Best TWAS P=1.41e-11 · Best GWAS P=6.89e-11 conditioned to 0.506
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ADAMTSL4 | 0.17 | 0.14 | lasso | 4 | 0.10 | 3.7e-06 | 6.5 | -6.5 | 8.2e-11 | -0.94 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-54A4.2 | 0.12 | 0.13 | lasso | 2 | 0.11 | 7.7e-07 | 6.5 | -6.5 | 9.8e-11 | -0.95 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | ADAMTSL4 | 0.10 | 0.06 | lasso | 4 | 0.08 | 6.4e-07 | 6.5 | -6.5 | 9.5e-11 | -0.93 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-54A4.2 | 0.10 | 0.07 | lasso | 4 | 0.09 | 1.3e-07 | 6.5 | -6.3 | 3.8e-10 | -0.90 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | ADAMTSL4 | 0.08 | 0.01 | lasso | 4 | 0.01 | 2.6e-02 | 6.5 | -6.4 | 1.8e-10 | -0.91 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-54A4.2 | 0.08 | 0.01 | lasso | 8 | 0.02 | 1.8e-02 | 5.5 | -5.8 | 6.2e-09 | -0.79 | 0.03 | 0.95 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ECM1 | 0.14 | 0.10 | lasso | 10 | 0.12 | 2.2e-08 | 6.5 | -6.8 | 1.4e-11 | -0.93 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Esophagus Mucosa | ADAMTSL4 | 0.40 | 0.40 | lasso | 5 | 0.41 | 5.8e-29 | 6.5 | -6.7 | 2.6e-11 | -0.97 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RP11-54A4.2 | 0.35 | 0.33 | enet | 15 | 0.34 | 1.6e-23 | 6.5 | -6.7 | 2.7e-11 | -0.96 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Muscle Skeletal | TARS2 | 0.11 | 0.09 | lasso | 1 | 0.07 | 8.5e-08 | 5.5 | 5.5 | 4.3e-08 | 0.69 | 0.44 | 0.56 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | MRPS21 | 0.09 | 0.06 | lasso | 3 | 0.06 | 2.6e-04 | 6.5 | -6.5 | 7.0e-11 | -0.91 | 0.01 | 0.97 | FALSE |
| 12 | GTEx | Thyroid | MRPS21 | 0.21 | 0.22 | lasso | 7 | 0.24 | 2.2e-18 | 5.5 | -5.4 | 7.7e-08 | -0.69 | 0.52 | 0.48 | FALSE |
| 13 | METSIM | Adipose | MRPS21 | 0.06 | 0.07 | lasso | 7 | 0.06 | 5.1e-10 | 5.4 | -5.3 | 1.0e-07 | -0.68 | 0.53 | 0.47 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C1orf54 | 0.06 | 0.02 | blup | 17 | 0.03 | 2.5e-03 | -4.7 | 5.2 | 1.6e-07 | 0.54 | 0.00 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADAMTSL4 | 0.11 | 0.07 | lasso | 4 | 0.07 | 1.2e-08 | 6.5 | -6.4 | 1.6e-10 | -0.93 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ECM1 | 0.04 | 0.04 | blup | 26 | 0.04 | 4.9e-05 | 6.5 | -6.0 | 1.7e-09 | -0.83 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAMTSL4 | 0.12 | 0.09 | lasso | 5 | 0.09 | 6.0e-06 | 6.5 | -6.1 | 1.1e-09 | -0.90 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADAMTSL4 | 0.07 | 0.05 | blup | 33 | 0.05 | 5.6e-06 | 6.5 | -5.8 | 5.6e-09 | -0.79 | 0.00 | 1.00 | FALSE |