TWAS hub - RHOC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.146	0.070	0.0073	-0.004	NA	-0.002	NA	-0.004	0.77000	NA	0.48000	NA	0.80000
2	GTEx	Skin Sun Exposed Lower leg	0.070	0.029	0.0015	0.023	NA	0.012	NA	0.016	0.00460	NA	0.03200	NA	0.01500
3	TCGA	Thyroid Carcinoma	0.037	0.019	0.0015	0.034	0.036	0.038	NA	0.035	0.00027	0.00017	0.00014	NA	0.00024

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Blood pressure	20.2	38.4	74.1	-2.4	-5.9	-8.6
Medication: Amlodipine	20.0	28.0	49.7	-3.3	-4.8	-7.0
Medication: Bendroflumethiazide	15.1	22.9	42.3	-1.9	-4.8	-6.5
High blood pressure	13.5	37.5	71.1	-3.3	-5.5	-8.4
Hypertension (Self-reported)	13.0	36.0	70.2	-2.9	-5.4	-8.4
Medication for cholesterol	12.9	19.6	37.9	1.8	4.2	6.2
Vascular/heart problems diagnosed by doctor	12.1	32.9	62.3	3.1	5.2	7.9
Systolic Blood Pressure	11.7	58.6	108.2	-2.4	-7.9	-10.4
Medication: Blood pressure	11.1	19.6	38.5	-1.9	-4.1	-6.2
Medication: Atenolol	10.7	13.4	19.4	-1.9	-4.1	-4.4
Cardiovascular Disease	10.0	33.1	56.9	-3.0	-5.8	-7.5
Diastolic blood pressure, automated reading	9.1	28.3	52.4	-0.3	-5.7	-7.2
Medication for cholesterol, blood pressure or diabetes	8.0	13.2	24.8	2.3	3.0	5.0
Systolic blood pressure, automated reading	7.6	22.0	41.5	-1.7	-4.6	-6.4
Myopia	7.2	10.4	18.3	0.3	4.3	3.6
Blood Platelet Count	6.9	80.0	141.6	11.9	7.7	6.3
Forced vital capacity (FVC)	6.1	23.5	34.8	4.6	3.8	5.9
Forced vital capacity (FVC), Best measure	5.4	19.6	25.6	5.1	3.1	4.9
Hand grip strength (right)	5.2	14.2	24.1	1.5	4.0	4.9
High blood pressure (siblings)	5.2	7.4	17.9	-0.9	-1.9	-4.2
High blood pressure (mother)	5.0	7.1	15.0	-0.5	-2.5	-3.9
Body Mass Index (BMI) (2010)	4.9	6.7	10.0	2.5	3.2	2.0
Medication: Lisinopril	4.3	5.5	12.5	-0.9	-1.8	-3.5
Forced expiratory volume in 1-second (FEV1)	4.1	13.9	21.6	3.4	2.9	4.6
Number of treatments/medications taken	4.0	7.2	16.0	0.9	-2.2	-4.0
Chronotype (morning person)	3.7	8.5	10.6	2.6	3.3	2.9
Illnesses of siblings	3.7	5.2	11.6	0.4	2.0	3.4
Exposure to tobacco smoke at home	3.7	4.1	5.1	2.1	2.3	1.7
Worry too long after embarrassment	3.6	6.0	9.0	-1.0	-2.8	-3.0
Tinnitus: Yes, now most or all of the time	3.6	4.2	6.7	-1.1	-2.6	-2.2
Ulcerative Colitis	3.5	5.0	5.8	2.3	2.4	2.0
Medication: Simvastatin	3.5	5.1	9.1	-2.1	-1.3	-3.0
Comparative body size at age 10	3.5	9.8	25.5	5.0	1.6	1.1
Schizophrenia (2018)	3.4	7.1	10.3	1.1	3.2	3.1
Hand grip strength (left)	3.4	9.0	15.1	1.2	3.2	3.9
Hearing difficulty/problems: Yes	3.4	5.2	7.4	-1.3	-2.7	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.8	14.0	3.7	2.2	3.7
Supplements: Glucosamine	3.3	4.3	7.2	-0.5	-2.7	-2.4
Medication: Ramipril	3.3	4.2	11.1	-0.1	-1.2	-3.3
Ulcerative Colitis (UC)	3.2	6.1	7.3	2.6	2.7	2.1
Medication: Aspirin	3.2	4.2	9.1	-0.5	-1.8	-3.0
