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chr1:242,590,540-244,359,621

Best TWAS P=6.74e-11 · Best GWAS P=8.19e-11 conditioned to 0.328

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SDCCAG8	0.18	0.10	enet	25	0.11	1.4e-09	6.2	6.1	1.1e-09	0.86	0.04	0.96	FALSE
2	GTEx	Artery Aorta	SDCCAG8	0.21	0.06	enet	21	0.09	8.9e-06	6.5	6.1	1.1e-09	0.91	0.02	0.98	FALSE
3	GTEx	Artery Tibial	SDCCAG8	0.14	0.02	lasso	3	0.03	1.9e-03	5.8	6.0	2.1e-09	0.93	0.02	0.97	FALSE
4	GTEx	Breast Mammary Tissue	SDCCAG8	0.15	0.04	enet	13	0.09	2.8e-05	5.0	5.6	1.7e-08	0.85	0.03	0.96	FALSE
5	GTEx	Breast Mammary Tissue	CEP170	0.16	0.09	enet	19	0.08	1.0e-04	6.4	5.7	1.1e-08	0.87	0.01	0.98	FALSE
6	GTEx	Breast Mammary Tissue (Female)	CEP170	0.26	0.04	lasso	4	0.09	1.5e-03	6.4	5.4	5.2e-08	0.90	0.02	0.85	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	SDCCAG8	0.36	0.24	lasso	8	0.34	5.7e-12	4.4	6.1	8.7e-10	0.86	0.03	0.97	FALSE
8	GTEx	Cells Transformed fibroblasts	SDCCAG8	0.23	0.25	enet	13	0.28	3.5e-21	6.2	6.5	6.7e-11	0.95	0.02	0.98	TRUE
9	GTEx	Cells Transformed fibroblasts	CEP170	0.21	0.17	enet	15	0.19	5.3e-14	6.2	6.1	8.0e-10	0.90	0.03	0.97	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-261C10.5	0.15	0.13	lasso	2	0.14	2.2e-10	6.2	6.2	5.5e-10	0.89	0.04	0.96	FALSE
11	GTEx	Colon Transverse	SDCCAG8	0.17	0.02	lasso	3	0.02	2.8e-02	6.2	5.9	3.9e-09	0.89	0.04	0.86	FALSE
12	GTEx	Esophagus Mucosa	SDCCAG8	0.17	0.15	lasso	4	0.15	3.3e-10	6.4	6.4	1.5e-10	0.97	0.01	0.99	FALSE
13	GTEx	Esophagus Muscularis	CEP170	0.09	0.11	lasso	4	0.10	1.2e-06	6.5	6.5	1.1e-10	0.97	0.01	0.99	FALSE
14	GTEx	Heart Atrial Appendage	SDCCAG8	0.14	0.06	lasso	7	0.06	1.6e-03	6.5	6.3	2.8e-10	0.95	0.02	0.96	FALSE
15	GTEx	Nerve Tibial	SDCCAG8	0.25	0.27	enet	14	0.27	2.3e-19	3.8	5.2	2.6e-07	0.85	0.84	0.16	FALSE
16	GTEx	Nerve Tibial	CEP170	0.09	0.08	lasso	1	0.05	1.1e-04	6.4	6.4	1.3e-10	0.97	0.01	0.98	FALSE
17	GTEx	Prostate	CEP170	0.28	0.05	lasso	4	0.12	6.9e-04	6.2	5.5	2.9e-08	0.79	0.02	0.81	FALSE
18	GTEx	Whole Blood	SDCCAG8	0.18	0.15	lasso	7	0.14	6.2e-13	5.9	6.3	2.4e-10	0.91	0.06	0.94	FALSE
19	METSIM	Adipose	SDCCAG8	0.12	0.13	enet	17	0.14	5.6e-21	6.2	6.2	6.1e-10	0.92	0.06	0.94	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SDCCAG8	0.09	0.04	blup	114	0.08	4.6e-07	6.2	6.1	1.3e-09	0.75	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP170	0.03	0.03	enet	4	0.02	7.9e-04	6.2	6.2	4.8e-10	0.88	0.03	0.91	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG8	0.06	0.02	blup	114	0.04	1.9e-05	-2.8	5.4	5.9e-08	0.70	0.13	0.83	FALSE
23	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP170	0.08	0.06	enet	7	0.06	2.0e-03	6.2	5.6	2.1e-08	0.85	0.02	0.46	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SDCCAG8	0.19	0.18	lasso	5	0.16	1.9e-07	5.9	5.6	2.5e-08	0.82	0.06	0.94	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP170	0.03	0.01	lasso	4	0.02	4.4e-03	-2.2	5.4	7.6e-08	0.78	0.01	0.67	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG8	0.10	0.05	lasso	4	0.06	5.8e-07	-3.9	5.7	1.1e-08	0.67	0.25	0.74	FALSE
27	The Cancer Genome Atlas	Rectum Adenocarcinoma	SDCCAG8	0.30	0.06	blup	113	0.12	8.0e-04	6.5	6.4	1.4e-10	0.86	0.01	0.90	FALSE