Hub : Genes

NUDT16L1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0950	0.0400	2.3e-03	0.007	NA	0.007	NA	0.014	8.0e-02	NA	7.5e-02	NA	2.4e-02
2	GTEx	Breast Mammary Tissue	0.1320	0.0530	7.9e-03	0.029	NA	-0.003	NA	0.010	1.2e-02	NA	5.0e-01	NA	9.4e-02
3	GTEx	Heart Atrial Appendage	0.1250	0.0510	1.3e-03	0.173	NA	0.086	NA	0.169	3.3e-08	NA	1.1e-04	NA	4.8e-08
4	GTEx	Testis	0.3850	0.0640	3.9e-16	0.491	NA	0.381	NA	0.288	1.4e-24	NA	5.9e-18	NA	3.1e-13
5	METSIM	Adipose	0.0582	0.0221	1.3e-04	0.032	0.035	0.032	0.038	0.013	1.1e-05	4.5e-06	1.2e-05	2.2e-06	3.5e-03
6	TCGA	Thyroid Carcinoma	0.0580	0.0340	4.2e-03	0.008	0.014	0.007	NA	0.015	4.7e-02	1.4e-02	6.3e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	1.1	-0.5	-1.1	-0.2	0.1	-0.9	-0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	8.1	0.5	-2.8	-0.3	0.6	-0.0	-1.2
Depressed Affect (Nagel 2018)	0.6	1.3	6.3	0.3	2.5	-0.3	0.4	-0.1	-1.2
Depression (Nagel 2018)	0.6	0.9	3.9	0.3	1.1	-0.4	0.0	0.1	-2.0
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.8	0.9	-0.7	-1.7	1.4	1.4	-1.9
Neuroticism (Nagel 2018)	0.6	1.3	4.9	-1.0	2.2	0.5	-0.4	-1.0	0.8
Schizophrenia (2018)	0.9	1.9	7.8	1.0	-2.8	-0.2	0.7	0.7	-1.2
Schizophrenia vs Biploar Disorder	1.7	2.3	6.0	1.7	-0.2	-0.8	1.5	2.5	-1.3
Worry (Nagel 2018)	0.4	0.8	2.9	-0.3	1.7	-0.0	0.6	-0.4	1.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	0.6	1.3	-0.4	0.7	0.4	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	-0.1	0.4	0.3	-0.3	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	-0.1	1.0	0.8	-0.1	-1.1	0.8
Crohns Disease (2017)	0.6	1.3	3.3	1.1	-1.8	-0.9	0.6	1.3	-0.7
Irritable Bowel Disease (IBD)	0.4	1.1	2.1	1.3	-0.2	-1.2	1.0	1.5	-0.5
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.8	1.2	-0.7	0.7	0.8	0.1
Major Depression (MDD)	0.5	0.6	1.3	0.6	-0.1	-1.0	1.1	0.9	0.0
Reaction Time	0.7	1.3	5.4	0.6	-0.0	-1.0	0.8	-0.5	-2.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.1	0.9	-1.3	-1.2	1.5	1.8	-2.3
Breast Cancer	0.1	0.3	1.9	-0.0	1.4	-0.1	-0.1	0.3	-0.3
Ovarian Cancer	0.1	0.1	0.2	0.2	-0.1	-0.5	-0.1	0.4	0.0
Prostate Cancer	2.3	3.2	5.7	-1.9	0.6	1.6	-1.6	-2.0	2.4
Age at First Birth	0.2	0.2	0.6	0.8	-0.6	-0.2	0.2	0.4	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1
Body Mass Index (BMI) (2010)	3.3	4.5	10.6	1.5	-1.7	-2.1	2.0	3.3	-1.6
Coronary Artery Disease (CAD)	0.1	0.1	0.5	-0.3	-0.7	0.1	0.1	-0.0	-0.4
Crohns Disease (2012)	0.5	0.9	2.4	0.9	-1.0	-0.7	0.7	0.0	-1.6
Mean Putamen Volume	1.0	1.1	2.0	-0.8	0.0	1.4	-1.1	-1.3	1.1
Fasting Glucose	1.7	2.0	5.0	1.0	-0.7	1.8	-2.2	-1.0	1.0
HbA1C	0.6	0.7	2.1	0.9	-0.8	0.5	-0.6	-0.3	-1.4
HDL Cholesterol	0.6	0.9	2.6	0.7	1.6	0.1	0.5	-0.0	1.5
LDL Cholesterol	1.0	1.6	5.4	0.6	-2.3	-0.9	0.7	1.0	-1.3
Lupus	0.7	1.0	3.7	-0.3	1.9	0.6	-0.2	-0.3	1.3
Neuroticism (2016)	1.0	1.5	2.1	-1.4	0.4	1.4	-1.2	-1.3	1.2
Primary Biliary Cirrhosis	0.2	0.3	1.0	0.7	0.2	-0.1	0.2	0.6	-1.0
Rheumatoid Arthritis	0.4	0.5	0.9	0.7	0.9	-0.6	0.6	1.0	-0.3
Schizophrenia (2014)	2.0	4.3	8.2	2.0	-2.9	-1.0	1.7	1.7	-2.6
