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chr15:74,042,497-76,108,550

Best TWAS P=9.12e-11 · Best GWAS P=9.54e-11 conditioned to 0.0664

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MPI	0.13	0.11	blup	277	0.14	1.6e-16	6.1	-6.0	2.2e-09	-0.82	0.13	0.87	FALSE
2	GTEx	Adipose Subcutaneous	FAM219B	0.07	0.01	lasso	6	0.02	1.4e-02	5.1	-6.0	1.8e-09	-0.77	0.07	0.84	FALSE
3	GTEx	Adipose Subcutaneous	MPI	0.05	0.05	lasso	7	0.04	6.6e-04	5.5	-5.7	1.2e-08	-0.73	0.06	0.84	FALSE
4	GTEx	Adipose Subcutaneous	CTD-2235H24.2	0.09	0.01	lasso	13	0.01	1.2e-01	5.8	-5.8	5.1e-09	-0.82	0.08	0.78	FALSE
5	GTEx	Adipose Visceral Omentum	ULK3	0.13	0.12	enet	8	0.11	3.3e-06	6.4	6.2	5.3e-10	0.89	0.03	0.97	FALSE
6	GTEx	Brain Caudate basal ganglia	MPI	0.23	0.25	lasso	4	0.23	3.1e-07	6.0	-6.2	4.5e-10	-0.81	0.03	0.96	FALSE
7	GTEx	Brain Cerebellum	MPI	0.14	0.09	enet	13	0.09	9.7e-04	-3.0	-5.1	3.1e-07	-0.76	0.09	0.78	FALSE
8	GTEx	Brain Frontal Cortex BA9	MPI	0.29	0.12	lasso	10	0.19	9.7e-06	6.2	-6.4	1.9e-10	-0.87	0.03	0.96	FALSE
9	GTEx	Brain Hippocampus	MPI	0.13	0.07	lasso	3	0.06	1.7e-02	5.8	-5.6	1.6e-08	-0.81	0.04	0.43	FALSE
10	GTEx	Breast Mammary Tissue	ULK3	0.15	0.11	lasso	3	0.09	1.6e-05	6.0	6.0	2.1e-09	0.80	0.04	0.96	FALSE
11	GTEx	Breast Mammary Tissue (Male)	PPCDC	0.07	0.00	enet	8	-0.01	7.9e-01	3.7	5.1	2.7e-07	0.75	0.04	0.18	FALSE
12	GTEx	Breast Mammary Tissue (Male)	ULK3	0.19	0.19	lasso	2	0.15	2.4e-04	6.1	5.7	9.3e-09	0.68	0.03	0.68	FALSE
13	GTEx	Breast Mammary Tissue (Female)	ULK3	0.08	0.01	lasso	2	0.01	1.8e-01	5.8	5.8	5.9e-09	0.83	0.03	0.40	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	ULK3	0.19	0.04	lasso	2	0.08	1.2e-03	5.8	5.9	4.8e-09	0.82	0.04	0.88	FALSE
15	GTEx	Cells Transformed fibroblasts	ULK3	0.12	0.04	lasso	5	0.10	8.4e-08	5.9	5.6	2.2e-08	0.82	0.11	0.89	FALSE
16	GTEx	Cells Transformed fibroblasts	MPI	0.21	0.16	enet	15	0.22	1.1e-16	6.2	-5.9	3.8e-09	-0.80	0.02	0.98	FALSE
17	GTEx	Esophagus Mucosa	SCAMP2	0.36	0.20	enet	20	0.27	1.8e-18	5.5	-5.2	2.0e-07	-0.60	0.57	0.43	FALSE
18	GTEx	Esophagus Mucosa	COX5A	0.11	0.02	enet	23	0.03	6.9e-03	6.1	-5.2	2.6e-07	-0.64	0.04	0.73	FALSE
19	GTEx	Esophagus Mucosa	MPI	0.11	0.11	lasso	7	0.10	2.3e-07	5.5	-5.9	3.3e-09	-0.77	0.16	0.84	FALSE
20	GTEx	Lung	CSK	0.09	0.06	lasso	3	0.05	1.4e-04	6.0	6.3	3.7e-10	0.86	0.04	0.96	FALSE
21	GTEx	Muscle Skeletal	UBL7	0.06	0.02	lasso	6	0.01	3.7e-02	5.9	-6.1	8.3e-10	-0.86	0.04	0.77	FALSE
22	GTEx	Nerve Tibial	MPI	0.10	0.12	enet	12	0.15	1.5e-10	4.1	-5.5	3.3e-08	-0.79	0.49	0.51	FALSE
23	GTEx	Ovary	ULK3	0.19	0.23	lasso	1	0.23	3.0e-06	5.8	5.8	6.0e-09	0.83	0.07	0.62	FALSE
24	GTEx	Pancreas	ULK3	0.12	0.10	lasso	4	0.07	6.9e-04	5.8	6.0	1.9e-09	0.85	0.04	0.94	FALSE
25	GTEx	Skin Sun Exposed Lower leg	MPI	0.04	0.01	lasso	4	0.02	7.4e-03	4.1	-5.4	7.4e-08	-0.71	0.05	0.92	FALSE
26	GTEx	Stomach	ULK3	0.16	0.13	lasso	2	0.11	9.7e-06	5.8	5.9	4.5e-09	0.82	0.06	0.93	FALSE
27	GTEx	Testis	MPI	0.09	0.08	enet	12	0.04	6.0e-03	5.3	-5.6	2.2e-08	-0.75	0.05	0.84	FALSE
28	GTEx	Thyroid	ULK3	0.11	0.09	lasso	4	0.13	5.9e-10	5.8	5.7	1.5e-08	0.77	0.07	0.93	FALSE
29	GTEx	Thyroid	MPI	0.06	0.07	enet	12	0.07	5.1e-06	5.4	-5.7	1.1e-08	-0.78	0.20	0.80	FALSE
30	GTEx	Uterus	ULK3	0.40	0.16	lasso	16	0.12	2.2e-03	5.8	6.0	2.3e-09	0.80	0.04	0.71	FALSE
31	GTEx	Vagina	COX5A	0.38	0.02	lasso	7	0.02	9.3e-02	6.3	-6.2	6.3e-10	-0.80	0.03	0.72	FALSE
32	GTEx	Whole Blood	ULK3	0.14	0.06	lasso	5	0.04	8.3e-05	5.8	5.4	8.5e-08	0.77	0.08	0.90	FALSE
33	GTEx	Whole Blood	MPI	0.04	0.04	lasso	2	0.01	1.7e-02	6.1	-6.0	1.6e-09	-0.81	0.04	0.85	FALSE
