Hub : Genes

C15orf17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0157	0.0091	0.00019	0.024	0.020	0.018	NA	0.022	9.2e-06	4.1e-05	0.0001	NA	1.9e-05
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0484	0.0301	0.00580	0.027	0.016	0.019	NA	0.022	4.1e-04	6.1e-03	0.0029	NA	1.5e-03
3	TCGA	Lung Adenocarcinoma	0.0220	0.0167	0.00680	0.025	0.018	0.014	NA	0.021	5.3e-04	3.4e-03	0.0087	NA	1.5e-03
4	TCGA	Pheochromocytoma and Paraganglioma	0.0600	0.0430	0.00670	0.056	0.016	0.018	NA	0.002	2.9e-03	7.7e-02	0.0620	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.1	6.5	12.3	-3.5	-0.7	-3.3	-1.5
Bipolar Disorder or Schizophrenia	1.8	4.4	10.0	-1.9	0.6	-1.8	-3.2
Depressed Affect (Nagel 2018)	0.9	1.9	3.1	-1.8	-1.4	-1.5	0.1
Depression (Nagel 2018)	4.4	6.7	17.9	-2.1	-4.2	-2.1	-0.0
Intelligence (Savage-Jansen 2018)	1.3	4.1	7.1	2.7	-0.1	2.6	1.6
Neuroticism (Nagel 2018)	0.6	1.4	2.5	-1.6	-1.0	-1.3	-0.5
Schizophrenia (2018)	1.2	2.5	8.3	0.3	1.3	0.3	-2.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	0.3	1.1	0.1	-1.3
Worry (Nagel 2018)	0.9	1.9	3.8	-1.3	-2.0	-1.2	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	0.5	-1.5	0.4	0.1
Alzheimer’s Disease (in father)	1.0	1.1	1.4	1.0	-1.2	0.9	1.2
Alzheimer’s Disease (including proxy)	1.3	1.9	3.3	1.4	-1.8	1.4	0.8
Crohns Disease (2017)	0.0	0.1	0.2	-0.1	-0.3	-0.2	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.0	-0.2	-0.0	0.8
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.5	-0.3	0.5	0.9
Major Depression (MDD)	0.3	0.4	0.8	-0.7	-0.9	-0.5	0.2
Reaction Time	0.1	0.3	0.5	0.3	0.6	0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.7	1.9	-0.6	1.9	0.9
Breast Cancer	4.3	10.3	15.7	-3.9	-1.1	-4.0	-3.0
Ovarian Cancer	0.2	0.3	0.4	0.5	-0.7	0.7	-0.4
Prostate Cancer	1.5	2.1	2.9	1.4	-1.1	1.5	1.7
Age at First Birth	1.1	1.5	3.1	-0.4	1.8	-0.4	-1.7
Bipolar Disorder (2011)	1.1	1.0	1.5	-1.1	-1.1	-1.2	-0.2
Body Mass Index (BMI) (2010)	1.9	2.5	4.6	2.1	0.7	2.1	0.9
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.6	0.6	-0.1	1.0
Crohns Disease (2012)	0.1	0.1	0.4	0.1	-0.3	0.0	0.6
Mean Putamen Volume	0.2	0.2	0.5	0.1	-0.7	0.2	0.4
Fasting Glucose	2.6	3.1	6.4	-2.5	-0.5	-2.1	-1.2
HbA1C	0.3	0.3	0.5	-0.7	-0.6	-0.6	-0.3
HDL Cholesterol	0.8	1.3	3.3	-0.1	-1.8	-0.3	1.4
LDL Cholesterol	4.9	7.8	13.9	3.6	-0.2	3.7	2.1
Lupus	1.6	2.4	3.9	-1.7	0.4	-2.0	-1.6
Neuroticism (2016)	1.3	1.8	2.9	-1.7	0.1	-1.6	-1.3
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.2	-0.8	0.2	0.4
Rheumatoid Arthritis	0.6	0.8	2.8	-0.5	-1.7	-0.5	0.3
Schizophrenia (2014)	1.5	3.4	9.7	-1.4	-0.0	-1.4	-3.1
Triglycerides	0.3	0.6	0.7	0.6	0.8	0.8	-0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.7	-1.3	-0.8	-1.1	-0.7