Triglycerides	0.6	1.0	4.3	0.1	-0.7	-0.6	0.3	0.9	-2.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.6	-0.8	-0.3	-0.5	-0.6	-0.1
Ulcerative Colitis	0.4	0.6	0.9	0.8	1.0	-0.8	0.7	0.4	-0.9
Blood Eosinophil Count	0.6	4.6	7.6	-2.5	-2.0	1.7	-1.2	-2.8	2.3
Blood Platelet Count	1.5	16.9	36.6	-4.0	-0.7	4.6	-3.9	-6.0	3.6
Blood Red Count	0.8	7.6	13.5	3.7	-0.5	-3.0	3.0	3.4	-1.5
Blood White Count	1.5	11.1	20.9	-3.4	-0.6	3.7	-3.2	-4.6	3.1
Heel T-Score	1.0	7.8	14.9	2.2	2.2	-3.9	3.4	2.8	-1.9
BMI	0.5	3.1	7.7	1.8	-0.4	-2.0	1.6	2.8	-1.0
Height	3.4	64.9	102.0	7.2	2.1	-10.1	8.1	8.4	-9.8
Waist Hip Ratio (WHR)	0.3	1.5	4.8	0.4	2.2	-1.0	1.0	1.2	-0.6
Systolic Blood Pressure	6.5	32.4	64.6	-4.8	2.8	6.2	-5.9	-8.0	5.0
Smoking Status	1.6	3.8	5.1	-2.3	1.5	2.0	-2.2	-1.9	1.7
Allergy or Eczema	0.5	1.2	2.0	-1.4	0.8	1.2	-1.1	-0.8	1.2
Cardiovascular Disease	2.5	8.3	19.1	-2.7	3.2	2.3	-2.5	-4.4	1.5
Hypothyroidism (self reported)	0.4	0.8	1.5	-0.7	-0.1	1.1	-1.2	-1.2	0.3
Respiratory disease	1.9	4.3	6.6	-2.3	0.1	2.2	-2.6	-2.0	2.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.9	-0.6	0.3	-0.7	-0.8	0.4
Lung FEV1/FVC ratio	0.4	1.9	3.5	-1.1	-0.3	1.9	-1.6	-0.9	1.8
Lung FVC	1.6	8.1	14.1	3.3	-0.6	-3.6	3.8	2.7	-1.9
Neuroticism	0.6	1.4	6.5	0.2	2.6	-0.7	0.9	-0.4	-0.7
Chronotype (morning person)	0.8	1.9	5.9	-1.2	0.9	1.0	-1.3	-2.4	0.8
Hair Pigment	0.4	12.1	15.0	-3.9	3.4	3.4	-3.6	-2.9	3.7
Tanning	0.1	1.1	2.0	-1.0	0.2	1.3	-1.4	-0.9	1.1
Hand grip strength (left)	6.5	17.1	23.8	4.4	-0.2	-4.6	4.9	4.3	-4.4
Number of treatments/medications taken	7.0	12.5	20.5	-3.7	2.7	3.3	-3.4	-4.5	3.4
Average weekly spirits intake	0.1	0.2	0.4	0.3	0.1	-0.2	0.6	-0.1	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.8	0.5	-0.5	-0.1	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.5	0.6	1.0	-0.3	-0.1	-0.3	-1.9
Hearing difficulty/problems: Yes	0.4	0.6	1.3	-0.7	0.7	0.9	-0.6	-1.1	-0.1
Relative age of first facial hair	0.3	0.6	1.7	-0.1	0.9	0.7	-0.7	-1.3	0.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.1	-1.3	-0.9	1.2	-1.4	-1.0	1.2
Ever used hormone-replacement therapy (HRT)	3.3	4.2	7.0	-2.2	-1.0	2.6	-2.2	-1.8	2.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.2	-0.9	-0.1	0.1	0.6	0.7
Systolic blood pressure, automated reading	6.1	17.7	28.6	-3.6	1.4	5.1	-4.7	-5.4	3.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	-0.3	-0.1	0.1	-0.4	-0.1
Angina	1.2	1.6	3.1	-1.6	0.3	1.1	-1.6	-1.8	-0.1
Medication for hormone replacement therapy	1.3	1.4	2.2	-1.2	-0.5	1.5	-1.5	-1.3	0.8
Vitamin and mineral supplements	0.9	1.2	1.9	1.4	-0.6	-1.0	1.1	1.0	-1.3
Supplements: Zinc	0.2	0.2	1.3	-0.0	-1.1	0.2	-0.1	-0.2	0.4
Medication: Co-codamol	0.4	0.4	0.9	0.5	-0.3	-0.4	0.6	0.9	-0.9
Medication: Metformin	0.5	0.7	2.1	-1.5	0.0	0.6	-0.9	-0.8	-0.6
Diabetes (father)	0.3	0.3	1.4	1.2	0.2	-0.1	0.1	0.7	-0.2
Diabetes (mother)	1.5	1.9	3.6	0.9	1.6	-1.9	1.2	1.4	-1.1
Severe depression (siblings)	0.2	0.3	1.0	-0.2	1.0	-0.3	0.1	-0.6	0.0
Pack years adult smoking proportion	0.9	1.3	3.7	0.2	1.9	-1.2	1.1	1.1	-0.4
Impedance of leg (right)	0.3	1.2	2.2	-0.7	-0.6	1.5	-0.8	-1.3	1.5
