Best TWAS P=8.36e-62 · Best GWAS P=5.11e-51 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IL1R1 | 0.14 | 0.09 | lasso | 3 | 0.10 | 4.0e-12 | -5.0 | 5.4 | 6.3e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC9A2 | 0.17 | 0.10 | lasso | 4 | 0.11 | 4.7e-13 | 7.2 | 7.1 | 1.2e-12 | -0.23 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Colon Transverse | IL18R1 | 0.14 | 0.00 | enet | 41 | 0.00 | 2.1e-01 | 3.9 | 11.7 | 1.8e-31 | -0.40 | 0.04 | 0.48 | TRUE |
| 4 | GTEx | Whole Blood | IL18R1 | 0.06 | 0.00 | enet | 14 | 0.01 | 2.1e-02 | -12.6 | 7.0 | 2.8e-12 | -0.24 | 0.17 | 0.05 | FALSE |
| 5 | NTR | Blood | IL18RAP | 0.14 | 0.16 | lasso | 7 | 0.19 | 1.1e-59 | 10.1 | -6.4 | 1.9e-10 | 0.26 | 1.00 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | IL1RL2 | 0.08 | 0.02 | enet | 33 | 0.03 | 2.3e-04 | 7.4 | -9.7 | 2.5e-22 | 0.48 | 0.17 | 0.18 | FALSE |
| 7 | YFS | Blood | IL18RAP | 0.41 | 0.55 | bslmm | 562 | 0.62 | 4.2e-269 | 10.1 | -7.0 | 1.8e-12 | 0.32 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL1RL1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 8.1e-04 | -12.6 | -12.9 | 4.7e-38 | 0.50 | 0.24 | 0.12 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL18R1 | 0.05 | 0.01 | blup | 108 | 0.03 | 1.8e-07 | -12.6 | 8.1 | 4.6e-16 | -0.08 | 0.99 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL1RL1 | 0.02 | 0.01 | blup | 78 | 0.01 | 1.5e-03 | 12.2 | -13.3 | 1.5e-40 | 0.63 | 0.15 | 0.24 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL1RL1 | 0.04 | 0.04 | lasso | 8 | 0.04 | 1.7e-05 | -15.0 | -16.0 | 6.0e-58 | 0.91 | 0.01 | 0.99 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL18R1 | 0.06 | 0.01 | blup | 108 | 0.04 | 2.6e-05 | -1.7 | -7.0 | 1.7e-12 | 0.63 | 0.02 | 0.85 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL18RAP | 0.03 | 0.02 | blup | 94 | 0.02 | 1.2e-03 | -12.6 | 13.2 | 1.2e-39 | -0.61 | 0.02 | 0.77 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL1 | 0.08 | 0.08 | enet | 9 | 0.08 | 1.2e-09 | -15.0 | -16.4 | 1.2e-60 | 0.95 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.9e-04 | -11.7 | -12.0 | 2.7e-33 | 0.70 | 0.06 | 0.41 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IL1RL1 | 0.18 | 0.06 | blup | 78 | 0.15 | 3.7e-09 | 12.2 | -16.0 | 1.7e-57 | 0.83 | 0.02 | 0.98 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL1RL1 | 0.03 | 0.01 | blup | 78 | 0.02 | 4.7e-03 | -14.3 | -16.6 | 8.4e-62 | 0.84 | 0.01 | 0.95 | TRUE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IL1RL1 | 0.19 | 0.05 | blup | 78 | 0.10 | 7.1e-05 | 12.4 | -15.0 | 4.7e-51 | 0.62 | 0.12 | 0.69 | TRUE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IL1R1 | 0.36 | 0.19 | enet | 28 | 0.23 | 1.1e-23 | -10.4 | 7.7 | 1.9e-14 | -0.51 | 0.68 | 0.32 | TRUE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | IL1RL1 | 0.05 | 0.03 | enet | 6 | 0.03 | 9.7e-04 | -15.0 | -15.1 | 1.5e-51 | 0.98 | 0.00 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A2 | 0.05 | 0.01 | blup | 93 | 0.02 | 8.6e-03 | 5.9 | 6.6 | 3.6e-11 | -0.17 | 0.02 | 0.78 | TRUE |