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chr2:241,978,472-243,048,760

Best TWAS P=1.16e-19 · Best GWAS P=1.78e-20 conditioned to 0.296

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	D2HGDH	0.29	0.12	enet	6	0.14	1.2e-16	-9.3	9.1	1.2e-19	-0.92	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	D2HGDH	0.43	0.28	lasso	7	0.28	3.0e-23	6.7	7.0	2.7e-12	-0.80	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC114730.7	0.42	0.24	lasso	6	0.22	4.9e-18	6.7	7.0	3.1e-12	-0.81	0.99	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	D2HGDH	0.52	0.26	lasso	4	0.27	2.3e-14	6.7	6.0	2.3e-09	-0.70	0.96	0.04	FALSE
5	GTEx	Adipose Visceral Omentum	AC114730.7	0.43	0.22	lasso	3	0.23	5.0e-12	6.7	6.3	2.1e-10	-0.73	0.97	0.03	FALSE
6	GTEx	Adrenal Gland	D2HGDH	0.39	0.32	lasso	1	0.31	1.3e-11	6.7	6.7	1.8e-11	-0.75	0.37	0.63	FALSE
7	GTEx	Adrenal Gland	AC114730.7	0.29	0.27	lasso	1	0.23	6.8e-09	6.7	6.7	1.8e-11	-0.75	0.59	0.40	FALSE
8	GTEx	Adrenal Gland	AC093642.3	0.31	0.17	enet	41	0.10	1.8e-04	-5.1	-6.9	4.5e-12	0.38	0.17	0.37	FALSE
9	GTEx	Artery Aorta	D2HGDH	0.23	0.15	lasso	2	0.15	1.1e-08	6.7	6.4	1.4e-10	-0.75	0.25	0.75	FALSE
10	GTEx	Artery Tibial	D2HGDH	0.50	0.32	lasso	7	0.31	7.7e-25	6.7	6.8	1.5e-11	-0.75	1.00	0.00	FALSE
11	GTEx	Artery Tibial	AC114730.8	0.15	0.12	lasso	1	0.12	2.6e-09	6.7	6.7	1.8e-11	-0.75	0.85	0.14	FALSE
12	GTEx	Artery Tibial	AC114730.7	0.40	0.27	lasso	5	0.26	1.7e-20	6.7	6.8	1.1e-11	-0.75	1.00	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	AC114730.7	0.54	0.37	lasso	2	0.36	3.5e-10	6.4	7.3	2.0e-13	-0.85	0.15	0.85	FALSE
14	GTEx	Brain Cerebellum	D2HGDH	0.55	0.32	lasso	5	0.29	2.9e-09	6.4	6.7	1.8e-11	-0.77	0.41	0.58	FALSE
15	GTEx	Brain Cerebellum	AC114730.7	0.58	0.40	lasso	5	0.42	6.9e-14	6.4	6.5	7.0e-11	-0.77	0.68	0.32	FALSE
16	GTEx	Brain Cortex	D2HGDH	0.56	0.31	enet	26	0.38	1.9e-11	6.4	6.5	7.2e-11	-0.78	0.03	0.97	FALSE
17	GTEx	Brain Cortex	AC114730.7	0.42	0.30	enet	22	0.33	8.3e-10	6.7	6.8	1.5e-11	-0.68	0.28	0.66	FALSE
18	GTEx	Brain Frontal Cortex BA9	D2HGDH	0.42	0.23	lasso	4	0.26	1.7e-07	6.4	7.9	3.9e-15	-0.90	0.01	0.98	FALSE
19	GTEx	Brain Frontal Cortex BA9	AC114730.7	0.36	0.22	lasso	4	0.19	1.2e-05	6.4	6.4	1.2e-10	-0.75	0.28	0.43	FALSE
20	GTEx	Brain Hypothalamus	D2HGDH	0.64	0.24	lasso	10	0.16	1.1e-04	7.2	6.9	4.2e-12	-0.74	0.10	0.85	FALSE
21	GTEx	Brain Hypothalamus	AC114730.7	0.55	0.21	enet	17	0.22	8.6e-06	7.2	6.9	4.6e-12	-0.73	0.18	0.39	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	D2HGDH	0.54	0.43	lasso	1	0.41	3.3e-12	6.7	6.7	1.8e-11	-0.75	0.70	0.30	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	AC114730.7	0.42	0.25	lasso	4	0.26	1.2e-07	6.7	6.7	2.9e-11	-0.76	0.54	0.31	FALSE