Leg fat-free mass (left)	3.8	19.9	30.4	4.0	1.1	-5.5	4.3	5.0	-5.3
Trunk fat percentage	2.4	9.8	15.4	3.9	-1.6	-3.1	3.1	3.5	-3.1
Hand grip strength (right)	4.5	12.2	17.5	3.4	1.8	-4.2	4.1	3.2	-3.7
Townsend deprivation index at recruitment	0.0	0.0	0.2	0.1	-0.5	0.1	0.1	0.0	-0.1
Current tobacco smoking	0.3	0.5	0.9	-0.8	0.5	0.7	-0.9	-0.6	0.3
Average weekly fortified wine intake	0.8	0.9	1.8	-1.3	-0.8	1.1	-0.7	-1.4	0.2
Maternal smoking around birth	1.7	2.5	4.3	-1.3	1.8	1.6	-1.6	-0.9	2.1
Fed-up feelings	0.3	0.5	1.7	-0.3	1.3	-0.5	0.4	-0.6	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.5	0.4	0.4	-0.2	0.1	-0.0	-1.2
Relative age voice broke	0.2	0.3	1.2	0.3	0.5	-0.1	0.4	-0.6	1.1
Taking other prescription medications	3.5	5.4	8.4	-2.5	0.7	2.5	-2.4	-2.9	2.3
Age when periods started (menarche)	0.9	2.2	5.5	-1.9	-1.1	1.1	-0.8	-1.1	2.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.0	1.4	-1.4	-0.6	0.8	1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	6.4	2.5	0.7	-2.4	2.2	1.8	-1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.0	1.0	0.4	-0.9	0.9	0.8	-0.8
Qualifications: CSEs or equivalent	1.2	1.6	3.5	-1.9	1.1	1.1	-1.4	-0.8	1.1
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.0	-0.1	0.6	-0.7	-0.1	0.5
High blood pressure	5.5	15.4	32.7	-3.8	2.7	3.6	-4.2	-5.7	2.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	-1.0	0.1	1.0	-0.9	-0.6	0.8
Multivitamins +/- minerals	0.4	0.5	2.9	-0.1	1.7	-0.1	0.1	-0.2	0.1
Stomach or abdominal pain in last month	0.1	0.2	0.7	0.0	0.3	0.4	-0.8	-0.0	-0.2
Supplements: Glucosamine	3.2	4.2	6.3	-2.4	-1.6	2.3	-2.5	-1.3	1.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	0.3	0.0	0.5	0.1	-0.1
Medication: Atenolol	0.7	0.9	2.0	-0.5	0.4	1.4	-1.2	-1.3	0.2
Medication: Levothyroxine sodium	0.4	0.7	1.3	-0.8	0.4	1.0	-1.0	-0.5	1.1
Sitting height	2.1	14.7	24.4	3.4	0.2	-4.9	3.5	4.2	-4.7
Chronic bronchitis/emphysema (father)	0.4	0.4	0.8	-0.6	0.2	0.7	-0.8	-0.5	-0.9
High blood pressure (mother)	0.3	0.4	1.2	-0.5	1.0	0.0	-0.2	-1.1	-0.5
Body mass index (BMI)	0.4	1.8	3.9	1.5	0.2	-1.3	1.1	2.0	-1.3
Impedance of leg (left)	0.2	0.8	1.7	-0.3	-0.5	1.3	-0.6	-1.2	1.1
Leg predicted mass (left)	3.7	19.6	29.9	4.0	1.1	-5.5	4.3	5.0	-5.3
Trunk fat mass	3.6	15.5	20.0	4.5	-0.9	-4.2	4.0	4.5	-4.3
Waist circumference	2.4	8.8	15.1	3.0	0.4	-3.2	2.9	3.9	-3.1
Number of incorrect matches in round	0.7	1.2	3.4	-0.8	0.1	1.1	-1.1	-1.8	-0.8
Past tobacco smoking	1.5	2.8	4.3	1.2	-1.0	-2.1	1.9	1.6	-2.0
Alcohol usually taken with meals	0.8	1.2	5.8	0.6	-2.4	0.3	-0.1	0.9	-0.6
Nervous feelings	0.7	1.4	6.9	0.1	2.6	0.6	-0.0	-0.9	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.4	-0.3	1.8	0.7	-0.9	-1.0	-0.0
Hearing difficulty/problems with background noise	1.1	1.8	4.5	-1.0	0.8	1.5	-1.3	-2.1	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.8	-0.5	0.8	-0.6	-0.2	0.6
Had menopause	4.7	5.9	9.3	-2.5	0.5	3.1	-2.2	-2.8	2.5
Had other major operations	1.4	1.7	4.3	-0.8	-2.1	1.4	-1.0	-0.5	1.5