Lung FVC	3.0	15.1	40.4	6.4	0.8	2.1
Hayfever, allergic rhinitis or eczema	3.0	6.5	10.6	-1.3	-3.2	-2.7
Diverticular disease/diverticulitis (self-reported)	3.0	3.6	6.4	-0.8	-2.5	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	11.2	3.3	-2.5	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	8.3	2.6	-2.9	-2.1
Hearing difficulty/problems with background noise	2.9	4.7	7.7	-1.7	-2.8	-1.9
High cholesterol (Self-reported)	2.9	5.2	8.2	-1.7	-2.1	-2.9
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	4.5	2.1	2.1	1.1
Medication: Aspirin	2.8	3.7	8.1	-0.4	-1.7	-2.8
Cholesterol lowering medication	2.8	4.1	7.8	-1.2	-1.7	-2.8
Illnesses of mother	2.7	3.3	8.1	-0.0	1.3	2.9
Pulse rate, automated reading	2.7	8.7	15.2	1.4	3.9	3.0
Age when periods started (menarche)	2.6	6.2	7.3	-2.6	-2.7	-2.1
Illnesses of father: High blood pressure	2.6	3.3	6.0	-1.3	-1.5	-2.4
Taking other prescription medications	2.5	3.9	7.8	2.8	1.5	1.3
Mouth/teeth dental problems: Dentures	2.5	4.2	6.7	-0.5	-2.6	-2.4
Medication: Paracetamol	2.5	4.1	8.1	1.2	-2.8	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	3.2	-1.7	-1.6	-1.8
Alcohol drinker status: Never	2.5	2.9	5.3	-0.4	-2.3	-1.8
Bipolar Disorder or Schizophrenia	2.4	5.8	9.8	0.6	2.7	3.1
Pulse rate	2.4	4.1	8.1	0.9	2.8	1.8
Breastfed as a baby	2.4	3.0	3.4	-1.7	-1.7	-1.8
Pulse wave reflection index	2.4	3.0	5.1	1.6	-2.3	-1.1
Allergy or Eczema	2.3	6.0	9.4	-1.3	-3.1	-2.6
Ever used hormone-replacement therapy (HRT)	2.3	3.0	4.1	-2.0	-1.1	-1.9
Impedance of leg (left)	2.3	11.3	16.2	-3.0	2.9	4.0
Impedance of arm (right)	2.3	10.6	27.0	-5.2	0.9	2.0
Noisy workplace	2.3	2.9	7.4	-2.7	-0.8	-0.8
Shortness of breath walking on level ground	2.3	2.7	5.0	-1.0	-1.5	-2.2
Eye problems/disorders: None of the above	2.3	2.7	4.1	-1.0	-1.7	-2.0
Primary Biliary Cirrhosis	2.2	3.1	4.9	1.1	2.2	1.8
Heel T-Score	2.1	16.6	19.7	4.4	-3.6	-4.2
Medication for pain relief, constipation, heartburn	2.1	3.7	4.3	-1.7	2.1	2.0
Impedance of whole body	2.1	10.6	18.0	-4.2	1.8	3.3
Irritable Bowel Disease (IBD)	2.0	4.7	10.6	3.2	1.6	1.1
Impedance of leg (right)	2.0	9.9	12.5	-3.3	2.5	3.5
Medication: Cholesterol lowering	2.0	3.1	5.9	-1.4	-1.1	-2.4
Schizophrenia (2014)	1.9	4.2	6.4	0.8	2.4	2.5
Hair/balding pattern: Pattern 4	1.9	4.5	6.1	-2.5	-2.0	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	9.8	0.8	1.3	3.1
Neuroticism	1.8	4.4	4.5	-2.0	-2.1	-2.1
Hair/balding pattern: Pattern 2	1.8	2.3	4.8	0.8	1.2	2.2
Lung cancer (father)	1.8	2.1	4.2	1.1	1.0	2.1
Impedance of arm (left)	1.8	8.5	19.1	-4.4	1.0	2.3
Arm fat-free mass (right)	1.8	9.1	16.9	4.1	2.0	2.5
Emphysema/chronic bronchitis	1.8	2.0	5.7	2.4	0.6	0.3
Number of self-reported non-cancer illnesses	1.8	3.1	8.4	0.3	-0.9	-2.9
