Hub : Genes

NUDT16L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0950 0.0400 2.3e-03 0.007 NA 0.007 NA 0.014 8.0e-02 NA 7.5e-02 NA 2.4e-02
2 GTEx Breast Mammary Tissue 0.1320 0.0530 7.9e-03 0.029 NA -0.003 NA 0.010 1.2e-02 NA 5.0e-01 NA 9.4e-02
3 GTEx Heart Atrial Appendage 0.1250 0.0510 1.3e-03 0.173 NA 0.086 NA 0.169 3.3e-08 NA 1.1e-04 NA 4.8e-08
4 GTEx Testis 0.3850 0.0640 3.9e-16 0.491 NA 0.381 NA 0.288 1.4e-24 NA 5.9e-18 NA 3.1e-13
5 METSIM Adipose 0.0582 0.0221 1.3e-04 0.032 0.035 0.032 0.038 0.013 1.1e-05 4.5e-06 1.2e-05 2.2e-06 3.5e-03
6 TCGA Thyroid Carcinoma 0.0580 0.0340 4.2e-03 0.008 0.014 0.007 NA 0.015 4.7e-02 1.4e-02 6.3e-02 NA 1.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.4 1.1 -0.5 -1.1 -0.2 0.1 -0.9 -0.2
Bipolar Disorder or Schizophrenia 0.7 1.7 8.1 0.5 -2.8 -0.3 0.6 -0.0 -1.2
Depressed Affect (Nagel 2018) 0.6 1.3 6.3 0.3 2.5 -0.3 0.4 -0.1 -1.2
Depression (Nagel 2018) 0.6 0.9 3.9 0.3 1.1 -0.4 0.0 0.1 -2.0
Intelligence (Savage-Jansen 2018) 0.7 2.0 3.8 0.9 -0.7 -1.7 1.4 1.4 -1.9
Neuroticism (Nagel 2018) 0.6 1.3 4.9 -1.0 2.2 0.5 -0.4 -1.0 0.8
Schizophrenia (2018) 0.9 1.9 7.8 1.0 -2.8 -0.2 0.7 0.7 -1.2
Schizophrenia vs Biploar Disorder 1.7 2.3 6.0 1.7 -0.2 -0.8 1.5 2.5 -1.3
Worry (Nagel 2018) 0.4 0.8 2.9 -0.3 1.7 -0.0 0.6 -0.4 1.0
Alzheimer’s Disease (in mother) 0.4 0.5 1.7 0.6 1.3 -0.4 0.7 0.4 -0.4
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.1 -0.1 0.4 0.3 -0.3 0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 -0.1 1.0 0.8 -0.1 -1.1 0.8
Crohns Disease (2017) 0.6 1.3 3.3 1.1 -1.8 -0.9 0.6 1.3 -0.7
Irritable Bowel Disease (IBD) 0.4 1.1 2.1 1.3 -0.2 -1.2 1.0 1.5 -0.5
Ulcerative Colitis (UC) 0.3 0.6 1.5 0.8 1.2 -0.7 0.7 0.8 0.1
Major Depression (MDD) 0.5 0.6 1.3 0.6 -0.1 -1.0 1.1 0.9 0.0
Reaction Time 0.7 1.3 5.4 0.6 -0.0 -1.0 0.8 -0.5 -2.3
Verbal and Numeric Reasoning (VNR) 1.0 2.4 5.1 0.9 -1.3 -1.2 1.5 1.8 -2.3
Breast Cancer 0.1 0.3 1.9 -0.0 1.4 -0.1 -0.1 0.3 -0.3
Ovarian Cancer 0.1 0.1 0.2 0.2 -0.1 -0.5 -0.1 0.4 0.0
Prostate Cancer 2.3 3.2 5.7 -1.9 0.6 1.6 -1.6 -2.0 2.4
Age at First Birth 0.2 0.2 0.6 0.8 -0.6 -0.2 0.2 0.4 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1
Body Mass Index (BMI) (2010) 3.3 4.5 10.6 1.5 -1.7 -2.1 2.0 3.3 -1.6
Coronary Artery Disease (CAD) 0.1 0.1 0.5 -0.3 -0.7 0.1 0.1 -0.0 -0.4
Crohns Disease (2012) 0.5 0.9 2.4 0.9 -1.0 -0.7 0.7 0.0 -1.6
Mean Putamen Volume 1.0 1.1 2.0 -0.8 0.0 1.4 -1.1 -1.3 1.1
Fasting Glucose 1.7 2.0 5.0 1.0 -0.7 1.8 -2.2 -1.0 1.0
HbA1C 0.6 0.7 2.1 0.9 -0.8 0.5 -0.6 -0.3 -1.4
HDL Cholesterol 0.6 0.9 2.6 0.7 1.6 0.1 0.5 -0.0 1.5
LDL Cholesterol 1.0 1.6 5.4 0.6 -2.3 -0.9 0.7 1.0 -1.3
Lupus 0.7 1.0 3.7 -0.3 1.9 0.6 -0.2 -0.3 1.3
Neuroticism (2016) 1.0 1.5 2.1 -1.4 0.4 1.4 -1.2 -1.3 1.2
Primary Biliary Cirrhosis 0.2 0.3 1.0 0.7 0.2 -0.1 0.2 0.6 -1.0
Rheumatoid Arthritis 0.4 0.5 0.9 0.7 0.9 -0.6 0.6 1.0 -0.3
Schizophrenia (2014) 2.0 4.3 8.2 2.0 -2.9 -1.0 1.7 1.7 -2.6
Triglycerides 0.6 1.0 4.3 0.1 -0.7 -0.6 0.3 0.9 -2.1
