEP41 CERS5 CHMP1A CHP1 CISD2 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 CYB5D1 DBR1 DCAF16 DEF8 DPEP1 ENPEP EXOC4 FAM108C1 FAM57B FBF1 FCF1P2 FCN3 FES FURIN GLTP GOPC GTF2B HAUS8 HEXIM1 HOXA10 HOXB9 HOXC8 HRCT1 IPO11 JARID2 KAT2B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 LDB3 LFNG LIME1 LOC338758 LSP1 MAP2K5 MED21 MGRN1 MPI MTHFR MYO9B NAT15 NCOA1 NDUFAF6 NELFCD NGF NOC3L NPPA-AS1 NPR3 NRBF2 NSUN6 NT5C2 NUCB2 PDE1A PDXK PHIP PIGV PLCB1 PMS2P5 PRDM8 PTPN12 PVRIG RGS19 RHOC RNASEH2C RNF34 RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP11-588K22.2 RP11-613D13.5 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RPP25 RYK SENP1 SENP3 SH2B3 SIK2 SLC2A4 SLC35F6 SLC4A7 SOX6 SPATA33 STAG3L1 SWAP70 TBC1D19 TDRD1 TEAD2 TEX15 TH1L TMEM133 TMEM170A TNKS1BP1 TNNI2 TNNT3 TPD52L2 TSPY26P TUBB1 UBL7 UFL1 ULK3 WDR66 WNT2B YEATS4 ZBTB46 ZC3HC1 ZNF318 ZNF652 ZNF831 ZNRF3
Medication: Blood pressure	11.45	89	45	100.0	0.99	6.7e-77	ACE ACP2 ADRB1 AGT AKR1B15 ARID3B ATG7 ATP2B1 C1GALT1 C4orf22 CACNB2 CENPW CERS5 CHMP1A CHP1 CISD2 CLCN6 CMIP COX5A CSK CWF19L2 CYB5D1 DBR1 DEF8 DPEP1 FAM108C1 FCF1P2 FES FURIN GTF2B HAUS8 HEXIM1 HOXA10 HOXC8 HRCT1 KAT8 KB-1107E3.1 KCNK3 KDM2B LFNG LIME1 LSP1 MGRN1 MPI MSRA MTHFR MYO9B NCOA1 NEIL2 NRBF2 NSUN6 NT5C2 PDLIM4 PDXK PIGV PLCB1 PRKD3 PTPN12 RGS19 RHOC RNASEH2C RNF34 RP11-436D10.3 RP11-588K22.2 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RPP25 SENP3 SH2B3 SIK2 SLC35F6 SLC4A7 SPATA33 TBC1D19 TDRD1 TEX15 TMEM133 TNKS1BP1 TNNI2 TNNT3 TPD52L2 UBL7 WNT2B WNT3 ZBTB46 ZNF318 ZNF831 ZNRF3
Medication: Blood pressure	10.09	69	30	66.7	0.99	5.1e-63	AC091133.1 ACE ACP2 ADRB1 ATP2B1 BICC1 C1GALT1 C20orf160 C4orf22 CEP41 CHMP1A CISD2 CLCN6 CMIP CSK CWF19L2 CYB5D1 DCAF16 FAM108C1 FAM57B FCF1P2 FES FURIN HOXA10 JARID2 KDM2B KLF16 LDB3 LFNG LOC338758 LSP1 MSRA MTHFR NELFCD NGF NOC3L NPPA-AS1 OSGIN2 PDXK PLCB1 PRDM8 PVRIG RHOC RNF34 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 SENP1 SENP3 SH2B3 SIK2 SLC2A4 SLC4A7 SOX6 SPATA33 STAG3L1 TH1L TMEM133 TNNI2 TNNT3 TSPY26P ULK3 WDR66 WNT2B ZBTB46 ZC3HC1 ZNF318 ZNF652 ZNF831
Systolic blood pressure, automated reading	9.69	94	60	133.3	0.98	4.6e-69	AC006111.1 ACP2 ADRB1 AGT ATG7 ATP2B1 BICC1 C22orf31 C4orf22 CACNB2 CERS5 CHP1 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 DCAF16 FAM108C1 FAM57B FCF1P2 FES FURIN GLTP GOPC GTF2B HAUS8 HDAC7 HEXIM1 HOXA10 HOXB9 HOXC8 IPO11 KLF16 LFNG LIME1 LOC338758 LSP1 MED21 MGRN1 MPI MSRA MTHFR MYO9B NAT15 NCOA1 NEIL2 NOC3L NPPA-AS1 NPR3 NRBF2 NSUN6 NT5C2 NUCB2 PHIP PIGV PMS2P5 PRKD3 RGS19 RHOC RNASEH2C RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP11-588K22.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RPP25 SENP3 SH2B3 SLC2A4 SLC4A7 SOX6 SRR STAG3L1 SWAP70 TBC1D19 TH1L TMEM133 TMEM170A TNNI2 TNNT3 TPD52L2 UBL7 UFL1 ULK3 WNT2B WNT3 ZBTB46 ZNF318 ZNF831 ZNRF3
Diastolic blood pressure, automated reading	9.24	93	60	133.3	0.97	1.8e-67	ABO AC006111.1 AC091133.1 ACE ACP2 ADRB1 AGT ATP2B1 C10orf118 C1GALT1 C20orf160 C22orf31 C4orf22 CACNB2 CENPW CEP41 CERS5 CHP1 CLCN6 CMIP COX5A CSK CTB-31O20.6 CWF19L2 CYB5D1 DCAF16 DPEP1 ENPEP FAM108C1 FCF1P2 FES FURIN GLTP HAUS8 HDAC7 HEXIM1 HOXA10 HRCT1 IPO11 KAT8 LFNG LIME1 LOC338758 LSP1 MAP2K5 MED21 MPI MSRA MTHFR MYO9B NCOA1 NDUFAF6 NEIL2 NELFCD NOC3L NPPA-AS1 NRBF2 NSUN6 NT5C2 PDE1A PDLIM4 PHIP PIGV PMS2P5 PVRIG RGS19 RHOC RNASEH2C RP11-296I10.6 RP11-436D10.3 RP11-538P18.2 RP4-671G15.2 RP5-1115A15.1 RPP25 RYK SENP3 SH2B3 SLC2A4 SRR STAG3L1 SWAP70 TBC1D19 TH1L TMEM133 TNNI2 TSPY26P TUBB1 UBL7 ULK3 WNT2B ZC3HC1 ZNF652 ZNF831
Tanning	8.17	9	7	15.6	-0.65	1.6e-02	CHMP1A DEF8 DPEP1 NRBF2 RP11-436D10.3 SH2B3 SPATA33 TSPY26P UBL7
Medication: Bendroflumethiazide	7.94	35	13	28.9	0.97	1.2e-25	ABCF3 ACP2 ADRB1 AGT ATP2B1 CACNB2 CHMP1A CLCN6 CSK FAM108C1 FAM57B FES HOXA10 JPH2 KAT8 LSP1 MGRN1 MYO9B NEIL2 NRBF2 PDLIM4 PIGV PLCB1 RHOC RP11-436D10.3 RP4-671G15.2 SENP3 SH2B3 SLC35F6 SLC4A7 TEX15 TMEM133 TNNI2 WNT2B ZNF831
Medication for cholesterol, blood pressure or diabetes	7.27	36	12	26.7	-0.98	5.7e-30	ACE ATP2B1 C1GALT1 C4orf22 CHP1 CISD2 CLCN6 CSK FAM108C1 FCF1P2 FES FURIN JARID2 LFNG LOC338758 LSP1 MTHFR NGF OSGIN2 PDXK PLCB1 PVRIG RGS19 RHOC RP11-296I10.6 RP11-588K22.2 SENP1 SH2B3 SIK2 SLC4A7 TH1L TMEM133 TSPY26P ZBTB46 ZNF652 ZNF831