Ulcerative Colitis	0.4	0.6	1.8	0.4	-0.1	0.5	1.3
Blood Eosinophil Count	0.0	0.2	0.9	0.1	-1.0	0.1	0.2
Blood Platelet Count	2.1	24.7	43.0	2.9	-6.2	3.0	6.6
Blood Red Count	3.6	34.7	52.3	-7.2	2.0	-7.2	-5.5
Blood White Count	1.3	9.5	20.5	-2.4	-4.5	-2.4	2.4
Heel T-Score	0.4	3.5	7.1	2.7	0.5	2.5	-0.7
BMI	1.5	8.8	19.0	1.9	-2.9	2.0	4.4
Height	0.1	1.8	6.7	0.5	2.6	0.5	0.1
Waist Hip Ratio (WHR)	1.3	5.8	8.7	2.7	-0.5	2.6	3.0
Systolic Blood Pressure	16.1	80.6	136.9	-11.7	-0.5	-11.7	-7.0
Smoking Status	1.8	4.4	6.6	-2.2	1.2	-2.2	-2.6
Allergy or Eczema	3.5	9.2	17.3	4.1	0.9	4.2	1.4
Cardiovascular Disease	11.9	39.2	67.9	-8.1	-1.8	-8.2	-4.4
Hypothyroidism (self reported)	0.4	0.9	1.1	1.0	-0.6	1.1	1.0
Respiratory disease	1.3	2.9	4.5	2.1	0.6	2.1	1.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.5	0.2	0.2	-0.6
Lung FEV1/FVC ratio	0.5	2.4	4.1	-1.9	-1.3	-2.0	-0.3
Lung FVC	0.5	2.8	4.0	-1.5	1.4	-1.6	-2.0
Neuroticism	1.0	2.5	4.6	-2.1	-0.8	-2.0	-0.9
Chronotype (morning person)	0.6	1.5	2.2	1.4	-0.3	1.3	1.5
Hair Pigment	0.0	0.5	1.4	-0.2	-0.6	-0.2	1.2
Tanning	0.7	8.4	14.3	3.8	1.8	3.8	1.3
Hand grip strength (left)	0.3	0.8	2.4	0.3	1.5	0.1	-0.8
Number of treatments/medications taken	2.4	4.2	8.6	-2.0	-2.9	-2.0	0.4
Average weekly spirits intake	0.5	0.6	1.9	-0.3	-1.4	-0.4	-0.2
Sensitivity / hurt feelings	0.6	1.0	1.7	-0.9	-0.8	-0.9	-1.3
Frequency of depressed mood in last 2 weeks	4.3	6.0	11.0	-2.5	-3.3	-2.5	-0.8
Hearing difficulty/problems: Yes	2.6	3.9	8.5	1.7	-0.2	2.0	2.9
Relative age of first facial hair	2.1	4.4	7.9	2.8	1.4	2.8	0.3
Other serious medical condition/disability diagnosed by doctor	5.3	6.8	9.0	2.8	-1.5	2.9	3.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.3	-0.6	-0.2	-0.6	-1.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-0.9	-0.4	-0.9	-0.3
Systolic blood pressure, automated reading	8.0	23.1	40.6	-6.3	-2.0	-6.4	-2.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.0	-0.9	0.2	-0.9	-1.0
Angina	1.0	1.4	3.6	-1.0	-1.9	-0.8	-0.3
Medication for hormone replacement therapy	0.4	0.5	0.9	0.6	-0.6	0.6	0.9
Vitamin and mineral supplements	0.9	1.2	2.2	-1.5	0.3	-1.3	-0.9
Supplements: Zinc	4.4	4.8	7.6	2.8	2.1	2.6	-0.7
Medication: Co-codamol	1.6	1.9	3.6	0.9	-1.9	1.0	1.5
Medication: Metformin	0.1	0.1	0.4	0.2	-0.7	-0.1	-0.1
Diabetes (father)	0.3	0.4	0.7	0.8	0.8	0.5	0.4
Diabetes (mother)	0.9	1.1	2.1	-1.0	1.4	-1.0	-0.6
Severe depression (siblings)	0.0	0.0	0.1	0.2	-0.2	0.4	0.0
Pack years adult smoking proportion	0.4	0.6	1.2	-1.1	0.4	-1.1	-0.0
Impedance of leg (right)	0.4	1.9	2.8	-1.6	-1.4	-1.7	-0.4
Leg fat-free mass (left)	0.4	2.0	3.1	1.7	0.9	1.8	1.0