Mouth/teeth dental problems	1.7	2.5	4.0	0.7	1.8	2.0
Standing height	1.7	17.0	39.6	1.1	3.2	6.3
Length of working week for main job	1.7	1.8	2.9	1.7	1.4	0.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	5.0	0.8	2.2	2.1
Mineral and other dietary supplements	1.7	2.2	3.6	-0.2	1.7	1.9
Medication: Paracetamol	1.7	2.6	4.5	1.1	-2.1	-1.4
Alcohol drinker status: Previous	1.7	2.0	3.3	0.2	1.8	1.6
Height	1.6	31.0	71.7	0.8	4.5	8.5
Past tobacco smoking	1.6	3.0	3.2	1.7	1.8	1.7
Nervous feelings	1.6	2.9	4.8	-0.7	-1.9	-2.2
Time employed in main current job	1.6	1.8	4.9	-2.2	-0.7	-0.2
Arm predicted mass (right)	1.6	8.4	15.4	3.9	2.1	2.4
Age at last live birth	1.6	2.3	6.2	0.8	-2.5	-0.3
Ever smoked	1.6	2.8	3.4	-1.8	-1.7	-1.5
HbA1C	1.5	1.6	3.5	-1.9	-0.8	-0.8
Knee pain experienced in last month	1.5	2.4	6.0	0.3	-1.0	-2.5
Arm predicted mass (left)	1.5	7.8	12.4	3.5	2.2	2.5
Alcohol usually taken with meals	1.4	2.2	6.1	2.5	0.2	0.8
Had menopause	1.4	1.8	3.9	-2.0	-0.5	-1.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.6	0.8	-1.4	-1.6
Arm fat-free mass (left)	1.4	7.0	11.4	3.4	2.0	2.3
Alzheimer’s Disease (in mother)	1.3	1.5	3.9	-0.7	2.0	0.4
Alzheimer’s Disease (in father)	1.3	1.4	2.2	0.4	-1.3	-1.5
Hypothyroidism (self reported)	1.3	3.1	3.9	1.3	2.0	1.9
Neuroticism score	1.3	2.8	4.0	-1.1	-1.8	-2.0
Trunk fat-free mass	1.3	7.3	14.6	3.8	1.6	2.2
Trunk predicted mass	1.3	7.4	14.8	3.9	1.6	2.2
Tense / ‘highly strung’	1.3	2.1	3.4	-0.2	-1.7	-1.8
Glaucoma (self-reported)	1.3	1.5	4.5	2.1	-0.1	-0.1
Whole body water mass	1.3	7.2	14.0	3.7	1.8	2.1
Sensitivity / hurt feelings	1.2	2.1	3.8	-1.1	-1.9	-1.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.5	-0.2	-0.6	-1.9
Financial difficulties in last 2 years	1.2	1.6	3.2	1.8	0.2	1.3
Chest pain or discomfort	1.2	1.7	2.6	1.3	-1.0	-1.6
Whole body fat-free mass	1.2	7.0	13.5	3.7	1.7	2.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.3	1.2	1.5	0.8
Qualifications: nursing, teaching	1.2	1.9	3.1	0.4	-1.8	-1.5
Basal metabolic rate	1.2	6.4	10.2	3.2	2.0	2.3
Diabetes (father)	1.1	1.4	2.5	-0.5	1.2	1.6
Heart attack	1.1	1.4	3.1	0.1	1.8	1.0
Allergy	1.1	2.5	3.8	0.8	1.7	1.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.7	1.9	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	6.3	2.5	-0.2	0.7
Average weekly beer plus cider intake	1.1	1.6	3.8	-1.9	0.1	-1.0
Unable to work because of sickness or disability	1.1	1.4	2.2	1.5	1.2	0.6
Supplements: Calcium	1.1	1.2	1.8	1.1	1.3	0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.0	0.4	1.7	1.0
Coronary Artery Disease (CAD)	1.0	1.2	1.8	-0.8	-1.0	-1.4
LDL Cholesterol	1.0	1.6	2.4	1.2	0.9	1.6
Pulse wave peak to peak time	1.0	1.1	1.4	-1.2	1.1	0.9
Friendships satisfaction	1.0	1.2	2.8	-1.7	-0.4	-0.8
Breast cancer (self-reported)	1.0	1.2	1.3	-1.1	-1.1	-1.0