Hair Pigment	7.20	21	12	26.7	0.35	7.6e-02	ACP2 ATP2B1 C20orf160 C22orf31 C4orf22 CHMP1A DBR1 DEF8 DPEP1 FES HOXB9 PIGV RNASEH2C RP5-1115A15.1 SH2B3 SOX6 SPATA33 TSPY26P WNT3 ZNF831 ZNRF3
Medication: Amlodipine	6.72	21	10	22.2	0.97	1.4e-15	CLCN6 FAM108C1 FES KCNK3 KDM2B LSP1 MTHFR NPPA-AS1 OSGIN2 RHOC RNF34 RP4-635E18.7 RP4-671G15.2 SENP1 SENP3 SLC35F6 TMEM133 TNNI2 TNNT3 WNT2B ZNF318
Medication for cholesterol	6.64	28	8	17.8	-0.97	3.5e-20	ACE ATG7 C4orf22 CENPW CISD2 CMIP DEF8 FES HAUS8 HOXA10 HOXC8 JARID2 KAT8 LIME1 LSP1 MGRN1 PIGV PLCB1 PRKD3 RHOC RP4-671G15.2 SENP1 SH2B3 TMEM133 WNT2B ZBTB46 ZNF831 ZNRF3
High blood pressure (mother)	5.88	14	4	8.9	0.98	1.1e-10	AGT CENPW CHMP1A CLCN6 FES FURIN HOXA10 HOXC8 LSP1 NT5C2 PIGV SENP1 SLC4A7 ZNF831
Medication: Atenolol	5.38	7	2	4.4	0.99	3.5e-06	CLCN6 FES FURIN PRKD3 RHOC SH2B3 TMEM133
Illnesses of father: High blood pressure	4.77	8	1	2.2	0.98	7.2e-08	ACE ACP2 C4orf22 CHMP1A FES NCOA1 PLCB1 SPATA33
Medication: Ramipril	4.74	8	2	4.4	0.98	3.9e-06	CISD2 CMIP CSK FES GOPC LSP1 TMEM133 ZC3HC1
High blood pressure (siblings)	4.74	9	4	8.9	0.98	4.9e-07	ACP2 CLCN6 FES KAT8 LSP1 NRBF2 RHOC SH2B3 TMEM133
Medication: Lisinopril	4.69	6	0	0.0	0.98	1.2e-05	ACP2 CSK FCF1P2 LSP1 NRBF2 ZNF831
Number of self-reported non-cancer illnesses	4.22	15	5	11.1	0.98	5.9e-10	CISD2 CLCN6 CYB5D1 HAUS8 HDAC7 KDM2B MYO9B PDLIM4 PMS2P5 RUVBL1 SH2B3 ZNF318 ZNF652 ZNF831 ZNRF3
Number of treatments/medications taken	3.95	14	6	13.3	0.94	7.0e-07	AC091133.1 ACE CHP1 CISD2 DCAF16 FAM108C1 FES SH2B3 STK32C TMEM133 TNKS1BP1 ZNF652 ZNF831 ZNRF3
Medication: Aspirin	3.69	2	1	2.2	0.00	1.0e+00	FES SIK2
Illnesses of mother	3.55	1	1	2.2	0.00	1.0e+00	FES
Medication: Aspirin	3.52	4	1	2.2	0.98	4.6e-03	AC091133.1 FES GOPC SIK2
Illnesses of siblings	3.44	6	1	2.2	-0.99	8.0e-06	FES KAT8 NRBF2 SH2B3 TMEM133 YEATS4
Medication: Cholesterol lowering	3.31	8	2	4.4	0.77	1.6e-02	ABO CHP1 FES PIGV PVRIG RNASEH2C TMEM133 ZNF831
Medication: Simvastatin	3.27	5	1	2.2	0.42	4.0e-01	ABO FES PIGV RNASEH2C ZNF831
Blood Platelet Count	3.14	44	33	73.3	-0.30	3.7e-02	ABCF3 AC091133.1 C20orf160 CERS5 COX5A CSK CWF19L2 DCAF16 FBF1 GTF2B HAUS8 HDAC7 HEXIM1 LFNG LIME1 MGRN1 MPI MTHFR MYO9B NELFCD NRBF2 NUCB2 PDLIM4 PHIP PIGV RHOC RNASEH2C RP11-436D10.3 RP4-671G15.2 RPP25 RUVBL1 SENP1 SH2B3 SIK2 SLC4A7 SWAP70 TH1L TMEM170A TNKS1BP1 TNNT3 TUBB1 UBL7 ZC3HC1 ZNF318
Birth weight of first child	2.77	13	4	8.9	-0.98	3.5e-11	CLCN6 COX5A CSK DCAF16 FES FURIN GTF2B MTHFR NPPA-AS1 RPP25 SH2B3 STAG3L1 TMEM170A
Blood clot in the leg (DVT)	2.72	1	1	2.2	0.00	1.0e+00	ABO
Deep venous thrombosis (DVT) (self-reported)	2.70	1	1	2.2	0.00	1.0e+00	ABO
Illnesses of father: None of the above (group 1)	2.65	2	1	2.2	0.00	1.0e+00	FES SH2B3
Blood Eosinophil Count	2.61	22	13	28.9	0.59	3.8e-03	ABO CERS5 FAM57B FBF1 GLTP KAT8 NAT15 NDUFAF6 NUCB2 PDLIM4 PDXK PIGV RP5-1115A15.1 SH2B3 SIK2 SLC2A4 STK32C TSPY26P WNT3 ZC3HC1 ZNF652 ZNF831
High cholesterol (Self-reported)	2.61	6	3	6.7	0.17	7.4e-01	ABO DCAF16 FBF1 PIGV RGS19 TMEM133
Angina (self-reported)	2.50	3	1	2.2	0.99	1.3e-02	FES FURIN ZNF652
Angina	2.48	3	3	6.7	0.98	2.1e-02	FES FURIN ZNF652
Cholesterol lowering medication	2.44	5	2	4.4	0.53	3.6e-01	ABO DCAF16 KAT8 PIGV RNF34
Breast Cancer	2.33	10	3	6.7	0.62	2.3e-02	CSK FES FURIN LSP1 PDLIM4 PMS2P5 RP11-436D10.3 SIK2 SLC4A7 UBL7
Father's age at death	2.30	4	2	4.4	-0.71	2.9e-01	ABO FES MPI SH2B3
Heart attack	2.26	3	1	2.2	0.00	1.0e+00	FES ZC3HC1 ZNF652
Heart attack/myocardial infarction (self-reported)	2.25	4	1	2.2	0.97	6.7e-03	FES SH2B3 ZC3HC1 ZNF652
Birth weight	2.23	10	8	17.8	-0.55	7.7e-02	ADRB1 DCAF16 FES FURIN SH2B3 SIK2 SLC2A4 SRR TNNT3 ZNRF3
Waist circumference	2.22	26	13	28.9	0.60	1.3e-03	CMIP COX5A CTB-31O20.6 FAM108C1 FAM57B HOXC8 KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 MPI NRBF2 PHIP RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15 UBL7
Arm fat percentage (right)	2.20	32	17	37.8	0.61	2.1e-04	ABO AC091133.1 CHP1 COX5A CTB-31O20.6 DCAF16 FAM108C1 FAM57B FBF1 HOXA10 HOXC8 KAT8 KCNK3 KDM2B KLF16 MAP2K5 MSRA NT5C2 PMS2P5 RNF34 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 SENP3 SLC2A4 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Body mass index (BMI)	2.19	27	19	42.2	0.76	2.4e-06	AC091133.1 CEP41 COX5A CTB-31O20.6 EXOC4 FAM108C1 FAM57B KAT8 KCNK3 KDM2B KLF16 MAP2K5 MSRA NEIL2 NRBF2 NT5C2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Allergy	2.17	10	6	13.3	-0.24	5.0e-01	ABO CHP1 FES HDAC7 HEXIM1 LIME1 PDLIM4 RP5-1115A15.1 SIK2 ZNF652