Trunk fat percentage	1.3	5.1	10.0	1.5	-2.4	1.6	3.2
Hand grip strength (right)	0.3	0.9	1.8	1.1	1.3	0.8	-0.1
Townsend deprivation index at recruitment	1.6	2.2	3.1	-1.8	-1.2	-1.6	1.4
Current tobacco smoking	3.2	5.2	9.2	-3.0	-0.4	-3.0	-1.5
Average weekly fortified wine intake	1.2	1.4	4.2	0.7	2.1	0.7	-0.4
Maternal smoking around birth	0.2	0.4	0.8	0.7	0.3	0.9	0.1
Fed-up feelings	0.5	1.0	1.4	-1.2	-1.0	-1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	5.9	7.9	24.0	-1.4	-4.9	-1.3	2.0
Relative age voice broke	1.0	1.6	2.7	1.6	1.0	1.6	-0.1
Taking other prescription medications	1.8	2.7	8.8	-0.7	-3.0	-0.7	1.1
Age when periods started (menarche)	0.5	1.2	1.7	-1.0	-1.3	-1.1	-0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.2	-1.1	-0.3	-1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	0.2	1.1	-0.1	-1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	-0.5	0.1	-0.6	-1.1
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.4	-0.9	-0.4	0.9
Serious illness, injury or assault to yourself	3.1	3.7	7.2	2.6	-0.1	2.7	0.8
High blood pressure	12.3	34.2	60.7	-7.7	-1.2	-7.8	-4.0
Hayfever, allergic rhinitis or eczema	4.0	8.7	16.0	4.0	0.5	4.0	1.6
Multivitamins +/- minerals	2.0	2.5	3.5	1.9	-1.4	1.7	1.3
Stomach or abdominal pain in last month	1.7	2.1	5.0	1.3	-0.2	1.3	2.2
Supplements: Glucosamine	6.8	8.8	16.8	4.1	0.2	3.9	1.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.1	0.5	0.0	-0.8
Medication: Atenolol	3.7	4.7	8.8	-2.8	-0.9	-3.0	-1.2
Medication: Levothyroxine sodium	0.3	0.5	0.7	0.4	-0.8	0.7	0.8
Sitting height	0.4	2.7	4.4	-1.4	1.5	-1.6	-2.1
Chronic bronchitis/emphysema (father)	2.5	2.9	6.4	0.0	-2.3	-0.0	2.5
High blood pressure (mother)	4.2	5.9	7.9	-2.6	1.1	-2.8	-2.8
Body mass index (BMI)	1.4	6.1	13.1	1.6	-2.3	1.8	3.6
Impedance of leg (left)	0.1	0.7	1.1	-0.9	-0.9	-1.0	0.0
Leg predicted mass (left)	0.4	2.1	3.3	1.8	1.0	1.8	1.0
Trunk fat mass	1.1	4.8	9.1	1.8	-1.9	1.9	3.0
Waist circumference	2.6	9.4	15.2	3.1	-1.6	3.2	3.9
Number of incorrect matches in round	0.4	0.7	1.5	-1.2	0.1	-1.2	-0.2
Past tobacco smoking	0.2	0.5	1.5	0.3	-0.4	0.3	1.2
Alcohol usually taken with meals	1.2	1.9	2.9	1.7	-0.6	1.6	1.3
Nervous feelings	0.2	0.3	0.7	-0.3	-0.8	-0.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.4	-0.4	-1.8	-0.3	-0.1
Hearing difficulty/problems with background noise	5.5	8.8	13.5	3.6	2.6	3.7	1.4
Hair/balding pattern: Pattern 2	1.4	1.8	4.3	1.0	0.6	1.2	2.1
Had menopause	1.0	1.3	2.5	0.8	1.1	0.8	-1.6
Had other major operations	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.2
