[Hub]/) : Traits : Asthma :

chr2:241,941,773-243,048,760

Best TWAS P=3.22e-23 · Best GWAS P=8.64e-24 conditioned to 0.324

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex D2HGDH 0.29 0.12 enet 6 0.14 1.2e-16 -10.1 9.9 3.2e-23 -0.92 0.00 1.00 TRUE
2 GTEx Adipose Subcutaneous D2HGDH 0.43 0.28 lasso 7 0.28 3.0e-23 7.9 8.3 9.9e-17 -0.80 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous AC114730.7 0.42 0.24 lasso 6 0.22 4.9e-18 7.9 8.4 5.6e-17 -0.81 0.99 0.01 FALSE
4 GTEx Adipose Visceral Omentum D2HGDH 0.52 0.26 lasso 4 0.27 2.3e-14 7.9 7.3 2.9e-13 -0.70 0.96 0.04 FALSE
5 GTEx Adipose Visceral Omentum AC114730.7 0.43 0.22 lasso 3 0.23 5.0e-12 7.9 7.6 2.5e-14 -0.73 0.97 0.03 FALSE
6 GTEx Adrenal Gland D2HGDH 0.39 0.32 lasso 1 0.31 1.3e-11 7.9 7.9 2.6e-15 -0.75 0.37 0.63 FALSE
7 GTEx Adrenal Gland AC114730.7 0.29 0.27 lasso 1 0.23 6.8e-09 7.9 7.9 2.6e-15 -0.75 0.59 0.40 FALSE
8 GTEx Adrenal Gland AC093642.3 0.31 0.17 enet 41 0.10 1.8e-04 -4.0 -5.7 1.4e-08 0.38 0.17 0.37 FALSE
9 GTEx Artery Aorta D2HGDH 0.23 0.15 lasso 2 0.15 1.1e-08 7.9 7.7 1.4e-14 -0.75 0.25 0.75 FALSE
10 GTEx Artery Tibial D2HGDH 0.50 0.32 lasso 7 0.31 7.7e-25 7.9 8.0 1.4e-15 -0.75 1.00 0.00 FALSE
11 GTEx Artery Tibial AC114730.8 0.15 0.12 lasso 1 0.12 2.6e-09 7.9 7.9 2.6e-15 -0.75 0.85 0.14 FALSE
12 GTEx Artery Tibial AC114730.7 0.40 0.27 lasso 5 0.26 1.7e-20 7.9 8.0 1.9e-15 -0.75 1.00 0.00 FALSE
13 GTEx Brain Cerebellar Hemisphere AC114730.7 0.54 0.37 lasso 2 0.36 3.5e-10 7.9 8.7 3.8e-18 -0.85 0.15 0.85 FALSE
14 GTEx Brain Cerebellum D2HGDH 0.55 0.32 lasso 5 0.29 2.9e-09 7.9 8.3 7.4e-17 -0.77 0.41 0.58 FALSE
15 GTEx Brain Cerebellum AC114730.7 0.58 0.40 lasso 5 0.42 6.9e-14 7.9 8.2 1.9e-16 -0.77 0.68 0.32 FALSE
16 GTEx Brain Cortex D2HGDH 0.56 0.31 enet 26 0.38 1.9e-11 7.9 7.0 3.3e-12 -0.78 0.03 0.97 TRUE
17 GTEx Brain Cortex AC114730.7 0.42 0.30 enet 22 0.33 8.3e-10 7.9 6.7 1.7e-11 -0.68 0.28 0.66 FALSE
18 GTEx Brain Frontal Cortex BA9 D2HGDH 0.42 0.23 lasso 4 0.26 1.7e-07 7.9 9.2 2.8e-20 -0.90 0.01 0.98 FALSE
19 GTEx Brain Frontal Cortex BA9 AC114730.7 0.36 0.22 lasso 4 0.19 1.2e-05 7.9 8.1 5.0e-16 -0.75 0.28 0.43 FALSE
20 GTEx Brain Hypothalamus D2HGDH 0.64 0.24 lasso 10 0.16 1.1e-04 8.0 7.8 4.1e-15 -0.74 0.10 0.85 FALSE
21 GTEx Brain Hypothalamus AC114730.7 0.55 0.21 enet 17 0.22 8.6e-06 8.0 8.2 2.0e-16 -0.73 0.18 0.39 FALSE
22 GTEx Brain Nucleus accumbens basal ganglia D2HGDH 0.54 0.43 lasso 1 0.41 3.3e-12 7.9 7.9 2.6e-15 -0.75 0.70 0.30 FALSE
23 GTEx Brain Nucleus accumbens basal ganglia AC114730.7 0.42 0.25 lasso 4 0.26 1.2e-07 7.9 8.0 1.6e-15 -0.76 0.54 0.31 FALSE