Hair/balding pattern: Pattern 4	2.17	10	6	13.3	0.41	2.3e-01	C4orf22 CENPW CERS5 HEXIM1 KAT2B PRDM8 RP5-1115A15.1 SPATA33 SRR WNT3
Arm fat percentage (left)	2.17	29	18	40.0	0.53	2.9e-03	ABO AC091133.1 CHP1 COX5A CTB-31O20.6 DCAF16 FAM108C1 FAM57B FBF1 HOXA10 HOXC8 KAT8 KCNK3 KDM2B KLF16 MAP2K5 MSRA NT5C2 PMS2P5 RNF34 RP11-296I10.6 RP11-613D13.5 RP5-1115A15.1 RPP25 SENP3 SRR STAG3L1 STK32C TEX15
Illnesses of father: Heart disease	2.16	3	1	2.2	0.73	2.7e-01	ABO FES RGS19
Leg fat percentage (left)	2.13	24	10	22.2	0.82	1.1e-06	CHP1 COX5A CTB-31O20.6 DCAF16 FAM108C1 FAM57B GTF2B KAT8 KCNK3 KDM2B MAP2K5 MSRA NOC3L NRBF2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SLC2A4 STAG3L1 STK32C TEX15
Leg fat percentage (right)	2.12	23	12	26.7	0.82	1.8e-06	CHP1 COX5A CTB-31O20.6 DCAF16 FAM108C1 FAM57B GTF2B KAT8 KCNK3 KDM2B MAP2K5 MSRA NOC3L NRBF2 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SLC2A4 STAG3L1 STK32C TEX15
Impedance of whole body	2.12	39	20	44.4	-0.39	1.2e-02	ABCF3 ABO ATG7 CENPW CEP41 CERS5 CISD2 CTB-31O20.6 EXOC4 FAM108C1 FAM57B HAUS8 HEXIM1 HOXC8 JPH2 KAT8 KCNK3 KLF16 LIME1 LSP1 MAP2K5 MSRA MYO9B NEIL2 NOC3L NT5C2 NUCB2 PDE1A PMS2P5 PRKD3 RP11-296I10.6 RYK SENP1 SENP3 SLC4A7 SRR STAG3L1 SWAP70 ZNF652
Body fat percentage	2.11	29	13	28.9	0.59	8.5e-04	ABO AC091133.1 CHP1 COX5A CTB-31O20.6 DBR1 DCAF16 FAM108C1 FAM57B HOXA10 HOXC8 KAT8 KCNK3 KDM2B MAP2K5 MYO9B NOC3L PMS2P5 RNF34 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SENP3 SRR STAG3L1 STK32C TEX15
Bipolar Disorder or Schizophrenia	2.10	11	4	8.9	-0.47	1.0e-01	CERS5 CHMP1A CLCN6 DPEP1 FAM57B FES FURIN NSUN6 NT5C2 SPATA33 TBC1D19
Impedance of leg (right)	2.09	39	18	40.0	-0.06	7.2e-01	ABCF3 AC091133.1 ATG7 CEP41 CERS5 CTB-31O20.6 FAM108C1 FAM57B FES FURIN HAUS8 HEXIM1 HOXC8 JPH2 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NELFCD NOC3L NT5C2 NUCB2 PMS2P5 PRKD3 RP11-296I10.6 RYK SENP1 SENP3 SLC35F6 SRR STAG3L1 SWAP70 TH1L TMEM133 WDR66 ZNF652
Coronary Artery Disease (CAD)	2.08	3	2	4.4	0.00	1.0e+00	ABO DBR1 SH2B3
BMI	2.08	33	23	51.1	0.69	6.3e-06	AC091133.1 C20orf160 C4orf22 CEP41 CHP1 CISD2 COX5A CTB-31O20.6 EXOC4 FAM108C1 FAM57B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 NRBF2 NT5C2 PMS2P5 RNF34 RP11-296I10.6 RP11-538P18.2 RP11-613D13.5 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15 TSPY26P
Impedance of leg (left)	2.08	34	20	44.4	-0.15	3.9e-01	ABCF3 AC091133.1 ATG7 CEP41 CERS5 CTB-31O20.6 FAM108C1 FAM57B FES FURIN HAUS8 HEXIM1 HOXC8 JPH2 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NELFCD NOC3L NT5C2 NUCB2 PMS2P5 PRKD3 RP11-296I10.6 SLC35F6 SRR STAG3L1 SWAP70 TMEM133 ZNF652
Arm fat mass (right)	2.08	26	13	28.9	0.68	1.5e-04	AC091133.1 COX5A CTB-31O20.6 FAM108C1 FAM57B HOXA10 KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 MSRA NT5C2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Taking other prescription medications	2.06	5	2	4.4	0.99	4.9e-04	CHP1 CISD2 PMS2P5 SH2B3 ZNF652
Impedance of arm (left)	2.05	31	15	33.3	-0.38	2.5e-02	ABO ARID3B C22orf31 CERS5 CISD2 CMIP FAM108C1 FAM57B HAUS8 HEXIM1 HOXA10 HOXC8 KAT8 LIME1 LSP1 MAP2K5 MSRA MYO9B NEIL2 NOC3L NRBF2 PDE1A PRKD3 RYK SENP1 SENP3 SH2B3 SLC4A7 STAG3L1 TSPY26P ZNF652
Overall health rating	2.05	10	3	6.7	0.98	4.6e-07	AC091133.1 C1GALT1 HEXIM1 KAT8 MSRA PMS2P5 RNASEH2C TEX15 TSPY26P ZNF652
Leg fat mass (left)	2.05	25	14	31.1	0.82	5.0e-07	AC091133.1 COX5A CTB-31O20.6 FAM108C1 FAM57B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 MSRA NRBF2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 STAG3L1 STK32C TDRD1 TEAD2 TEX15 TSPY26P
Leg fat mass (right)	2.04	23	12	26.7	0.88	2.9e-08	AC091133.1 CTB-31O20.6 FAM108C1 FAM57B KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 MSRA NRBF2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 STAG3L1 STK32C TEAD2 TEX15 TSPY26P
Trunk fat percentage	2.03	27	13	28.9	0.60	1.1e-03	ABO AC091133.1 CHP1 COX5A CTB-31O20.6 DBR1 FAM108C1 FAM57B HOXA10 HOXC8 KAT8 KCNK3 KDM2B MAP2K5 MYO9B NOC3L RNF34 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 SENP3 SRR STAG3L1 STK32C TEX15 WNT3