Forced vital capacity (FVC)	0.3	1.1	2.5	0.5	1.6	0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.4	0.8	0.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.0	0.9	-0.9	1.0	1.0
Qualifications: None of the above	1.8	3.8	7.5	-2.7	-0.8	-2.6	0.7
Financial difficulties in last 2 years	3.6	4.9	6.3	2.4	-1.3	2.5	2.4
Mouth/teeth dental problems	1.2	1.9	4.5	-1.1	0.6	-1.2	-2.1
Heart attack	2.2	2.8	4.1	-2.0	-1.8	-1.9	-0.5
Allergy	3.0	6.8	11.9	-3.4	-1.0	-3.4	-1.7
Pain all over the body in last month	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.0
Diabetes (self-reported)	0.7	1.1	3.6	0.4	0.8	0.1	-1.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.1	1.0	-1.0	1.0	1.1
Medication: Ramipril	4.3	5.5	8.6	-2.8	0.1	-2.9	-2.3
Medication: Simvastatin	1.8	2.6	5.1	-2.1	-0.9	-2.3	-0.4
Fluid intelligence score	0.4	0.8	1.3	1.1	0.6	1.1	0.5
Illnesses of siblings	2.4	3.4	4.7	2.1	2.2	2.1	0.0
Neuroticism score	0.9	1.9	2.8	-1.7	-1.3	-1.5	-0.9
Weight	0.9	4.4	6.4	2.3	-0.7	2.4	2.5
Impedance of arm (right)	0.3	1.6	2.7	-1.2	0.5	-1.4	-1.6
Arm fat percentage (right)	1.2	4.7	8.6	1.4	-2.5	1.5	2.9
Trunk fat-free mass	0.3	1.5	2.3	1.4	1.5	1.3	-0.1
Hip circumference	0.7	3.0	4.5	2.0	-0.3	2.1	1.9
Time employed in main current job	1.0	1.1	1.5	1.2	1.2	1.2	0.5
Alcohol intake versus 10 years previously	0.6	1.0	1.7	-1.2	-0.5	-1.3	0.5
Father’s age at death	7.8	10.5	18.7	4.3	1.1	4.3	2.0
Worrier / anxious feelings	3.1	5.9	11.5	-3.4	-1.0	-3.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	8.8	0.5	-3.0	0.6	2.6
Falls in the last year	1.7	2.3	3.8	1.9	1.2	2.0	0.6
Hair/balding pattern: Pattern 3	3.3	4.9	8.3	-2.8	-0.3	-2.9	-1.9
Number of live births	1.6	2.2	3.4	-1.6	0.0	-1.9	-1.7
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.3	0.1	0.6	0.0	-0.6
Pulse rate	0.1	0.2	0.7	0.0	0.4	0.1	0.8
Happiness	0.0	0.0	0.0	0.1	0.1	0.0	0.2
Noisy workplace	0.3	0.3	0.7	-0.3	-0.6	-0.4	-0.8
Qualifications: A levels/AS levels or equivalent	2.1	4.6	8.1	2.8	-0.7	2.8	1.3
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	4.2	2.0	1.8	1.9	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-0.5	-0.7	-0.3	1.3
Asthma	0.8	1.7	2.6	1.6	-0.0	1.6	1.2
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.1	9.4	2.2	-0.8	2.3	3.1
Medication: Cholesterol lowering	3.3	5.2	7.8	-2.7	-2.0	-2.8	-1.2
Depression (self-reported)	1.2	1.4	5.0	0.5	0.2	0.7	2.2
Medication: Lansoprazole	1.2	1.4	2.2	-1.5	-1.1	-1.4	-0.1
Prospective memory result	1.6	2.0	3.7	-0.8	1.7	-0.8	-1.9
Lung cancer (father)	0.6	0.7	1.2	-0.8	-0.1	-0.8	-1.1
Illnesses of mother	2.2	2.7	4.9	1.7	0.3	1.8	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	-0.0	1.1	-0.1	-0.6
Pulse wave Arterial Stiffness index	3.8	4.5	6.3	-2.3	0.3	-2.5	-2.5
