Best TWAS P=9.19e-09 · Best GWAS P=8.41e-08 conditioned to 0.0676
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SPPL3 | 0.13 | 0.14 | lasso | 5 | 0.14 | 1.2e-10 | 5.1 | 5.1 | 2.9e-07 | -0.68 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Nerve Tibial | SPPL3 | 0.24 | 0.16 | enet | 33 | 0.21 | 4.8e-15 | 4.4 | 5.7 | 9.2e-09 | -0.71 | 0.14 | 0.85 | TRUE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPPL3 | 0.04 | 0.04 | blup | 95 | 0.04 | 3.7e-05 | 4.5 | 5.2 | 2.4e-07 | -0.76 | 0.09 | 0.90 | FALSE |