Forced vital capacity (FVC)	5.5	21.3	34.5	4.8	1.0	-5.9	5.5	4.4	-4.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.3	1.5	2.3	-1.8	1.6	0.5	-1.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	3.7	0.6	1.9	0.5	-0.2	-0.5	0.4
Qualifications: None of the above	5.4	11.5	19.9	-3.0	2.4	3.6	-3.2	-4.5	3.4
Financial difficulties in last 2 years	0.2	0.2	0.9	0.0	0.4	-0.9	0.4	0.4	-0.1
Mouth/teeth dental problems	1.7	2.7	4.2	1.5	-1.6	-1.7	1.9	2.0	-0.4
Heart attack	1.1	1.4	2.0	-1.4	0.7	1.4	-1.4	-1.4	0.5
Allergy	1.3	3.0	3.9	1.9	-0.5	-2.0	1.9	1.6	-1.9
Pain all over the body in last month	2.8	3.0	3.7	-1.9	-1.4	1.9	-1.8	-1.5	1.9
Diabetes (self-reported)	0.3	0.4	1.0	-1.0	-0.3	0.4	-0.9	-0.7	-0.0
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	5.7	-2.1	0.7	2.0	-2.2	-2.3	2.4
Medication: Ramipril	1.3	1.7	6.9	-0.9	0.1	0.9	-1.3	-2.6	0.3
Medication: Simvastatin	1.8	2.6	3.9	-2.0	0.7	1.5	-1.6	-1.9	1.6
Fluid intelligence score	0.7	1.5	3.2	1.3	-0.5	-1.3	1.3	1.8	-0.8
Illnesses of siblings	0.7	1.0	1.7	1.1	-0.4	-0.9	0.8	1.3	-1.2
Neuroticism score	0.7	1.4	7.0	0.1	2.7	-0.5	0.6	-0.6	-0.5
Weight	3.4	16.9	23.2	4.0	0.7	-4.8	4.0	4.8	-4.8
Impedance of arm (right)	0.8	3.6	8.4	1.9	-2.9	-1.6	2.1	1.1	-1.0
Arm fat percentage (right)	1.7	6.6	9.6	3.1	-1.5	-2.5	2.4	3.1	-2.5
Trunk fat-free mass	3.0	17.4	26.6	3.2	2.7	-5.0	3.8	4.5	-5.2
Hip circumference	3.4	14.6	19.7	4.2	0.2	-4.4	3.9	4.3	-4.1
Time employed in main current job	0.4	0.5	1.3	0.8	0.3	-0.5	0.7	1.2	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	4.2	0.9	2.0	-1.1	0.6	0.4	-0.7
Father’s age at death	0.7	1.0	1.1	-0.9	-0.8	1.1	-1.0	-1.0	1.0
Worrier / anxious feelings	0.6	1.2	6.0	-0.6	2.5	0.1	0.3	-0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.5	-0.8	-0.4	0.1	0.7	0.1
Falls in the last year	1.1	1.6	3.2	-0.8	-0.1	1.8	-1.6	-1.3	1.2
Hair/balding pattern: Pattern 3	2.2	3.3	6.6	1.8	2.6	-1.6	2.0	1.5	-1.1
Number of live births	0.2	0.3	0.7	-0.1	-0.5	0.9	-0.5	-0.7	0.3
Forced expiratory volume in 1-second (FEV1)	5.1	17.3	26.8	4.6	1.0	-5.2	4.9	3.9	-3.9
Pulse rate	3.3	5.5	9.2	-2.1	-1.0	2.7	-2.2	-2.5	3.0
Happiness	1.2	1.5	3.1	0.5	-0.2	-1.5	1.8	0.2	-1.7
Noisy workplace	1.2	1.5	3.2	-1.6	1.4	0.7	-0.9	-1.8	-0.3
Qualifications: A levels/AS levels or equivalent	4.2	9.2	17.5	3.3	-1.8	-3.0	3.0	4.2	-2.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.6	0.5	-1.9	-1.1	0.9	0.8	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.6	2.5	0.1	1.6	0.3	-0.2	-0.2	-0.9
Asthma	3.0	5.8	8.4	-2.8	0.1	2.6	-2.9	-2.2	2.7
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.8	-0.5	0.6	1.8	-1.5	-0.9	1.9
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.2	0.0	0.1	-0.3	-0.6	-0.6
Depression (self-reported)	0.5	0.5	2.5	0.6	0.1	-0.2	-0.2	0.6	-1.6
Medication: Lansoprazole	0.2	0.2	0.9	0.4	1.0	-0.1	-0.0	0.1	0.4
Prospective memory result	1.1	1.3	2.4	-0.8	-1.6	1.4	-1.4	-0.8	0.2
Lung cancer (father)	0.4	0.5	2.5	-0.6	-1.6	-0.2	-0.1	-0.2	-0.0
Illnesses of mother	0.2	0.2	0.8	0.2	-0.3	0.9	-0.6	0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.8	25.4	4.5	0.8	-5.0	5.0	3.9	-3.8
Pulse wave Arterial Stiffness index	3.9	4.5	7.9	-2.7	0.6	2.0	-2.3	-2.8	1.5