24 GTEx Brain Putamen basal ganglia D2HGDH 0.46 0.20 enet 15 0.30 6.7e-08 7.9 8.1 4.4e-16 -0.73 0.01 0.95 FALSE
25 GTEx Brain Putamen basal ganglia AC114730.7 0.39 0.24 enet 24 0.26 6.4e-07 7.9 7.5 5.7e-14 -0.62 0.04 0.86 FALSE
26 GTEx Breast Mammary Tissue D2HGDH 0.31 0.19 enet 5 0.19 2.8e-10 7.9 7.8 4.9e-15 -0.76 0.99 0.01 FALSE
27 GTEx Breast Mammary Tissue AC114730.7 0.27 0.18 enet 8 0.18 1.9e-09 7.9 8.0 1.0e-15 -0.75 0.98 0.02 FALSE
28 GTEx Breast Mammary Tissue (Male) D2HGDH 0.43 0.24 lasso 6 0.20 1.9e-05 7.9 8.9 4.4e-19 -0.83 0.02 0.89 FALSE
29 GTEx Breast Mammary Tissue (Male) AC114730.7 0.30 0.17 lasso 3 0.20 2.8e-05 7.9 9.1 6.7e-20 -0.88 0.01 0.92 FALSE
30 GTEx Cells EBV-transformed lymphocytes D2HGDH 0.23 0.26 lasso 1 0.24 1.9e-08 7.9 7.9 2.6e-15 -0.75 0.35 0.57 FALSE
31 GTEx Cells Transformed fibroblasts D2HGDH 0.44 0.27 lasso 11 0.30 1.2e-22 7.9 9.1 9.7e-20 -0.86 0.97 0.03 FALSE
32 GTEx Cells Transformed fibroblasts AC114730.8 0.32 0.12 lasso 4 0.16 4.5e-12 8.0 9.6 5.2e-22 -0.89 0.01 0.99 FALSE
33 GTEx Cells Transformed fibroblasts AC114730.7 0.27 0.17 lasso 4 0.16 3.6e-12 7.9 7.9 3.6e-15 -0.77 0.99 0.01 FALSE
34 GTEx Colon Transverse D2HGDH 0.48 0.27 lasso 4 0.25 2.8e-12 8.0 8.7 3.0e-18 -0.80 0.34 0.66 FALSE
35 GTEx Colon Transverse AC114730.7 0.53 0.26 enet 26 0.24 1.1e-11 8.0 7.9 3.9e-15 -0.71 0.78 0.22 FALSE
36 GTEx Esophagus Mucosa D2HGDH 0.34 0.21 enet 7 0.22 8.7e-15 8.0 8.3 9.0e-17 -0.82 0.61 0.39 FALSE
37 GTEx Esophagus Mucosa AC114730.7 0.31 0.18 enet 6 0.18 2.3e-12 7.9 8.5 1.6e-17 -0.81 0.38 0.62 FALSE
38 GTEx Esophagus Muscularis D2HGDH 0.21 0.19 lasso 2 0.18 7.0e-11 7.9 7.9 2.6e-15 -0.75 0.94 0.06 FALSE
39 GTEx Heart Left Ventricle D2HGDH 0.23 0.12 enet 14 0.17 3.7e-09 7.9 8.0 1.0e-15 -0.83 0.02 0.98 FALSE
40 GTEx Muscle Skeletal D2HGDH 0.26 0.11 lasso 2 0.14 3.0e-13 -10.1 9.8 1.2e-22 -0.94 0.00 1.00 FALSE
41 GTEx Muscle Skeletal AC114730.7 0.17 0.09 lasso 2 0.09 9.5e-09 8.0 8.0 8.7e-16 -0.75 0.86 0.14 FALSE
42 GTEx Nerve Tibial AC114730.8 0.26 0.10 lasso 4 0.07 1.0e-05 7.9 8.1 6.2e-16 -0.76 0.27 0.71 FALSE
43 GTEx Pancreas D2HGDH 0.48 0.32 lasso 11 0.31 1.4e-13 7.9 8.1 8.2e-16 -0.74 0.77 0.23 FALSE
44 GTEx Pancreas AC114730.8 0.20 0.15 lasso 3 0.14 1.7e-06 7.9 8.1 5.0e-16 -0.73 0.07 0.81 FALSE
45 GTEx Pancreas AC114730.7 0.36 0.25 lasso 4 0.25 6.4e-11 7.9 7.7 1.8e-14 -0.73 0.71 0.29 FALSE
46 GTEx Pituitary D2HGDH 0.42 0.30 enet 27 0.28 8.7e-08 7.9 6.6 3.9e-11 -0.66 0.31 0.54 FALSE