Arm fat mass (left)	2.03	25	12	26.7	0.67	2.5e-04	AC091133.1 COX5A CTB-31O20.6 FAM108C1 FAM57B HOXA10 KAT8 KCNK3 KDM2B KLF16 MAP2K5 MSRA NT5C2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Impedance of arm (right)	2.02	32	13	28.9	-0.50	2.3e-03	ABO ARID3B C22orf31 CEP41 CERS5 CISD2 CMIP CTB-31O20.6 FAM57B HAUS8 HEXIM1 HOXA10 HOXC8 KAT8 KLF16 LIME1 LSP1 MAP2K5 MSRA MYO9B NEIL2 NOC3L NRBF2 NUCB2 PDE1A RYK SENP1 SENP3 SLC4A7 STAG3L1 TSPY26P ZNF652
Allergy or Eczema	2.01	15	6	13.3	0.13	6.5e-01	ABO CHP1 CLCN6 HDAC7 HEXIM1 LIME1 MPI NRBF2 PDLIM4 PDXK RNF34 RP5-1115A15.1 SIK2 SRR ZNF652
Lung FEV1/FVC ratio	1.99	27	16	35.6	-0.31	1.0e-01	ABO ATG7 ATP2B1 C1GALT1 C22orf31 CACNB2 CENPW CEP41 CTB-31O20.6 CYB5D1 GOPC HDAC7 HOXC8 KB-1107E3.1 NRBF2 PDLIM4 PVRIG RP11-436D10.3 RP11-810M2.2 RP5-1115A15.1 RUVBL1 STK32C TMEM133 TMEM170A TSPY26P WNT3 ZNF652
Whole body fat mass	1.98	27	14	31.1	0.63	4.3e-04	AC091133.1 COX5A CTB-31O20.6 DBR1 FAM108C1 FAM57B HOXA10 KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 MSRA NT5C2 PMS2P5 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Blood White Count	1.96	27	13	28.9	0.53	3.1e-03	ABO C10orf118 CERS5 CMIP CYB5D1 DCAF16 FES FURIN GTF2B HOXC8 KAT2B KB-1107E3.1 KCNK3 LSP1 MGRN1 NRBF2 NT5C2 PDLIM4 PLCB1 RP5-1115A15.1 SH2B3 SRR TEX15 TMEM133 TNNI2 UBE2E3 ZNF652
Hayfever, allergic rhinitis or eczema	1.94	6	5	11.1	0.37	4.7e-01	CHP1 MPI PDLIM4 RP5-1115A15.1 SIK2 ZNF652
Trunk fat mass	1.94	25	10	22.2	0.52	7.1e-03	COX5A CTB-31O20.6 DBR1 FAM108C1 FAM57B HOXA10 HOXC8 KAT8 KB-1107E3.1 KCNK3 KDM2B KLF16 MAP2K5 NT5C2 RP11-296I10.6 RP11-613D13.5 RP11-810M2.2 RP5-1115A15.1 RPP25 SRR STAG3L1 STK32C TDRD1 TEAD2 TEX15
Asthma	1.94	6	4	8.9	0.67	1.4e-01	HDAC7 PDLIM4 RP5-1115A15.1 RUVBL1 SIK2 ZNF652
Asthma (self-reported)	1.93	7	4	8.9	0.51	2.4e-01	FBF1 HDAC7 PDLIM4 RP5-1115A15.1 RUVBL1 SIK2 ZNF652
Bipolar Disorder (2018)	1.91	2	0	0.0	0.00	1.0e+00	SPATA33 ZC3HC1
Schizophrenia (2014)	1.91	9	3	6.7	-0.46	1.8e-01	CERS5 DPEP1 FAM57B FES FURIN NSUN6 NT5C2 NUCB2 RP5-1115A15.1
Diabetes diagnosed by doctor	1.91	3	2	4.4	0.00	1.0e+00	DBR1 PMS2P5 ZBTB46
Blood Red Count	1.89	45	25	55.6	0.31	3.0e-02	ABO ARID3B BICC1 C20orf160 C4orf22 CENPW CHMP1A CLCN6 COX5A CSK CYB5D1 DEF8 FAM57B FBF1 GTF2B HEXIM1 HOXB9 IPO11 KAT8 LSP1 MAP2K5 MGRN1 MPI MTHFR NCOA1 NDUFAF6 NELFCD NPPA-AS1 NRBF2 NT5C2 PDXK PVRIG RNASEH2C RPP25 SENP1 SH2B3 SLC35F6 SPATA33 TDRD1 TH1L TSPY26P TUBB1 UBE2E3 UBL7 WNT3
Weight	1.88	26	14	31.1	0.47	1.5e-02	C10orf118 CTB-31O20.6 DCAF16 FAM108C1 FAM57B KAT8 KB-1107E3.1 KCNK3 KLF16 MAP2K5 MSRA NEIL2 NT5C2 PDLIM4 RP11-296I10.6 RP11-436D10.3 RP11-613D13.5 RP11-810M2.2 RPP25 SH2B3 SRR STAG3L1 STK32C TDRD1 TEAD2 WDR66
Diabetes (self-reported)	1.83	2	1	2.2	0.00	1.0e+00	PMS2P5 ZBTB46
Arm predicted mass (left)	1.83	28	11	24.4	0.24	2.2e-01	ABO C10orf118 CENPW CHMP1A CMIP DCAF16 FAM108C1 FAM57B HEXIM1 KAT8 KCNK3 KLF16 LIME1 MAP2K5 MSRA NCOA1 NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-613D13.5 SENP3 SH2B3 SLC35F6 STAG3L1 TEAD2 WDR66
Schizophrenia (2018)	1.82	5	3	6.7	-0.52	2.9e-01	FAM57B FES FURIN NT5C2 TBC1D19
Heel T-Score	1.82	38	27	60.0	-0.17	2.9e-01	ABO ACP2 ATG7 BICC1 C20orf160 CHMP1A CMIP CYB5D1 DCAF16 FAM57B GTF2B HEXIM1 KAT8 LFNG LOC338758 NCOA1 NELFCD NT5C2 PDE1A PMS2P5 RHOC RNASEH2C RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 SENP3 SLC2A4 SOX6 STK32C TH1L TMEM133 TUBB1 UBE2E3 WNT2B WNT3 ZNF318 ZNRF3
Trunk fat-free mass	1.82	28	15	33.3	0.04	8.3e-01	ABO C10orf118 CENPW CHMP1A DCAF16 FAM108C1 FAM57B HAUS8 HEXIM1 JARID2 KAT8 KCNK3 KLF16 LIME1 MYO9B NCOA1 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 SLC4A7 TEAD2 TMEM133 WDR66
Hip circumference	1.82	25	12	26.7	0.47	1.8e-02	C10orf118 CLCN6 CTB-31O20.6 DCAF16 FAM108C1 FAM57B KAT8 KB-1107E3.1 KCNK3 KLF16 MAP2K5 MSRA NPPA-AS1 NT5C2 PHIP PMS2P5 RP11-296I10.6 RP11-436D10.3 RP11-613D13.5 RP11-810M2.2 SH2B3 SRR STAG3L1 STK32C WDR66
Trunk predicted mass	1.82	27	14	31.1	0.05	7.9e-01	ABO C10orf118 CENPW CHMP1A DCAF16 FAM108C1 FAM57B HAUS8 HEXIM1 JARID2 KAT8 KCNK3 KLF16 LIME1 MYO9B NCOA1 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 SLC4A7 TEAD2 WDR66