Impedance of arm (left)	1.0	4.7	8.2	2.5	-2.9	-1.8	2.5	1.3	-1.5
Arm fat mass (right)	2.1	8.5	13.3	3.2	-0.5	-3.1	2.8	3.6	-3.1
Trunk predicted mass	3.0	17.0	26.0	3.2	2.6	-4.9	3.8	4.5	-5.1
Standing height	4.1	40.9	62.6	5.8	1.5	-7.9	6.7	6.5	-7.8
Length of working week for main job	1.5	1.6	3.1	-0.7	-1.5	1.4	-1.2	-0.7	1.8
Exposure to tobacco smoke at home	2.4	2.7	4.2	-2.0	-0.6	1.7	-1.5	-2.0	1.7
Breastfed as a baby	0.1	0.2	0.4	-0.7	0.0	0.7	0.1	-0.1	0.2
Tense / ‘highly strung’	0.5	0.8	2.9	-1.1	-0.1	0.1	-0.4	-1.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.9	-2.0	0.5	1.5	-1.7	-1.8	0.7
Hair/balding pattern: Pattern 4	2.9	7.0	10.4	3.1	-1.4	-2.7	2.4	3.2	-2.6
Birth weight of first child	1.7	3.1	7.9	1.3	0.2	-2.3	1.9	2.8	-0.4
Peak expiratory flow (PEF)	3.8	8.9	12.7	3.6	2.2	-3.5	3.3	2.8	-2.1
Pulse wave reflection index	1.3	1.6	3.3	-1.8	1.0	0.7	-1.4	-1.6	0.6
Ever highly irritable/argumentative for 2 days	2.4	2.9	6.2	1.4	1.6	-1.9	1.5	0.9	-2.5
Loud music exposure frequency	1.0	1.0	4.1	-0.3	2.0	0.3	-0.5	-1.3	-0.3
Qualifications: O levels/GCSEs or equivalent	10.5	16.7	28.5	4.4	-2.4	-4.1	4.0	5.3	-3.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.2	-0.1	-0.7	0.7	-0.2	-0.4
Blood clot in the leg (DVT)	0.3	0.3	0.9	0.7	1.0	-0.6	0.5	0.1	-0.2
Medication: Paracetamol	2.1	3.5	5.1	-1.6	2.3	2.1	-2.0	-1.7	1.4
Headache pain in last month	0.9	1.5	3.2	1.6	-0.1	-0.7	0.7	1.4	-1.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.6	0.6	-0.6	-0.3	0.6	1.3	-0.4
Glaucoma (self-reported)	0.3	0.4	1.7	-0.4	-1.3	0.4	-0.3	-0.5	0.2
Gout (self-reported)	0.3	0.4	1.9	0.5	-1.4	-0.2	-0.2	0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.5	-1.1	0.0	1.0	-1.2	-1.2	0.9
Medication: Amlodipine	2.3	3.3	6.8	-1.8	1.7	1.3	-1.9	-2.6	1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	-0.2	-0.4	-0.3	0.6	-0.2
Birth weight	0.1	0.1	0.7	-0.0	0.1	-0.1	0.3	0.3	-0.8
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.3	-1.1	0.9	1.1	-1.0	-1.1	-0.8
High blood pressure (siblings)	2.0	2.8	7.0	-1.7	1.4	1.6	-1.6	-2.6	0.6
Forced vital capacity (FVC), Best measure	5.9	21.7	33.3	5.1	1.4	-5.8	5.5	4.4	-4.3
Body fat percentage	1.6	6.4	10.5	3.2	-1.4	-2.4	2.4	2.9	-2.6
Leg fat percentage (right)	0.2	0.7	1.8	1.1	-1.0	-0.3	0.3	1.3	-0.5
Arm fat-free mass (right)	2.3	11.8	16.9	2.8	2.5	-4.0	3.0	3.9	-4.1
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.1	-1.1	-0.2	0.1	0.2	-0.4
Comparative body size at age 10	1.3	3.6	7.6	1.1	-1.3	-1.8	2.0	2.0	-2.8
Number of full brothers	0.3	0.4	1.0	0.0	1.0	0.3	0.2	-0.4	0.9
Worry too long after embarrassment	0.7	1.2	4.0	-1.2	0.7	0.5	-0.5	-0.8	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	1.6	-0.8	1.1	1.0	-1.3	-0.7	0.0
Wheeze or whistling in the chest in last year	1.0	1.8	3.7	-1.9	-0.2	1.2	-1.5	-1.4	1.2
Number of children fathered	1.6	1.8	3.6	-1.4	1.1	1.4	-1.3	-1.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.7	0.0	1.3	0.1	-0.1	-1.0	0.0
Age at first live birth	1.1	1.9	3.6	1.1	-1.9	-1.3	1.2	1.9	-0.5