Impedance of arm (left)	0.3	1.4	2.0	-1.3	-0.1	-1.4	-1.4
Arm fat mass (right)	1.2	5.1	9.1	2.0	-1.8	2.1	3.0
Trunk predicted mass	0.3	1.5	2.4	1.4	1.5	1.3	-0.1
Standing height	0.5	5.0	12.3	1.5	3.5	1.4	-1.9
Length of working week for main job	0.8	0.9	1.9	0.9	-0.5	0.6	1.4
Exposure to tobacco smoke at home	2.4	2.7	4.7	-1.4	-2.2	-1.4	1.5
Breastfed as a baby	2.2	2.8	7.2	1.0	2.7	0.8	-1.5
Tense / ‘highly strung’	0.4	0.6	1.9	-0.3	-1.4	-0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.9	0.5	-0.4	0.7	1.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.5	-0.6	-0.7	-0.7	-0.2
Birth weight of first child	4.2	7.7	14.0	3.5	-0.6	3.7	2.1
Peak expiratory flow (PEF)	2.9	6.7	10.8	-3.3	-1.1	-3.3	-2.1
Pulse wave reflection index	1.5	1.9	3.0	-1.4	0.3	-1.6	-1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	-0.2	-0.8	-0.0	0.6
Loud music exposure frequency	0.0	0.0	0.0	-0.0	0.2	0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	4.9	7.8	14.8	3.8	-0.8	3.6	1.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.4	-0.5	0.3	0.7
Blood clot in the leg (DVT)	0.8	1.1	3.1	-0.4	-1.0	-0.2	1.7
Medication: Paracetamol	1.8	3.0	5.8	1.6	-0.6	1.8	2.4
Headache pain in last month	1.3	2.2	3.8	-2.0	-1.0	-1.8	0.8
Medication for cholesterol, blood pressure or diabetes	5.3	8.8	14.5	3.7	1.9	3.8	1.9
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	0.5	0.0	-0.4
Gout (self-reported)	1.3	1.7	2.5	-1.5	0.6	-1.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	0.6	-0.6	0.8	0.9
Medication: Amlodipine	2.3	3.2	5.5	-2.1	-0.0	-2.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.6	-0.8	-0.7	-0.8	-0.4
Birth weight	1.2	2.6	4.7	-1.6	0.8	-1.6	-2.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.7	1.2	0.8	1.3	1.0
High blood pressure (siblings)	3.4	4.8	7.7	-2.8	-2.0	-2.6	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.4	3.7	0.5	1.9	0.3	-1.2
Body fat percentage	1.5	5.8	11.4	1.2	-2.9	1.3	3.4
Leg fat percentage (right)	2.0	7.1	14.1	0.4	-3.7	0.6	3.8
Arm fat-free mass (right)	0.4	1.8	2.8	1.7	0.8	1.7	1.1
Exposure to tobacco smoke outside home	1.0	1.3	4.3	-0.5	-2.1	-0.4	0.8
Comparative body size at age 10	0.9	2.5	3.1	1.7	-1.1	1.7	1.7
Number of full brothers	1.6	2.0	3.0	1.7	0.3	1.7	1.5
Worry too long after embarrassment	0.1	0.2	0.4	0.3	0.6	0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.0	1.0	0.1	1.3	1.4
Wheeze or whistling in the chest in last year	1.7	3.0	4.9	1.7	-0.9	1.8	2.2
Number of children fathered	0.3	0.3	0.6	0.8	0.4	0.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	-1.1	-0.4	-1.4	-1.7
Age at first live birth	1.2	2.2	3.5	1.3	1.9	1.4	-1.2