Medication for pain relief, constipation, heartburn	1.81	5	2	4.4	-0.98	4.1e-03	ACE C20orf160 FAM108C1 STK32C UFL1
Long-standing illness, disability or infirmity	1.81	3	0	0.0	0.00	1.0e+00	CHP1 PMS2P5 ZNF652
Whole body water mass	1.81	26	14	31.1	0.10	6.2e-01	C10orf118 CENPW DCAF16 FAM108C1 FAM57B HAUS8 HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 SLC4A7 STAG3L1 TEAD2 WDR66
Arm fat-free mass (left)	1.81	28	12	26.7	0.23	2.3e-01	ABO C10orf118 CENPW CMIP DCAF16 FAM108C1 FAM57B HEXIM1 KAT8 KCNK3 KLF16 LIME1 MAP2K5 MSRA NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-613D13.5 RP11-810M2.2 SENP3 SH2B3 SLC35F6 STAG3L1 TEAD2 TSPY26P WDR66
Arm fat-free mass (right)	1.80	25	12	26.7	0.09	6.6e-01	ABO C10orf118 CENPW CHMP1A DCAF16 FAM108C1 FAM57B HAUS8 HEXIM1 KAT8 KCNK3 KLF16 LIME1 MAP2K5 MYO9B NEIL2 NPR3 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 STAG3L1 WDR66
Arm predicted mass (right)	1.80	24	12	26.7	0.17	4.3e-01	ABO C10orf118 CENPW CMIP DCAF16 FAM108C1 FAM57B HEXIM1 KAT8 KCNK3 KLF16 LIME1 MAP2K5 MYO9B NEIL2 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 STAG3L1 TSPY26P WDR66
Whole body fat-free mass	1.80	25	14	31.1	0.05	8.0e-01	C10orf118 CENPW DCAF16 FAM108C1 FAM57B HAUS8 HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MYO9B NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SENP3 SH2B3 SLC35F6 SLC4A7 STAG3L1 TEAD2 WDR66
Type 2 Diabetes (T2D) (2018)	1.79	7	1	2.2	0.97	2.9e-04	ACE DBR1 FAM57B NDUFAF6 PMS2P5 SH2B3 ZBTB46
Leg fat-free mass (right)	1.79	29	15	33.3	0.06	7.7e-01	ABCF3 C10orf118 CENPW DCAF16 FAM108C1 FAM57B FES FURIN HAUS8 HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SH2B3 SLC35F6 SRR STAG3L1 TDRD1 TMEM133 WDR66
Leg predicted mass (right)	1.79	29	15	33.3	0.05	7.8e-01	ABCF3 C10orf118 CENPW DCAF16 FAM108C1 FAM57B FES FURIN HAUS8 HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 SH2B3 SLC35F6 SRR STAG3L1 TDRD1 TMEM133 WDR66
Basal metabolic rate	1.79	24	16	35.6	0.21	3.2e-01	C10orf118 CENPW DCAF16 FAM108C1 FAM57B HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 RP11-613D13.5 SH2B3 SLC35F6 STAG3L1 TDRD1 TEAD2 WDR66
Leg fat-free mass (left)	1.77	28	14	31.1	0.26	1.8e-01	ABCF3 C10orf118 CENPW CTB-31O20.6 DCAF16 FAM108C1 FAM57B FES FURIN HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 RP11-613D13.5 SLC35F6 SRR STAG3L1 TDRD1 TEAD2 WDR66
Leg predicted mass (left)	1.77	30	14	31.1	0.23	2.3e-01	ABCF3 C10orf118 CENPW CTB-31O20.6 DCAF16 FAM108C1 FAM57B FES FURIN HAUS8 HEXIM1 KAT8 KCNK3 KLF16 MAP2K5 MSRA MYO9B NEIL2 NPR3 NT5C2 PDE1A PDLIM4 RP11-436D10.3 RP11-613D13.5 SLC35F6 SRR STAG3L1 TDRD1 TEAD2 WDR66
Respiratory disease	1.75	8	4	8.9	0.74	3.5e-02	CHP1 HDAC7 HEXIM1 PDLIM4 RP5-1115A15.1 RUVBL1 SIK2 ZNF652
Height	1.74	55	42	93.3	-0.31	2.0e-02	ABO AC091133.1 ACE ACP2 ADRB1 ARID3B BICC1 CENPW CERS5 CHMP1A CHP1 DBR1 DCAF16 DEF8 FAM57B FES FURIN GOPC GTF2B HEXIM1 HRCT1 KANK1 LSP1 MGRN1 NAT15 NCOA1 NPR3 NRBF2 NT5C2 NUCB2 PDE1A PDLIM4 PIGV PTPN12 RHOC RP11-436D10.3 RP11-538P18.2 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RYK SENP3 SH2B3 SLC35F6 SLC4A7 STAG3L1 TMEM133 TMEM170A TNKS1BP1 WDR66 WNT2B ZNF318 ZNF652 ZNF831
Hair/balding pattern: Pattern 3	1.74	4	2	4.4	0.71	2.9e-01	C4orf22 HEXIM1 PRDM8 WNT3
Age when periods started (menarche)	1.73	9	4	8.9	-0.55	1.2e-01	CTB-31O20.6 FAM57B KLF16 LSP1 MAP2K5 PMS2P5 RP11-613D13.5 STAG3L1 TNNI2
Supplements: Glucosamine	1.72	2	1	2.2	0.00	1.0e+00	CSK NRBF2
Forced expiratory volume in 1-second (FEV1)	1.71	16	3	6.7	-0.22	4.1e-01	ABO CHMP1A DCAF16 GOPC KAT8 MSRA NCOA1 NRBF2 PDLIM4 RHOC RP11-538P18.2 RUVBL1 TMEM133 TSPY26P UBE2E3 WNT3
Wheeze or whistling in the chest in last year	1.71	2	0	0.0	0.00	1.0e+00	SIK2 ZNF652
Osteoarthritis (self-reported)	1.69	3	0	0.0	0.00	1.0e+00	CHMP1A COX5A RPP25
Medication: Atorvastatin	1.68	1	0	0.0	0.00	1.0e+00	ABO
Forced expiratory volume in 1-second (FEV1), Best measure	1.67	11	5	11.1	-0.28	4.0e-01	ABO DCAF16 KAT8 MSRA NCOA1 NRBF2 PDLIM4 RP11-538P18.2 RUVBL1 TMEM133 WNT3
Standing height	1.67	41	26	57.8	-0.23	1.5e-01	AC091133.1 ACP2 ADRB1 C10orf118 CENPW CERS5 CHMP1A CHP1 DCAF16 FAM57B GOPC GTF2B HEXIM1 LSP1 MGRN1 MSRA NCOA1 NPR3 NRBF2 NUCB2 PDE1A PDLIM4 PIGV PTPN12 RHOC RP11-436D10.3 RP11-538P18.2 RP11-810M2.2 RP4-635E18.7 RP4-671G15.2 RP5-1115A15.1 RYK SH2B3 SLC35F6 SLC4A7 TMEM170A WDR66 WNT2B ZNF318 ZNF652 ZNF831