Pulse wave peak to peak time	5.3	6.2	10.7	3.1	-0.4	-2.4	2.7	3.3	-1.9
Health satisfaction	0.4	0.5	1.2	0.8	0.3	-0.5	0.8	0.1	-1.1
Shortness of breath walking on level ground	2.3	2.8	5.7	-1.4	0.3	1.5	-1.8	-1.9	2.4
Qualifications: College or University degree	2.2	6.9	8.2	2.7	-2.0	-2.8	2.8	2.9	-2.6
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.1	0.8	-0.5	0.3	0.6	-0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.1	1.5	-0.3	-1.1	1.1	1.4	-1.4
Emphysema/chronic bronchitis	2.1	2.3	4.3	-2.1	0.2	1.8	-1.7	-1.2	1.6
Medication for pain relief, constipation, heartburn	5.8	9.9	14.2	3.1	-2.7	-3.4	3.1	3.8	-2.6
Neck or shoulder pain in last month	0.9	1.3	2.4	-1.0	1.5	0.8	-1.5	-1.0	1.0
Medication: Blood pressure	1.1	1.9	4.8	-1.1	1.4	0.8	-1.0	-2.2	1.3
Angina (self-reported)	1.1	1.5	3.1	-1.5	0.4	1.0	-1.5	-1.8	-0.0
Migraine (self-reported)	0.1	0.2	0.5	-0.1	0.7	0.4	0.0	0.3	0.4
Medication: Ibuprofen	0.9	1.1	3.8	-0.1	0.5	1.2	-1.0	-0.3	2.0
Medication: Allopurinol	0.4	0.5	0.9	-0.8	-0.3	0.7	-0.9	-0.4	0.9
Medication: Omeprazole	2.6	3.1	7.2	-1.4	2.7	1.5	-1.8	-1.7	1.1
Medication: Seretide 50 evohaler	0.8	0.9	1.3	-1.1	-1.0	0.6	-1.0	-0.5	1.2
Mean time to correctly identify matches	0.3	0.6	2.4	0.5	-0.1	-0.4	0.4	-0.8	-1.6
Heart disease (mother)	0.4	0.4	1.2	-0.6	-0.3	0.1	-0.2	-1.0	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.5	-1.4	0.4	1.7	-1.9	-1.6	0.6
Whole body fat mass	2.7	11.4	15.4	3.8	-0.8	-3.6	3.3	3.9	-3.8
Leg fat mass (right)	1.1	4.4	8.4	2.3	-0.5	-2.2	1.7	2.9	-2.3
Arm predicted mass (right)	2.4	12.2	18.4	2.8	2.4	-4.1	3.0	3.9	-4.3
Pulse rate, automated reading	5.6	18.0	28.5	-4.1	-0.8	4.8	-4.3	-4.5	5.3
Alcohol intake frequency.	1.0	2.3	5.1	1.5	0.5	-1.5	1.4	1.5	-2.3
Comparative height size at age 10	3.9	21.3	31.6	4.3	1.7	-5.5	5.0	4.4	-5.6
Number of full sisters	1.6	1.9	3.6	-1.4	-1.2	1.9	-1.6	-1.0	1.1
Suffer from ‘nerves’	0.3	0.4	1.2	0.6	1.1	-0.5	0.8	0.4	0.2
Overall health rating	2.6	5.6	8.9	-2.7	-0.5	2.7	-3.0	-2.6	1.8
Chest pain or discomfort	0.2	0.3	1.1	-1.1	0.3	0.1	-0.0	-0.6	0.0
Had major operations	0.2	0.2	0.5	0.0	0.2	-0.5	0.7	0.7	0.2
Age at last live birth	0.3	0.4	1.4	0.1	-1.2	-0.4	0.3	0.2	0.8
Family relationship satisfaction	1.3	1.6	6.0	1.1	-0.1	-1.0	0.9	0.5	-2.5
Leg pain on walking	1.3	1.7	3.8	-1.9	-0.3	1.2	-1.4	-1.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.2	0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.6	0.2	-0.3	-0.0	0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	1.1	0.1	-0.9	0.9	0.7	-0.4
Medication: Aspirin	2.3	3.0	7.0	-1.9	1.1	1.5	-1.2	-2.7	1.5
Supplements: Vitamin C	1.6	1.8	3.8	-2.0	1.0	0.9	-1.3	-1.2	1.5
Knee pain experienced in last month	1.2	1.9	4.0	-1.8	-0.3	1.4	-1.5	-2.0	0.3
Hypertension (Self-reported)	5.5	15.2	32.4	-3.8	2.4	3.5	-4.2	-5.7	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.7	-0.1	0.7	-0.9	-0.6	-0.6
Illnesses of father: Heart disease	0.2	0.3	1.7	0.1	1.3	-0.3	0.0	-0.1	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.9	-0.3	-0.8	-0.3	0.3	0.3	1.4
