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chr22:21,075,537-22,685,340

Best TWAS P=2.8e-09 · Best GWAS P=2.71e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	CCDC116	0.14	0.15	lasso	5	0.14	2.7e-11	5.9	-5.9	2.8e-09	-1.00	0.02	0.98	TRUE
20	YFS	Blood	UBE2L3	0.13	0.25	bslmm	330	0.25	1.3e-82	5.8	5.9	2.9e-09	1.00	0.02	0.98	FALSE
17	GTEx	Thyroid	CCDC116	0.10	0.07	lasso	4	0.07	3.7e-06	5.9	-5.9	3.2e-09	-1.00	0.02	0.98	FALSE
18	GTEx	Thyroid	HIC2	0.07	0.00	lasso	4	0.00	5.9e-01	5.9	5.9	3.7e-09	1.00	0.03	0.65	FALSE
15	GTEx	Nerve Tibial	CCDC116	0.22	0.25	enet	9	0.29	1.8e-20	5.9	-5.9	4.0e-09	-1.00	0.02	0.98	FALSE
11	GTEx	Esophagus Mucosa	CCDC116	0.10	0.06	lasso	4	0.06	8.7e-05	5.9	-5.9	4.4e-09	-1.00	0.03	0.97	FALSE
8	GTEx	Brain Cortex	CCDC116	0.17	0.17	lasso	2	0.15	7.3e-05	5.9	-5.9	4.5e-09	-0.99	0.02	0.93	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC116	0.11	0.14	enet	14	0.12	2.3e-05	5.8	-5.9	4.5e-09	-1.00	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC116	0.09	0.05	lasso	3	0.03	1.4e-02	5.8	-5.9	4.9e-09	-1.00	0.03	0.95	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC116	0.10	0.06	blup	39	0.07	4.4e-03	5.6	-5.8	5.2e-09	-0.97	0.01	0.82	FALSE
12	GTEx	Esophagus Muscularis	CCDC116	0.15	0.20	lasso	1	0.19	6.5e-12	5.8	-5.8	5.4e-09	-1.00	0.02	0.98	FALSE
4	GTEx	Artery Aorta	CCDC116	0.18	0.18	lasso	10	0.18	5.5e-10	5.8	-5.8	5.5e-09	-1.00	0.02	0.98	FALSE
13	GTEx	Heart Atrial Appendage	CCDC116	0.11	0.03	lasso	3	0.05	1.8e-03	5.7	-5.8	6.2e-09	-0.96	0.03	0.95	FALSE
14	GTEx	Lung	CCDC116	0.12	0.15	lasso	2	0.14	5.3e-11	5.7	-5.8	6.8e-09	-0.99	0.02	0.98	FALSE
7	GTEx	Brain Cerebellum	CCDC116	0.25	0.16	lasso	4	0.10	6.5e-04	5.8	-5.7	1.0e-08	-0.99	0.03	0.95	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	CCDC116	0.20	0.08	lasso	8	0.12	6.0e-05	5.8	-5.7	1.2e-08	-1.00	0.03	0.95	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC116	0.02	0.02	lasso	2	0.02	1.4e-03	5.7	-5.7	1.3e-08	-0.96	0.01	0.86	FALSE
1	CommonMind	Brain Pre-frontal Cortex	UBE2L3	0.10	0.12	enet	16	0.11	9.7e-14	5.9	5.6	1.7e-08	0.97	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCDC116	0.05	0.06	lasso	1	0.05	1.3e-03	5.6	-5.6	2.1e-08	-0.96	0.01	0.85	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC116	0.07	0.02	blup	40	0.03	1.5e-02	5.9	-5.6	2.2e-08	-0.96	0.01	0.80	FALSE
16	GTEx	Ovary	CCDC116	0.54	0.15	lasso	10	0.20	1.5e-05	5.8	-5.6	2.4e-08	-0.85	0.02	0.82	FALSE
5	GTEx	Artery Coronary	CCDC116	0.16	0.06	lasso	4	0.09	5.6e-04	5.8	-5.5	4.3e-08	-0.97	0.03	0.95	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC116	0.07	0.12	blup	40	0.11	1.2e-12	5.8	-5.4	6.0e-08	-0.96	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC116	0.05	0.07	blup	40	0.07	4.6e-07	5.9	-5.4	6.2e-08	-0.97	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	YDJC	0.08	0.14	blup	34	0.15	2.9e-16	5.7	5.4	7.2e-08	0.98	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	CCDC116	0.15	0.12	lasso	7	0.13	1.7e-10	5.9	-5.4	8.6e-08	-0.98	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	YDJC	0.04	0.00	blup	34	0.02	4.0e-02	5.8	5.3	1.2e-07	0.94	0.01	0.66	FALSE
9	GTEx	Colon Sigmoid	CCDC116	0.30	0.14	lasso	5	0.24	6.0e-09	2.8	-5.2	1.7e-07	-0.85	0.03	0.97	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC116	0.06	0.05	blup	40	0.06	4.3e-07	5.9	-5.2	1.8e-07	-0.91	0.01	0.98	FALSE
19	METSIM	Adipose	CCDC116	0.06	0.07	enet	22	0.08	4.6e-12	5.8	-5.2	1.9e-07	-0.93	0.03	0.97	FALSE