Heart disease (siblings)	1.67	2	0	0.0	0.00	1.0e+00	FES PVRIG
Peak expiratory flow (PEF)	1.66	7	3	6.7	-0.21	6.5e-01	ABO C1GALT1 CHMP1A DCAF16 MSRA TMEM170A WNT3
Comparative body size at age 10	1.66	9	6	13.3	0.42	2.6e-01	ATG7 CERS5 FAM57B FCF1P2 KAT8 MAP2K5 MSRA SRR ZNF652
Medication: Metformin	1.63	3	0	0.0	0.00	1.0e+00	CISD2 DBR1 PMS2P5
Hand grip strength (right)	1.63	8	3	6.7	-0.78	2.3e-02	ABO DCAF16 HEXIM1 JARID2 PDLIM4 RHOC RP4-671G15.2 WNT2B
Forced vital capacity (FVC)	1.61	13	6	13.3	-0.41	1.6e-01	ACP2 CENPW CHMP1A DCAF16 HOXC8 KAT8 NCOA1 RHOC RP11-538P18.2 RP4-671G15.2 WDR66 WNT2B WNT3
Body Mass Index (BMI) (2010)	1.60	2	1	2.2	0.00	1.0e+00	MAP2K5 STAG3L1
Back pain experienced in last month	1.60	1	0	0.0	0.00	1.0e+00	WDR66
Heel bone mineral density (BMD) T-score, automated (left)	1.59	9	3	6.7	-0.11	7.8e-01	ACP2 CMIP CYB5D1 MSRA NEIL2 RNASEH2C RP5-1115A15.1 WNT2B ZNRF3
Heel bone mineral density (BMD) T-score, automated (right)	1.59	9	4	8.9	-0.04	9.2e-01	ACP2 CYB5D1 DCAF16 MSRA NEIL2 RNASEH2C RP5-1115A15.1 WNT2B ZNRF3
Prostate Cancer	1.56	2	1	2.2	0.00	1.0e+00	RUVBL1 TNNT3
Hand grip strength (left)	1.56	8	2	4.4	-0.55	1.6e-01	CHMP1A DCAF16 FAM57B FES HEXIM1 MGRN1 PDLIM4 WNT2B
Hypothyroidism (self reported)	1.55	2	1	2.2	0.00	1.0e+00	RP5-1115A15.1 SH2B3
Medication: Levothyroxine sodium	1.55	2	1	2.2	0.00	1.0e+00	MSRA SH2B3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.55	5	3	6.7	-0.20	7.5e-01	KAT8 NRBF2 RP11-538P18.2 TMEM170A WNT3
Comparative height size at age 10	1.54	20	11	24.4	-0.11	6.6e-01	CENPW CHMP1A DCAF16 FAM108C1 FAM57B FES GTF2B NAT15 NCOA1 NPR3 NUCB2 PDLIM4 PIGV RP11-613D13.5 RP11-810M2.2 RP4-635E18.7 RP5-1115A15.1 RYK SH2B3 WDR66
Fasting Glucose	1.53	1	1	2.2	0.00	1.0e+00	ACP2
LDL Cholesterol	1.53	3	1	2.2	0.00	1.0e+00	ABO PIGV SH2B3
Waist Hip Ratio (WHR)	1.52	18	9	20.0	0.44	6.9e-02	C22orf31 CEP41 CMIP DBR1 GTF2B HAUS8 HOXC8 MYO9B NCOA1 PTPN12 RGS19 RNASEH2C SIK2 SWAP70 TBC1D19 WNT3 ZNF318 ZNRF3
Medication: Allopurinol	1.52	3	0	0.0	0.00	1.0e+00	CYB5D1 SH2B3 WDR66
Lung FVC	1.51	17	10	22.2	0.00	9.9e-01	C1GALT1 CHP1 DBR1 DCAF16 HOXA10 HOXC8 KAT8 MAP2K5 NAT15 NCOA1 NRBF2 PDLIM4 RP11-538P18.2 RP11-613D13.5 SH2B3 WNT3 ZBTB46
Current tobacco smoking	1.51	1	0	0.0	0.00	1.0e+00	MSRA
Medication: Paracetamol	1.51	1	0	0.0	0.00	1.0e+00	UFL1
Medication: Paracetamol	1.50	1	0	0.0	0.00	1.0e+00	UFL1
Medication: Ventolin 100micrograms inhaler	1.49	1	0	0.0	0.00	1.0e+00	ZNF652
Forced vital capacity (FVC), Best measure	1.49	10	5	11.1	-0.30	4.0e-01	ACP2 CENPW CHMP1A DCAF16 KAT8 NCOA1 RHOC RP11-538P18.2 RP11-613D13.5 WNT3
Hearing difficulty/problems with background noise	1.48	4	1	2.2	-1.00	5.7e-05	CSK MPI UBL7 ZNF318
Headache pain in last month	1.48	4	1	2.2	-0.24	7.6e-01	MAP2K5 TMEM170A UFL1 WNT3
Hypothyroidism/myxoedema (self-reported)	1.47	3	1	2.2	0.00	1.0e+00	MSRA RP5-1115A15.1 SH2B3
Knee pain experienced in last month	1.46	1	0	0.0	0.00	1.0e+00	ARID3B
Forced expiratory volume in 1-second (FEV1), predicted	1.45	4	2	4.4	-0.95	5.0e-02	DCAF16 HEXIM1 MGRN1 PDLIM4
Average weekly red wine intake	1.45	2	0	0.0	0.00	1.0e+00	MPI NRBF2
Alzheimer’s Disease (including proxy)	1.44	4	2	4.4	-0.99	7.2e-03	ACE KAT8 PRKD3 PVRIG
Alcohol intake frequency.	1.44	6	2	4.4	0.99	2.5e-04	ARID3B FAM57B KAT8 PMS2P5 TEX15 ZNF318
Hair/balding pattern: Pattern 2	1.43	2	1	2.2	0.00	1.0e+00	C4orf22 PRDM8
Mineral and other dietary supplements	1.43	1	1	2.2	0.00	1.0e+00	NRBF2
Irritable Bowel Disease (IBD)	1.41	5	2	4.4	0.12	8.5e-01	LSP1 PDLIM4 PMS2P5 RP11-436D10.3 TNNI2
Ulcerative Colitis	1.41	2	0	0.0	0.00	1.0e+00	LSP1 TNNI2
Worrier / anxious feelings	1.41	4	1	2.2	-0.60	4.0e-01	KAT8 MSRA NEIL2 NT5C2
Crohns Disease (2017)	1.39	3	2	4.4	0.00	1.0e+00	PDLIM4 PMS2P5 RP11-436D10.3
Triglycerides	1.39	3	0	0.0	-0.40	6.0e-01	KAT8 NEIL2 NRBF2
Gout (self-reported)	1.38	1	0	0.0	0.00	1.0e+00	SH2B3
Medication: Gliclazide	1.38	1	0	0.0	0.00	1.0e+00	DBR1
HDL Cholesterol	1.37	4	1	2.2	-0.70	3.0e-01	ACP2 ADRB1 PIGV RNASEH2C
Number of incorrect matches in round	1.37	4	1	2.2	-1.00	4.5e-05	FAM57B FES FURIN KAT8
Sensitivity / hurt feelings	1.36	4	3	6.7	-0.64	2.4e-01	AC091133.1 FES FURIN WNT3
Sitting height	1.36	25	13	28.9	-0.11	6.1e-01	AC091133.1 ADRB1 C10orf118 C20orf160 CENPW CERS5 CHMP1A CHP1 DCAF16 FCN3 GOPC GTF2B HEXIM1 JARID2 NPR3 PDLIM4 RP11-436D10.3 RP11-538P18.2 SLC35F6 SLC4A7 WDR66 WNT3 ZNF652 ZNF831 ZNRF3