Smoking status: Previous	0.9	1.3	3.1	-0.8	0.6	1.5	-1.1	-0.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted	7.3	15.1	20.7	3.6	1.9	-4.5	4.2	4.1	-4.3
Whole body fat-free mass	3.3	18.6	28.4	3.6	2.1	-5.2	4.0	4.7	-5.3
Leg fat-free mass (right)	3.8	20.3	31.1	4.0	1.1	-5.6	4.3	4.9	-5.5
Arm fat percentage (left)	1.7	6.8	10.6	3.3	-1.4	-2.5	2.5	3.1	-2.5
Average weekly red wine intake	0.6	0.9	2.3	-0.7	-1.5	0.8	-1.3	0.2	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.6	1.6	-0.3	-0.5	0.5	0.6	-0.3
Mood swings	1.0	1.7	5.6	0.9	2.4	-1.2	0.9	-0.2	-1.4
Loneliness, isolation	0.8	1.1	5.7	-0.2	2.4	0.2	-0.1	-0.4	-0.7
Long-standing illness, disability or infirmity	2.3	3.5	6.1	-2.5	1.1	1.6	-2.1	-2.5	0.7
Ever had bowel cancer screening	1.7	2.0	4.1	-1.2	-2.0	1.6	-1.3	-0.3	1.4
Diabetes diagnosed by doctor	0.5	0.8	1.6	-1.3	-0.2	0.5	-1.2	-1.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-0.6	-0.2	0.1	-0.2	0.3	1.1
Friendships satisfaction	0.7	0.9	2.4	0.2	0.8	-0.8	1.2	0.0	-1.6
Qualifications: nursing, teaching	5.2	8.0	13.8	2.8	-1.5	-3.0	3.0	3.7	-2.5
Commuting to job workplace: Walk	0.8	0.8	2.8	-0.2	-1.7	0.7	-0.5	1.0	0.6
Eye problems/disorders: Cataract	0.8	0.9	1.6	-1.0	-0.8	1.0	-0.8	-0.7	1.3
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	10.6	-2.2	-0.1	2.8	-3.3	-2.0	2.0
Medication for cholesterol	12.1	18.4	31.8	4.6	-1.9	-4.4	4.7	5.6	-3.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.1	2.8	-1.5	-0.2	1.6	-1.6	-1.5	1.7
Back pain experienced in last month	0.9	1.3	2.5	-1.4	-1.0	1.5	-1.6	-0.6	0.4
Mineral and other dietary supplements	4.8	6.4	11.3	2.9	-0.1	-2.5	2.5	2.4	-3.4
Breast cancer (self-reported)	3.4	4.1	6.8	-2.1	0.3	2.0	-2.2	-2.2	2.6
Asthma (self-reported)	2.9	5.9	8.2	-2.9	0.0	2.6	-2.9	-2.2	2.7
Osteoporosis (self-reported)	0.5	0.6	2.0	-0.6	0.1	0.7	-0.8	-0.1	1.4
Osteoarthritis (self-reported)	4.2	5.4	10.3	-2.6	-0.4	2.4	-2.6	-3.2	1.6
Medication: Aspirin	1.1	1.4	4.7	-1.3	0.4	1.0	-0.6	-2.2	0.7
Medication: Gliclazide	1.2	1.3	2.2	-1.2	-0.9	1.2	-1.5	-1.5	0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	4.7	-0.2	-2.2	-0.7	0.9	0.6	0.2
Smoking status: Current	0.5	0.8	1.6	-1.0	0.6	0.9	-1.2	-1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.1	1.7	1.1	-1.6	1.8	0.5	-1.0
Whole body water mass	3.2	18.1	27.6	3.5	2.2	-5.2	3.9	4.7	-5.2
Leg predicted mass (right)	3.8	20.1	30.9	4.0	1.2	-5.6	4.3	4.9	-5.5
Arm fat mass (left)	2.3	9.6	15.0	3.5	-0.3	-3.3	3.0	3.9	-3.3
Number of self-reported non-cancer illnesses	6.5	11.2	20.3	-4.0	0.9	3.1	-3.5	-4.5	3.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.7	0.1	0.1	-0.2	-0.7	0.5
Miserableness	0.7	1.3	6.7	-0.1	2.6	0.1	-0.3	-0.6	-0.8
Guilty feelings	0.2	0.2	1.0	0.3	1.0	-0.2	0.5	-0.1	0.2
Wears glasses or contact lenses	0.5	0.6	3.2	-0.3	1.8	0.1	0.1	-0.1	0.2
Ever taken oral contraceptive pill	1.4	1.5	4.4	1.2	2.1	-1.0	1.1	0.5	-0.9
Hearing aid user	0.1	0.1	0.4	-0.0	-0.1	-0.1	0.2	-0.4	0.7
Mother’s age at death	0.8	0.9	3.8	0.1	-1.9	0.5	-0.2	1.1	0.7
Financial situation satisfaction	0.1	0.1	0.4	-0.6	0.0	0.2	-0.1	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.5	0.1	0.7	-0.7	-0.5	0.0
