TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Medication for cholesterol
:
←
→
chr16:3,969,463-5,441,125
Best TWAS P=4.75e-09 · Best GWAS P=6.3e-08 conditioned to 0.318
4M
4.2M
4.4M
4.6M
4.8M
5M
5.2M
5.4M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Heart Left Ventricle
MGRN1
0.32
0.10
enet
18
0.33
3.6e-18
-2.8
-5.9
4.8e-09
-0.56
0.27
0.66
TRUE
3
METSIM
Adipose
NUDT16L1
0.06
0.03
bslmm
392
0.04
2.2e-06
4.4
5.6
1.7e-08
0.84
0.01
0.98
TRUE
2
GTEx
Muscle Skeletal
MGRN1
0.16
0.06
lasso
7
0.15
1.1e-14
-2.9
-5.5
4.0e-08
-0.51
0.47
0.41
FALSE