Relative age of first facial hair	1.35	5	3	6.7	-0.74	1.5e-01	ATG7 C4orf22 HEXIM1 NRBF2 WNT3
Past tobacco smoking	1.35	2	1	2.2	0.00	1.0e+00	MAP2K5 SH2B3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.35	1	0	0.0	0.00	1.0e+00	ADRB1
Neck or shoulder pain in last month	1.35	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Pain experienced in last month	1.35	2	0	0.0	0.00	1.0e+00	KAT8 UFL1
Chest pain or discomfort	1.34	1	0	0.0	0.00	1.0e+00	KB-1107E3.1
Medication: Seretide 50 evohaler	1.33	2	0	0.0	0.00	1.0e+00	PDLIM4 ZNF652
Number of full sisters	1.33	1	0	0.0	0.00	1.0e+00	NRBF2
Alcohol usually taken with meals	1.31	1	0	0.0	0.00	1.0e+00	FES
Crohns Disease (2012)	1.30	2	1	2.2	0.00	1.0e+00	PDLIM4 RP11-436D10.3
Breast cancer (self-reported)	1.30	1	0	0.0	0.00	1.0e+00	SLC4A7
Nervous feelings	1.29	3	1	2.2	0.00	1.0e+00	KAT8 MSRA NT5C2
Mouth/teeth dental problems	1.29	1	0	0.0	0.00	1.0e+00	PMS2P5
Age at first live birth	1.29	1	0	0.0	0.00	1.0e+00	DCAF16
Pack years adult smoking proportion	1.26	1	0	0.0	0.00	1.0e+00	PMS2P5
Qualifications: None of the above	1.26	2	1	2.2	0.00	1.0e+00	NRBF2 PHIP
Ever smoked	1.26	3	0	0.0	0.00	1.0e+00	MAP2K5 SH2B3 SRR
Neuroticism (2016)	1.25	2	0	0.0	0.00	1.0e+00	MSRA NEIL2
Smoking Status	1.25	6	0	0.0	-0.01	9.9e-01	FAM108C1 FES MAP2K5 RP5-1115A15.1 SRR ZNF652
Worry too long after embarrassment	1.25	1	0	0.0	0.00	1.0e+00	MSRA
Depression (Nagel 2018)	1.24	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Worry (Nagel 2018)	1.24	3	2	4.4	0.00	1.0e+00	KAT8 NT5C2 STK32C
Frequency of tiredness / lethargy in last 2 weeks	1.24	2	0	0.0	0.00	1.0e+00	AC091133.1 RP5-1115A15.1
Qualifications: A levels/AS levels or equivalent	1.24	2	0	0.0	0.00	1.0e+00	DCAF16 STAG3L1
Mouth/teeth dental problems: Mouth ulcers	1.24	1	0	0.0	0.00	1.0e+00	OSGIN2
Primary Biliary Cirrhosis	1.23	2	1	2.2	0.00	1.0e+00	CISD2 SH2B3
Frequency of depressed mood in last 2 weeks	1.23	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Migraine (self-reported)	1.23	1	1	2.2	0.00	1.0e+00	UFL1
Myopia	1.23	2	0	0.0	0.00	1.0e+00	RP4-671G15.2 WNT2B
Basal cell carcinoma (self-reported)	1.23	1	0	0.0	0.00	1.0e+00	SPATA33
Pack years of smoking	1.23	1	0	0.0	0.00	1.0e+00	PMS2P5
Maternal smoking around birth	1.22	1	0	0.0	0.00	1.0e+00	C20orf160
Fed-up feelings	1.22	2	1	2.2	0.00	1.0e+00	SH2B3 TEX15
Had major operations	1.21	1	0	0.0	0.00	1.0e+00	ZNF652
Mood swings	1.21	3	0	0.0	0.00	1.0e+00	ACP2 OSGIN2 WNT3
Risk taking	1.21	2	0	0.0	0.00	1.0e+00	KCNK3 STK32C
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.20	1	0	0.0	0.00	1.0e+00	KDM2B
Smoking status: Previous	1.20	2	0	0.0	0.00	1.0e+00	MAP2K5 SH2B3
Loneliness, isolation	1.20	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Ever had bowel cancer screening	1.20	1	0	0.0	0.00	1.0e+00	SIK2
Ulcerative Colitis (UC)	1.19	3	1	2.2	0.00	1.0e+00	LSP1 RGS19 TNNI2
Townsend deprivation index at recruitment	1.19	2	0	0.0	0.00	1.0e+00	KLF16 MAP2K5
Depressed Affect (Nagel 2018)	1.17	5	3	6.7	-0.50	3.9e-01	ACP2 OSGIN2 RP5-1115A15.1 SH2B3 WNT3
Multivitamins +/- minerals	1.17	1	0	0.0	0.00	1.0e+00	NRBF2
Pulse rate, automated reading	1.16	5	1	2.2	0.06	9.2e-01	ABO ACP2 C4orf22 PVRIG SIK2
Supplements: Fish oil (including cod liver oil)	1.16	1	0	0.0	0.00	1.0e+00	HEXIM1
Neuroticism	1.15	5	2	4.4	-0.49	4.1e-01	FURIN MAP2K5 NT5C2 RP5-1115A15.1 WNT3
Diabetes (father)	1.15	1	0	0.0	0.00	1.0e+00	AC091133.1
Neuroticism score	1.15	4	3	6.7	-0.99	1.2e-02	MSRA NEIL2 RP5-1115A15.1 WNT3
Suffer from 'nerves'	1.15	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Eye problems/disorders: Glaucoma	1.15	1	0	0.0	0.00	1.0e+00	TEX15
Major Depression (MDD)	1.13	1	0	0.0	0.00	1.0e+00	FES
Neuroticism (Nagel 2018)	1.12	5	2	4.4	-0.39	5.1e-01	ACP2 FURIN KAT8 RP5-1115A15.1 WNT3
Ovarian Cancer	1.12	2	0	0.0	0.00	1.0e+00	ABO WNT3
Hearing difficulty/problems: Yes	1.12	1	1	2.2	0.00	1.0e+00	ZNF318
Mouth/teeth dental problems: Dentures	1.11	1	0	0.0	0.00	1.0e+00	HOXB9
Tense / 'highly strung'	1.11	3	0	0.0	0.00	1.0e+00	KAT8 NT5C2 RP5-1115A15.1
Relative age voice broke	1.09	2	0	0.0	0.00	1.0e+00	RP11-613D13.5 WNT3
Miserableness	1.09	3	0	0.0	0.00	1.0e+00	ACP2 RP5-1115A15.1 WNT3
