Best TWAS P=5.7e-09 · Best GWAS P=2.1e-09 conditioned to 2.17e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | POLI | 0.48 | 0.38 | lasso | 7 | 0.34 | 1.3e-09 | 5.6 | -5.3 | 1.2e-07 | 0.24 | 0.08 | 0.91 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | POLI | 0.31 | 0.35 | lasso | 3 | 0.32 | 4.5e-08 | 5.6 | -5.6 | 2.3e-08 | 0.28 | 0.08 | 0.88 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | POLI | 0.33 | 0.30 | lasso | 5 | 0.34 | 1.0e-11 | 5.6 | -5.1 | 3.0e-07 | 0.25 | 0.08 | 0.91 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | POLI | 0.46 | 0.36 | enet | 18 | 0.36 | 9.9e-28 | 5.6 | -5.1 | 2.7e-07 | 0.24 | 0.09 | 0.91 | FALSE |
| 5 | GTEx | Colon Transverse | POLI | 0.24 | 0.26 | lasso | 4 | 0.25 | 4.5e-12 | 5.6 | -5.3 | 1.3e-07 | 0.28 | 0.09 | 0.91 | FALSE |
| 6 | GTEx | Lung | POLI | 0.39 | 0.31 | lasso | 5 | 0.35 | 2.1e-27 | 5.7 | -5.5 | 4.3e-08 | 0.32 | 0.08 | 0.92 | FALSE |
| 7 | GTEx | Testis | POLI | 0.32 | 0.25 | lasso | 4 | 0.23 | 1.4e-10 | 5.6 | -5.3 | 1.0e-07 | 0.25 | 0.09 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | POLI | 0.18 | 0.12 | lasso | 3 | 0.11 | 8.2e-10 | 5.6 | -5.5 | 2.9e-08 | 0.28 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POLI | 0.11 | 0.11 | lasso | 4 | 0.11 | 2.1e-22 | 5.7 | -5.5 | 4.1e-08 | 0.26 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLI | 0.16 | 0.13 | lasso | 3 | 0.13 | 2.0e-14 | 5.6 | -5.5 | 3.0e-08 | 0.28 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POLI | 0.18 | 0.16 | enet | 4 | 0.16 | 1.4e-17 | 5.6 | -5.3 | 9.8e-08 | 0.25 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | POLI | 0.08 | 0.07 | blup | 43 | 0.08 | 7.1e-10 | 5.7 | -5.5 | 4.4e-08 | 0.28 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POLI | 0.20 | 0.17 | lasso | 4 | 0.14 | 1.6e-06 | 5.6 | -5.6 | 2.5e-08 | 0.28 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLI | 0.16 | 0.17 | lasso | 7 | 0.17 | 3.5e-17 | 5.7 | -5.2 | 1.7e-07 | 0.24 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | POLI | 0.20 | 0.03 | blup | 43 | 0.05 | 3.3e-02 | 5.6 | -5.8 | 5.7e-09 | 0.34 | 0.00 | 0.59 | TRUE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | POLI | 0.10 | 0.07 | lasso | 2 | 0.06 | 2.7e-04 | 5.6 | -5.6 | 2.0e-08 | 0.28 | 0.00 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POLI | 0.13 | 0.11 | enet | 5 | 0.11 | 1.8e-08 | 5.6 | -5.4 | 7.1e-08 | 0.30 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | POLI | 0.14 | 0.05 | lasso | 3 | 0.04 | 1.1e-02 | 5.6 | -5.3 | 1.4e-07 | 0.25 | 0.00 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | POLI | 0.24 | 0.28 | lasso | 2 | 0.28 | 7.3e-27 | 5.7 | -5.6 | 1.7e-08 | 0.28 | 0.00 | 1.00 | FALSE |