Medication: Gliclazide	1.0	1.1	1.9	-0.5	-1.1	-1.4
Pain experienced in last month	1.0	1.7	2.5	-1.6	0.6	1.5
Neuroticism (Nagel 2018)	0.9	2.1	3.1	-0.7	-1.7	-1.8
Schizophrenia vs Biploar Disorder	0.9	1.1	3.2	-0.1	1.8	0.5
Number of incorrect matches in round	0.9	1.6	3.0	0.4	-1.7	-1.3
Number of live births	0.9	1.3	2.8	-0.0	-1.7	-1.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.1	0.5	1.1	1.4
Loneliness, isolation	0.9	1.3	1.6	-1.0	1.1	1.3
Basal cell carcinoma (self-reported)	0.9	1.1	2.0	1.1	0.4	1.4
Worry (Nagel 2018)	0.8	1.8	2.9	-0.3	-1.5	-1.7
Crohns Disease (2017)	0.8	1.8	5.0	2.2	-0.7	-0.3
Neuroticism (2016)	0.8	1.1	2.3	0.2	-1.0	-1.5
Leg fat-free mass (left)	0.8	4.2	8.8	3.0	1.2	1.5
Maternal smoking around birth	0.8	1.2	1.8	0.3	1.4	1.3
Relative age voice broke	0.8	1.2	1.8	-1.4	-1.3	-0.1
Leg predicted mass (left)	0.8	4.3	8.8	3.0	1.3	1.6
Peak expiratory flow (PEF)	0.8	1.7	2.5	1.0	1.3	1.6
Exposure to tobacco smoke outside home	0.8	1.1	2.4	-0.2	1.5	1.0
Heart disease (mother)	0.8	0.9	1.3	1.0	1.1	0.7
Suffer from ‘nerves’	0.8	1.2	2.1	-0.2	-1.2	-1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.2	-0.5	-0.8	-1.5
Leg fat-free mass (right)	0.8	4.5	9.4	3.1	1.2	1.6
Long-standing illness, disability or infirmity	0.8	1.2	1.8	1.1	1.3	0.6
Osteoporosis (self-reported)	0.8	1.0	1.3	-0.8	1.0	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	-0.5	1.0	1.3
Leg predicted mass (right)	0.8	4.5	9.4	3.1	1.2	1.6
Medication: Atorvastatin	0.8	1.0	2.1	0.1	-0.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.5	1.2	-0.5	-1.2
Blood Red Count	0.7	7.0	11.9	1.7	2.5	3.5
Average weekly spirits intake	0.7	0.9	1.9	0.5	1.4	0.8
Trunk fat percentage	0.7	2.7	4.1	-1.2	2.0	1.6
Qualifications: CSEs or equivalent	0.7	0.9	1.5	1.0	1.2	0.4
Serious illness, injury or assault to yourself	0.7	0.9	0.9	-1.0	0.9	0.9
Multivitamins +/- minerals	0.7	0.9	1.8	-0.6	0.8	1.3
Trunk fat mass	0.7	3.1	5.1	-0.1	2.3	2.1
Weight	0.7	3.3	3.8	1.6	1.9	1.9
Falls in the last year	0.7	0.9	1.1	-1.0	-1.0	-0.9
Birth weight	0.7	1.4	3.5	1.9	-0.8	0.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.5	-1.6	0.1	0.4
Medication: Omeprazole	0.7	0.9	1.5	1.2	-0.1	-1.1
Overall health rating	0.7	1.5	3.6	-0.3	-1.0	-1.9
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.2	0.7	1.1	0.9
Smoking status: Previous	0.7	1.1	1.3	-1.1	-0.9	-1.0
Miserableness	0.7	1.3	3.4	-0.3	-0.6	-1.8
Irritability	0.7	1.1	1.9	-1.4	-0.9	-0.8
Fractured/broken bones in last 5 years	0.7	0.9	1.2	-1.1	1.0	0.7
Age started oral contraceptive pill	0.7	0.8	1.2	-0.3	-1.1	-1.1
Reaction Time	0.6	1.1	3.1	1.8	-0.4	0.2
Age at First Birth	0.6	0.9	1.8	0.1	-1.3	-0.9
Crohns Disease (2012)	0.6	1.0	2.2	1.5	-0.8	-0.3
Blood White Count	0.6	4.3	7.7	0.9	2.8	2.1
