Best TWAS P=2.54e-12 · Best GWAS P=2.17e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC15A2 | 0.07 | 0.08 | lasso | 6 | 0.08 | 1.7e-09 | 5.2 | -5.3 | 9.8e-08 | 0.53 | 0.98 | 0.02 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SLC15A2 | 0.17 | 0.03 | lasso | 15 | 0.02 | 9.7e-02 | -6.8 | -7.0 | 2.5e-12 | 0.99 | 0.04 | 0.86 | TRUE |
3 | GTEx | Brain Cerebellum | SLC15A2 | 0.33 | 0.47 | lasso | 18 | 0.44 | 1.8e-14 | -6.9 | -6.9 | 5.3e-12 | 1.00 | 0.03 | 0.97 | FALSE |
4 | GTEx | Breast Mammary Tissue | IQCB1 | 0.36 | 0.22 | enet | 23 | 0.33 | 2.3e-17 | -4.9 | -5.3 | 1.4e-07 | 0.47 | 1.00 | 0.00 | FALSE |
5 | GTEx | Esophagus Muscularis | SLC15A2 | 0.12 | 0.01 | enet | 19 | 0.04 | 2.7e-03 | -6.3 | -6.3 | 2.9e-10 | 0.68 | 0.06 | 0.87 | FALSE |
6 | GTEx | Heart Atrial Appendage | SLC15A2 | 0.23 | 0.25 | lasso | 14 | 0.24 | 2.3e-11 | -7.0 | -6.8 | 8.4e-12 | 1.00 | 0.03 | 0.97 | FALSE |
7 | GTEx | Heart Left Ventricle | SLC15A2 | 0.16 | 0.19 | lasso | 6 | 0.20 | 8.6e-11 | -6.9 | -6.8 | 1.2e-11 | 0.99 | 0.03 | 0.97 | FALSE |
8 | GTEx | Liver | EAF2 | 0.16 | 0.06 | enet | 32 | 0.07 | 5.4e-03 | -6.3 | -5.9 | 3.0e-09 | 0.66 | 0.07 | 0.51 | FALSE |
9 | GTEx | Muscle Skeletal | EAF2 | 0.05 | 0.04 | lasso | 6 | 0.02 | 1.5e-03 | -5.3 | -5.6 | 2.2e-08 | 0.61 | 0.07 | 0.68 | FALSE |
10 | GTEx | Muscle Skeletal | SLC15A2 | 0.11 | 0.05 | enet | 43 | 0.07 | 8.4e-08 | -7.0 | -5.3 | 1.3e-07 | 0.83 | 0.03 | 0.97 | FALSE |
11 | GTEx | Nerve Tibial | SLC15A2 | 0.08 | 0.10 | lasso | 8 | 0.07 | 8.0e-06 | -6.9 | -6.5 | 7.2e-11 | 0.99 | 0.03 | 0.97 | FALSE |
12 | GTEx | Spleen | IQCB1 | 0.29 | 0.08 | enet | 18 | 0.12 | 6.9e-04 | -4.9 | -5.1 | 3.0e-07 | 0.43 | 0.08 | 0.20 | FALSE |
13 | GTEx | Whole Blood | IQCB1 | 0.14 | 0.04 | enet | 36 | 0.07 | 2.6e-07 | 5.1 | -5.4 | 6.5e-08 | 0.53 | 0.96 | 0.03 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EAF2 | 0.05 | 0.01 | blup | 70 | 0.04 | 3.3e-05 | -7.0 | -5.6 | 2.3e-08 | 0.78 | 0.03 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | ILDR1 | 0.06 | 0.00 | blup | 48 | 0.02 | 3.5e-03 | 5.0 | 5.7 | 1.2e-08 | -0.62 | 0.01 | 0.54 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC15A2 | 0.06 | 0.04 | blup | 73 | 0.05 | 8.0e-06 | 4.9 | 6.8 | 1.3e-11 | -0.80 | 0.10 | 0.88 | FALSE |