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 -0.6 -0.8 -0.3 -0.5 -0.6 -0.1
Ulcerative Colitis 0.4 0.6 0.9 0.8 1.0 -0.8 0.7 0.4 -0.9
Blood Eosinophil Count 0.6 4.6 7.6 -2.5 -2.0 1.7 -1.2 -2.8 2.3
Blood Platelet Count 1.5 16.9 36.6 -4.0 -0.7 4.6 -3.9 -6.0 3.6
Blood Red Count 0.8 7.6 13.5 3.7 -0.5 -3.0 3.0 3.4 -1.5
Blood White Count 1.5 11.1 20.9 -3.4 -0.6 3.7 -3.2 -4.6 3.1
Heel T-Score 1.0 7.8 14.9 2.2 2.2 -3.9 3.4 2.8 -1.9
BMI 0.5 3.1 7.7 1.8 -0.4 -2.0 1.6 2.8 -1.0
Height 3.4 64.9 102.0 7.2 2.1 -10.1 8.1 8.4 -9.8
Waist Hip Ratio (WHR) 0.3 1.5 4.8 0.4 2.2 -1.0 1.0 1.2 -0.6
Systolic Blood Pressure 6.5 32.4 64.6 -4.8 2.8 6.2 -5.9 -8.0 5.0
Smoking Status 1.6 3.8 5.1 -2.3 1.5 2.0 -2.2 -1.9 1.7
Allergy or Eczema 0.5 1.2 2.0 -1.4 0.8 1.2 -1.1 -0.8 1.2
Cardiovascular Disease 2.5 8.3 19.1 -2.7 3.2 2.3 -2.5 -4.4 1.5
Hypothyroidism (self reported) 0.4 0.8 1.5 -0.7 -0.1 1.1 -1.2 -1.2 0.3
Respiratory disease 1.9 4.3 6.6 -2.3 0.1 2.2 -2.6 -2.0 2.3
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.9 -0.9 -0.6 0.3 -0.7 -0.8 0.4
Lung FEV1/FVC ratio 0.4 1.9 3.5 -1.1 -0.3 1.9 -1.6 -0.9 1.8
Lung FVC 1.6 8.1 14.1 3.3 -0.6 -3.6 3.8 2.7 -1.9
Neuroticism 0.6 1.4 6.5 0.2 2.6 -0.7 0.9 -0.4 -0.7
Chronotype (morning person) 0.8 1.9 5.9 -1.2 0.9 1.0 -1.3 -2.4 0.8
Hair Pigment 0.4 12.1 15.0 -3.9 3.4 3.4 -3.6 -2.9 3.7
Tanning 0.1 1.1 2.0 -1.0 0.2 1.3 -1.4 -0.9 1.1
Hand grip strength (left) 6.5 17.1 23.8 4.4 -0.2 -4.6 4.9 4.3 -4.4
Number of treatments/medications taken 7.0 12.5 20.5 -3.7 2.7 3.3 -3.4 -4.5 3.4
Average weekly spirits intake 0.1 0.2 0.4 0.3 0.1 -0.2 0.6 -0.1 -0.6
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.8 0.5 -0.5 -0.1 0.3 0.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.5 0.6 1.0 -0.3 -0.1 -0.3 -1.9
Hearing difficulty/problems: Yes 0.4 0.6 1.3 -0.7 0.7 0.9 -0.6 -1.1 -0.1
Relative age of first facial hair 0.3 0.6 1.7 -0.1 0.9 0.7 -0.7 -1.3 0.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.1 -1.3 -0.9 1.2 -1.4 -1.0 1.2
Ever used hormone-replacement therapy (HRT) 3.3 4.2 7.0 -2.2 -1.0 2.6 -2.2 -1.8 2.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.9 0.2 -0.9 -0.1 0.1 0.6 0.7
Systolic blood pressure, automated reading 6.1 17.7 28.6 -3.6 1.4 5.1 -4.7 -5.4 3.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 -0.5 -0.3 -0.1 0.1 -0.4 -0.1
Angina 1.2 1.6 3.1 -1.6 0.3 1.1 -1.6 -1.8 -0.1
Medication for hormone replacement therapy 1.3 1.4 2.2 -1.2 -0.5 1.5 -1.5 -1.3 0.8
Vitamin and mineral supplements 0.9 1.2 1.9 1.4 -0.6 -1.0 1.1 1.0 -1.3
Supplements: Zinc 0.2 0.2 1.3 -0.0 -1.1 0.2 -0.1 -0.2 0.4
Medication: Co-codamol 0.4 0.4 0.9 0.5 -0.3 -0.4 0.6 0.9 -0.9
Medication: Metformin 0.5 0.7 2.1 -1.5 0.0 0.6 -0.9 -0.8 -0.6
Diabetes (father) 0.3 0.3 1.4 1.2 0.2 -0.1 0.1 0.7 -0.2
Diabetes (mother) 1.5 1.9 3.6 0.9 1.6 -1.9 1.2 1.4 -1.1
Severe depression (siblings) 0.2 0.3 1.0 -0.2 1.0 -0.3 0.1 -0.6 0.0
Pack years adult smoking proportion 0.9 1.3 3.7 0.2 1.9 -1.2 1.1 1.1 -0.4
Impedance of leg (right) 0.3 1.2 2.2 -0.7 -0.6 1.5 -0.8 -1.3 1.5
Leg fat-free mass (left) 3.8 19.9 30.4 4.0 1.1 -5.5 4.3 5.0 -5.3