Lung FEV1/FVC ratio	0.6	2.8	8.2	-2.9	-0.1	-0.4
Relative age of first facial hair	0.6	1.2	3.3	-0.4	-1.8	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	1.0	-0.1	-0.9
Average weekly fortified wine intake	0.6	0.7	1.1	-0.3	1.0	1.0
Stomach or abdominal pain in last month	0.6	0.8	1.3	-0.4	0.9	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	1.1	0.5	0.9
Pulse wave Arterial Stiffness index	0.6	0.8	1.6	1.3	-0.8	-0.3
Birth weight of first child	0.6	1.1	1.1	-1.0	1.1	1.0
Loud music exposure frequency	0.6	0.6	1.0	-1.0	-0.9	-0.2
Headache pain in last month	0.6	1.0	1.2	1.1	-0.9	-1.1
Angina (self-reported)	0.6	0.7	1.4	-0.8	-0.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	-1.5	0.1	0.1
Commuting to job workplace: Walk	0.6	0.6	1.1	-1.0	0.5	0.8
Average weekly champagne plus white wine intake	0.6	0.8	1.9	0.1	-1.4	-0.8
Mother’s age at death	0.6	0.7	1.5	1.2	0.2	0.7
Alzheimer’s Disease (including proxy)	0.5	0.8	1.4	-1.2	0.8	-0.5
Major Depression (MDD)	0.5	0.6	1.0	0.9	0.1	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	-0.9	-1.5	-0.6
Ovarian Cancer	0.5	0.7	0.9	0.9	-0.7	-0.8
Angina	0.5	0.7	1.6	-0.7	-0.2	-1.2
Supplements: Zinc	0.5	0.6	1.1	0.7	-0.4	-1.0
Medication: Co-codamol	0.5	0.6	1.3	1.1	0.5	-0.3
Sitting height	0.5	3.8	8.2	1.6	0.7	2.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	1.2	-0.7	-0.1
Hip circumference	0.5	2.1	2.4	1.6	1.6	1.1
Prospective memory result	0.5	0.6	1.2	-0.7	-0.4	-1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.3	1.1	0.5
Body fat percentage	0.5	1.9	3.7	-0.9	1.9	1.1
Whole body fat mass	0.5	2.1	4.0	0.1	2.0	1.5
Leg fat mass (right)	0.5	1.9	3.6	0.8	1.9	1.2
Comparative height size at age 10	0.5	2.7	6.2	-0.2	1.3	2.5
Number of full sisters	0.5	0.6	1.2	-1.1	0.7	-0.3
Family relationship satisfaction	0.5	0.6	1.7	-1.3	-0.0	-0.0
Leg pain on walking	0.5	0.6	1.5	-1.2	-0.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.0	0.9	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	1.2	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	-0.7	-0.6	-1.1
Heart disease (siblings)	0.5	0.6	0.8	0.4	-0.9	-0.9
Leg fat mass (left)	0.5	2.1	3.9	0.8	2.0	1.4
Lupus	0.4	0.6	1.0	-0.3	0.9	1.0
Waist Hip Ratio (WHR)	0.4	1.9	3.3	-0.3	1.5	1.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-1.2	-0.4	-0.7
Vitamin and mineral supplements	0.4	0.5	0.8	-0.1	-0.8	-0.9
Fed-up feelings	0.4	0.7	0.9	0.6	-1.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.5	-0.7	-0.7	-0.5
Medication: Levothyroxine sodium	0.4	0.7	1.0	-0.2	1.0	1.0
Qualifications: None of the above	0.4	0.9	1.7	-1.1	-0.2	-1.3
Pain all over the body in last month	0.4	0.4	1.1	1.0	0.3	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.9	-0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	1.1	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.4	-1.0	-0.8