24	GTEx	Brain Putamen basal ganglia	D2HGDH	0.46	0.20	enet	15	0.30	6.7e-08	6.7	6.1	1.0e-09	-0.73	0.01	0.95	FALSE
25	GTEx	Brain Putamen basal ganglia	AC114730.7	0.39	0.24	enet	24	0.26	6.4e-07	6.4	5.1	2.8e-07	-0.62	0.04	0.86	FALSE
26	GTEx	Breast Mammary Tissue	D2HGDH	0.31	0.19	enet	5	0.19	2.8e-10	6.7	6.4	1.3e-10	-0.76	0.99	0.01	FALSE
27	GTEx	Breast Mammary Tissue	AC114730.7	0.27	0.18	enet	8	0.18	1.9e-09	6.7	6.4	1.5e-10	-0.75	0.98	0.02	FALSE
28	GTEx	Breast Mammary Tissue (Male)	D2HGDH	0.43	0.24	lasso	6	0.20	1.9e-05	6.7	7.5	5.0e-14	-0.83	0.02	0.89	FALSE
29	GTEx	Breast Mammary Tissue (Male)	AC114730.7	0.30	0.17	lasso	3	0.20	2.8e-05	6.7	8.0	1.2e-15	-0.88	0.01	0.92	FALSE
30	GTEx	Cells EBV-transformed lymphocytes	D2HGDH	0.23	0.26	lasso	1	0.24	1.9e-08	6.7	6.7	1.8e-11	-0.75	0.35	0.57	FALSE
31	GTEx	Cells Transformed fibroblasts	D2HGDH	0.44	0.27	lasso	11	0.30	1.2e-22	6.4	7.6	2.1e-14	-0.86	0.97	0.03	FALSE
32	GTEx	Cells Transformed fibroblasts	AC114730.8	0.32	0.12	lasso	4	0.16	4.5e-12	7.2	8.5	1.4e-17	-0.89	0.01	0.99	FALSE
33	GTEx	Cells Transformed fibroblasts	AC114730.7	0.27	0.17	lasso	4	0.16	3.6e-12	6.4	6.5	1.0e-10	-0.77	0.99	0.01	TRUE
34	GTEx	Colon Transverse	D2HGDH	0.48	0.27	lasso	4	0.25	2.8e-12	7.2	7.8	5.1e-15	-0.80	0.34	0.66	FALSE
35	GTEx	Colon Transverse	AC114730.7	0.53	0.26	enet	26	0.24	1.1e-11	7.2	6.2	6.4e-10	-0.71	0.78	0.22	FALSE
36	GTEx	Esophagus Mucosa	D2HGDH	0.34	0.21	enet	7	0.22	8.7e-15	7.2	7.2	8.3e-13	-0.82	0.61	0.39	FALSE
37	GTEx	Esophagus Mucosa	AC114730.7	0.31	0.18	enet	6	0.18	2.3e-12	6.7	7.4	1.0e-13	-0.81	0.38	0.62	FALSE
38	GTEx	Esophagus Muscularis	D2HGDH	0.21	0.19	lasso	2	0.18	7.0e-11	6.7	6.7	1.8e-11	-0.75	0.94	0.06	FALSE
39	GTEx	Heart Left Ventricle	D2HGDH	0.23	0.12	enet	14	0.17	3.7e-09	6.7	7.5	8.1e-14	-0.83	0.02	0.98	FALSE
40	GTEx	Muscle Skeletal	D2HGDH	0.26	0.11	lasso	2	0.14	3.0e-13	-9.3	9.0	3.3e-19	-0.94	0.00	1.00	FALSE
41	GTEx	Muscle Skeletal	AC114730.7	0.17	0.09	lasso	2	0.09	9.5e-09	7.2	7.1	1.1e-12	-0.75	0.86	0.14	FALSE
42	GTEx	Nerve Tibial	AC114730.8	0.26	0.10	lasso	4	0.07	1.0e-05	6.7	7.0	2.3e-12	-0.76	0.27	0.71	FALSE
43	GTEx	Pancreas	D2HGDH	0.48	0.32	lasso	11	0.31	1.4e-13	6.7	7.1	1.6e-12	-0.74	0.77	0.23	FALSE
44	GTEx	Pancreas	AC114730.8	0.20	0.15	lasso	3	0.14	1.7e-06	6.7	6.8	1.3e-11	-0.73	0.07	0.81	FALSE
