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chr3:120,799,666-122,356,172

Best TWAS P=2.54e-12 · Best GWAS P=2.17e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Brain Cerebellar Hemisphere	SLC15A2	0.17	0.03	lasso	15	0.02	9.7e-02	-6.8	-7.0	2.5e-12	0.99	0.04	0.86	TRUE
3	GTEx	Brain Cerebellum	SLC15A2	0.33	0.47	lasso	18	0.44	1.8e-14	-6.9	-6.9	5.3e-12	1.00	0.03	0.97	FALSE
6	GTEx	Heart Atrial Appendage	SLC15A2	0.23	0.25	lasso	14	0.24	2.3e-11	-7.0	-6.8	8.4e-12	1.00	0.03	0.97	FALSE
7	GTEx	Heart Left Ventricle	SLC15A2	0.16	0.19	lasso	6	0.20	8.6e-11	-6.9	-6.8	1.2e-11	0.99	0.03	0.97	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	SLC15A2	0.06	0.04	blup	73	0.05	8.0e-06	4.9	6.8	1.3e-11	-0.80	0.10	0.88	FALSE
11	GTEx	Nerve Tibial	SLC15A2	0.08	0.10	lasso	8	0.07	8.0e-06	-6.9	-6.5	7.2e-11	0.99	0.03	0.97	FALSE
5	GTEx	Esophagus Muscularis	SLC15A2	0.12	0.01	enet	19	0.04	2.7e-03	-6.3	-6.3	2.9e-10	0.68	0.06	0.87	FALSE
8	GTEx	Liver	EAF2	0.16	0.06	enet	32	0.07	5.4e-03	-6.3	-5.9	3.0e-09	0.66	0.07	0.51	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	ILDR1	0.06	0.00	blup	48	0.02	3.5e-03	5.0	5.7	1.2e-08	-0.62	0.01	0.54	FALSE
9	GTEx	Muscle Skeletal	EAF2	0.05	0.04	lasso	6	0.02	1.5e-03	-5.3	-5.6	2.2e-08	0.61	0.07	0.68	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	EAF2	0.05	0.01	blup	70	0.04	3.3e-05	-7.0	-5.6	2.3e-08	0.78	0.03	0.96	FALSE
13	GTEx	Whole Blood	IQCB1	0.14	0.04	enet	36	0.07	2.6e-07	5.1	-5.4	6.5e-08	0.53	0.96	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SLC15A2	0.07	0.08	lasso	6	0.08	1.7e-09	5.2	-5.3	9.8e-08	0.53	0.98	0.02	FALSE
10	GTEx	Muscle Skeletal	SLC15A2	0.11	0.05	enet	43	0.07	8.4e-08	-7.0	-5.3	1.3e-07	0.83	0.03	0.97	FALSE
4	GTEx	Breast Mammary Tissue	IQCB1	0.36	0.22	enet	23	0.33	2.3e-17	-4.9	-5.3	1.4e-07	0.47	1.00	0.00	FALSE
12	GTEx	Spleen	IQCB1	0.29	0.08	enet	18	0.12	6.9e-04	-4.9	-5.1	3.0e-07	0.43	0.08	0.20	FALSE