Trunk fat percentage 2.4 9.8 15.4 3.9 -1.6 -3.1 3.1 3.5 -3.1
Hand grip strength (right) 4.5 12.2 17.5 3.4 1.8 -4.2 4.1 3.2 -3.7
Townsend deprivation index at recruitment 0.0 0.0 0.2 0.1 -0.5 0.1 0.1 0.0 -0.1
Current tobacco smoking 0.3 0.5 0.9 -0.8 0.5 0.7 -0.9 -0.6 0.3
Average weekly fortified wine intake 0.8 0.9 1.8 -1.3 -0.8 1.1 -0.7 -1.4 0.2
Maternal smoking around birth 1.7 2.5 4.3 -1.3 1.8 1.6 -1.6 -0.9 2.1
Fed-up feelings 0.3 0.5 1.7 -0.3 1.3 -0.5 0.4 -0.6 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.5 0.4 0.4 -0.2 0.1 -0.0 -1.2
Relative age voice broke 0.2 0.3 1.2 0.3 0.5 -0.1 0.4 -0.6 1.1
Taking other prescription medications 3.5 5.4 8.4 -2.5 0.7 2.5 -2.4 -2.9 2.3
Age when periods started (menarche) 0.9 2.2 5.5 -1.9 -1.1 1.1 -0.8 -1.1 2.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.0 1.4 -1.4 -0.6 0.8 1.0 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 6.4 2.5 0.7 -2.4 2.2 1.8 -1.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.0 1.0 0.4 -0.9 0.9 0.8 -0.8
Qualifications: CSEs or equivalent 1.2 1.6 3.5 -1.9 1.1 1.1 -1.4 -0.8 1.1
Serious illness, injury or assault to yourself 0.1 0.2 0.5 0.0 -0.1 0.6 -0.7 -0.1 0.5
High blood pressure 5.5 15.4 32.7 -3.8 2.7 3.6 -4.2 -5.7 2.8
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.0 -1.0 0.1 1.0 -0.9 -0.6 0.8
Multivitamins +/- minerals 0.4 0.5 2.9 -0.1 1.7 -0.1 0.1 -0.2 0.1
Stomach or abdominal pain in last month 0.1 0.2 0.7 0.0 0.3 0.4 -0.8 -0.0 -0.2
Supplements: Glucosamine 3.2 4.2 6.3 -2.4 -1.6 2.3 -2.5 -1.3 1.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.5 0.3 0.0 0.5 0.1 -0.1
Medication: Atenolol 0.7 0.9 2.0 -0.5 0.4 1.4 -1.2 -1.3 0.2
Medication: Levothyroxine sodium 0.4 0.7 1.3 -0.8 0.4 1.0 -1.0 -0.5 1.1
Sitting height 2.1 14.7 24.4 3.4 0.2 -4.9 3.5 4.2 -4.7
Chronic bronchitis/emphysema (father) 0.4 0.4 0.8 -0.6 0.2 0.7 -0.8 -0.5 -0.9
High blood pressure (mother) 0.3 0.4 1.2 -0.5 1.0 0.0 -0.2 -1.1 -0.5
Body mass index (BMI) 0.4 1.8 3.9 1.5 0.2 -1.3 1.1 2.0 -1.3
Impedance of leg (left) 0.2 0.8 1.7 -0.3 -0.5 1.3 -0.6 -1.2 1.1
Leg predicted mass (left) 3.7 19.6 29.9 4.0 1.1 -5.5 4.3 5.0 -5.3
Trunk fat mass 3.6 15.5 20.0 4.5 -0.9 -4.2 4.0 4.5 -4.3
Waist circumference 2.4 8.8 15.1 3.0 0.4 -3.2 2.9 3.9 -3.1
Number of incorrect matches in round 0.7 1.2 3.4 -0.8 0.1 1.1 -1.1 -1.8 -0.8
Past tobacco smoking 1.5 2.8 4.3 1.2 -1.0 -2.1 1.9 1.6 -2.0
Alcohol usually taken with meals 0.8 1.2 5.8 0.6 -2.4 0.3 -0.1 0.9 -0.6
Nervous feelings 0.7 1.4 6.9 0.1 2.6 0.6 -0.0 -0.9 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.4 -0.3 1.8 0.7 -0.9 -1.0 -0.0
Hearing difficulty/problems with background noise 1.1 1.8 4.5 -1.0 0.8 1.5 -1.3 -2.1 0.9
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 -0.8 -0.5 0.8 -0.6 -0.2 0.6
Had menopause 4.7 5.9 9.3 -2.5 0.5 3.1 -2.2 -2.8 2.5
Had other major operations 1.4 1.7 4.3 -0.8 -2.1 1.4 -1.0 -0.5 1.5
Forced vital capacity (FVC) 5.5 21.3 34.5 4.8 1.0 -5.9 5.5 4.4 -4.4