Pulse wave peak to peak time	3.8	4.5	6.4	2.4	-0.1	2.5	2.4
Health satisfaction	1.3	1.7	3.1	1.8	-0.3	1.7	0.7
Shortness of breath walking on level ground	0.1	0.1	0.5	0.1	0.3	0.2	-0.7
Qualifications: College or University degree	1.9	6.1	8.8	3.0	2.7	2.9	-0.4
Eye problems/disorders: None of the above	0.3	0.4	1.1	-0.3	1.1	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.7	1.1	-0.9	1.1	2.2
Emphysema/chronic bronchitis	2.1	2.4	3.9	2.0	1.0	2.0	0.8
Medication for pain relief, constipation, heartburn	1.2	2.1	4.0	1.1	2.0	1.0	-1.5
Neck or shoulder pain in last month	1.1	1.6	2.0	1.4	-0.6	1.4	1.4
Medication: Blood pressure	7.6	13.4	22.5	-4.5	-2.2	-4.7	-2.3
Angina (self-reported)	1.3	1.7	5.0	-1.1	-2.2	-0.9	-0.3
Migraine (self-reported)	0.7	0.9	1.2	-1.1	0.5	-1.0	-1.0
Medication: Ibuprofen	2.7	3.2	5.7	1.8	-0.7	1.9	2.4
Medication: Allopurinol	1.4	1.8	3.0	-1.3	0.8	-1.4	-1.7
Medication: Omeprazole	1.1	1.3	2.4	-1.5	-0.9	-1.5	-0.2
Medication: Seretide 50 evohaler	1.4	1.6	6.0	-0.1	-2.4	-0.4	0.4
Mean time to correctly identify matches	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1
Heart disease (mother)	1.7	2.0	3.3	-1.8	-0.7	-1.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.7	0.5	0.6	-0.3
Whole body fat mass	1.2	4.9	9.6	1.7	-1.9	1.8	3.1
Leg fat mass (right)	1.3	4.9	11.0	1.3	-2.2	1.4	3.3
Arm predicted mass (right)	0.4	2.2	3.7	1.9	0.8	1.9	1.1
Pulse rate, automated reading	0.9	3.1	6.6	-1.5	-1.2	-1.4	2.6
Alcohol intake frequency.	3.0	6.9	13.8	-3.7	-0.3	-3.6	-1.0
Comparative height size at age 10	0.7	3.6	6.8	-0.8	2.6	-1.0	-2.5
Number of full sisters	0.5	0.6	2.3	-0.5	-1.5	-0.3	0.2
Suffer from ‘nerves’	1.0	1.6	3.2	0.9	-1.1	1.0	1.8
Overall health rating	1.0	2.1	4.6	-0.7	-2.1	-0.7	1.7
Chest pain or discomfort	1.7	2.5	4.3	1.1	-1.7	1.2	2.1
Had major operations	0.7	0.8	2.9	-0.0	-1.7	-0.2	0.5
Age at last live birth	1.1	1.6	5.6	0.1	0.8	-0.1	-2.4
Family relationship satisfaction	1.1	1.3	2.3	1.5	0.3	1.4	0.8
Leg pain on walking	0.4	0.5	1.0	1.0	-0.0	1.0	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	0.3	1.0	0.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	0.3	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	3.9	-2.0	0.6	-1.8	0.4
Medication: Aspirin	2.1	2.8	4.8	-2.2	-1.3	-2.2	-0.5
Supplements: Vitamin C	1.7	2.1	4.3	1.4	2.1	1.4	0.1
Knee pain experienced in last month	1.7	2.6	4.1	2.0	0.3	2.0	1.5
Hypertension (Self-reported)	11.4	31.8	56.0	-7.3	-1.4	-7.5	-3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.8	-1.0	-0.8	-0.3
Illnesses of father: Heart disease	3.4	4.8	6.5	-2.5	-2.1	-2.5	-1.4
Illnesses of siblings: Diabetes	0.6	0.7	1.1	-1.0	-0.7	-1.0	0.5