Frequency of tenseness / restlessness in last 2 weeks	1.08	1	0	0.0	0.00	1.0e+00	NT5C2
Chronotype (morning person)	1.06	3	0	0.0	0.00	1.0e+00	RP11-810M2.2 RP4-671G15.2 RP5-1115A15.1
Alcohol intake versus 10 years previously	1.06	1	0	0.0	0.00	1.0e+00	FAM57B
Mean time to correctly identify matches	1.06	2	1	2.2	0.00	1.0e+00	RP11-810M2.2 SH2B3
Intelligence (Savage-Jansen 2018)	1.05	3	1	2.2	0.00	1.0e+00	DCAF16 GTF2B NRBF2
Fluid intelligence score	1.05	1	1	2.2	0.00	1.0e+00	DCAF16
Qualifications: College or University degree	1.05	6	2	4.4	-0.71	1.1e-01	DCAF16 FAM57B GTF2B STAG3L1 TEX15 WNT3
Reaction Time	1.04	1	1	2.2	0.00	1.0e+00	SH2B3
Verbal and Numeric Reasoning (VNR)	1.02	2	1	2.2	0.00	1.0e+00	DCAF16 TEX15
Irritability	1.02	2	2	4.4	0.00	1.0e+00	MSRA NEIL2
Had menopause	1.01	1	0	0.0	0.00	1.0e+00	CHP1
Depression (self-reported)	1.01	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Guilty feelings	0.98	1	0	0.0	0.00	1.0e+00	NEIL2
Rheumatoid Arthritis	0.95	1	0	0.0	0.00	1.0e+00	SH2B3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Ovary	11	1.21	3.3
GTEx	Prostate	10	1.20	3.2
GTEx	Artery Aorta	41	1.38	3.1
GTEx	Brain Cortex	8	0.77	3.1
GTEx	Stomach	18	1.24	3.1
GTEx	Adipose Subcutaneous	31	0.89	3.0
GTEx	Adipose Visceral Omentum	15	0.74	3.0
GTEx	Artery Tibial	37	0.98	3.0
GTEx	Brain Cerebellum	15	0.76	3.0
GTEx	Brain Frontal Cortex BA9	8	0.87	3.0
GTEx	Esophagus Gastroesophageal Junction	12	0.83	3.0
GTEx	Heart Left Ventricle	15	0.98	3.0
GTEx	Lung	22	0.77	3.0
GTEx	Skin Not Sun Exposed Suprapubic	25	1.02	3.0
GTEx	Small Intestine Terminal Ileum	2	0.43	3.0
ROSMAP	Brain Pre-frontal Cortex	50	1.14	3.0
GTEx	Adrenal Gland	13	0.89	2.9
GTEx	Artery Coronary	8	0.68	2.9
GTEx	Brain Caudate basal ganglia	5	0.54	2.9
GTEx	Brain Cerebellar Hemisphere	14	0.94	2.9
GTEx	Brain Hippocampus	2	0.38	2.9
GTEx	Brain Nucleus accumbens basal ganglia	3	0.35	2.9
GTEx	Breast Mammary Tissue	14	0.71	2.9
GTEx	Breast Mammary Tissue (Male)	12	1.01	2.9
GTEx	Breast Mammary Tissue (Female)	14	0.85	2.9
GTEx	Cells EBV-transformed lymphocytes	8	0.56	2.9
GTEx	Cells Transformed fibroblasts	34	0.81	2.9
GTEx	Colon Sigmoid	11	0.75	2.9
GTEx	Colon Transverse	16	0.78	2.9
GTEx	Esophagus Mucosa	28	0.84	2.9
GTEx	Esophagus Muscularis	34	1.05	2.9
GTEx	Heart Atrial Appendage	12	0.76	2.9
GTEx	Muscle Skeletal	18	0.62	2.9
GTEx	Pancreas	12	0.74	2.9
GTEx	Pituitary	9	0.81	2.9
GTEx	Skin Sun Exposed Lower leg	38	1.04	2.9
GTEx	Testis	30	0.95	2.9
GTEx	Thyroid	37	0.93	2.9
GTEx	Vagina	6	0.94	2.9
GTEx	Nerve Tibial	32	0.74	2.8
GTEx	Spleen	11	0.78	2.8
GTEx	Uterus	6	1.06	2.8
GTEx	Whole Blood	13	0.65	2.8
NTR	Blood	20	0.83	2.8
The Cancer Genome Atlas	Colon Adenocarcinoma	20	0.97	2.8
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	41	1.00	2.8
The Cancer Genome Atlas	Stomach Adenocarcinoma	13	0.77	2.8
GTEx	Brain Putamen basal ganglia	4	0.64	2.7
GTEx	Liver	3	0.42	2.7
CommonMind	Brain Pre-frontal Cortex	44	0.82	2.7
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	17	0.62	2.7
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	15	0.73	2.7
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	13	0.52	2.7
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	13	0.78	2.7
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	9	0.68	2.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	5	0.72	2.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	2	0.37	2.7
GTEx	Brain Hypothalamus	2	0.34	2.6
METSIM	Adipose	21	0.46	2.6
YFS	Blood	25	0.54	2.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	10	0.60	2.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	33	0.75	2.6
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.36	2.6
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.29	2.6
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.49	2.6
The Cancer Genome Atlas	Brain Lower Grade Glioma	29	0.67	2.6
The Cancer Genome Atlas	Lung Adenocarcinoma	23	0.78	2.6
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	10	0.63	2.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	6	0.56	2.6
The Cancer Genome Atlas	Testicular Germ Cell Tumors	5	0.39	2.6
The Cancer Genome Atlas	Thyroid Carcinoma	34	0.66	2.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	3	0.59	2.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.45	2.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	21	0.45	2.5