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 5.3 1.5 2.3 -1.8 1.6 0.5 -1.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.7 0.6 1.9 0.5 -0.2 -0.5 0.4
Qualifications: None of the above 5.4 11.5 19.9 -3.0 2.4 3.6 -3.2 -4.5 3.4
Financial difficulties in last 2 years 0.2 0.2 0.9 0.0 0.4 -0.9 0.4 0.4 -0.1
Mouth/teeth dental problems 1.7 2.7 4.2 1.5 -1.6 -1.7 1.9 2.0 -0.4
Heart attack 1.1 1.4 2.0 -1.4 0.7 1.4 -1.4 -1.4 0.5
Allergy 1.3 3.0 3.9 1.9 -0.5 -2.0 1.9 1.6 -1.9
Pain all over the body in last month 2.8 3.0 3.7 -1.9 -1.4 1.9 -1.8 -1.5 1.9
Diabetes (self-reported) 0.3 0.4 1.0 -1.0 -0.3 0.4 -0.9 -0.7 -0.0
Hayfever/allergic rhinitis (self-reported) 3.1 4.1 5.7 -2.1 0.7 2.0 -2.2 -2.3 2.4
Medication: Ramipril 1.3 1.7 6.9 -0.9 0.1 0.9 -1.3 -2.6 0.3
Medication: Simvastatin 1.8 2.6 3.9 -2.0 0.7 1.5 -1.6 -1.9 1.6
Fluid intelligence score 0.7 1.5 3.2 1.3 -0.5 -1.3 1.3 1.8 -0.8
Illnesses of siblings 0.7 1.0 1.7 1.1 -0.4 -0.9 0.8 1.3 -1.2
Neuroticism score 0.7 1.4 7.0 0.1 2.7 -0.5 0.6 -0.6 -0.5
Weight 3.4 16.9 23.2 4.0 0.7 -4.8 4.0 4.8 -4.8
Impedance of arm (right) 0.8 3.6 8.4 1.9 -2.9 -1.6 2.1 1.1 -1.0
Arm fat percentage (right) 1.7 6.6 9.6 3.1 -1.5 -2.5 2.4 3.1 -2.5
Trunk fat-free mass 3.0 17.4 26.6 3.2 2.7 -5.0 3.8 4.5 -5.2
Hip circumference 3.4 14.6 19.7 4.2 0.2 -4.4 3.9 4.3 -4.1
Time employed in main current job 0.4 0.5 1.3 0.8 0.3 -0.5 0.7 1.2 -0.2
Alcohol intake versus 10 years previously 0.8 1.2 4.2 0.9 2.0 -1.1 0.6 0.4 -0.7
Father’s age at death 0.7 1.0 1.1 -0.9 -0.8 1.1 -1.0 -1.0 1.0
Worrier / anxious feelings 0.6 1.2 6.0 -0.6 2.5 0.1 0.3 -0.8 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.5 -0.8 -0.4 0.1 0.7 0.1
Falls in the last year 1.1 1.6 3.2 -0.8 -0.1 1.8 -1.6 -1.3 1.2
Hair/balding pattern: Pattern 3 2.2 3.3 6.6 1.8 2.6 -1.6 2.0 1.5 -1.1
Number of live births 0.2 0.3 0.7 -0.1 -0.5 0.9 -0.5 -0.7 0.3
Forced expiratory volume in 1-second (FEV1) 5.1 17.3 26.8 4.6 1.0 -5.2 4.9 3.9 -3.9
Pulse rate 3.3 5.5 9.2 -2.1 -1.0 2.7 -2.2 -2.5 3.0
Happiness 1.2 1.5 3.1 0.5 -0.2 -1.5 1.8 0.2 -1.7
Noisy workplace 1.2 1.5 3.2 -1.6 1.4 0.7 -0.9 -1.8 -0.3
Qualifications: A levels/AS levels or equivalent 4.2 9.2 17.5 3.3 -1.8 -3.0 3.0 4.2 -2.5
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.6 0.5 -1.9 -1.1 0.9 0.8 -1.5
Mouth/teeth dental problems: Dentures 0.4 0.6 2.5 0.1 1.6 0.3 -0.2 -0.2 -0.9
Asthma 3.0 5.8 8.4 -2.8 0.1 2.6 -2.9 -2.2 2.7
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.8 -0.5 0.6 1.8 -1.5 -0.9 1.9
Medication: Cholesterol lowering 0.1 0.1 0.4 -0.2 0.0 0.1 -0.3 -0.6 -0.6
Depression (self-reported) 0.5 0.5 2.5 0.6 0.1 -0.2 -0.2 0.6 -1.6
Medication: Lansoprazole 0.2 0.2 0.9 0.4 1.0 -0.1 -0.0 0.1 0.4
Prospective memory result 1.1 1.3 2.4 -0.8 -1.6 1.4 -1.4 -0.8 0.2
Lung cancer (father) 0.4 0.5 2.5 -0.6 -1.6 -0.2 -0.1 -0.2 -0.0
Illnesses of mother 0.2 0.2 0.8 0.2 -0.3 0.9 -0.6 0.4 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 5.3 16.8 25.4 4.5 0.8 -5.0 5.0 3.9 -3.8
Pulse wave Arterial Stiffness index 3.9 4.5 7.9 -2.7 0.6 2.0 -2.3 -2.8 1.5