Smoking status: Previous	0.4	0.5	0.9	0.5	0.9	0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.0	1.7	-0.2	1.7	0.7
Whole body fat-free mass	0.4	2.3	3.4	1.9	1.5	1.8	0.4
Leg fat-free mass (right)	0.6	3.2	5.0	2.2	1.4	2.2	1.1
Arm fat percentage (left)	1.5	5.8	11.5	1.3	-2.9	1.4	3.4
Average weekly red wine intake	7.4	11.0	21.6	4.7	0.1	4.6	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.2	-0.3	-1.5	-0.2	1.0
Mood swings	3.6	6.6	13.4	-3.7	-1.1	-3.4	-0.0
Loneliness, isolation	0.4	0.6	1.1	-1.1	-0.3	-1.0	-0.4
Long-standing illness, disability or infirmity	2.8	4.2	12.1	0.1	-3.5	0.1	2.2
Ever had bowel cancer screening	3.8	4.5	7.2	2.6	1.9	2.7	-0.4
Diabetes diagnosed by doctor	0.5	0.8	2.8	0.3	0.5	0.0	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	0.9	0.4	0.8	0.2
Friendships satisfaction	1.6	2.0	3.2	1.8	1.4	1.7	0.1
Qualifications: nursing, teaching	1.7	2.6	5.3	2.3	0.6	2.1	0.1
Commuting to job workplace: Walk	0.3	0.3	0.7	0.4	-0.9	0.4	-0.2
Eye problems/disorders: Cataract	0.7	0.8	1.8	0.3	-1.3	0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.3	-0.1	0.5	-0.1
Medication for cholesterol	4.5	6.9	12.7	3.6	1.3	3.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.0	-1.3	-1.7	-1.2	0.6
Back pain experienced in last month	1.6	2.3	4.0	2.0	-0.8	1.8	1.1
Mineral and other dietary supplements	4.4	5.9	11.1	-3.3	-1.4	-3.2	-0.7
Breast cancer (self-reported)	1.4	1.6	2.8	1.7	0.7	1.6	0.8
Asthma (self-reported)	0.8	1.6	2.3	1.4	-0.5	1.4	1.5
Osteoporosis (self-reported)	0.3	0.4	1.4	-0.0	-0.1	-0.3	-1.2
Osteoarthritis (self-reported)	4.2	5.4	6.5	2.3	-2.1	2.4	2.5
Medication: Aspirin	4.1	5.3	9.4	-3.0	-1.4	-3.1	-0.8
Medication: Gliclazide	0.1	0.1	0.2	-0.0	0.1	-0.1	0.5
Illnesses of father: None of the above (group 1)	1.8	2.3	6.0	1.0	2.5	1.2	-0.7
Smoking status: Current	2.6	4.2	7.3	-2.7	-0.2	-2.6	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	0.5	1.0	0.4	-0.3
Whole body water mass	0.3	1.9	2.8	1.7	1.4	1.6	0.6
Leg predicted mass (right)	0.5	2.9	4.4	2.1	1.3	2.1	1.0
Arm fat mass (left)	1.3	5.2	10.3	1.7	-2.0	1.9	3.2
Number of self-reported non-cancer illnesses	2.1	3.7	5.9	-2.4	-1.8	-2.4	-0.0
Average weekly champagne plus white wine intake	2.4	3.3	5.4	2.3	0.6	2.3	1.5
Miserableness	0.6	1.0	1.9	-0.2	-1.4	0.1	1.4
Guilty feelings	0.3	0.4	0.8	-0.9	-0.2	-0.7	-0.4
Wears glasses or contact lenses	0.8	0.9	3.0	0.5	1.7	0.4	-0.5
Ever taken oral contraceptive pill	2.9	3.2	5.4	2.3	0.5	2.2	1.6
Hearing aid user	1.0	1.1	2.1	0.7	-1.0	0.9	1.5
Mother’s age at death	1.0	1.3	3.0	-0.2	1.4	-0.2	-1.7
Financial situation satisfaction	1.4	1.8	2.9	1.7	0.4	1.6	1.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.9	0.1	-0.8	0.3
