Best TWAS P=7.19e-10 · Best GWAS P=8.2e-10 conditioned to 0.101
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | STMN3 | 0.39 | 0.08 | lasso | 5 | 0.22 | 2.1e-06 | -5.9 | -5.2 | 2.6e-07 | 0.73 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Brain Cerebellum | STMN3 | 0.33 | 0.12 | lasso | 10 | 0.20 | 1.8e-06 | -4.9 | -6.1 | 9.2e-10 | 0.81 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Brain Cortex | STMN3 | 0.25 | 0.09 | lasso | 7 | 0.11 | 6.8e-04 | -5.1 | -6.2 | 7.2e-10 | 0.86 | 0.04 | 0.87 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | GMEB2 | 0.36 | 0.06 | lasso | 4 | 0.05 | 1.2e-02 | -6.1 | -5.8 | 4.9e-09 | 0.92 | 0.01 | 0.92 | FALSE |
| 5 | GTEx | Testis | RTEL1 | 0.19 | 0.06 | lasso | 5 | 0.14 | 8.0e-07 | -5.1 | -5.3 | 1.2e-07 | 0.76 | 0.02 | 0.96 | FALSE |
| 6 | GTEx | Thyroid | SLC2A4RG | 0.12 | 0.06 | lasso | 5 | 0.04 | 2.4e-04 | -4.9 | 5.2 | 2.2e-07 | -0.80 | 0.06 | 0.93 | FALSE |
| 7 | GTEx | Whole Blood | STMN3 | 0.10 | 0.00 | lasso | 3 | 0.00 | 1.2e-01 | -5.3 | 6.0 | 1.9e-09 | -0.75 | 0.04 | 0.59 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STMN3 | 0.02 | 0.02 | blup | 43 | 0.02 | 1.7e-03 | -5.3 | -5.4 | 5.4e-08 | 0.91 | 0.01 | 0.90 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TNFRSF6B | 0.03 | 0.01 | blup | 44 | 0.02 | 7.1e-04 | -4.9 | -5.4 | 5.5e-08 | 0.86 | 0.03 | 0.89 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -5.1 | -5.3 | 1.0e-07 | 0.82 | 0.03 | 0.68 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.05 | 7.2e-07 | -5.0 | 5.5 | 3.9e-08 | -0.78 | 0.04 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | -4.0 | -5.6 | 2.1e-08 | 0.75 | 0.03 | 0.42 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | STMN3 | 0.07 | 0.01 | blup | 41 | 0.05 | 4.2e-04 | -5.9 | -5.4 | 8.3e-08 | 0.86 | 0.01 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | -5.3 | 5.3 | 1.0e-07 | -0.85 | 0.45 | 0.55 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | LIME1 | 0.05 | 0.03 | blup | 47 | 0.04 | 3.9e-05 | -5.0 | -5.7 | 1.0e-08 | 0.75 | 0.03 | 0.96 | FALSE |