Impedance of arm (left) 1.0 4.7 8.2 2.5 -2.9 -1.8 2.5 1.3 -1.5
Arm fat mass (right) 2.1 8.5 13.3 3.2 -0.5 -3.1 2.8 3.6 -3.1
Trunk predicted mass 3.0 17.0 26.0 3.2 2.6 -4.9 3.8 4.5 -5.1
Standing height 4.1 40.9 62.6 5.8 1.5 -7.9 6.7 6.5 -7.8
Length of working week for main job 1.5 1.6 3.1 -0.7 -1.5 1.4 -1.2 -0.7 1.8
Exposure to tobacco smoke at home 2.4 2.7 4.2 -2.0 -0.6 1.7 -1.5 -2.0 1.7
Breastfed as a baby 0.1 0.2 0.4 -0.7 0.0 0.7 0.1 -0.1 0.2
Tense / ‘highly strung’ 0.5 0.8 2.9 -1.1 -0.1 0.1 -0.4 -1.7 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 3.9 -2.0 0.5 1.5 -1.7 -1.8 0.7
Hair/balding pattern: Pattern 4 2.9 7.0 10.4 3.1 -1.4 -2.7 2.4 3.2 -2.6
Birth weight of first child 1.7 3.1 7.9 1.3 0.2 -2.3 1.9 2.8 -0.4
Peak expiratory flow (PEF) 3.8 8.9 12.7 3.6 2.2 -3.5 3.3 2.8 -2.1
Pulse wave reflection index 1.3 1.6 3.3 -1.8 1.0 0.7 -1.4 -1.6 0.6
Ever highly irritable/argumentative for 2 days 2.4 2.9 6.2 1.4 1.6 -1.9 1.5 0.9 -2.5
Loud music exposure frequency 1.0 1.0 4.1 -0.3 2.0 0.3 -0.5 -1.3 -0.3
Qualifications: O levels/GCSEs or equivalent 10.5 16.7 28.5 4.4 -2.4 -4.1 4.0 5.3 -3.5
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.5 0.2 -0.1 -0.7 0.7 -0.2 -0.4
Blood clot in the leg (DVT) 0.3 0.3 0.9 0.7 1.0 -0.6 0.5 0.1 -0.2
Medication: Paracetamol 2.1 3.5 5.1 -1.6 2.3 2.1 -2.0 -1.7 1.4
Headache pain in last month 0.9 1.5 3.2 1.6 -0.1 -0.7 0.7 1.4 -1.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.6 0.6 -0.6 -0.3 0.6 1.3 -0.4
Glaucoma (self-reported) 0.3 0.4 1.7 -0.4 -1.3 0.4 -0.3 -0.5 0.2
Gout (self-reported) 0.3 0.4 1.9 0.5 -1.4 -0.2 -0.2 0.5 -0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.5 -1.1 0.0 1.0 -1.2 -1.2 0.9
Medication: Amlodipine 2.3 3.3 6.8 -1.8 1.7 1.3 -1.9 -2.6 1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 0.1 -0.2 -0.4 -0.3 0.6 -0.2
Birth weight 0.1 0.1 0.7 -0.0 0.1 -0.1 0.3 0.3 -0.8
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.3 -1.1 0.9 1.1 -1.0 -1.1 -0.8
High blood pressure (siblings) 2.0 2.8 7.0 -1.7 1.4 1.6 -1.6 -2.6 0.6
Forced vital capacity (FVC), Best measure 5.9 21.7 33.3 5.1 1.4 -5.8 5.5 4.4 -4.3
Body fat percentage 1.6 6.4 10.5 3.2 -1.4 -2.4 2.4 2.9 -2.6
Leg fat percentage (right) 0.2 0.7 1.8 1.1 -1.0 -0.3 0.3 1.3 -0.5
Arm fat-free mass (right) 2.3 11.8 16.9 2.8 2.5 -4.0 3.0 3.9 -4.1
Exposure to tobacco smoke outside home 0.2 0.3 1.2 0.1 -1.1 -0.2 0.1 0.2 -0.4
Comparative body size at age 10 1.3 3.6 7.6 1.1 -1.3 -1.8 2.0 2.0 -2.8
Number of full brothers 0.3 0.4 1.0 0.0 1.0 0.3 0.2 -0.4 0.9
Worry too long after embarrassment 0.7 1.2 4.0 -1.2 0.7 0.5 -0.5 -0.8 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.8 1.6 -0.8 1.1 1.0 -1.3 -0.7 0.0
Wheeze or whistling in the chest in last year 1.0 1.8 3.7 -1.9 -0.2 1.2 -1.5 -1.4 1.2
Number of children fathered 1.6 1.8 3.6 -1.4 1.1 1.4 -1.3 -1.9 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.7 0.0 1.3 0.1 -0.1 -1.0 0.0
Age at first live birth 1.1 1.9 3.6 1.1 -1.9 -1.3 1.2 1.9 -0.5
Pulse wave peak to peak time 5.3 6.2 10.7 3.1 -0.4 -2.4 2.7 3.3 -1.9