47 GTEx Pituitary AC114730.7 0.49 0.32 enet 20 0.34 1.7e-09 7.9 6.1 1.1e-09 -0.63 0.36 0.55 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic D2HGDH 0.37 0.17 lasso 2 0.18 6.1e-10 7.9 7.9 2.4e-15 -0.76 0.95 0.05 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic AC114730.7 0.35 0.19 lasso 2 0.18 5.3e-10 7.9 7.9 2.5e-15 -0.75 0.96 0.04 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic AC114730.11 0.19 0.13 lasso 6 0.12 3.0e-07 -4.0 -5.7 1.6e-08 0.39 0.83 0.12 FALSE
51 GTEx Skin Sun Exposed Lower leg ING5 0.14 0.12 enet 7 0.12 6.1e-10 -4.0 -5.8 8.4e-09 0.40 1.00 0.00 FALSE
52 GTEx Skin Sun Exposed Lower leg D2HGDH 0.38 0.25 lasso 6 0.25 1.3e-20 7.9 8.0 1.6e-15 -0.78 1.00 0.00 FALSE
53 GTEx Skin Sun Exposed Lower leg AC114730.7 0.35 0.28 lasso 3 0.28 6.2e-23 7.9 7.7 1.5e-14 -0.75 1.00 0.00 FALSE
54 GTEx Spleen ING5 0.49 0.20 lasso 8 0.20 9.7e-06 -4.0 -6.6 5.0e-11 0.44 0.15 0.11 TRUE
55 GTEx Spleen AC114730.7 0.31 0.22 lasso 3 0.20 6.3e-06 7.9 7.9 2.3e-15 -0.76 0.16 0.48 FALSE
56 GTEx Testis D2HGDH 0.64 0.39 enet 20 0.42 4.5e-20 7.9 7.3 2.7e-13 -0.72 0.99 0.01 FALSE
57 GTEx Testis AC114730.8 0.18 0.04 enet 57 0.03 2.1e-02 7.9 7.1 1.4e-12 -0.45 0.01 0.87 FALSE
58 GTEx Testis AC114730.7 0.53 0.30 enet 17 0.29 3.3e-13 7.9 7.4 1.4e-13 -0.71 0.99 0.01 FALSE
59 GTEx Thyroid D2HGDH 0.42 0.30 lasso 5 0.30 2.3e-23 7.9 7.8 4.6e-15 -0.75 1.00 0.00 FALSE
60 GTEx Thyroid AC114730.8 0.17 0.10 lasso 2 0.10 2.6e-08 7.9 8.0 1.6e-15 -0.75 0.94 0.05 FALSE
61 GTEx Thyroid AC114730.7 0.35 0.26 lasso 3 0.26 5.0e-20 7.9 7.9 3.6e-15 -0.75 1.00 0.00 FALSE
62 GTEx Uterus AC093642.3 0.35 -0.01 enet 25 0.07 1.8e-02 -3.3 -7.7 1.3e-14 0.46 0.02 0.28 FALSE
63 GTEx Whole Blood D2HGDH 0.12 0.08 lasso 3 0.08 5.7e-08 8.0 8.8 1.9e-18 -0.81 0.09 0.91 FALSE
64 GTEx Whole Blood AC114730.7 0.11 0.08 lasso 3 0.08 4.1e-08 7.9 8.5 2.6e-17 -0.80 0.12 0.88 FALSE
65 METSIM Adipose PDCD1 0.05 0.00 blup 171 0.02 1.9e-03 -10.1 -6.9 7.1e-12 0.44 0.00 0.92 FALSE
66 ROSMAP Brain Pre-frontal Cortex GAL3ST2 0.10 0.09 lasso 1 0.08 5.8e-11 8.0 -8.0 1.8e-15 0.73 1.00 0.00 FALSE
67 ROSMAP Brain Pre-frontal Cortex D2HGDH 0.44 0.33 lasso 6 0.35 2.1e-46 8.0 8.5 1.7e-17 -0.74 1.00 0.00 FALSE
68 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GAL3ST2 0.05 0.00 enet 7 0.03 8.1e-05 8.0 -6.6 5.3e-11 0.52 0.01 0.64 FALSE
69 The Cancer Genome Atlas Lung Squamous Cell Carcinoma D2HGDH 0.06 0.02 blup 28 0.04 1.3e-05 -10.1 8.8 1.6e-18 -0.86 0.00 1.00 FALSE
70 The Cancer Genome Atlas Prostate Adenocarcinoma D2HGDH 0.08 0.03 blup 28 0.04 4.6e-05 8.0 6.1 9.0e-10 -0.52 0.01 0.70 FALSE
71 The Cancer Genome Atlas Prostate Adenocarcinoma GAL3ST2 0.03 0.03 enet 3 0.03 8.9e-04 8.0 -8.1 7.9e-16 0.76 0.03 0.75 FALSE