Gout (self-reported)	0.4	0.6	1.3	1.1	0.4	0.6
Qualifications: College or University degree	0.4	1.3	2.3	1.3	-0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.1	0.2	-1.1	-1.0
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.3	1.1	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	1.1	-0.3	-0.3
Leg fat percentage (left)	0.4	1.5	3.6	-0.1	1.9	0.8
Ever depressed for a whole week	0.4	0.5	0.8	0.9	0.9	-0.2
Bipolar Disorder (2018)	0.3	0.5	1.0	-0.5	0.3	1.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-1.3	-0.9	0.6
Mean Putamen Volume	0.3	0.3	0.7	-0.2	-0.5	-0.8
Rheumatoid Arthritis	0.3	0.4	1.1	0.2	-0.3	-1.1
Triglycerides	0.3	0.5	1.3	-1.1	0.4	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.2	0.9	0.6
Diabetes (mother)	0.3	0.4	0.6	0.8	0.4	-0.7
Severe depression (siblings)	0.3	0.3	0.5	-0.4	0.6	0.7
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.6	1.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	1.1	0.3	-0.2
Diabetes (self-reported)	0.3	0.4	1.1	-0.1	-0.4	-1.1
Father’s age at death	0.3	0.4	0.6	0.5	-0.8	-0.6
Leg fat percentage (right)	0.3	1.0	2.6	-0.2	1.6	0.6
Age at first live birth	0.3	0.6	1.3	-0.5	-1.1	0.5
Medication: Ibuprofen	0.3	0.4	0.8	0.9	0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	-0.2	-0.6	-0.8
Alcohol intake frequency.	0.3	0.7	1.5	0.7	-0.0	1.2
Had major operations	0.3	0.4	1.0	1.0	0.3	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.3	0.1	-1.0
Average weekly red wine intake	0.3	0.5	0.9	0.9	-0.2	-0.8
Ever had bowel cancer screening	0.3	0.4	0.9	-0.3	-0.4	-1.0
Back pain experienced in last month	0.3	0.4	0.6	-0.8	-0.3	-0.7
Guilty feelings	0.3	0.5	0.9	0.3	-0.6	-1.0
Ever taken oral contraceptive pill	0.3	0.4	0.5	-0.3	-0.7	-0.7
Commuting to job workplace: Public transport	0.3	0.3	0.4	-0.6	0.6	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.0	-1.0	-0.3	-0.1
Prostate Cancer	0.2	0.3	0.7	-0.8	-0.5	0.1
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.8	-0.2	0.2
HDL Cholesterol	0.2	0.3	0.6	-0.3	0.5	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	-0.5	0.5	0.3
BMI	0.2	1.1	2.0	1.4	1.2	-0.2
Smoking Status	0.2	0.6	1.6	-1.3	-0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.2	0.7	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.3	-0.3	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	0.1	0.4
Medication: Metformin	0.2	0.2	0.5	0.7	0.2	-0.4
Current tobacco smoking	0.2	0.3	0.7	-0.9	0.2	-0.3
Body mass index (BMI)	0.2	0.8	1.3	1.1	0.4	-1.0
Waist circumference	0.2	0.6	0.8	0.8	0.9	0.6
Had other major operations	0.2	0.2	0.4	0.7	-0.4	0.1
Fluid intelligence score	0.2	0.3	0.7	-0.4	-0.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.3	-0.9	-0.6
Happiness	0.2	0.2	0.6	-0.8	-0.1	0.1
