Best TWAS P=3.8e-14 · Best GWAS P=2.19e-17 conditioned to 0.0545
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | UBAC2 | 0.09 | 0.06 | lasso | 3 | 0.04 | 1.5e-05 | -7.51 | 7.6 | 3.8e-14 | -0.59 | 0.62 | 0.37 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | DOCK9-AS2 | 0.21 | 0.00 | lasso | 5 | -0.01 | 5.2e-01 | -7.43 | -7.3 | 3.8e-13 | 0.51 | 0.07 | 0.06 | FALSE |
| 3 | YFS | Blood | UBAC2 | 0.06 | 0.03 | bslmm | 612 | 0.05 | 2.1e-15 | 4.11 | -6.4 | 1.6e-10 | 0.56 | 0.94 | 0.06 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TM9SF2 | 0.02 | 0.00 | blup | 93 | 0.01 | 4.6e-04 | -4.86 | -5.3 | 1.0e-07 | 0.20 | 0.01 | 0.71 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBAC2 | 0.05 | 0.00 | blup | 118 | 0.02 | 2.8e-04 | -0.57 | -7.3 | 2.2e-13 | 0.49 | 0.15 | 0.18 | TRUE |