Health satisfaction 0.4 0.5 1.2 0.8 0.3 -0.5 0.8 0.1 -1.1
Shortness of breath walking on level ground 2.3 2.8 5.7 -1.4 0.3 1.5 -1.8 -1.9 2.4
Qualifications: College or University degree 2.2 6.9 8.2 2.7 -2.0 -2.8 2.8 2.9 -2.6
Eye problems/disorders: None of the above 0.2 0.2 0.7 0.1 0.8 -0.5 0.3 0.6 -0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.1 1.5 -0.3 -1.1 1.1 1.4 -1.4
Emphysema/chronic bronchitis 2.1 2.3 4.3 -2.1 0.2 1.8 -1.7 -1.2 1.6
Medication for pain relief, constipation, heartburn 5.8 9.9 14.2 3.1 -2.7 -3.4 3.1 3.8 -2.6
Neck or shoulder pain in last month 0.9 1.3 2.4 -1.0 1.5 0.8 -1.5 -1.0 1.0
Medication: Blood pressure 1.1 1.9 4.8 -1.1 1.4 0.8 -1.0 -2.2 1.3
Angina (self-reported) 1.1 1.5 3.1 -1.5 0.4 1.0 -1.5 -1.8 -0.0
Migraine (self-reported) 0.1 0.2 0.5 -0.1 0.7 0.4 0.0 0.3 0.4
Medication: Ibuprofen 0.9 1.1 3.8 -0.1 0.5 1.2 -1.0 -0.3 2.0
Medication: Allopurinol 0.4 0.5 0.9 -0.8 -0.3 0.7 -0.9 -0.4 0.9
Medication: Omeprazole 2.6 3.1 7.2 -1.4 2.7 1.5 -1.8 -1.7 1.1
Medication: Seretide 50 evohaler 0.8 0.9 1.3 -1.1 -1.0 0.6 -1.0 -0.5 1.2
Mean time to correctly identify matches 0.3 0.6 2.4 0.5 -0.1 -0.4 0.4 -0.8 -1.6
Heart disease (mother) 0.4 0.4 1.2 -0.6 -0.3 0.1 -0.2 -1.0 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.5 -1.4 0.4 1.7 -1.9 -1.6 0.6
Whole body fat mass 2.7 11.4 15.4 3.8 -0.8 -3.6 3.3 3.9 -3.8
Leg fat mass (right) 1.1 4.4 8.4 2.3 -0.5 -2.2 1.7 2.9 -2.3
Arm predicted mass (right) 2.4 12.2 18.4 2.8 2.4 -4.1 3.0 3.9 -4.3
Pulse rate, automated reading 5.6 18.0 28.5 -4.1 -0.8 4.8 -4.3 -4.5 5.3
Alcohol intake frequency. 1.0 2.3 5.1 1.5 0.5 -1.5 1.4 1.5 -2.3
Comparative height size at age 10 3.9 21.3 31.6 4.3 1.7 -5.5 5.0 4.4 -5.6
Number of full sisters 1.6 1.9 3.6 -1.4 -1.2 1.9 -1.6 -1.0 1.1
Suffer from ‘nerves’ 0.3 0.4 1.2 0.6 1.1 -0.5 0.8 0.4 0.2
Overall health rating 2.6 5.6 8.9 -2.7 -0.5 2.7 -3.0 -2.6 1.8
Chest pain or discomfort 0.2 0.3 1.1 -1.1 0.3 0.1 -0.0 -0.6 0.0
Had major operations 0.2 0.2 0.5 0.0 0.2 -0.5 0.7 0.7 0.2
Age at last live birth 0.3 0.4 1.4 0.1 -1.2 -0.4 0.3 0.2 0.8
Family relationship satisfaction 1.3 1.6 6.0 1.1 -0.1 -1.0 0.9 0.5 -2.5
Leg pain on walking 1.3 1.7 3.8 -1.9 -0.3 1.2 -1.4 -1.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.2 -0.4 0.5 -0.2 0.6 -0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 0.6 0.2 -0.3 -0.0 0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.3 1.1 0.1 -0.9 0.9 0.7 -0.4
Medication: Aspirin 2.3 3.0 7.0 -1.9 1.1 1.5 -1.2 -2.7 1.5
Supplements: Vitamin C 1.6 1.8 3.8 -2.0 1.0 0.9 -1.3 -1.2 1.5
Knee pain experienced in last month 1.2 1.9 4.0 -1.8 -0.3 1.4 -1.5 -2.0 0.3
Hypertension (Self-reported) 5.5 15.2 32.4 -3.8 2.4 3.5 -4.2 -5.7 3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.7 -0.7 -0.1 0.7 -0.9 -0.6 -0.6
Illnesses of father: Heart disease 0.2 0.3 1.7 0.1 1.3 -0.3 0.0 -0.1 -0.4
Illnesses of siblings: Diabetes 0.4 0.5 1.9 -0.3 -0.8 -0.3 0.3 0.3 1.4
Smoking status: Previous 0.9 1.3 3.1 -0.8 0.6 1.5 -1.1 -0.7 1.8