Arm fat mass (right)	0.2	1.0	2.1	0.7	1.4	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.3	-0.4	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.5	-0.2	-0.8
Migraine (self-reported)	0.2	0.2	0.3	0.4	0.6	0.5
Medication: Seretide 50 evohaler	0.2	0.3	0.5	-0.2	-0.7	-0.5
Mean time to correctly identify matches	0.2	0.4	0.8	0.9	-0.6	-0.4
Supplements: Vitamin C	0.2	0.2	0.4	0.2	0.7	0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	0.3	0.7	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	0.6	-0.5	-0.4
Smoking status: Current	0.2	0.3	0.8	-0.9	0.2	-0.1
Arm fat mass (left)	0.2	1.0	1.6	1.0	1.3	0.6
Wears glasses or contact lenses	0.2	0.2	0.6	-0.8	0.1	-0.1
Hearing aid user	0.2	0.2	0.4	0.4	-0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.5	-0.2	0.5
Pack years of smoking	0.2	0.3	0.6	-0.6	0.1	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.6	-0.3
Depression (Nagel 2018)	0.1	0.1	0.3	-0.0	-0.2	-0.5
Breast Cancer	0.1	0.2	0.3	0.6	0.1	0.4
Fasting Glucose	0.1	0.1	0.2	0.2	-0.4	-0.0
Blood Eosinophil Count	0.1	0.4	0.6	-0.8	0.7	0.5
Respiratory disease	0.1	0.3	0.5	0.5	0.7	0.5
Tanning	0.1	1.0	2.0	-0.6	-0.7	-1.4
Pack years adult smoking proportion	0.1	0.2	0.4	-0.1	0.2	-0.7
Arm fat percentage (right)	0.1	0.4	0.6	-0.8	0.6	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.7	0.1	0.2
Worrier / anxious feelings	0.1	0.3	0.5	0.5	-0.3	-0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.1	-0.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.2	-0.7	-0.0
Asthma	0.1	0.2	0.3	0.5	0.4	0.2
Medication: Lansoprazole	0.1	0.1	0.3	0.0	-0.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.2	0.5	-0.3
Number of full brothers	0.1	0.1	0.3	-0.1	-0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	-0.4	-0.2
Number of children fathered	0.1	0.1	0.3	-0.2	-0.2	-0.5
Health satisfaction	0.1	0.1	0.1	0.3	0.3	-0.3
Arm fat percentage (left)	0.1	0.2	0.7	-0.1	0.8	-0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.0	0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	-0.4	-0.2
Financial situation satisfaction	0.1	0.2	0.3	0.3	0.4	0.5
Number of operations (self-reported)	0.1	0.1	0.3	-0.2	-0.2	-0.6
Risk taking	0.1	0.2	0.5	0.7	-0.1	-0.2
Hair Pigment	0.0	0.6	1.4	0.5	0.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3	-0.3
Depression (self-reported)	0.0	0.0	0.1	0.4	-0.0	-0.0
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.1	0.2	-0.4
Neck or shoulder pain in last month	0.0	0.1	0.1	-0.1	0.3	0.3
Medication: Allopurinol	0.0	0.0	0.1	0.2	-0.1	-0.1
Mood swings	0.0	0.1	0.1	-0.2	-0.4	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.2	-0.1	0.2
Asthma (self-reported)	0.0	0.0	0.0	0.2	0.2	-0.0

Hub : Genes

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Trait associations