34	METSIM	Adipose	MPI	0.08	0.06	blup	273	0.07	3.1e-11	6.2	-5.5	3.8e-08	-0.68	0.03	0.97	FALSE
35	METSIM	Adipose	ULK3	0.14	0.14	lasso	10	0.15	3.2e-22	5.8	6.1	1.1e-09	0.87	0.08	0.92	FALSE
36	YFS	Blood	CSK	0.13	0.15	lasso	11	0.16	6.7e-51	6.3	6.3	2.5e-10	0.93	0.02	0.98	FALSE
37	YFS	Blood	MPI	0.02	0.02	lasso	4	0.03	1.2e-09	6.1	-6.5	9.1e-11	-0.85	0.05	0.95	TRUE
38	YFS	Blood	ULK3	0.09	0.11	lasso	6	0.11	1.1e-33	5.8	6.1	1.2e-09	0.87	0.22	0.78	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MPI	0.09	0.00	blup	36	0.02	7.9e-03	6.1	-5.1	2.9e-07	-0.77	0.01	0.27	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	C15orf17	0.02	0.02	lasso	1	0.02	1.9e-05	6.3	-6.3	3.1e-10	-0.71	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	MPI	0.04	0.07	enet	13	0.06	5.8e-13	5.5	-5.9	3.3e-09	-0.74	0.38	0.62	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPP25	0.02	0.01	blup	23	0.02	6.8e-05	6.1	5.7	9.2e-09	0.78	0.01	0.98	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK3	0.02	0.02	blup	49	0.02	1.1e-05	5.8	6.3	2.9e-10	0.89	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ULK3	0.21	0.02	enet	8	0.07	1.9e-04	6.0	5.1	2.6e-07	0.73	0.01	0.70	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	MPI	0.07	0.03	blup	36	0.04	2.1e-03	6.1	-6.5	1.0e-10	-0.83	0.01	0.94	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	MPI	0.11	0.03	blup	36	0.02	8.4e-02	6.1	-6.5	1.1e-10	-0.83	0.01	0.71	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MPI	0.02	0.01	blup	36	0.01	1.2e-02	6.1	-6.2	5.7e-10	-0.79	0.01	0.73	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSK	0.02	0.00	blup	57	0.01	1.8e-02	5.9	5.3	1.4e-07	0.74	0.02	0.61	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK3	0.03	0.03	lasso	3	0.03	5.3e-04	5.8	6.1	8.1e-10	0.86	0.02	0.96	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MPI	0.06	0.04	blup	35	0.05	8.5e-04	6.0	-6.4	1.8e-10	-0.81	0.01	0.95	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPP25	0.05	0.03	blup	23	0.04	3.7e-03	-4.2	5.4	7.4e-08	0.73	0.01	0.71	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	MPI	0.07	0.09	lasso	4	0.10	2.4e-11	6.1	-6.3	3.2e-10	-0.80	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAMP2	0.18	0.04	enet	5	0.06	6.1e-07	6.5	-5.5	3.6e-08	-0.85	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK3	0.10	0.02	blup	49	0.07	2.5e-04	6.4	5.7	1.3e-08	0.76	0.02	0.97	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	C15orf17	0.02	0.03	lasso	1	0.02	1.5e-03	6.2	-6.2	4.1e-10	-0.72	0.01	0.88	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MPI	0.04	0.03	blup	36	0.05	8.8e-07	6.3	-6.2	7.1e-10	-0.79	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK3	0.04	0.06	lasso	4	0.04	7.6e-06	5.8	5.9	2.9e-09	0.85	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MPI	0.09	0.07	blup	36	0.08	3.9e-06	-5.2	-5.6	2.5e-08	-0.71	0.15	0.85	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPI	0.07	0.07	blup	36	0.10	3.3e-10	5.5	-6.0	1.8e-09	-0.75	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	COX5A	0.03	0.03	blup	32	0.03	2.9e-03	-4.2	-5.7	1.2e-08	-0.72	0.02	0.64	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	MPI	0.04	0.02	blup	36	0.03	1.7e-03	6.3	-6.2	5.1e-10	-0.77	0.01	0.95	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MPI	0.12	0.11	lasso	7	0.12	5.3e-05	6.1	-6.3	3.1e-10	-0.75	0.01	0.98	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	MPI	0.13	0.18	enet	10	0.16	3.7e-15	5.4	-6.0	2.2e-09	-0.77	0.52	0.48	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ULK3	0.08	0.11	lasso	5	0.10	4.6e-10	5.8	6.0	1.7e-09	0.86	0.06	0.94	FALSE