Forced expiratory volume in 1-second (FEV1), predicted 7.3 15.1 20.7 3.6 1.9 -4.5 4.2 4.1 -4.3
Whole body fat-free mass 3.3 18.6 28.4 3.6 2.1 -5.2 4.0 4.7 -5.3
Leg fat-free mass (right) 3.8 20.3 31.1 4.0 1.1 -5.6 4.3 4.9 -5.5
Arm fat percentage (left) 1.7 6.8 10.6 3.3 -1.4 -2.5 2.5 3.1 -2.5
Average weekly red wine intake 0.6 0.9 2.3 -0.7 -1.5 0.8 -1.3 0.2 0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.6 1.6 -0.3 -0.5 0.5 0.6 -0.3
Mood swings 1.0 1.7 5.6 0.9 2.4 -1.2 0.9 -0.2 -1.4
Loneliness, isolation 0.8 1.1 5.7 -0.2 2.4 0.2 -0.1 -0.4 -0.7
Long-standing illness, disability or infirmity 2.3 3.5 6.1 -2.5 1.1 1.6 -2.1 -2.5 0.7
Ever had bowel cancer screening 1.7 2.0 4.1 -1.2 -2.0 1.6 -1.3 -0.3 1.4
Diabetes diagnosed by doctor 0.5 0.8 1.6 -1.3 -0.2 0.5 -1.2 -1.1 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 -0.6 -0.2 0.1 -0.2 0.3 1.1
Friendships satisfaction 0.7 0.9 2.4 0.2 0.8 -0.8 1.2 0.0 -1.6
Qualifications: nursing, teaching 5.2 8.0 13.8 2.8 -1.5 -3.0 3.0 3.7 -2.5
Commuting to job workplace: Walk 0.8 0.8 2.8 -0.2 -1.7 0.7 -0.5 1.0 0.6
Eye problems/disorders: Cataract 0.8 0.9 1.6 -1.0 -0.8 1.0 -0.8 -0.7 1.3
Mouth/teeth dental problems: Mouth ulcers 3.3 5.2 10.6 -2.2 -0.1 2.8 -3.3 -2.0 2.0
Medication for cholesterol 12.1 18.4 31.8 4.6 -1.9 -4.4 4.7 5.6 -3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.1 2.8 -1.5 -0.2 1.6 -1.6 -1.5 1.7
Back pain experienced in last month 0.9 1.3 2.5 -1.4 -1.0 1.5 -1.6 -0.6 0.4
Mineral and other dietary supplements 4.8 6.4 11.3 2.9 -0.1 -2.5 2.5 2.4 -3.4
Breast cancer (self-reported) 3.4 4.1 6.8 -2.1 0.3 2.0 -2.2 -2.2 2.6
Asthma (self-reported) 2.9 5.9 8.2 -2.9 0.0 2.6 -2.9 -2.2 2.7
Osteoporosis (self-reported) 0.5 0.6 2.0 -0.6 0.1 0.7 -0.8 -0.1 1.4
Osteoarthritis (self-reported) 4.2 5.4 10.3 -2.6 -0.4 2.4 -2.6 -3.2 1.6
Medication: Aspirin 1.1 1.4 4.7 -1.3 0.4 1.0 -0.6 -2.2 0.7
Medication: Gliclazide 1.2 1.3 2.2 -1.2 -0.9 1.2 -1.5 -1.5 0.1
Illnesses of father: None of the above (group 1) 0.9 1.1 4.7 -0.2 -2.2 -0.7 0.9 0.6 0.2
Smoking status: Current 0.5 0.8 1.6 -1.0 0.6 0.9 -1.2 -1.0 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 3.1 1.7 1.1 -1.6 1.8 0.5 -1.0
Whole body water mass 3.2 18.1 27.6 3.5 2.2 -5.2 3.9 4.7 -5.2
Leg predicted mass (right) 3.8 20.1 30.9 4.0 1.2 -5.6 4.3 4.9 -5.5
Arm fat mass (left) 2.3 9.6 15.0 3.5 -0.3 -3.3 3.0 3.9 -3.3
Number of self-reported non-cancer illnesses 6.5 11.2 20.3 -4.0 0.9 3.1 -3.5 -4.5 3.0
Average weekly champagne plus white wine intake 0.1 0.2 0.5 -0.7 0.1 0.1 -0.2 -0.7 0.5
Miserableness 0.7 1.3 6.7 -0.1 2.6 0.1 -0.3 -0.6 -0.8
Guilty feelings 0.2 0.2 1.0 0.3 1.0 -0.2 0.5 -0.1 0.2
Wears glasses or contact lenses 0.5 0.6 3.2 -0.3 1.8 0.1 0.1 -0.1 0.2
Ever taken oral contraceptive pill 1.4 1.5 4.4 1.2 2.1 -1.0 1.1 0.5 -0.9
Hearing aid user 0.1 0.1 0.4 -0.0 -0.1 -0.1 0.2 -0.4 0.7
Mother’s age at death 0.8 0.9 3.8 0.1 -1.9 0.5 -0.2 1.1 0.7
Financial situation satisfaction 0.1 0.1 0.4 -0.6 0.0 0.2 -0.1 -0.2 -0.3
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.5 0.1 0.7 -0.7 -0.5 0.0
