Best TWAS P=3.47e-17 · Best GWAS P=1.83e-20 conditioned to 5.77e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | 4.8 | 5.5 | 3.2e-08 | 0.33 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | WNT2B | 0.10 | 0.10 | enet | 19 | 0.06 | 1.2e-05 | -4.8 | -6.1 | 1.3e-09 | -0.12 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | WNT2B | 0.15 | 0.01 | enet | 7 | 0.01 | 1.0e-01 | -5.8 | -5.8 | 8.0e-09 | -0.16 | 0.24 | 0.04 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 2.3e-02 | -5.7 | -6.1 | 9.0e-10 | -0.16 | 0.08 | 0.05 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | WNT2B | 0.01 | -0.01 | enet | 24 | 0.00 | 3.4e-01 | 1.3 | -5.7 | 9.7e-09 | -0.11 | 0.03 | 0.05 | FALSE |
| 6 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 9.4e-04 | -5.7 | -7.1 | 1.6e-12 | -0.14 | 0.56 | 0.02 | FALSE |
| 7 | GTEx | Nerve Tibial | RP4-671G15.2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.9e-05 | -5.0 | 5.4 | 7.5e-08 | 0.17 | 0.94 | 0.00 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | RHOC | 0.07 | 0.02 | lasso | 3 | 0.02 | 1.5e-02 | -5.6 | -5.5 | 3.4e-08 | -0.16 | 0.54 | 0.02 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CAPZA1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.1e-07 | -5.6 | -5.5 | 4.1e-08 | -0.16 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTTNBP2NL | 0.04 | 0.00 | blup | 53 | 0.02 | 2.1e-03 | -5.7 | -6.3 | 3.3e-10 | -0.27 | 0.03 | 0.19 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | -5.7 | -7.7 | 1.9e-14 | -0.30 | 0.06 | 0.10 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | -7.6 | -8.4 | 3.5e-17 | -0.30 | 0.01 | 0.98 | TRUE |