Commuting to job workplace: Public transport	0.0	0.1	0.2	-0.4	-0.1	0.1	0.0	-0.3	-0.1
Eye problems/disorders: Glaucoma	0.4	0.4	1.5	-0.2	-1.2	0.4	-0.3	-0.8	0.4
Medication: Blood pressure	10.9	20.7	36.1	-4.8	2.1	4.7	-5.3	-6.0	3.3
Pain type(s) experienced in last month: Hip pain	1.6	2.1	4.9	-1.5	0.2	1.8	-2.2	-1.2	0.7
Supplements: Fish oil (including cod liver oil)	2.3	3.1	7.8	-1.6	0.2	1.7	-1.5	-1.7	2.8
High cholesterol (Self-reported)	0.5	0.9	2.5	-1.3	-0.4	0.8	-0.7	-1.6	0.1
Medication: Bendroflumethiazide	3.2	4.8	9.3	-2.1	1.5	2.0	-2.4	-3.1	1.8
Medication: Paracetamol	2.2	3.4	5.1	-1.5	2.3	2.2	-2.0	-1.5	1.5
Medication: Lisinopril	2.5	3.3	4.1	-1.8	1.3	1.9	-1.8	-1.9	2.0
Medication: Atorvastatin	1.3	1.7	3.0	-1.3	-0.6	1.5	-1.6	-1.7	0.0
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.5	1.0	-0.1	0.2	0.6	0.9
Alcohol drinker status: Never	0.1	0.1	0.3	0.1	0.0	0.4	-0.6	0.2	0.4
Ever smoked	1.4	2.5	4.1	-0.9	0.5	2.0	-2.0	-1.4	2.0
Basal metabolic rate	3.7	20.2	29.5	4.0	1.8	-5.4	4.2	5.1	-5.4
Leg fat percentage (left)	0.3	1.0	2.0	1.4	-0.9	-0.4	0.5	1.4	-0.8
Arm fat-free mass (left)	2.2	11.2	15.9	2.7	2.2	-3.9	2.9	4.0	-4.0
Number of operations (self-reported)	1.5	2.2	3.3	-1.8	-0.0	1.4	-1.5	-1.6	1.6
Average weekly beer plus cider intake	0.1	0.2	0.7	-0.2	-0.4	-0.4	0.3	-0.3	-0.8
Irritability	0.9	1.5	5.9	-0.7	2.4	-0.7	-0.2	-1.3	-0.6
Risk taking	1.9	2.8	3.9	-1.8	1.0	1.4	-1.8	-2.0	1.8
Ever had prostate specific antigen (PSA) test	4.4	5.1	7.1	2.7	-1.3	-2.4	2.0	2.5	-2.4
Fractured/broken bones in last 5 years	0.4	0.6	2.3	-0.3	-0.4	0.7	-0.6	-0.2	1.5
Age started oral contraceptive pill	0.7	0.9	2.2	-0.6	0.0	1.5	-1.1	-1.2	0.1
Diastolic blood pressure, automated reading	4.6	14.3	24.6	-3.3	1.4	4.0	-3.8	-5.0	4.2
Ever depressed for a whole week	1.4	1.8	3.0	1.4	1.7	-1.1	1.0	0.8	-1.6
Unable to work because of sickness or disability	0.8	1.0	2.5	-1.1	-0.9	0.8	-1.6	-0.9	-0.0
Commuting to job workplace: Cycle	0.2	0.3	0.7	-0.8	0.3	-0.7	0.5	-0.3	-0.3
Myopia	0.4	0.6	1.8	-1.0	-0.7	0.1	-0.1	0.5	1.3
Vascular/heart problems diagnosed by doctor	6.0	16.5	35.5	3.9	-2.8	-3.8	4.3	6.0	-2.8
Cholesterol lowering medication	7.6	11.2	15.0	-3.8	-0.1	3.7	-3.9	-3.6	3.3
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.7	-1.2	1.9	1.3	-1.5	-1.2	1.0
Pain experienced in last month	1.7	2.8	4.5	2.0	-1.1	-1.8	2.1	1.9	-0.8
Supplements: Calcium	1.0	1.1	1.9	-0.8	-1.1	1.2	-1.0	-0.7	1.4
Basal cell carcinoma (self-reported)	1.4	1.7	4.1	-1.2	-0.3	0.9	-1.3	-1.4	2.0
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.8	-1.6	0.6	1.5	-1.5	-1.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.6	0.7	-0.7	0.5	0.3	-0.1
Heart disease (siblings)	0.2	0.3	1.0	0.0	0.6	0.1	-0.4	-0.0	1.0
Alcohol drinker status: Previous	2.2	2.5	7.6	1.6	-0.4	-1.4	1.1	1.2	-2.8
Pack years of smoking	0.7	1.0	2.2	0.2	1.5	-1.1	1.0	1.3	-0.3
Impedance of whole body	0.2	1.2	4.5	1.2	-2.1	-0.3	1.1	0.1	-0.1
Leg fat mass (left)	1.2	4.7	8.5	2.4	-0.4	-2.2	1.8	2.9	-2.4
Arm predicted mass (left)	2.1	10.9	15.7	2.7	2.1	-3.8	2.8	4.0	-4.0