Commuting to job workplace: Public transport 0.0 0.1 0.2 -0.4 -0.1 0.1 0.0 -0.3 -0.1
Eye problems/disorders: Glaucoma 0.4 0.4 1.5 -0.2 -1.2 0.4 -0.3 -0.8 0.4
Medication: Blood pressure 10.9 20.7 36.1 -4.8 2.1 4.7 -5.3 -6.0 3.3
Pain type(s) experienced in last month: Hip pain 1.6 2.1 4.9 -1.5 0.2 1.8 -2.2 -1.2 0.7
Supplements: Fish oil (including cod liver oil) 2.3 3.1 7.8 -1.6 0.2 1.7 -1.5 -1.7 2.8
High cholesterol (Self-reported) 0.5 0.9 2.5 -1.3 -0.4 0.8 -0.7 -1.6 0.1
Medication: Bendroflumethiazide 3.2 4.8 9.3 -2.1 1.5 2.0 -2.4 -3.1 1.8
Medication: Paracetamol 2.2 3.4 5.1 -1.5 2.3 2.2 -2.0 -1.5 1.5
Medication: Lisinopril 2.5 3.3 4.1 -1.8 1.3 1.9 -1.8 -1.9 2.0
Medication: Atorvastatin 1.3 1.7 3.0 -1.3 -0.6 1.5 -1.6 -1.7 0.0
Illnesses of father: High blood pressure 0.3 0.4 1.0 0.5 1.0 -0.1 0.2 0.6 0.9
Alcohol drinker status: Never 0.1 0.1 0.3 0.1 0.0 0.4 -0.6 0.2 0.4
Ever smoked 1.4 2.5 4.1 -0.9 0.5 2.0 -2.0 -1.4 2.0
Basal metabolic rate 3.7 20.2 29.5 4.0 1.8 -5.4 4.2 5.1 -5.4
Leg fat percentage (left) 0.3 1.0 2.0 1.4 -0.9 -0.4 0.5 1.4 -0.8
Arm fat-free mass (left) 2.2 11.2 15.9 2.7 2.2 -3.9 2.9 4.0 -4.0
Number of operations (self-reported) 1.5 2.2 3.3 -1.8 -0.0 1.4 -1.5 -1.6 1.6
Average weekly beer plus cider intake 0.1 0.2 0.7 -0.2 -0.4 -0.4 0.3 -0.3 -0.8
Irritability 0.9 1.5 5.9 -0.7 2.4 -0.7 -0.2 -1.3 -0.6
Risk taking 1.9 2.8 3.9 -1.8 1.0 1.4 -1.8 -2.0 1.8
Ever had prostate specific antigen (PSA) test 4.4 5.1 7.1 2.7 -1.3 -2.4 2.0 2.5 -2.4
Fractured/broken bones in last 5 years 0.4 0.6 2.3 -0.3 -0.4 0.7 -0.6 -0.2 1.5
Age started oral contraceptive pill 0.7 0.9 2.2 -0.6 0.0 1.5 -1.1 -1.2 0.1
Diastolic blood pressure, automated reading 4.6 14.3 24.6 -3.3 1.4 4.0 -3.8 -5.0 4.2
Ever depressed for a whole week 1.4 1.8 3.0 1.4 1.7 -1.1 1.0 0.8 -1.6
Unable to work because of sickness or disability 0.8 1.0 2.5 -1.1 -0.9 0.8 -1.6 -0.9 -0.0
Commuting to job workplace: Cycle 0.2 0.3 0.7 -0.8 0.3 -0.7 0.5 -0.3 -0.3
Myopia 0.4 0.6 1.8 -1.0 -0.7 0.1 -0.1 0.5 1.3
Vascular/heart problems diagnosed by doctor 6.0 16.5 35.5 3.9 -2.8 -3.8 4.3 6.0 -2.8
Cholesterol lowering medication 7.6 11.2 15.0 -3.8 -0.1 3.7 -3.9 -3.6 3.3
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 3.7 -1.2 1.9 1.3 -1.5 -1.2 1.0
Pain experienced in last month 1.7 2.8 4.5 2.0 -1.1 -1.8 2.1 1.9 -0.8
Supplements: Calcium 1.0 1.1 1.9 -0.8 -1.1 1.2 -1.0 -0.7 1.4
Basal cell carcinoma (self-reported) 1.4 1.7 4.1 -1.2 -0.3 0.9 -1.3 -1.4 2.0
Heart attack/myocardial infarction (self-reported) 1.4 1.8 2.8 -1.6 0.6 1.5 -1.5 -1.7 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 0.6 0.7 -0.7 0.5 0.3 -0.1
Heart disease (siblings) 0.2 0.3 1.0 0.0 0.6 0.1 -0.4 -0.0 1.0
Alcohol drinker status: Previous 2.2 2.5 7.6 1.6 -0.4 -1.4 1.1 1.2 -2.8
Pack years of smoking 0.7 1.0 2.2 0.2 1.5 -1.1 1.0 1.3 -0.3
Impedance of whole body 0.2 1.2 4.5 1.2 -2.1 -0.3 1.1 0.1 -0.1
Leg fat mass (left) 1.2 4.7 8.5 2.4 -0.4 -2.2 1.8 2.9 -2.4
Arm predicted mass (left) 2.1 10.9 15.7 2.7 2.1 -3.8 2.8 4.0 -4.0