Commuting to job workplace: Public transport	0.9	1.1	2.0	1.2	0.5	1.4	0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.5	0.2	-0.7	-0.5
Medication: Blood pressure	10.9	20.8	39.6	-6.3	-0.4	-6.2	-2.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	1.1	-0.4	1.0	0.4
Supplements: Fish oil (including cod liver oil)	1.8	2.3	4.1	2.0	1.3	1.9	-0.1
High cholesterol (Self-reported)	0.5	1.0	1.4	-1.0	-0.6	-1.0	-1.2
Medication: Bendroflumethiazide	6.5	9.9	19.8	-4.5	-0.7	-4.3	-0.9
Medication: Paracetamol	1.3	2.0	3.6	1.3	-0.9	1.4	1.9
Medication: Lisinopril	6.7	8.6	16.6	-4.0	-1.1	-4.1	-1.0
Medication: Atorvastatin	0.9	1.1	2.4	-0.7	-1.0	-0.7	-1.5
Illnesses of father: High blood pressure	2.1	2.6	6.0	-1.0	1.4	-1.2	-2.4
Alcohol drinker status: Never	1.2	1.4	2.8	-1.7	-0.4	-1.6	0.0
Ever smoked	0.5	0.8	1.4	-0.8	0.8	-0.7	-1.2
Basal metabolic rate	0.4	2.3	3.6	1.9	0.9	1.9	1.1
Leg fat percentage (left)	2.0	7.1	15.4	0.9	-3.3	1.1	3.9
Arm fat-free mass (left)	0.5	2.4	3.6	1.9	1.3	1.9	1.0
Number of operations (self-reported)	0.8	1.2	2.7	0.7	-1.6	0.6	1.1
Average weekly beer plus cider intake	3.0	4.4	7.7	-2.6	0.7	-2.8	-1.6
Irritability	0.3	0.5	0.9	0.6	0.3	0.7	-0.9
Risk taking	0.8	1.2	2.1	1.5	0.3	1.4	0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.5	0.4	0.5	-0.2
Fractured/broken bones in last 5 years	2.7	3.4	7.1	1.7	2.7	1.9	-0.1
Age started oral contraceptive pill	2.8	3.5	5.1	2.1	2.1	2.2	0.4
Diastolic blood pressure, automated reading	16.9	52.5	89.1	-9.3	-1.3	-9.4	-5.6
Ever depressed for a whole week	1.0	1.2	3.3	0.7	0.7	0.9	1.8
Unable to work because of sickness or disability	0.8	1.0	2.3	-0.8	-1.5	-0.7	0.9
Commuting to job workplace: Cycle	0.8	1.0	1.6	1.0	0.6	1.0	-1.3
Myopia	0.1	0.2	0.5	-0.2	0.5	-0.2	-0.7
Vascular/heart problems diagnosed by doctor	13.5	36.9	65.3	8.1	1.6	8.1	3.8
Cholesterol lowering medication	0.3	0.5	0.8	-0.7	0.1	-0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	-1.3	-1.0	-1.2	0.2
Pain experienced in last month	0.8	1.3	3.2	-0.6	1.1	-0.5	-1.8
Supplements: Calcium	0.9	1.0	1.7	0.9	1.3	1.0	0.6
Basal cell carcinoma (self-reported)	2.6	3.1	5.3	2.3	1.2	2.3	0.6
Heart attack/myocardial infarction (self-reported)	2.1	2.7	4.2	-2.0	-1.7	-1.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.6	-0.2	-0.8	-0.0	1.9
Heart disease (siblings)	1.0	1.2	2.1	-1.4	-1.0	-1.4	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.2	0.0	0.3	0.1	0.5
Pack years of smoking	0.2	0.3	0.6	-0.8	0.5	-0.8	-0.0
Impedance of whole body	0.2	1.0	1.6	-1.2	-0.2	-1.3	-1.0
Leg fat mass (left)	1.4	5.5	12.5	1.7	-1.9	1.8	3.5
Arm predicted mass (left)	0.4	2.2	3.4	1.8	0.9	1.8	1.2