45	GTEx	Pancreas	AC114730.7	0.36	0.25	lasso	4	0.25	6.4e-11	6.7	6.4	1.2e-10	-0.73	0.71	0.29	FALSE
46	GTEx	Pituitary	D2HGDH	0.42	0.30	enet	27	0.28	8.7e-08	6.4	5.4	7.8e-08	-0.66	0.31	0.54	FALSE
47	GTEx	Pituitary	AC114730.7	0.49	0.32	enet	20	0.34	1.7e-09	6.4	5.2	2.4e-07	-0.63	0.36	0.55	FALSE
48	GTEx	Prostate	RP11-341N2.1	0.42	0.10	enet	22	0.30	2.1e-08	-2.9	-5.1	2.7e-07	0.38	0.06	0.09	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	D2HGDH	0.37	0.17	lasso	2	0.18	6.1e-10	6.7	6.7	2.5e-11	-0.76	0.95	0.05	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	AC114730.7	0.35	0.19	lasso	2	0.18	5.3e-10	6.7	6.7	2.0e-11	-0.75	0.96	0.04	FALSE
51	GTEx	Skin Sun Exposed Lower leg	D2HGDH	0.38	0.25	lasso	6	0.25	1.3e-20	6.7	6.8	1.4e-11	-0.78	1.00	0.00	FALSE
52	GTEx	Skin Sun Exposed Lower leg	AC114730.7	0.35	0.28	lasso	3	0.28	6.2e-23	6.7	6.4	2.0e-10	-0.75	1.00	0.00	FALSE
53	GTEx	Spleen	AC114730.7	0.31	0.22	lasso	3	0.20	6.3e-06	6.7	6.6	3.9e-11	-0.76	0.16	0.48	FALSE
54	GTEx	Testis	D2HGDH	0.64	0.39	enet	20	0.42	4.5e-20	6.7	6.4	2.0e-10	-0.72	0.99	0.01	FALSE
55	GTEx	Testis	AC114730.8	0.18	0.04	enet	57	0.03	2.1e-02	6.7	5.2	1.7e-07	-0.45	0.01	0.87	FALSE
56	GTEx	Testis	AC114730.7	0.53	0.30	enet	17	0.29	3.3e-13	6.7	6.5	1.2e-10	-0.71	0.99	0.01	FALSE
57	GTEx	Thyroid	D2HGDH	0.42	0.30	lasso	5	0.30	2.3e-23	6.7	6.7	2.7e-11	-0.75	1.00	0.00	FALSE
58	GTEx	Thyroid	AC114730.8	0.17	0.10	lasso	2	0.10	2.6e-08	6.7	6.7	1.8e-11	-0.75	0.94	0.05	FALSE
59	GTEx	Thyroid	AC114730.7	0.35	0.26	lasso	3	0.26	5.0e-20	6.7	6.8	1.3e-11	-0.75	1.00	0.00	FALSE
60	GTEx	Uterus	AC093642.3	0.35	-0.01	enet	25	0.07	1.8e-02	-4.7	-7.5	7.6e-14	0.46	0.02	0.28	FALSE
61	GTEx	Whole Blood	D2HGDH	0.12	0.08	lasso	3	0.08	5.7e-08	7.2	7.8	7.7e-15	-0.81	0.09	0.91	FALSE
62	GTEx	Whole Blood	AC114730.7	0.11	0.08	lasso	3	0.08	4.1e-08	6.7	7.4	1.8e-13	-0.80	0.12	0.88	FALSE
63	METSIM	Adipose	PDCD1	0.05	0.00	blup	171	0.02	1.9e-03	-9.3	-5.5	5.0e-08	0.44	0.00	0.92	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	GAL3ST2	0.10	0.09	lasso	1	0.08	5.8e-11	7.2	-7.2	7.0e-13	0.73	1.00	0.00	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	D2HGDH	0.44	0.33	lasso	6	0.35	2.1e-46	7.2	7.1	1.1e-12	-0.74	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GAL3ST2	0.05	0.00	enet	7	0.03	8.1e-05	7.2	-5.1	3.0e-07	0.52	0.01	0.64	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	D2HGDH	0.06	0.02	blup	28	0.04	1.3e-05	-9.3	6.4	1.4e-10	-0.86	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAL3ST2	0.03	0.03	enet	3	0.03	8.9e-04	7.2	-7.0	3.0e-12	0.76	0.03	0.75	FALSE