Best TWAS P=4.04e-10 · Best GWAS P=4.46e-09 conditioned to 0.0187
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ADAM19 | 0.16 | 0.02 | enet | 17 | 0.06 | 3.0e-05 | -2.8 | 5.3 | 1.4e-07 | 0.48 | 0.73 | 0.19 | FALSE |
| 2 | GTEx | Colon Sigmoid | CYFIP2 | 0.24 | 0.26 | lasso | 5 | 0.24 | 6.2e-09 | 5.1 | 5.1 | 2.9e-07 | 0.71 | 0.09 | 0.90 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ADAM19 | 0.14 | 0.03 | enet | 19 | 0.09 | 2.4e-06 | -4.0 | 6.3 | 4.0e-10 | 0.65 | 0.03 | 0.94 | TRUE |
| 4 | GTEx | Muscle Skeletal | ADAM19 | 0.06 | 0.02 | lasso | 4 | 0.01 | 1.5e-02 | 4.1 | 5.5 | 3.1e-08 | 0.70 | 0.12 | 0.79 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | ADAM19 | 0.10 | 0.01 | lasso | 4 | 0.08 | 5.2e-05 | 4.9 | 6.0 | 2.4e-09 | 0.84 | 0.06 | 0.92 | FALSE |
| 6 | GTEx | Whole Blood | ADAM19 | 0.12 | 0.07 | enet | 20 | 0.07 | 9.8e-07 | 5.4 | 6.0 | 2.5e-09 | 0.86 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAM19 | 0.08 | 0.02 | blup | 159 | 0.03 | 5.3e-04 | 3.1 | 5.5 | 3.5e-08 | 0.63 | 0.12 | 0.26 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADAM19 | 0.09 | 0.03 | lasso | 4 | 0.05 | 2.4e-06 | 4.1 | 5.8 | 5.1e-09 | 0.81 | 0.08 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADAM19 | 0.05 | 0.01 | blup | 159 | 0.03 | 9.5e-04 | -2.7 | 5.2 | 2.6e-07 | 0.59 | 0.06 | 0.30 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ADAM19 | 0.07 | 0.00 | blup | 159 | 0.02 | 2.0e-03 | -4.0 | 5.6 | 1.8e-08 | 0.46 | 0.16 | 0.10 | FALSE |