Best TWAS P=7.41e-10 · Best GWAS P=1.05e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 5.7 | -5.3 | 1.1e-07 | -0.89 | 0.13 | 0.85 | FALSE |
| 2 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 5.8 | -5.7 | 1.4e-08 | -0.95 | 0.04 | 0.93 | FALSE |
| 3 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | 4.7 | -5.3 | 1.4e-07 | -0.40 | 0.05 | 0.62 | FALSE |
| 4 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 6.1 | -6.2 | 7.4e-10 | -0.96 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | -4.8 | -5.3 | 1.5e-07 | -0.53 | 0.41 | 0.55 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK6 | 0.06 | 0.01 | blup | 87 | 0.04 | 1.0e-04 | -4.8 | -6.1 | 1.2e-09 | -0.72 | 0.01 | 0.97 | FALSE |